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    ILLUMINATION UNIT FOR DIGITAL PATHOLOGY SCANNING
    3.
    发明申请
    ILLUMINATION UNIT FOR DIGITAL PATHOLOGY SCANNING 审中-公开
    数字病理扫描的照明单元

    公开(公告)号：WO2016142153A1

    公开(公告)日：2016-09-15

    申请号：PCT/EP2016/053584

    申请日：2016-02-19

    Applicant: KONINKLIJKE PHILIPS N.V.

    Inventor： BOAMFA, Marius, Iosif ,  RAS, Arnoldus, Johannes, Martinus, Jozeph ,  HADDEMAN, Theodoor, Bastiaan, Johannes

    IPC: G02B21/08 ,  G01N21/64 ,  G02B21/36 ,  G02B5/02

    CPC classification number: G02B21/364 ,  G01N21/251 ,  G01N21/64 ,  G01N2201/103 ,  G02B5/0236 ,  G02B5/0278 ,  G02B21/086 ,  G02B21/365

    Abstract: The present invention relates to digital pathology, and relates in particular to a digital pathology scanner illumination unit. In order to provide digital pathology scanning with improved illumination, a digital pathology scanner illumination unit (10) is provided that comprises a light source (12), a light mixing chamber (14), and a light diffuser (16). The light source comprises a plurality of light elements (18) that are arranged longitudinally along a linear extension direction. The mixing chamber comprises a transparent volume (22) providing a mixing distance (DM) between the plurality of the light elements and the light diffuser such that light with a uniform intensity is provided at a downstream edge (26) of the mixing chamber; and the mixing chamber is arranged, in terms of light propagation, between the plurality of the light elements and the light diffuser. Further, the light diffuser comprises a diffusing material such that the light is transformed into light that has uniformity at different angles, in particular low angles.

    Abstract translation: 本发明涉及数字病理学，特别涉及数字病理扫描仪照明单元。 为了提供具有改进的照明的数字病理扫描，提供了包括光源（12），光混合室（14）和光扩散器（16）的数字病理扫描器照明单元（10）。 光源包括沿着线性延伸方向纵向布置的多个光元件（18）。 混合室包括透明体积（22），其提供多个光元件和光漫射体之间的混合距离（DM），使得在混合室的下游边缘（26）处设置具有均匀强度的光; 并且混合室在光传播方面被布置在多个光元件和光扩散器之间。 此外，光扩散器包括漫射材料，使得光被转换成具有不同角度，特别是低角度的均匀性的光。

    METHOD AND DEVICE FOR MICROSCOPY IMAGING
    4.
    发明申请
    METHOD AND DEVICE FOR MICROSCOPY IMAGING 审中-公开
    用于在显微镜下成像的方法和装置

    公开(公告)号：WO2016029913A1

    公开(公告)日：2016-03-03

    申请号：PCT/DE2015200444

    申请日：2015-08-27

    Applicant: FRAUNHOFER GES ZUR FOERDERUNGDER ANGEWANDTEN FORSCHUNG E V

    Inventor： SCHENK FRIEDRICH ,  BRILL NICOLAI ,  MARX ULRICH

    IPC: G02B7/28 ,  G02B21/08 ,  G02B21/24 ,  G02B21/36

    CPC classification number: G02B21/36 ,  G02B7/28 ,  G02B21/086 ,  G02B21/241

    Abstract: With a view to dependable imaging with a particularly high possible throughput of objects to be investigated, a method for microscopy imaging, in particular for high throughput imaging, is provided, wherein an image plane of an object to be investigated is defined, wherein multiple images are recorded in focus on the image plane of the object when the object is moved along a predeterminable path in an X-Y plane by means of a camera using a lens, and wherein a point in time of the image recordings is controlled path-dependently by way of a trigger signal with flash activation. The method is characterized in that automatic setting of the focus on the image plane is performed for the image recordings on the basis of Z position values of the object and/or the image plane that are obtained interferometrically in a Z direction. A corresponding device for microscopy imaging is also provided.

    Abstract translation: 用在特别高的吞吐量相对于安全成像要被检查的对象是用于显微术成像的方法，特别是用于高通量摄像，与被检查对象的图像平面指示的定义，其中，多个图像具有焦点的对象的图像平面上 沿着XY平面移动物体中的预定路径通过透镜通过照相机获取，并且其中，通过启动闪光照明来控制图像记录的时间与触发信号的路径依赖性。 该方法的特征在于，用于图像记录，聚焦在像平面上的对象和/或图像平面的Z方向Z衍生Positionsswerte干涉进行的基础上的自动调整。 此外，指定了用于显微镜成像的相应装置。

    SYSTEMS AND METHODS FOR STRUCTURED ILLUMINATION SUPER-RESOLUTION PHASE MICROSCOPY
    5.
    发明申请
    SYSTEMS AND METHODS FOR STRUCTURED ILLUMINATION SUPER-RESOLUTION PHASE MICROSCOPY 审中-公开
    用于结构化照明超分辨率相显微镜的系统和方法

    公开(公告)号：WO2014169197A1

    公开(公告)日：2014-10-16

    申请号：PCT/US2014/033776

    申请日：2014-04-11

    Applicant: DUKY UNIVERSITY

    Inventor： IZATT, Joseph, A. ,  CHOWDHURY, Shwetadwip

    IPC: G02B21/00

    CPC classification number: G02B21/361 ,  G02B5/18 ,  G02B21/06 ,  G02B21/086 ,  G02B21/14 ,  G02B2005/1804 ,  H04N5/2256

    Abstract: Systems and methods for structured illumination super-resolution phase microscopy are disclosed. According to an aspect, an imaging system includes a light source configured to generate light. The system also includes a diffraction grating positioned to receive and diffract the output light. The system also includes a sample holder positioned to receive the diffracted light for transmission through a sample. Further, the system includes an image detector positioned to receive the light transmitted through the sample and configured to generate image data based on the received light. The system also includes a computing device configured to apply subdiffraction resolution reconstruction to the image data for generating an image of the sample.

    Abstract translation: 公开了用于结构照明超分辨率相位显微镜的系统和方法。 根据一个方面，一种成像系统包括被配置为产生光的光源。 该系统还包括定位成接收和衍射输出光的衍射光栅。 该系统还包括定位以接收衍射光以透过样品的样品架。 此外，该系统包括图像检测器，该图像检测器被定位成接收透过样本的光并被配置为基于接收到的光生成图像数据。 该系统还包括计算装置，其被配置为将子衍射分辨率重构应用于图像数据以生成样本的图像。

    COHERENT ANTI-STOKES RAMAN HOLOGRAPHY
    7.
    发明申请
    COHERENT ANTI-STOKES RAMAN HOLOGRAPHY 审中-公开
    相关的反倾销拉曼全息图

    公开(公告)号：WO2011152834A1

    公开(公告)日：2011-12-08

    申请号：PCT/US2010/037440

    申请日：2010-06-04

    Applicant: THE PENN STATE RESEARCH FOUNDATION ,  LIU, Zhiwen ,  SHI, Kebin ,  PSALTIS, Demetri ,  XU, Qian

    Inventor： LIU, Zhiwen ,  SHI, Kebin ,  PSALTIS, Demetri ,  XU, Qian

    IPC: G01J3/44 ,  G02B5/32

    CPC classification number: G01J3/44 ,  G01N21/65 ,  G01N2021/653 ,  G02B21/0004 ,  G02B21/086 ,  G02B21/14 ,  G03H1/0005 ,  G03H1/02 ,  G03H1/04 ,  G03H1/0443 ,  G03H1/0866 ,  G03H2001/0212 ,  G03H2001/0445 ,  G03H2001/0447 ,  G03H2222/10

    Abstract: Apparatus and methods of four wave mixing (FWM) holography are described, including illuminating a sample with a first beam, a second beam, and a third beam, and combining the generated FWM signal with a reference beam at a imaging device to obtain holographic image data. In some examples, the first and second beams may be provided by a single pump-probe beam. The third beam may be a Stokes beam or an anti-Stokes beam. A representative example is coherent anti-Stokes Raman holography (CARS holography), which includes illuminating a sample with a pump/probe beam and a Stokes beam to obtain a CARS signal from the sample; and combining the CARS signal with a reference beam to obtain a CARS hologram.

    Abstract translation: 描述了四波混合（FWM）全息术的装置和方法，包括用第一光束，第二光束和第三光束照射样本，并将所产生的FWM信号与成像装置处的参考光束组合以获得全息图像 数据。 在一些示例中，第一和第二梁可以由单个泵 - 探针梁提供。 第三光束可以是斯托克斯光束或反斯托克斯光束。 一个典型的例子是相干反斯托克斯拉曼全息术（CARS holography），其包括用泵/探针光束和斯托克斯光束照射样品以从样品获得CARS信号; 并将CARS信号与参考光束组合以获得CARS全息图。

    MASK INSPECTION MICROSCOPE WITH VARIABLE ILLUMINATION SETTING
    8.
    发明申请
    MASK INSPECTION MICROSCOPE WITH VARIABLE ILLUMINATION SETTING 审中-公开
    具有可变照明设置的屏蔽检测显微镜

    公开(公告)号：WO2011029535A3

    公开(公告)日：2011-05-05

    申请号：PCT/EP2010005293

    申请日：2010-08-28

    Applicant: ZEISS CARL SMS GMBH ,  STROESSNER ULRICH ,  SEITZ HOLGER ,  ROSENKRANZ NORBERT ,  LAENGLE MARIO

    Inventor： STROESSNER ULRICH ,  SEITZ HOLGER ,  ROSENKRANZ NORBERT ,  LAENGLE MARIO

    IPC: G03F1/00

    CPC classification number: G02B21/086 ,  G02B5/005 ,  G03F1/84

    Abstract: During mask inspection it is necessary to identify defects which also occur during wafer exposure. Therefore, the aerial images generated in the resist and on the detector have to be as far as possible identical. In order to achieve an equivalent image generation, during mask inspection the illumination and, on the object side, the numerical aperture are adapted to the scanner used. The invention relates to a mask inspection microscope for variably setting the illumination. It serves for generating an image of the structure (150) of a reticle (145) arranged in an object plane in a field plane of the mask inspection microscope. It comprises a light source (5) that emits projection light, at least one illumination beam path (3, 87, 88), and a diaphragm for generating a resultant intensity distribution of the projection light in a pupil plane (135) of the illumination beam path (3, 87, 88) that is optically conjugate with respect to the object plane. According to the invention, the diaphragm is embodied in such a way that the resultant intensity distribution of the projection light has at least one further intensity value between a minimum and a maximum intensity value.

    Abstract translation: 在面罩检查期间，有必要识别在晶片曝光期间也会发生的缺陷。 因此，在抗蚀剂和检测器上产生的空中图像必须尽可能相同。 为了实现等效图像生成，在掩模检查期间，照明和物体侧的数值孔径适用于所使用的扫描仪。 本发明涉及一种用于可变地设定照明的掩模检查显微镜。 其用于生成布置在掩模检查显微镜的场平面中的物平面中的掩模版（145）的结构（150）的图像。 它包括发射投射光的光源（5），至少一个照明光束路径（3,87,88）和用于产生投影光在照明光瞳面（135）中的合成强度分布的光阑 光束路径（3,87,88），其相对于物平面光学共轭。 根据本发明，隔膜的实施方式是使投影光的合成强度分布在最小和最大强度值之间具有至少一个另外的强度值。

    SHG QUANTIFICATION OF MATRIX-RELATED TISSUE DYNAMIC AND DISEASE
    9.
    发明申请
    SHG QUANTIFICATION OF MATRIX-RELATED TISSUE DYNAMIC AND DISEASE 审中-公开
    基质相关组织动态和疾病的SHG量化

    公开(公告)号：WO2008002278A1

    公开(公告)日：2008-01-03

    申请号：PCT/SG2007/000194

    申请日：2007-06-29

    Applicant: AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH ,  SUN, Wanxin ,  YU, Hanry

    Inventor： SUN, Wanxin ,  YU, Hanry

    IPC: G02F1/37 ,  G02B21/00

    CPC classification number: G02B21/0024 ,  G01N21/6458 ,  G01N21/6486 ,  G02B21/086

    Abstract: A microscope (200) for optical imaging of high optical scattering coefficient biological tissue, comprising an optical excitation source (201) for irradiating a scan area of the sample (205) and generating optical emissions, wherein the sample has a first face facing away from the source and a second face facing the source. A two dimensional element (207) for scanning the light over the sample; a focussing element (209) having a numerical aperture NAi to focus the light onto the sample; a first optical condenser (213) to collect light from the first face, the collected light comprising source transmitted light and first optical emission generated in the sample, the condenser having a NA2 larger than NAi; an optical filter(215) to block the transmitted source light; an aperture with a size corresponding to the irradiated area of the sample, the aperture at the conjugate image position of the sample generated by the condenser; and an optical detector (217) collecting light from the first face for detecting the first optical emission from the scan area.

    Abstract translation: 一种用于高光学散射系数生物组织的光学成像的显微镜（200），包括用于照射样品（205）的扫描区域并产生光学发射的光学激发源（201），其中所述样品具有面向远离 来源和面向源的第二面。 用于扫描样品上的光的二维元件（207）; 具有数值孔径NAi以将光聚焦到样品上的聚焦元件（209）; 收集来自第一面的光的第一光学冷凝器（213），所收集的光包括源透射光和在样品中产生的第一光发射，冷凝器具有大于NAi的NA2; 滤光器（215），用于阻挡所发射的光源; 具有对应于样品的照射面积的尺寸的孔，由冷凝器产生的样品的共轭图像位置处的孔; 以及收集来自第一面的光的光学检测器（217），用于检测来自扫描区域的第一光发射。

    APPARATUS, SYSTEMS AND METHODS RELATING TO ILLUMINATION FOR MICROSCOPES
    10.
    发明申请
    APPARATUS, SYSTEMS AND METHODS RELATING TO ILLUMINATION FOR MICROSCOPES 审中-公开
    装置，系统和与微光照明有关的方法

    公开(公告)号：WO2005114292A2

    公开(公告)日：2005-12-01

    申请号：PCT/US2005/017840

    申请日：2005-05-19

    Applicant: LIFESPAN BIOSCIENCES, INC. ,  KLEIN, Gerald, L. ,  FREUND, Phillip

    Inventor： KLEIN, Gerald, L. ,  FREUND, Phillip

    IPC: G02B21/06

    CPC classification number: G02B21/086 ,  G02B5/02

    Abstract: Systems, apparatus and methods pertaining generally, in some embodiments, to improved illumination for microscopes. For example, certain embodiments relate to the use of an array of multiple wavelength light-emitting diodes that are coupled to an integrating sphere. Light exiting the sphere is relayed using a fused fiber optic bundle. The systems, etc., effectively improve the illumination system over the traditional illumination system used by most microscope manufacturers, and can be particularly useful when applied to photomicrography.

    Abstract translation: 在一些实施例中通常涉及用于显微镜的改进照明的系统，装置和方法。 例如，某些实施例涉及耦合到积分球的多个波长发光二极管的阵列的使用。 离开球体的光线使用熔融光纤束进行中继。 系统等有效地改善了大多数显微镜制造商使用的传统照明系统的照明系统，并且在应用于显微照相术时尤其有用。

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