公开(公告)号：WO2017050291A1

公开(公告)日：2017-03-30

申请号：PCT/CN2016/100090

申请日：2016-09-26

Applicant: NOVOZYMES A/S ,  GUO, Xinyan

Inventor： GUO, Xinyan ,  KREEL, Nathaniel Edward ,  JUMP, Joseph ,  HOOSS, Melissa C. ,  ROBERTS, Madison ,  VIDAL, Bernardo, Jr. ,  JENSEN, Kenneth ,  FRISNER, Henrik ,  HOFF, Tine ,  LIU, Ye ,  TANG, Lan

IPC: C12N9/54 ,  C12P1/00 ,  C12P7/06 ,  C12N9/30 ,  C12N9/34 ,  C12N9/40 ,  C12N15/63 ,  C12N9/48 ,  C12N9/58 ,  C12N9/50

CPC classification number: C12N9/48 ,  C12N9/50 ,  C12N9/54 ,  C12N9/58 ,  C12N15/63 ,  C12P7/06 ,  C12P2203/00 ,  C12Y302/01001 ,  C12Y304/14 ,  C12Y304/21 ,  Y02E50/17

Abstract: S53 proteases and the use of S53 protease in processes for converting starch to ethanol are provided.

Abstract translation: 提供S53蛋白酶和在淀粉转化为乙醇的方法中使用S53蛋白酶。

公开(公告)号：WO2017075505A2

公开(公告)日：2017-05-04

申请号：PCT/US2016/059541

申请日：2016-10-28

Applicant: TUFTS UNIVERSITY ,  TUFTS MEDICAL CENTER

Inventor： KUMAR, Krishna ,  MONTANARI, Vittorio ,  BEINBORN, Martin ,  RAMAN, Venkata

IPC: A61K38/16 ,  C07K14/435

CPC classification number: C07K14/7155 ,  A61K38/00 ,  C07K1/1077 ,  C07K14/605 ,  C12N9/48 ,  C12Y304/14

Abstract: The present invention includes methods of improving proteolytic stability of a polypeptide, comprising alkylating at least one selected from the group consisting of a N-terminus amino group, the NH group of the N-terminus first internal amide bond, another primary amino group, a thiol group and a thioether group within the polypeptide. The present invention further includes polypeptides incorporating such chemical modifications.

公开(公告)号：WO2016065238A1

公开(公告)日：2016-04-28

申请号：PCT/US2015/057079

申请日：2015-10-23

Applicant: DANISCO US INC.

Inventor： MIASNIKOV, Andrei ,  MA, Maria ,  POWER, Scott D.

IPC: C12P7/10 ,  C12P7/16

CPC classification number: C12P7/10 ,  C12P7/16 ,  C12P7/48 ,  C12P7/56 ,  C12Y304/14 ,  C12Y304/14009 ,  C12Y304/1401 ,  C12Y304/14012 ,  Y02E50/10 ,  Y02E50/16

Abstract: The present invention provides a method for producing an alcohol comprising: (a) admixing a tripeptidyl peptidase, predominantly having exopeptidase activity, with a feedstock or a fraction thereof before, during or after fermentation of said feedstock or a fraction thereof; and (b) recovering an alcohol. Also provided are uses of a tripeptidyl peptidase and by-products of alcohol production obtainable by the method of the invention.

Abstract translation: 本发明提供了一种制备醇的方法，包括：（a）在所述原料或其馏分发酵之前，期间或之后，将主要具有外肽酶活性的三肽基肽酶与原料或其部分混合; 和（b）回收醇。 还提供了通过本发明的方法获得的三肽基肽酶和醇生产的副产物的用途。

公开(公告)号：WO2017075522A2

公开(公告)日：2017-05-04

申请号：PCT/US2016/059563

申请日：2016-10-28

Applicant: TUFTS UNIVERSITY ,  TUFTS MEDICAL CENTER

Inventor： KUMAR, Krishna ,  MONTANARI, Vittorio ,  BEINBORN, Martin ,  KOPIN, Alan ,  RAMAN, Venkata ,  RODENSTEIN, Marissa

IPC: A61K38/26 ,  C07K14/605

CPC classification number: C07K14/7155 ,  A61K38/00 ,  C07K1/1077 ,  C07K14/605 ,  C12N9/48 ,  C12Y304/14

Abstract: The present invention includes methods of improving proteolytic stability of a polypeptide, comprising alkylating at least one selected from the group consisting of a N-terminus amino group, the NH group of the N-terminus first internal amide bond, another primary amino group, a thiol group and a thioether group within the polypeptide. The present invention further includes polypeptides incorporating such chemical modifications.

Abstract translation: 本发明包括提高多肽的蛋白水解稳定性的方法，所述方法包括将选自N-末端氨基，N-末端第一内酰胺的NH基团 键，另一个伯氨基，巯基和硫醚基团。 本发明还包括掺入了这种化学修饰的多肽。

公开(公告)号：WO2015020876A1

公开(公告)日：2015-02-12

申请号：PCT/US2014/049159

申请日：2014-07-31

Applicant: DANISCO US INC.

Inventor： MIASNIKOV, Andrei

IPC: C12N15/63 ,  C12N15/67 ,  C12N15/85

CPC classification number: C12N15/67 ,  C12N9/127 ,  C12N9/16 ,  C12N9/242 ,  C12N9/2437 ,  C12N9/485 ,  C12N15/63 ,  C12N15/80 ,  C12N15/85 ,  C12Y207/07048 ,  C12Y301/26003 ,  C12Y302/01001 ,  C12Y302/01091 ,  C12Y304/14

Abstract: Described are methods for increasing the expression of a transgene in eukaryotic cells by reducing RNA interference (RNAi), and variant cells produce by the method. The methods and variant cells are useful, for example, for the efficient production of therapeutic and industrial polypeptides in eukaryotic cells.

Abstract translation: 描述了通过减少RNA干扰（RNAi）增加真核细胞中转基因表达的方法，并且通过该方法产生变体细胞。 方法和变体细胞可用于例如真核细胞中有效生产治疗和工业多肽。

公开(公告)号：WO2009152627A3

公开(公告)日：2010-03-18

申请号：PCT/CH2009000201

申请日：2009-06-15

Applicant: GIVAUDAN SA ,  BHOWMIK TARUN ,  MYAKA STEFKA IVANOVA ,  VAN LEERSUM JOHAN PETER ,  SMITH ROY WADE

Inventor： BHOWMIK TARUN ,  MYAKA STEFKA IVANOVA ,  VAN LEERSUM JOHAN PETER ,  SMITH ROY WADE

IPC: A23J3/34 ,  A23L27/00 ,  A23L27/10 ,  A23L27/24 ,  A23L27/40 ,  A23L29/00

CPC classification number: A23L27/45 ,  A23J3/346 ,  A23L1/2375 ,  A23L27/24 ,  A23L27/40 ,  A23L27/88 ,  A23V2002/00 ,  C12Y302/01058 ,  C12Y304/11 ,  C12Y304/13 ,  C12Y304/14 ,  C12Y304/15 ,  C12Y304/16 ,  C12Y304/17 ,  C12Y304/18 ,  C12Y304/19 ,  C12Y304/21 ,  C12Y304/21062 ,  C12Y304/22 ,  C12Y304/23 ,  C12Y304/24 ,  C12Y304/25 ,  C12Y305/01002

Abstract: Provided is an enzymatic process that hydrolyzes spinach plant material to form a salt-enhancing ingredient, the formed salt-enhancing ingredient, food products comprising said salt-enhancing ingredient and a method of enhancing the salty taste of food products.

Abstract translation: 提供了水解菠菜植物材料以形成盐增强成分，形成的盐增强成分，包含所述盐增强成分的食品和增强食品咸味的方法的酶法。

公开(公告)号：WO2018192830A1

公开(公告)日：2018-10-25

申请号：PCT/EP2018/059355

申请日：2018-04-12

Applicant: DSM IP ASSETS B.V.

Inventor： STREEKSTRA, Hugo ,  PRICE, Claire Emile

IPC: A23C9/12 ,  A23C9/123 ,  A23C9/127

CPC classification number: C12N9/485 ,  A23C9/1209 ,  A23C9/1275 ,  A23C13/16 ,  A23C15/065 ,  A23C17/02 ,  A23C19/076 ,  C12Y304/11 ,  C12Y304/13 ,  C12Y304/14 ,  C12Y304/15 ,  C12Y304/16 ,  C12Y304/17 ,  C12Y304/18 ,  C12Y304/19

Abstract: The present invention relates to a process for preparing a fermented milk product, comprising contacting a milk substrate with an enzyme preparation having exopeptidase activity; contacting a milk substrate with lactic acid bacteria; wherein the lactic acid bacteria have a time to reach a pH of 4.6 of a solution of 12% skimmed milk powder which is at least 30% shorter in the presence 0.5% (w/w) of a yeast extract in the solution of 12% skimmed milk powder than without the presence of the yeast extract in the 12% skimmed milk powder, and wherein said enzyme preparation is a substantially pure exopeptidase preparation. Likewise envisaged is a fermented milk product comprising an enzyme having exopeptidase activity, a kit of parts comprising lactic acid bacteria and enzyme having exopeptidase activity and the use of an exopeptidase for accelerating acidification speed of lactic acid bacteria.

公开(公告)号：WO2015124672A1

公开(公告)日：2015-08-27

申请号：PCT/EP2015/053504

申请日：2015-02-19

Applicant: CLARIANT PRODUKTE (DEUTSCHLAND) GMBH

Inventor： SOHLING, Ulrich ,  SUCK, Kirstin ,  BUBENHEIM, Paul

IPC: A23L1/015 ,  C11B3/00 ,  C11B3/04 ,  C11B3/16

CPC classification number: C11B3/003 ,  A23D9/04 ,  A23L5/25 ,  A23V2002/00 ,  C11B3/001 ,  C11B3/006 ,  C11B3/04 ,  C11B3/16 ,  C12N9/16 ,  C12N9/20 ,  C12N9/52 ,  C12N9/54 ,  C12Y301/01003 ,  C12Y301/01004 ,  C12Y301/01032 ,  C12Y301/04003 ,  C12Y301/04004 ,  C12Y304/11 ,  C12Y304/13 ,  C12Y304/14 ,  C12Y304/15 ,  C12Y304/16 ,  C12Y304/17 ,  C12Y304/18 ,  C12Y304/19 ,  C12Y304/23 ,  C12Y304/25

Abstract: Die Erfindung betrifft eine Zusammensetzung umfassend mindestens ein Phospholipid-spaltendes Enzym und mindestens eine Protease. Weiterhin betrifft die Erfindung ein Verfahren zur Entschleimung von Triglycerid-haltigen Zusammensetzungen unter Verwendung der erfindungsgemäßen Zusammensetzung sowie die Verwendung der erfindungsgemäßen Zusammensetzung zur Entschleimung von Triglycerid-haltigen Zusammensetzungen.

Abstract translation: 本发明涉及包含至少一种磷脂切割酶和至少一种蛋白酶的组合物。 此外，本发明涉及一种用于使用本发明的组合物以及根据本发明的用于含甘油三酯的组合物的脱胶使用该组合物的脱胶含甘油三酯的组合物的方法。

公开(公告)号：WO2009152627A2

公开(公告)日：2009-12-23

申请号：PCT/CH2009/000201

申请日：2009-06-15

Applicant: GIVAUDAN SA ,  BHOWMIK, Tarun ,  MYAKA, Stefka, Ivanova ,  VAN LEERSUM, Johan, Peter ,  SMITH, Roy, Wade

Inventor： BHOWMIK, Tarun ,  MYAKA, Stefka, Ivanova ,  VAN LEERSUM, Johan, Peter ,  SMITH, Roy, Wade

IPC: A23L27/00 ,  A23L27/10 ,  A23L27/24 ,  A23L27/40 ,  A23L29/00

CPC classification number: A23L27/45 ,  A23J3/346 ,  A23L27/24 ,  A23L27/40 ,  A23L27/88 ,  A23V2002/00 ,  C12Y302/01058 ,  C12Y304/11 ,  C12Y304/13 ,  C12Y304/14 ,  C12Y304/15 ,  C12Y304/16 ,  C12Y304/17 ,  C12Y304/18 ,  C12Y304/19 ,  C12Y304/21 ,  C12Y304/21062 ,  C12Y304/22 ,  C12Y304/23 ,  C12Y304/24 ,  C12Y304/25 ,  C12Y305/01002

Abstract: Provided is an enzymatic process that hydrolyzes spinach plant material to form a salt-enhancing ingredient, the formed salt-enhancing ingredient, food products comprising said salt-enhancing ingredient and a method of enhancing the salty taste of food products.

Abstract translation: 提供了水解菠菜植物材料以形成盐增强成分，形成的盐增强成分，包含所述盐增强成分的食品和增强食品咸味的方法的酶法。

公开(公告)号：WO1996022699A1

公开(公告)日：1996-08-01

申请号：PCT/EP1996000147

申请日：1996-01-16

Applicant: HENKEL KOMMANDITGESELLSCHAFT AUF AKTIEN ,  VON KRIES, Edith ,  HEILEMANN, Andrea ,  SANDER, Andreas

Inventor： HENKEL KOMMANDITGESELLSCHAFT AUF AKTIEN

IPC: A23J03/34

CPC classification number: A23J3/346 ,  A61K8/645 ,  A61Q19/00 ,  C12Y304/11 ,  C12Y304/13 ,  C12Y304/14 ,  C12Y304/15 ,  C12Y304/16 ,  C12Y304/17 ,  C12Y304/18 ,  C12Y304/19 ,  C12Y304/21 ,  C12Y304/22 ,  C12Y304/23 ,  C12Y304/24

Abstract: The proposal is for an improved process for producing wheat protein hydrolysates in which protein-containing basic substances are first hydrolysed in with proteinases and then with peptidases. The resultant hydrolysates are particularly suitable for producing light-coloured condensation products with fatty acids with a long shelf life.

Abstract translation: 它提出了一种用于生产小麦蛋白质水解产物，其中第一水解的随后的含蛋白质起始蛋白酶和肽酶的材料的改进方法。 将得到的水解产物是特别适合于生产的浅色，储存稳定的缩合产物与脂肪酸。