公开(公告)号：WO2010134814A3

公开(公告)日：2011-01-27

申请号：PCT/NL2010050306

申请日：2010-05-20

Applicant: AMC AMSTERDAM ,  REITS ERIC ALBERT JULIUS

Inventor： REITS ERIC ALBERT JULIUS

IPC: A61K38/17 ,  A61K38/48 ,  A61P25/14 ,  C12N15/62 ,  G01N33/68

CPC classification number: A61K38/4813 ,  C07K14/00 ,  C07K2319/00 ,  C07K2319/95 ,  C12Q1/37 ,  C12Y304/1401 ,  G01N33/5008 ,  G01N33/6893 ,  G01N33/6896 ,  G01N2500/00 ,  G01N2800/10 ,  G01N2800/2835

Abstract: The present invention provides means and methods for counteracting and/or preventing aggregation of a polyQ protein. Further provided are improved poly constructs which are, amongst other things, useful for testing assays. According to the invention, several peptidases like, e.g. tripeptidyl peptidase II (TPPII), appear to be capable of cleaving long polyQ peptides comprising at least 45 glutamine residues. Hence, according to the invention, administration of such peptidases to an individual suffering from a polyQ expansion disorder results in degradation of long polyQ peptides.

Abstract translation: 本发明提供了用于抵抗和/或阻止polyQ蛋白聚集的方法和方法。 还提供了改进的聚构造物，其尤其对于测试测定是有用的。 根据本发明，几种肽酶例如， 三肽基肽酶II（TPPII）似乎能够切割包含至少45个谷氨酰胺残基的长polyQ肽。 因此，根据本发明，将这种肽酶给予患有多聚Q扩张性疾病的个体导致长polyQ肽的降解。

公开(公告)号：WO2017147060A1

公开(公告)日：2017-08-31

申请号：PCT/US2017/018686

申请日：2017-02-21

Applicant: DUPONT NUTRITION BIOSCIENCES APS ,  2. E. I. DU PONT DE NEMOURS AND COMPANY

Inventor： KRAGH, Karsten Matthias ,  HAANING, Svend ,  MEINJOHANNS, Ernst ,  DEGN, Peter Edvard ,  BAK, Steffen Yde ,  EISELE, Thomas

IPC: C12P21/06 ,  A23J3/34 ,  C12N9/48 ,  A23K10/10

CPC classification number: C12P21/06 ,  A23J3/341 ,  A23J3/346 ,  A23K10/10 ,  A23K10/14 ,  A23K20/147 ,  A23K20/189 ,  A23K50/30 ,  A23K50/60 ,  A23K50/75 ,  C12N9/485 ,  C12Y304/14009 ,  C12Y304/1401

Abstract: The present invention relates to compositions and methods for the production of a hydrolysate comprising at least one endoprotease and a tripeptidyl peptidase capable of cleaving tripeptides from the N-terminus a peptide and/or proteins having one or more of lysine, arginine or glycine in the P1 position wherein said tripeptidyl peptidase is capable of being used at a temperature between 45ºC and 70ºC.

公开(公告)号：WO2010134814A2

公开(公告)日：2010-11-25

申请号：PCT/NL2010/050306

申请日：2010-05-20

Applicant: ACADEMISCH MEDISCH CENTRUM BIJ DE UNIVERSITEIT VAN AMSTERDAM ,  REITS, Eric, Albert, Julius

Inventor： REITS, Eric, Albert, Julius

IPC: A61K38/17 ,  A61K38/48 ,  C12N15/62 ,  G01N33/68 ,  A61P25/14

CPC classification number: A61K38/4813 ,  C07K14/00 ,  C07K2319/00 ,  C07K2319/95 ,  C12Q1/37 ,  C12Y304/1401 ,  G01N33/5008 ,  G01N33/6893 ,  G01N33/6896 ,  G01N2500/00 ,  G01N2800/10 ,  G01N2800/2835

Abstract: The present invention provides means and methods for counteracting and/or preventing aggregation of a polyQ protein. Further provided are improved polyQ constructs which are, amongst other things, useful for testing assays.

Abstract translation: 本发明提供了用于抵抗和/或阻止polyQ蛋白聚集的方法和方法。 进一步提供的是改进的polyQ构建体，其尤其对于测试测定是有用的。

公开(公告)号：WO2016065238A1

公开(公告)日：2016-04-28

申请号：PCT/US2015/057079

申请日：2015-10-23

Applicant: DANISCO US INC.

Inventor： MIASNIKOV, Andrei ,  MA, Maria ,  POWER, Scott D.

IPC: C12P7/10 ,  C12P7/16

CPC classification number: C12P7/10 ,  C12P7/16 ,  C12P7/48 ,  C12P7/56 ,  C12Y304/14 ,  C12Y304/14009 ,  C12Y304/1401 ,  C12Y304/14012 ,  Y02E50/10 ,  Y02E50/16

Abstract: The present invention provides a method for producing an alcohol comprising: (a) admixing a tripeptidyl peptidase, predominantly having exopeptidase activity, with a feedstock or a fraction thereof before, during or after fermentation of said feedstock or a fraction thereof; and (b) recovering an alcohol. Also provided are uses of a tripeptidyl peptidase and by-products of alcohol production obtainable by the method of the invention.

Abstract translation: 本发明提供了一种制备醇的方法，包括：（a）在所述原料或其馏分发酵之前，期间或之后，将主要具有外肽酶活性的三肽基肽酶与原料或其部分混合; 和（b）回收醇。 还提供了通过本发明的方法获得的三肽基肽酶和醇生产的副产物的用途。

公开(公告)号：WO2003006478A1

公开(公告)日：2003-01-23

申请号：PCT/US2002/021664

申请日：2002-07-10

Applicant: OLIGOS ETC. INC. ,  DALE, Roderic, M., K. ,  ARROW, Amy ,  THOMPSON, Terry

Inventor： DALE, Roderic, M., K. ,  ARROW, Amy ,  THOMPSON, Terry

IPC: C07H21/04

CPC classification number: C12N15/1137 ,  A61K8/606 ,  A61K38/00 ,  A61K2800/74 ,  A61Q19/00 ,  C12N15/113 ,  C12N15/1136 ,  C12N15/1138 ,  C12N2310/11 ,  C12N2310/321 ,  C12N2320/35 ,  C12Y101/01088 ,  C12Y103/99005 ,  C12Y111/01006 ,  C12Y113/11012 ,  C12Y114/99001 ,  C12Y203/01026 ,  C12Y203/01085 ,  C12Y301/01003 ,  C12Y301/03048 ,  C12Y304/1401 ,  C12Y304/15001 ,  C12Y304/24011 ,  C12Y306/0301 ,  C12Y604/01002 ,  C12N2310/3521

Abstract: The present invention relates to methods and compositions containing oligonucleotides suitable for administration to humans and other mammals.

Abstract translation: 本发明涉及含有适用于给予人和其它哺乳动物的寡核苷酸的方法和组合物。