公开(公告)号：WO1994019023A1

公开(公告)日：1994-09-01

申请号：PCT/US1993001579

申请日：1993-02-19

Applicant: ISIS PHARMACEUTICALS, INC.

Inventor： ISIS PHARMACEUTICALS, INC. ,  COOK, Phillip, Dan ,  BASCHANG, Gerhard

IPC: A61K48/00

CPC classification number: C07D473/00 ,  A61K38/00 ,  C07D473/34 ,  C07F7/1804 ,  C07F9/65616 ,  C07H21/00 ,  C12N15/113 ,  C12N15/1133 ,  C12N15/1137 ,  C12N2310/323 ,  C12Y113/11012

Abstract: Oligonucleotide surrogates comprising a plurality of cyclobutyl moieties covalently joined by linking moieties are prepared and used as antisense diagnostics, therapeutics and research reagents. Methods of synthesis and use of both the oligonucleotide surrogates and intermediates thereof are disclosed.

Abstract translation: 制备包含通过连接部分共价连接的多个环丁基部分的寡核苷酸替代物，并用作反义诊断，治疗和研究试剂。 公开了寡核苷酸替代物及其中间体的合成和使用方法。

公开(公告)号：WO1991016901A1

公开(公告)日：1991-11-14

申请号：PCT/US1991002628

申请日：1991-04-17

Applicant: ISIS PHARMACEUTICALS, INC. ,  BENNETT, Clarence, Frank ,  ECKER, David, J. ,  CROOKE, Stanely, T. ,  MIRABELLI, Christopher, K.

Inventor： ISIS PHARMACEUTICALS, INC.

IPC: A61K31/70

CPC classification number: C12N15/1137 ,  C12N9/0006 ,  C12N2310/15 ,  C12N2310/315 ,  C12Q1/68 ,  C12Q1/6839 ,  C12Q1/6883 ,  C12Q2600/158 ,  C12Y113/11012 ,  C12Y301/01004 ,  C12Y301/04003 ,  C12Y303/02006 ,  G01N33/88

Abstract: Compositions and methods are provided for the treatment and diagnosis of diseases amenable to modulation of the synthesis or metabolism of arachidonic acid and related compounds. In accordance with preferred embodiments, oligonucleotides and oligonucleotide analogs are provided which are specifically hybridizable with nucleic acids encoding 5-lipoxygenase, 5-lipoxygenase activating proteins, LTA4 hydrolase, phospholipase A2, phospholipase C, and coenzyme A-independent transacylase. The oligonucleotide comprises nucleotide units sufficient in identity and number to effect said specific hybridization. In other preferred embodiments, the oligonucleotides are specifically hybridizable with a transcription initiation site, a translation initiation site, and intron/exon junction. Methods of treating animals suffering from disease amenable to therapeutic intervention by modulating arachidonic acid synthesis or metabolism with an oligonucleotide or oligonucleotide analog specifically hybridizable with RNA or DNA corresponding to one of the foregoing proteins are disclosed. Methods for treatment of diseases responding to modulation of arachidonic acid synthesis or metabolism are disclosed.

Abstract translation: 提供组合物和方法用于治疗和诊断适于调节花生四烯酸和相关化合物的合成或代谢的疾病。 根据优选实施方案，提供寡核苷酸和寡核苷酸类似物，其与编码5-脂氧合酶，5-脂氧合酶活化蛋白，LTA4水解酶，磷脂酶A2，磷脂酶C和辅酶A非转基因酶的核酸特异性杂交。 所述寡核苷酸包含足以实现所述特异性杂交的同一性和数目的核苷酸单元。 在其它优选的实施方案中，寡核苷酸与转录起始位点，翻译起始位点和内含子/外显子连接区特异性杂交。 公开了通过用与上述蛋白质之一相对应的RNA或DNA特异性杂交的寡核苷酸或寡核苷酸类似物调节花生四烯酸合成或代谢来治疗适于治疗性干预的疾病的方法。 公开了治疗花生四烯酸合成或代谢调节的疾病的方法。

公开(公告)号：WO2007015854A1

公开(公告)日：2007-02-08

申请号：PCT/US2006/027829

申请日：2006-07-17

Applicant: NOVOZYMES A/S ,  SOLAE, LLC ,  BUDOLFSEN, Gitte ,  FUGLSANG, Claus Crone ,  WONG, Theodore M. ,  KERR, Phillip S.

Inventor： BUDOLFSEN, Gitte ,  FUGLSANG, Claus Crone ,  WONG, Theodore M. ,  KERR, Phillip S.

IPC: A23J3/16 ,  A23L1/305

CPC classification number: A23C9/1315 ,  A23C9/13 ,  A23C9/152 ,  A23J3/16 ,  A23L13/426 ,  A23L13/65 ,  C12Y101/03004 ,  C12Y101/03005 ,  C12Y101/99018 ,  C12Y110/03001 ,  C12Y110/03002 ,  C12Y110/03004 ,  C12Y113/11012

Abstract: The present invention relates to a method for producing a soy protein product by treatment of soy protein with at least one oxidoreductase.

Abstract translation: 本发明涉及通过用至少一种氧化还原酶处理大豆蛋白来生产大豆蛋白产品的方法。

公开(公告)号：WO2005004616A1

公开(公告)日：2005-01-20

申请号：PCT/EP2004/007292

申请日：2004-07-01

Applicant: DSM IP Assets B.V. ,  ROOS, De, Andre, Leonardus ,  DIJK, Van, Albertus, Alard ,  FOLKERTSMA, Baukje

Inventor： ROOS, De, Andre, Leonardus ,  DIJK, Van, Albertus, Alard ,  FOLKERTSMA, Baukje

IPC: A23C19/04

CPC classification number: C12Y113/11012 ,  A23C19/043 ,  A23C19/063 ,  A23C21/02

Abstract: The present invention provides a method for bleaching or whitening a dairy product, comprising adding a lipoxygenase (LOX) to the dairy product. The method of the invention may be used to whiten milk, cheese, butter oil, cream or whey products. The invention further provides the use of a LOX to bleach a dairy product and a dairy product whitened by the methods of the invention.

Abstract translation: 本发明提供了一种乳制品漂白或增白的方法，包括向乳制品中加入脂氧合酶（LOX）。 本发明的方法可用于增白牛奶，奶酪，黄油，奶油或乳清产品。 本发明还提供了LOX漂白乳制品和通过本发明的方法增白的乳制品的用途。

公开(公告)号：WO02053720A1

公开(公告)日：2002-07-11

申请号：PCT/IB2000/002045

申请日：2000-12-29

IPC: C12C1/18 ,  C12N9/02 ,  C12N15/82 ,  A01H5/10

CPC classification number: C12C12/00 ,  C12C1/18 ,  C12N9/0069 ,  C12N15/8242 ,  C12N15/8243 ,  C12N15/8247 ,  C12Y113/11012

Abstract: Barley plants having reduced lipoxygenase-1 enzyme activity are provided, for example, barley plants expressing mutant LOX-1 protein. The barley plants of the invention are useful in the production of plant products such as malt and brewed beverages, particularly beer, having increased stability and reduced T2N potential.

Abstract translation: 提供具有降低的脂氧合酶-1酶活性的大麦植物，例如表达突变型LOX-1蛋白的大麦植物。 本发明的大麦植物可用于生产具有增加的稳定性和降低的T2N潜力的植物产品如麦芽和酿造的饮料，特别是啤酒。

公开(公告)号：WO1993017717A1

公开(公告)日：1993-09-16

申请号：PCT/US1993002057

申请日：1993-03-05

Applicant: ISIS PHARMACEUTICALS, INC. ,  COOK, Phillip, Dan ,  BRUICE, Thomas ,  GUINOSSO, Charles, John ,  KAWASAKI, Andrew, Mamoru ,  GRIFFEY, Richard

Inventor： ISIS PHARMACEUTICALS, INC.

IPC: A61K48/00

CPC classification number: C12N15/113 ,  A61K38/00 ,  A61K48/00 ,  C07H19/04 ,  C07H19/06 ,  C07H19/10 ,  C07H19/16 ,  C07H19/20 ,  C07H21/00 ,  C07H23/00 ,  C07J43/003 ,  C07K14/005 ,  C12N9/0069 ,  C12N15/1137 ,  C12N2310/3125 ,  C12N2310/315 ,  C12N2310/32 ,  C12N2310/321 ,  C12N2310/322 ,  C12N2310/33 ,  C12N2310/333 ,  C12N2310/336 ,  C12N2310/3511 ,  C12N2310/3521 ,  C12N2310/3523 ,  C12N2310/3527 ,  C12N2310/3531 ,  C12N2310/3533 ,  C12N2740/16322 ,  C12Q1/68 ,  C12Q1/6813 ,  C12Y113/11012

Abstract: Compositions and methods for modulating the activity of RNA are disclosed. In accordance with preferred embodiments, antisense compositions are prepared comprising targeting and reactive portions. The reactive portions preferably comprise one or two imidazole functionalities conjugated to the targeting oligonucleotide via linkers with or without intervening intercalating moieties. Therapeutics, diagnostics and research methods also are disclosed, as are synthetic nucleosides and nucleoside fragments that can be elaborated into oligonucleotides.

Abstract translation: 公开了调节RNA活性的组合物和方法。 根据优选实施方案，制备包含靶向和反应部分的反义组合物。 反应性部分优选包含通过具有或不具有插入插入部分的接头与靶向寡核苷酸缀合的一个或两个咪唑官能团。 还公开了治疗学，诊断和研究方法，合成核苷和可以被制成寡核苷酸的核苷片段也是公开的。

公开(公告)号：WO2005063035A1

公开(公告)日：2005-07-14

申请号：PCT/IN2003/000428

申请日：2003-12-31

Applicant: COUNCIL OF SCIENTIFIC & INDUSTRIAL RESEARCH ,  SREEKANTAYYA, Nagalakshmi ,  RAO, Lingamallu, Jagan, Mohan ,  NANJUNDASWAMY, Chandrasekhar ,  KUMAR, Ramaswamy, Shanmughasundaram, Senthil

Inventor： SREEKANTAYYA, Nagalakshmi ,  RAO, Lingamallu, Jagan, Mohan ,  NANJUNDASWAMY, Chandrasekhar ,  KUMAR, Ramaswamy, Shanmughasundaram, Senthil

IPC: A23F3/10

CPC classification number: C12Y101/01001 ,  A23F3/10 ,  C12Y113/11012 ,  C12Y301/01003

Abstract: The present invention provides an enzymatic process for the prevention of development of pacha taint in CTC tea which comprises: (I) mixing an enzyme in water to form an enzyme solution; (II) spraying the enzyme solution homogeneously on rolled and distorted tea leafy material used in the black tea manufacturing process; (III) fermenting the enzyme solution sprayed rolled and distorted tea leafy material obtained at the end of step (II) (iv) drying the fermented material obtained in step (III). The enzyme can be mixture of any of lipase, lipoxygenase anel alcoholdehydrogenase.

Abstract translation: 本发明提供了一种用于预防CTC茶中pacha污点发展的酶促方法，其包括：（I）将酶在水中混合以形成酶溶液; （II）将酶溶液均匀地喷洒在用于红茶制造过程的卷曲变形茶叶材料上; （III）发酵步骤（II）结束时得到的挥发和扭曲的茶叶材料的酶溶液（iv）干燥步骤（III）中获得的发酵材料。 该酶可以是任何脂肪酶，脂氧合酶阿塞醇脱氢酶的混合物。

公开(公告)号：WO2003009701A1

公开(公告)日：2003-02-06

申请号：PCT/EP2002/008159

申请日：2002-07-22

Applicant: DSM N.V. ,  KIES, Arie, Karst

Inventor： KIES, Arie, Karst

IPC: A23K1/16

CPC classification number: C12Y101/03004 ,  A23K20/10 ,  A23K20/158 ,  A23K20/189 ,  A23K50/70 ,  A23V2002/00 ,  A61K31/20 ,  C12Y113/11012 ,  A23V2200/10 ,  A23V2250/1862 ,  A23V2250/1882

Abstract: The use of low concentrations of (a) PUFA (s) in an animal feed for monogastric and/or non-ruminant animals is disclosed to improve growth and feed conversion ratio. The concentration can be much lower than expected from the art, namely from 0.1 to 0.0001 g/kg feed, and yet still be effective. This may enable farmers to use lower concentrations of PUFA (s) in feed and hence reduce the cost of the feed. The feed may also have one or more antimicrobial enzymes present.

Abstract translation: 公开了在单胃和/或非反刍动物的动物饲料中使用低浓度的（a）PUFA以改善生长和饲料转化率。 浓度可以远远低于本领域的预期值，即0.1至0.0001g / kg饲料，仍然有效。 这可能使农民在饲料中使用较低浓度的PUFA，从而降低饲料的成本。 饲料还可以具有一种或多种存在的抗微生物酶。

公开(公告)号：WO00060093A1

公开(公告)日：2000-10-12

申请号：PCT/EP2000/002545

申请日：2000-03-22

IPC: C12N9/02 ,  C12N15/53 ,  C12P7/64 ,  A01H5/00 ,  C12N15/82

CPC classification number: C12N9/0069 ,  C12P7/6427 ,  C12P7/6472 ,  C12Y113/11012

Abstract: The invention relates to a method for producing plant lipoxygenases with modified position specificity, to the lipoxygenases obtained using this method and to the use of said lipoxygenases for hydroperoxylating substrates. In particular, the inventive LOXs provide the first means of producing novel gamma -linolenic acid derivatives on a large scale. To this end, gamma -linolenic acid is incubated with the inventive LOXs in suitable conditions as a substrate. The gamma -linolenic acid is then hydroperoxylated according to the LOXs mutants used, preferably in position 6 or position 9 or positions 6 and 9.

Abstract translation: 本发明涉及一种用于生产具有改变的特异性的植物脂氧合酶，以及通过该方法获得的位置脂氧合酶和它们用于基材的Hydroperoxylierung使用的方法。 特别地，本发明允许LOXs首次在大规模生产新的γ-亚麻酸的衍生物。 为了这个目的，γ-亚麻酸作为底物温育。用适当的条件下本发明的LOXs。 然后进行，这取决于所插入的突变体LOXs一个Hydroperoxylierung的γ-亚麻酸，优选在6位或9位或6位，和第九

公开(公告)号：WO1997013851A1

公开(公告)日：1997-04-17

申请号：PCT/US1996016387

申请日：1996-10-11

Applicant: PURDUE RESEARCH FOUNDATION ,  HANDA, Avtar, K. ,  KAUSCH, Kurt, D.

Inventor： PURDUE RESEARCH FOUNDATION

IPC: C12N15/00

CPC classification number: C12N15/1137 ,  C12N9/0069 ,  C12N15/8249 ,  C12N2310/111 ,  C12Y113/11012

Abstract: The present invention relates generally to a transgenic fruit-bearing plant having a foreign nucleotide sequence inserted therein which is substantially similar to a portion of the plant's fruit ripening specific lipoxygenase cDNA. Transgenic plants according to the present invention produce fruits having modified and surprinsingly superior ripening characteristics, including improved quality and texture, greater firmness, longer shelf life, better packaging and storage characteristics and improved processing characteristics. Also provided are transgenic fruits; transgenic plant cells; methods for making inventive transgenic plants, fruits and plant cells; methods for inhibiting lipoxygenase production in plants; isolated nucleotide sequences; and vectors comprising these isolated nucleotide sequences.

Abstract translation: 本发明一般涉及其中插入有外来核苷酸序列的转基因果实植物，其基本上与植物的果实成熟特异性脂氧合酶cDNA的一部分相似。 根据本发明的转基因植物产生具有改良和突出优越成熟特征的水果，包括改进的质量和质地，更坚固，更长的保质期，更好的包装和储存特性以及改善的加工特性。 还提供了转基因水果; 转基因植物细胞; 制造本发明的转基因植物，水果和植物细胞的方法; 抑制植物脂氧合酶生成的方法; 分离的核苷酸序列; 和包含这些分离的核苷酸序列的载体。