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公开(公告)号：WO2017015463A2
公开(公告)日：2017-01-26
申请号：PCT/US2016/043348
申请日：2016-07-21
申请人： MODERNATX, INC.
CPC分类号： A61K9/0019 , A61K9/5123 , A61K39/12 , A61K2039/505 , A61K2039/5252 , A61K2039/53 , A61K2039/543 , A61K2039/6056 , C07K14/005 , C07K16/1081 , C07K16/2851 , C07K2317/33 , C07K2317/76 , C12N2770/24122 , C12N2770/24123 , C12N2770/24134 , C12N2770/36122 , C12N2770/36123 , C12N2770/36134 , Y02A50/383 , Y02A50/386 , Y02A50/39 , Y02A50/392
摘要： Aspects of the disclosure relate to nucleic acid vaccines. The vaccines include one or more RNA polynucleotides having an open reading frame encoding one or more Chikungunya antigen(s), one or more Zika virus antigens, and one or more Dengue antigens. Methods for preparing and using such vaccines are also described.
摘要翻译： 本公开的方面涉及核酸疫苗。 疫苗包括一种或多种具有编码一种或多种基孔肯雅抗原，一种或多种Zika病毒抗原和一种或多种登革热抗原的开放阅读框的RNA多核苷酸。 还描述了制备和使用这种疫苗的方法。
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2.发明申请RECOMBINANT MEASLES VIRUS EXPRESSING CHIKUNGUNYA VIRUS POLYPEPTIDES AND THEIR APPLICATIONS 审中-公开CHIKUNGUNYA VIRUS POLYPEPTIDES的重组测量病毒及其应用
公开(公告)号：WO2014049094A1
公开(公告)日：2014-04-03
申请号：PCT/EP2013/070137
申请日：2013-09-26
CPC分类号： A61K39/12 , A61K38/00 , A61K2039/5254 , A61K2039/5256 , A61K2039/5258 , A61K2039/70 , C07K14/005 , C12N7/00 , C12N15/86 , C12N2760/18421 , C12N2760/18434 , C12N2760/18443 , C12N2760/18444 , C12N2770/36122 , C12N2770/36123 , C12N2770/36134 , Y02A50/383
摘要： The invention relates to recombinant Measles virus expressing Chikungunya virus polypeptides, and concerns in particular virus like particles (VLP) that contain envelope and capsid proteins of a Chikungunya virus at their surface. These particles are recombinant infectious particles able to replicate in a host after an administration. The invention provides means, in particular nucleic acids, vectors, cells and rescue systems to produce these recombinant infectious particles. The invention also relates to the use of these recombinant infectious particles, in particular under the form of a composition, more particularly in a vaccine formulation, for the treatment or prevention of an infection by Chikungunya virus.
摘要翻译： 本发明涉及表达基孔肯雅病毒多肽的重组麻疹病毒，特别涉及其表面上包含基孔肯雅病毒的包膜和衣壳蛋白的病毒样颗粒（VLP）。 这些颗粒是能够在给药后在宿主中复制的重组感染性颗粒。 本发明提供了手段，特别是核酸，载体，细胞和营养系统以产生这些重组感染性颗粒。 本发明还涉及这些重组感染性颗粒，特别是组合物形式，更具体地在疫苗制剂中用于治疗或预防基孔肯雅病毒感染的用途。
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公开(公告)号：WO2004071492A1
公开(公告)日：2004-08-26
申请号：PCT/NL2004/000101
申请日：2004-02-11
申请人： BESTEWIL HOLDING B.V. , HUCKRIEDE, Anke, Luise, Wilhelmine , DE JONGE, Jørgen, Martin , STEGMANN, Antonius, Johannes, Hendrikus , SCHOEN, Pieter, Joseph , WILSCHUT, Jan, Christiaan
发明人： HUCKRIEDE, Anke, Luise, Wilhelmine , DE JONGE, Jørgen, Martin , STEGMANN, Antonius, Johannes, Hendrikus , SCHOEN, Pieter, Joseph , WILSCHUT, Jan, Christiaan
IPC分类号： A61K9/127
CPC分类号： A61K9/127 , A61K9/1271 , A61K39/12 , A61K39/145 , A61K39/39 , A61K2039/5258 , A61K2039/55516 , A61K2039/55555 , C12N2760/16122 , C12N2760/16123 , C12N2760/16134 , C12N2770/36122 , C12N2770/36123
摘要： The invention relates to the production of virosome-like-particles. The invention provides a method for producing a virosome-like-particle comprising contacting an enveloped virus with a solution containing a short-chain phospholipid allowing solubilisation of the viral envelope of said virus further comprising removing short-chain phospholipid from said solution allowing formation of a functionally reconstituted viral envelope.
摘要翻译： 本发明涉及病毒颗粒状颗粒的生产。 本发明提供了一种用于生产病毒颗粒样颗粒的方法，包括使包膜病毒与含有短链磷脂的溶液接触，所述溶液允许溶解所述病毒的病毒包膜，进一步包括从所述溶液中除去短链磷脂，形成 功能重建的病毒包膜。
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4.发明申请CANCER IMMUNOTHERAPY BY DELIVERING CLASS II MHC ANTIGENS USING A VLP-REPLICON 审中-公开通过使用VLP-REPLICON递送II类MHC抗原来进行癌症免疫治疗
公开(公告)号：WO2015095167A2
公开(公告)日：2015-06-25
申请号：PCT/US2014070552
申请日：2014-12-16
IPC分类号： A61K39/00
CPC分类号： C12N15/86 , A61K39/0011 , A61K39/12 , A61K45/06 , A61K2039/5258 , A61K2039/53 , A61K2039/585 , C12N7/00 , C12N2740/11023 , C12N2740/11042 , C12N2770/36123 , C12N2770/36134 , C12N2770/36143 , C12N2770/36145 , C12N2770/36152 , C12N2770/36171 , C12N2800/24 , C12N2810/6081
摘要： Described herein is a method of preventing or treating a disease in a mammalian subject, comprising administering to the subject who is in need thereof an effective dosage of a pharmaceutical composition comprising a virus like particle (VLP) comprising: an alphavirus replicon comprising a recombinant polynucleotide, wherein the polynucleotide comprises a sequence encoding both subunits of a human class II major histocompatibility antigen, a retroviral gag protein, and a fusogenic envelope protein, wherein the VLP does not contain an alphavirus structural protein gene.
摘要翻译： 本文描述了一种预防或治疗哺乳动物受试者的疾病的方法，其包括向有需要的受试者施用有效剂量的包含病毒样颗粒（VLP）的药物组合物，其包含：包含重组多核苷酸的甲病毒复制子 其中所述多核苷酸包含编码人类II主要组织相容性抗原的两个亚基的序列，逆转录病毒gag蛋白和融合包膜蛋白，其中所述VLP不含有甲病毒属结构蛋白基因。
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5.发明申请
公开(公告)号：WO2015005500A1
公开(公告)日：2015-01-15
申请号：PCT/JP2014/069122
申请日：2014-07-11
发明人： AKAHATA, Wataru , UENO, Ryuji
IPC分类号： C12N7/00
CPC分类号： C07K14/70503 , A61K39/00 , A61K39/0011 , A61K39/12 , A61K2039/5256 , A61K2039/5258 , C07K14/005 , C07K14/705 , C07K14/70596 , C07K2319/40 , C07K2319/735 , C12N7/00 , C12N2770/36122 , C12N2770/36123 , C12N2770/36134
摘要： The present invention provides a virus like particle comprising a virus structural protein and an antigen derived from PD-1 or a ligand of PD-1, and a composition or kit comprising thereof, its use in immune response etc.
摘要翻译： 本发明提供了包含病毒结构蛋白和衍生自PD-1或PD-1配体的抗原的病毒样颗粒及其组合物或试剂盒，其在免疫应答等中的用途。
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公开(公告)号：WO2013122262A1
公开(公告)日：2013-08-22
申请号：PCT/JP2013/054422
申请日：2013-02-15
发明人： UENO, Ryuji , AKAHATA, Wataru
IPC分类号： C07K19/00 , A61K39/00 , A61P35/00 , A61P37/00 , C07K14/18 , C07K14/525 , C07K14/705 , C12N15/09 , C12P21/08
CPC分类号： C07K14/005 , A61K39/0005 , A61K39/0008 , A61K39/0011 , A61K2039/5256 , A61K2039/5258 , A61K2039/53 , C07K14/525 , C07K14/70521 , C07K14/70596 , C07K2319/00 , C07K2319/735 , C12N7/00 , C12N2770/24122 , C12N2770/36122 , C12N2770/36123 , C12N2770/36134 , C12N2770/36143
摘要： The present invention provides a particle comprising a polypeptide and at least one antigen, and a composition comprising thereof.
摘要翻译： 本发明提供包含多肽和至少一种抗原的颗粒及其组合物。
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7.发明申请
公开(公告)号：WO2012172574A1
公开(公告)日：2012-12-20
申请号：PCT/IN2012/000432
申请日：2012-06-18
CPC分类号： A61K39/12 , A61K2039/5252 , A61K2039/55505 , A61K2039/55566 , A61K2039/55583 , A61K2039/70 , C12N2770/24134 , C12N2770/36121 , C12N2770/36122 , C12N2770/36123 , C12N2770/36134 , G01N2333/181 , G01N2333/185 , G01N2469/20 , G01N2800/26 , Y02A50/383 , Y02A50/39
摘要： A vaccine composition for prophylaxis and treatment of Chikungunya virus infections is disclosed which is capable of conferring immunity against any genotypic variants of the Chikungunya virus. More particularly the invention discloses particular nucleotide sequences and their translated proteins thereof, which may be expressed as Virus Like Paricles which for use as a vaccine antigens against Chikungunya virus infections. The compositions disclosed in this invention are also protective against any genotypic variants of the Chikungunya virus which may be propagated by any suitable vector of the disease including Aedis albopictus and Aedis aegypti
摘要翻译： 公开了用于预防和治疗基孔肯雅病毒感染的疫苗组合物，其能够赋予对基孔肯雅病毒的任何基因型变体的免疫力。 更具体地，本发明公开了特定的核苷酸序列及其翻译的蛋白质，其可以表达为病毒样细胞，其用作针对基孔肯雅病毒感染的疫苗抗原。 本发明公开的组合物还可以防止可以通过任何合适的疾病载体繁殖的基孔肯雅病毒的基因型变异体，包括白纹伊蚊（Aedis albopictus）和埃及伊蚊
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公开(公告)号：WO2012106356A2
公开(公告)日：2012-08-09
申请号：PCT/US2012/023361
申请日：2012-01-31
申请人： GOVERNMENT OF THE USA, as represented by THE SECRETARY, DEPARTMENT OF HEALTH & HUMAN SERVICES , NABEL, Gary, J. , AKAHATA, Wataru
发明人： NABEL, Gary, J. , AKAHATA, Wataru
IPC分类号： C12N7/00
CPC分类号： C07K14/005 , A61K39/12 , A61K2039/5258 , A61K2039/53 , A61K2039/55566 , A61K2039/575 , C12N7/00 , C12N2770/36122 , C12N2770/36123 , C12N2770/36134 , C12N2770/36151
摘要： The invention features modified alphavirus or flavivirus virus-like particles (VLPs). The invention provides methods, compositions, and kits featuring the modified VLPs. The invention also features methods for enhancing production of modified VLPs for use in the prevention or treatment of alphavirus and flavivirus-mediated diseases. The invention also provides methods for delivering agents to a cell using the modified VLPs.
摘要翻译： 本发明的特征在于修饰的甲病毒病毒或黄病毒病毒样颗粒（VLPs）。 本发明提供了具有修饰的VLP的方法，组合物和试剂盒。 本发明还涉及用于增强用于预防或治疗甲病毒和黄病毒介导的疾病的修饰的VLP的产生的方法。 本发明还提供了使用经修改的VLP将药剂递送至细胞的方法。
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公开(公告)号：WO2014196648A1
公开(公告)日：2014-12-11
申请号：PCT/JP2014/065166
申请日：2014-06-02
发明人： UENO, Ryuji , AKAHATA, Wataru
IPC分类号： C12N15/09 , A61K39/015 , C07K14/18 , C07K14/445 , C07K19/00 , C12N7/00
CPC分类号： A61K39/015 , A61K38/162 , A61K39/12 , A61K39/193 , A61K2039/5258 , C07K14/005 , C07K14/445 , C07K2319/85 , C12N2770/36034 , C12N2770/36123 , C12N2770/36134 , Y02A50/412 , A61K2300/00
摘要： The present invention provides a particle comprising a polypeptide and at least one malaria antigen, and a composition or vaccine comprising thereof, its use in medicine, particularly in the prevention or treatment of malaria infections.
摘要翻译： 本发明提供了包含多肽和至少一种疟疾抗原的颗粒及其组合物或疫苗，其在医学中的用途，特别是在预防或治疗疟疾感染中。
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公开(公告)号：WO2013148302A1
公开(公告)日：2013-10-03
申请号：PCT/US2013/031876
申请日：2013-03-15
CPC分类号： C12N7/00 , A61K35/76 , A61K38/1774 , A61K48/0066 , C12N15/113 , C12N15/86 , C12N2310/11 , C12N2310/141 , C12N2320/32 , C12N2740/11022 , C12N2740/11023 , C12N2740/11042 , C12N2740/11051 , C12N2740/13022 , C12N2740/13051 , C12N2770/36123 , C12N2770/36143 , C12N2770/36145 , C12N2770/36152 , C12N2800/24 , C12N2810/6081
摘要： Described herein are compositions relating to alphavirus-based virus-like particles (VLPs) and methods for making and using the described VLPs. The described compositions include VLPs and vectors and cells used to produce the VLPs. Also included are related methods to produce the VLPs, to transduce cells using the VLPs, and to produce a protein or polynucleotide of interest in a target cell using the VLPs. Also described are alphavirus-based replicons that allow for expression of proteins or polynucleotides of interest in a target cell without a cytopathic effect.
摘要翻译： 本文描述了与基于甲病毒病毒的病毒样颗粒（VLP）有关的组合物以及制备和使用所描述的VLP的方法。 所描述的组合物包括用于产生VLP的VLP和载体和细胞。 还包括产生VLP的相关方法，使用VLP转导细胞，以及使用VLP在靶细胞中产生感兴趣的蛋白质或多核苷酸。 还描述了基于甲病毒病毒的复制子，其允许在目标细胞中表达目的蛋白质或多核苷酸而没有细胞病变效应。
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