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76 条记录 (耗时 0.019 秒)

    USE OF STEREOISOMERS OF CALENDULA GLYCOSIDES FOR THE TREATMENT OF PSORIASIS
    6.
    发明申请
    USE OF STEREOISOMERS OF CALENDULA GLYCOSIDES FOR THE TREATMENT OF PSORIASIS 审中-公开
    用于治疗PSORIASIS的万寿菊糖苷的立体异构体的使用

    公开(公告)号：WO98032761A1

    公开(公告)日：1998-07-30

    申请号：PCT/GB1998/000183

    申请日：1998-01-23

    IPC分类号： C07H15/20 ,  A61K31/70

    CPC分类号： C07H15/20 ,  Y10S514/86 ,  Y10S514/861 ,  Y10S514/863 ,  Y10S514/864

    摘要： Use of stereoisomeric glycosidic compounds of formula (I) as phar maceutical agents against psoriasis, compounds therefor and pharmaceutical formulation thereof wherein R and R are independently selected from H, -OH, (1) and (2) and related esters and ethers thereto; R is selected from -OH, (3), (4), (5), (6), (7) and (8) and related esters and ethers thereto; R is (9); R is selected from the group -CH, -CHO, -COOH, -CH OH and related esters and ethers thereto; R is selected from OH, (10), (11), (12), (13) and (14) in the preparation of a medicament for the treatment of disease involving hyperproliferation of dermis cells.

    摘要翻译： 使用式（I）的立体异构糖苷化合物作为抗银屑病的药物，其化合物及其药物组合物，其中R 1和R 2独立地选自H，-OH，（1）和（2）和 相关的酯和醚; R 3选自-OH，（3），（4），（5），（6），（7）和（8）及其相关的酯和醚; R 4为（9）; R 5选自-CH，-CHO，-COOH，-CHOH和相关的酯和醚; R 6选自OH，（10），（11），（12），（13）和（14）在制备用于治疗涉及真皮细胞过度增殖的疾病的药物中的用途。

    EXTERNAL PREPARATIONS FOR TREATING DERMATOSES
    7.
    发明申请
    EXTERNAL PREPARATIONS FOR TREATING DERMATOSES 审中-公开
    用于治疗皮肤的外用制剂

    公开(公告)号：WO1996032933A1

    公开(公告)日：1996-10-24

    申请号：PCT/JP1996001081

    申请日：1996-04-22

    申请人： SEKISUI KAGAKU KOGYO KABUSHIKI KAISHA ,  SHIMIZU, Tatsuo ,  HORIGUCHI, Tomoko ,  KURIYAMA, Kiyoshi ,  WATABE, Mitsuo

    发明人： SEKISUI KAGAKU KOGYO KABUSHIKI KAISHA

    IPC分类号： A61K31/01

    CPC分类号： A61K31/01 ,  A61K31/355 ,  A61K31/575 ,  A61K45/06 ,  Y10S514/861 ,  Y10S514/863 ,  Y10S514/864 ,  A61K2300/00

    摘要： The first invention provides an external preparation for treating dermatoses comprising vitamin E and squalane, which has an efficacy at least equivalent to that of external preparations containing adrenocortical hormones as the active ingredient. The second invention provides an external preparation for treating dermatoses comprising an adrenocortical hormone, vitamin E and squalane, which is reduced in adrenocortical hormone content as compared with conventional preparations, is also reduced in side effects, and has high clinical efficacy. The third invention provides an external preparation for treating dermatoses comprising a nonsteroidal antiinflammatory agent, vitamin E, and squalane and/or squalene, which is reduced in side effects and is highly efficacious. The fourth invention provides an external preparation for treating dermatoses comprising an antihistaminic agent, vitamin E, and squalane and/or squalene, which is reduced in side effects and is highly efficacious like the above preparation. The fifth invention provides an external preparation for treating dermatoses comprising vitamin E, squalene and squalane, which is reduced in side effects and is highly efficacious.

    摘要翻译： 第一项发明提供了用于治疗包括维生素E和角鲨烷的皮肤病的外用制剂，其具有至少相当于含有肾上腺皮质激素作为活性成分的外用制剂的功效。 第二发明提供了用于治疗皮肤病的外用制剂，其包含与常规制剂相比降低肾上腺皮质激素含量的肾上腺皮质激素，维生素E和角鲨烷，还减少副作用，并具有高临床疗效。 第三发明提供了用于治疗皮肤病的外用制剂，其包含非甾体抗炎剂，维生素E和角鲨烷和/或角鲨烯，其减少副作用并且是高度有效的。 第四发明提供了用于治疗皮肤病的外用制剂，其包含抗组胺剂，维生素E和角鲨烷和/或角鲨烯，其降低了副作用，并且与上述制剂一样高度有效。 第五发明提供了用于治疗皮肤病的外用制剂，其包含维生素E，角鲨烯和角鲨烷，其减少副作用并且是高度有效的。

    INHIBITORS OF TESTOSTERONE 5'alpha'-REDUCTASE ACTIVITY
    10.
    发明申请
    INHIBITORS OF TESTOSTERONE 5'alpha'-REDUCTASE ACTIVITY 审中-公开
    TESTOSTERONE5α-去激酶活性的抑制剂

    公开(公告)号：WO1993023053A1

    公开(公告)日：1993-11-25

    申请号：PCT/CA1993000192

    申请日：1993-05-06

    申请人： ENDORECHERCHE INC.

    发明人： ENDORECHERCHE INC. ,  LABRIE, Fernand ,  MERAND, Yves, M. ,  SINGH, Shankar, M.

    IPC分类号： A61K31/58

    CPC分类号： C07J73/005 ,  A61K31/58 ,  Y10S514/859 ,  Y10S514/864

    摘要： Inhibitors of testosterone 5 alpha -reductase activity, for example those of formula (I) wherein novel substituents are provided at the R , R , R , R and/or R positions are useful for the treatment of diseases whose progress is aided by activation of androgen receptors, e.g., prostate cancer, benign prostatic hyperplasia, acne, seborrhea, hirsutism, androgenic alopecia and the like.

    摘要翻译： 睾酮5α-还原酶活性的抑制剂，例如其中在R 4，R 6，R 7，R 17和/或R 17上提供新的取代基的式（I） β位置可用于治疗通过激活雄激素受体（例如前列腺癌，良性前列腺增生症，痤疮，皮脂溢，多毛症，雄激素性脱发等）进展的疾病。