公开(公告)号：WO2022183223A1

公开(公告)日：2022-09-01

申请号：PCT/ZA2022/050006

申请日：2022-02-23

Applicant: MEDICAL DIAGNOSTECH (PTY) LTD

Inventor： UYS, Ashley Thurston ,  MUNGUR, Lyndon Barry

IPC: C10L1/00 ,  C07D311/00 ,  C07D311/80 ,  C07C37/00 ,  C07D307/91 ,  C07D311/58

Abstract: A method is provided for marking a petroleum fuel or other carbonaceous fluid with a marker or tracer. The method may include introducing the marker into the fluid. The marker may be a substance that is extractable from a plant (including derivatives thereof and synthetically manufactured versions of such substances and derivatives). The plant may be a Cannabis plant and the marker may comprise cannabis oil or a cannabinoid. A detection method is further provided for detecting the presence of the marker in the fuel or other carbonaceous fluid. The detection method may comprise extracting the marker from the fluid into an aqueous layer, and analysing the aqueous layer for the presence of the marker. A marked carbonaceous product is also provided, comprising a carbonaceous fluid and a marker as described.

公开(公告)号：WO2022178527A1

公开(公告)日：2022-08-25

申请号：PCT/US2022/070714

申请日：2022-02-17

Applicant: LOMA LINDA UNIVERSITY

Inventor： DUERKSEN-HUGHES, Penelope J. ,  CHITSIKE, Lennox

IPC: C07D311/00 ,  A61P35/00 ,  A61K31/00 ,  A61K31/01 ,  A61K31/015 ,  A61K31/33

Abstract: Provided here are compositions and methods for management of human papillomavirus-associated cancers. One such method of treating a human papillomavirus-associated cancer in a subject includes administering to the subject a therapeutically effective amount of gambogic acid or 30-hydroxygambogic acid or a pharmaceutically acceptable derivative thereof. These methods can also include administering one or more of radiation or a chemotherapeutic agent.

公开(公告)号：WO2021241246A1

公开(公告)日：2021-12-02

申请号：PCT/JP2021/018197

申请日：2021-05-13

Applicant: ＪＳＲ株式会社

Inventor： 根本　龍一 ,  宮尾　健介

IPC: C07D317/72 ,  C07D339/06 ,  C07D407/12 ,  C07D497/10 ,  C07D311/00 ,  G03F7/004 ,  G03F7/038 ,  G03F7/039 ,  G03F7/20 ,  C07D307/00

Abstract: 感度やＬＷＲ性能、ＣＤＵ性能を十分なレベルで発揮可能な感放射線性樹脂組成物及びパターン形成方法を提供する。下記式（１）で表される構造を含むオニウム塩化合物と、溶剤とを含む感放射線性樹脂組成物。(上記式（１）中、　Ｒｆ１及びＲｆ２は、それぞれ独立して、フッ素原子又は炭素数１～２０の１価のフッ素化炭化水素基である。　Ｒ１は水素原子、炭素数１～２０の１価の炭化水素基、フッ素原子又は炭素数１～２０の１価のフッ素化炭化水素基である。　Ｒ２、Ｒ３、Ｒ４、Ｒ５、Ｒ６及びＲ７は、それぞれ独立して、水素原子又は炭素数１～２０の１価の炭化水素基である。　ｎ１は０～４の整数である。Ｒｆ１及びＲｆ２がそれぞれ複数ある場合、複数のＲｆ１及びＲｆ２は互いに同一又は異なる。　ｎ２は０～４の整数である。Ｒ１及びＲ２がそれぞれ複数ある場合、複数のＲ１及びＲ２は互いに同一又は異なる。　但し、ｎ１＋ｎ２は２～８の整数である。　ｎ３は０～５の整数である。Ｒ３及びＲ４がそれぞれ複数ある場合、複数のＲ３及びＲ４は互いに同一又は異なる。　Ｘ１及びＸ２は、それぞれ独立して、酸素原子又は硫黄原子である。　＊はそれぞれ他の構造との結合手である。　Ｚ＋は、１価の感放射線性オニウムカチオンである。）

公开(公告)号：WO2020077428A1

公开(公告)日：2020-04-23

申请号：PCT/BR2019/050447

申请日：2019-10-17

Applicant: UNIÃO BRASILEIRA DE EDUCAÇÃO E ASSISTÊNCIA - MANTENEDORA DA PUCRS ,  UNIVERSIDADE FEDERAL DO RIO GRANDE DO SUL

Inventor： SOUTO, André ,  VOLKART, Priscylla ,  LENZ, Guido ,  ONZI, Giovana

IPC: C07D493/00 ,  C07D311/00 ,  C07D311/58 ,  A61K31/352 ,  A61P29/00 ,  A61P35/00 ,  A61P39/00 ,  A61P39/06

Abstract: A presente invenção descreve compostos, o uso de compostos na preparação de uma composição farmacêutica e uma composição farmacêutica compreendendo os compostos conforme fórmula A, seus derivados ou análogos, neutros ou ionizados, para prevenção e/ou terapia senolítica. Especificamente, a presente invenção compreende os compostos de fórmula A, seus derivados ou análogos, neutros ou ionizados, para prevenção e/ou terapia senolítica, por meio de eliminação seletiva de células senescentes.

公开(公告)号：WO2019111093A1

公开(公告)日：2019-06-13

申请号：PCT/IB2018/059285

申请日：2018-11-26

Applicant: CRYSTALMORPHIX TECHNOLOGIES PVT. LTD ,  MUPPIDI, Vamsee Krishna ,  CHINTA, Satyanarayana

Inventor： MUPPIDI, Vamsee Krishna ,  CHINTA, Satyanarayana

IPC: C07D311/00 ,  A61K31/00

Abstract: The present invention relates to an improved process for the separation of gallated epicatechins (EGCG & ECG) from green tea extract or green tea dust. The present invention specifically relates to an improved process for the separation of gallated epicatechins (EGCG & ECG) from green tea extract or green tea dust by forming hydrated gallated epicatechins (EGCG & ECG)-isonicotinic acid complex using isonicotinic acid as acid, organic solvents for liberating gallated epicatechins. The present invention more specifically relates to the process for the separation of gallated epicatechins (EGCG & ECG) from green tea extract or green tea dust, wherein processes comprises steps of dissolving, concentrating by centrifugation, adding, precipitating, filtering, slurrying, removing supernatant liquid, washing, extracting and freeze drying. The present invention also relates to hydrated gallated epicatechins (EGCG &ECG)-isonicotinic acid complex.

公开(公告)号：WO2019070807A1

公开(公告)日：2019-04-11

申请号：PCT/US2018/054102

申请日：2018-10-03

Applicant: RUSH UNIVERSITY MEDICAL CENTER ,  BORENSTEIN, Ronen

Inventor： BORENSTEIN, Ronen

IPC: A61K36/16 ,  A61K9/14 ,  C07D311/00 ,  C07D307/77

CPC classification number: A61P31/12 ,  A61K9/0014 ,  A61K9/0019 ,  A61K9/0043 ,  A61K9/0053 ,  A61K36/16 ,  A61P31/16 ,  A61P31/22

Abstract: Methods of treating a viral infection in a subject are provided. The methods include administering a therapeutically effective amount of a pharmaceutical composition comprising ginkgolic acid (GA) to the subject in need thereof, where the virus comprises an enveloped virus. Further provided are specific viral infections that can be treated using the methods.

公开(公告)号：WO2017175064A1

公开(公告)日：2017-10-12

申请号：PCT/IB2017/000453

申请日：2017-04-04

Applicant: FULL SPECTRUM LABORATORIES LTD

Inventor： KAVARANA, Malcolm J. ,  PEET, Richard C.

IPC: C12P17/06 ,  C07D311/00 ,  C12M1/40 ,  C12P7/22 ,  C12P7/42

Abstract: A method for the bio-enzymatic synthesis of tetrahydrocannabivarin (THC-v), cannabivarin (CBV) and cannabinol (CBN) by contacting a compound according to Formula I with a cannabinoid synthase enzyme. The cannabinoids are produced in the presence of a solvent in a bioreactor equipped with a controller.

Abstract translation: 通过使根据式I的化合物与大麻素合酶接触来生物酶促合成四氢大麻素（THC-v），大麻素（CBV）和大麻酚（CBN）的方法。 大麻素是在装有控制器的生物反应器中在溶剂存在下生产的。

公开(公告)号：WO2017055619A1

公开(公告)日：2017-04-06

申请号：PCT/EP2016/073527

申请日：2016-09-30

Applicant: BIONORICA ETHICS GMBH

Inventor： RUTZ, Andreas ,  ENGLERT, Michael

IPC: B01D11/02 ,  B03D1/10 ,  C07D311/00

CPC classification number: B01D11/02 ,  B03D1/10 ,  C07C37/74 ,  C07C2601/16 ,  C07C39/23

Abstract: Die vorliegende Erfindung betrifft ein Verfahren zur Herstellung, Gewinnung und Anreicherung von Cannabidiol und Verwendung. Die Erfindung betrifft ferner einen Cannabidiol-Extrakt und die Verwendung eines erhaltenen Cannabidiol-Extraktes in der Pharmazie und Kosmetik.

Abstract translation: 本发明涉及一种用于大麻二酚和使用的生产，萃取和浓缩的方法。 本发明还涉及一种大麻二酚提取物和使用的提取物在制药和化妆品获得大麻二酚。

公开(公告)号：WO2014074365A1

公开(公告)日：2014-05-15

申请号：PCT/US2013/067466

申请日：2013-10-30

Applicant: ELI LILLY AND COMPANY

Inventor： AGEJAS-CHICHARRO, Francisco Javier ,  DIAZ BUEZO, Nuria ,  GRUBER, Joseph Michael ,  STACK, Douglas Richard

IPC: C07D309/00 ,  C07D311/00 ,  C07D217/00 ,  C07D319/00 ,  C07D263/00 ,  C07D207/00 ,  C07D273/00 ,  C07D307/00

CPC classification number: C07D491/056 ,  C07D207/00 ,  C07D207/14 ,  C07D217/00 ,  C07D217/24 ,  C07D263/00 ,  C07D263/58 ,  C07D265/30 ,  C07D265/36 ,  C07D273/00 ,  C07D307/00 ,  C07D307/22 ,  C07D307/79 ,  C07D307/87 ,  C07D309/00 ,  C07D309/04 ,  C07D311/00 ,  C07D311/58 ,  C07D311/76 ,  C07D319/00 ,  C07D319/12 ,  C07D319/20 ,  C07D491/052

Abstract: The present invention provides compounds of Formula I. Wherein Rl, L, and A are as described herein, or a pharmaceutical salt thereof, processes for preparing the compounds, and methods of treating a condition, such as hypertriglyceridemia, using the compounds.

Abstract translation: 本发明提供式I化合物。其中R1，L和A如本文所述，或其药学盐，制备化合物的方法，以及使用该化合物治疗诸如高甘油三酯血症的病症的方法。

公开(公告)号：WO2014059228A1

公开(公告)日：2014-04-17

申请号：PCT/US2013/064466

申请日：2013-10-11

Applicant: L'OREAL ,  LAUTEN, Elizabeth, Hunter ,  SIMONNET, Jean-Thierry ,  PAN, Zhi ,  BALOOCH, Guive

Inventor： LAUTEN, Elizabeth, Hunter ,  SIMONNET, Jean-Thierry ,  PAN, Zhi ,  BALOOCH, Guive

IPC: C07D311/00

CPC classification number: A61K31/7076 ,  A61K8/347 ,  A61K8/368 ,  A61K8/4913 ,  A61K8/4926 ,  A61K8/4953 ,  A61K8/498 ,  A61K31/353 ,  A61K2300/00 ,  A61Q19/00 ,  A61Q19/08

Abstract: Aqueous compositions comprising at least one hydrotrope and at least one active compound. The at least one hydrotrope is present in an amount: (a) effective to solubilize said at least one active compound in water; and/or (b) effective to increase transdermal penetration of said at least one active compound; and/or (c) effective to increase the bioavailability of said at least one active compound. The aqueous compositions are provided for cosmetic and other uses. Also provided are methods for preparing and using said compositions.

Abstract translation: 包含至少一种水溶助长剂和至少一种活性化合物的含水组合物。 所述至少一种水溶助长剂存在的量为：（a）有效地将所述至少一种活性化合物溶解在水中; 和/或（b）有效地增加所述至少一种活性化合物的透皮渗透; 和/或（c）有效地增加所述至少一种活性化合物的生物利用度。 水性组合物用于化妆品和其它用途。 还提供了制备和使用所述组合物的方法。