公开(公告)号：WO2022079308A1

公开(公告)日：2022-04-21

申请号：PCT/EP2021/078721

申请日：2021-10-15

申请人： INSTITUT PASTEUR ,  INVECTYS

发明人： CAVAL, Vincent ,  WAIN-HOBSON, Simon

IPC分类号： A61K39/00 ,  A61K39/12 ,  A61P31/00 ,  A61P33/00 ,  A61P35/00 ,  C07K14/78 ,  A61K39/385 ,  A61K2039/60 ,  A61K2039/64 ,  C07K14/70503 ,  C07K2319/735 ,  C12N2760/16134 ,  C12N2770/20034

摘要： The present invention provides nucleic acid constructs that encodes chimeric protein comprising, from N to C term, i) an oligomerization domain of a ficolin or collectin protein, followed by a collagen-like domain of a ficolin or collectin protein; and ii) a heterologous protein or peptide of interest.

公开(公告)号：WO2022211624A1

公开(公告)日：2022-10-06

申请号：PCT/NL2022/050173

申请日：2022-03-30

申请人： RIJKSUNIVERSITEIT GRONINGEN

发明人： MARIC, Ivana ,  OTTO, Sijbren ,  PAPPAS, Charalampos

IPC分类号： C07K5/00 ,  A61K38/00 ,  A61L27/52 ,  A61K47/6935 ,  A61L2400/12 ,  A61L27/227 ,  A61L27/3804 ,  A61L27/56 ,  C07K1/1075 ,  C07K2/00 ,  C07K2319/735

摘要： The invention relates to self-assembling peptide (nano)fibers, hydrogels, and methods, uses and intermediate products and kits relating thereto. Provided is a method for providing peptide-based functionally modified (nano)fibers, comprising (i) providing a fiber forming solution comprising pseudopeptide building blocks of the formula A-Peptide-B, wherein: Peptide is a moiety of 1 to 8 amino acid residues having a sequence that is predisposed to form a one-dimensional array, such as β-sheet fibrils; A is an aromatic moiety carrying two reactive thiol groups; and B is a reactive α-nucleophile; (ii) exposing the fiber forming solution to oxidizing conditions to induce supramolecular self-assembly of the pseudopeptide building blocks into peptide-based (nano)fibers; and (iii) contacting said (nano)fibers with at least one biologically relevant functional group of interest comprising reactivity C forming a reactive pair with B to obtain covalently functionally modified nanofibers.

公开(公告)号：WO2021252450A1

公开(公告)日：2021-12-16

申请号：PCT/US2021/036342

申请日：2021-06-08

申请人： ADAPTIVE PHAGE THERAPEUTICS, INC. ,  UNITED STATES OF AMERICA AS REPRESENTED BY THE SECRETARY OF THE NAVY

发明人： MERRIL, Carl ,  BISWAS, Biswajit

IPC分类号： A61K39/12 ,  A61P11/00 ,  A61P31/14 ,  C12N7/00 ,  C12N15/73 ,  A61K39/00 ,  A61K2039/5254 ,  A61K2039/57 ,  C07K2319/00 ,  C07K2319/735 ,  C12N2795/00034 ,  C12N2795/16034

摘要： Vaccines directed to the SARS-CoV-2 antigen, methods of administering and/or treating a subject (including prophylactic treatment) infected and/or at risk of being infected with SARS-CoV-2. A transdermal membrane comprising a non-infectious icosahedral phage vaccine displaying a SARS-CoV-2 antigen is described wherein the membrane is stable at room temperature for greater than 3 months and uses thereof to vaccinate a subject against the SARS-CoV-2 antigen.

公开(公告)号：WO2021113598A2

公开(公告)日：2021-06-10

申请号：PCT/US2020/063245

申请日：2020-12-04

申请人： CHAN ZUCKERBERG BIOHUB, INC. ,  THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY

发明人： LASKER, Keren ,  BOEYNAEMS, Steven ,  GITLER, Aaron David ,  SHAPIRO, Lucy

IPC分类号： C07K14/195 ,  C12N15/62 ,  C07K2319/735 ,  C12P21/02

摘要： Proteins and fusion proteins for forming menbraneless droplets in cells are provided. Described herein, is the development of a protein, named PopTag, that drives phase separation when it is part of a chimeric fusion protein. PopTag is engineered from the PopZ protein, found in a-proteobacteria (including Caulobacter crescentus). Despite PopZ being exclusively found in this clade of bacteria, the PopTag can drive protein phase separation in other prokaryotes (e.g., E. coli) and eukaryotes (e.g., human cells).

公开(公告)号：WO2023057777A1

公开(公告)日：2023-04-13

申请号：PCT/GB2022/052555

申请日：2022-10-07

申请人： PENCIL BIOSCIENCES LIMITED

发明人： IBRAHIM, Mohamed Rajik Mohamed ,  KANWAR, Nisha ,  RAITSKIN, Oleg

IPC分类号： C12N15/62 ,  C12N15/11 ,  C12N9/22 ,  C12N15/10 ,  C07K2319/735 ,  C07K2319/80 ,  C07K2319/85 ,  C12N15/102 ,  C12N2310/20

摘要： The present invention provides a synthetic, modular system for DNA modification as may be employed for genome editing comprising a targeting nucleic acid possessing both DNA targeting ability and ability to bind a recognition module of a modular polypeptide component, where the modular polypeptide component also includes an effector component and a short peptide DNA-binding sequence (DBD) which binds a pre-determined sequence (PBS) in the target. The DBD may preferably be no more than a 15 mer and serves to destabilize the structure of a targeted dsDNA upon binding thereby facilitating the desired DNA modification. The effector component may, for example, be an artificial nickase comprising linked self-assembling peptides thereby providing a complete genome-editing system of advantageous small size for vector delivery to cells.

公开(公告)号：WO2022246199A1

公开(公告)日：2022-11-24

申请号：PCT/US2022/030256

申请日：2022-05-20

申请人： GASILUS PHARMACEUTICALS, INC.

发明人： LI, Ning

IPC分类号： C12N15/70 ,  C07K14/32 ,  C07K2319/735 ,  C12N15/62

摘要： The present disclosure features the chimeric gas vesicle (CGV) and its expression in E. coli. The chimeric gas vesicle comprises two or more gas vesicle rib proteins. The heterologous peptides, 6-AA to 56-AA long, can be inserted into one recombinant rib protein in frame. The resulting CGV carrying the heterologous peptide can be used in many applications.

公开(公告)号：WO2022200582A1

公开(公告)日：2022-09-29

申请号：PCT/EP2022/057945

申请日：2022-03-25

申请人： GLAXOSMITHKLINE BIOLOGICALS SA ,  UNITED STATES OF AMERICA, as represented by THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES

发明人： VASSILEV, Ventzislav Bojidarov ,  MALLETT, Corey ,  ROUXEL, Ronan ,  BLAIS, Normand ,  KANEKIYO, Masaru ,  GRAHAM, Barney, Scott

IPC分类号： A61K39/12 ,  A61K39/145 ,  A61K39/39 ,  A61P31/16 ,  A61K2039/55505 ,  A61K2039/55555 ,  A61K2039/55566 ,  C07K14/005 ,  C07K2319/00 ,  C07K2319/735 ,  C12N2760/16122 ,  C12N2760/16134

摘要： The present invention relates to influenza virus immunisation using at least one influenza HA stem polypeptide in conjunction with squalene emulsion adjuvants, and to related aspects.

公开(公告)号：WO2022109275A2

公开(公告)日：2022-05-27

申请号：PCT/US2021/060099

申请日：2021-11-19

申请人： WAKE FOREST UNIVERSITY HEALTH SCIENCES

发明人： LU, Baisong ,  ATALA, Anthony

IPC分类号： C12N15/113 ,  C12N15/115 ,  C12N15/86 ,  C12N9/22 ,  C12N9/78 ,  C07K14/155 ,  C07K14/005 ,  C07K2319/735 ,  C12N2310/16 ,  C12N2310/20 ,  C12N2310/3519 ,  C12N2320/32 ,  C12N2740/16023 ,  C12N2740/16043 ,  C12Y305/04004

摘要： Provided herein are compositions and methods for editing the genome of a eukaryotic cell.

公开(公告)号：WO2022035739A2

公开(公告)日：2022-02-17

申请号：PCT/US2021/045178

申请日：2021-08-09

申请人： THE SCRIPPS RESEARCH INSTITUTE

发明人： HE, Linling ,  ZHU, Jiang ,  CHAUDHARY, Anshul ,  WILSON, Ian

IPC分类号： A61K39/12 ,  C07K14/005 ,  C07K14/08 ,  C07K14/473 ,  C07K2317/34 ,  C07K2319/735 ,  C12N2760/14134 ,  C12N7/00

摘要： The present invention provides novel engineered Ebolavirus GP proteins and polypeptides, as well as scaffolded vaccine compositions that display the engineered proteins. The invention also provides methods of using such engineered Ebolavirus GP proteins and vaccine compositions in various therapeutic applications, e.g., for preventing or treating Ebolavirus infections.

公开(公告)号：WO2021252688A1

公开(公告)日：2021-12-16

申请号：PCT/US2021/036689

申请日：2021-06-09

申请人： ICOSAVAX, INC. ,  SHEPARD, Scot R. ,  LIEN, Hans R. ,  TAYLOR, Ross M.

发明人： RICHARDSON, Charles

IPC分类号： C07K14/005 ,  A61K39/12 ,  B82Y5/00 ,  C12N15/62 ,  C07K14/115 ,  A61K2039/5258 ,  C07K2319/40 ,  C07K2319/735 ,  C12N2760/18534

摘要： Disclosed are methods of a method of making a nanostructure, comprising adding a component A (compA) protein to a solution comprising a component B (compB) protein under conditions that minimize shear stress, thereby forming a compA:compB complex. Further disclosed are methods of making a nanostructure, comprising (i) providing a first inlet fluid stream comprising a first protein and a second inlet fluid stream comprising a second protein, and (ii) contacting the first inlet fluid stream and the second inlet fluid stream to form an outlet stream, wherein mixing of the first protein and the second protein occurs in the outlet stream, thereby forming a protein complex comprises the first protein and the second protein. A microfluidic mixer may be used. The methods may further comprise purifying the compA:compB complex from excess compA, excess compB, and/or other impurities by filtering the solution with a 1,000 kDa membrane or an equivalent thereof.