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发明授权
CN105566213B 具有高穿透性的抗微生物剂和抗微生物剂相关化合物的前药组合物 有权 质押 转让

具有高穿透性的抗微生物剂和抗微生物剂相关化合物的前药组合物
摘要：
在此提供了抗微生物剂和抗微生物剂相关化合物的具有高穿透性的组合物(high penetration compositions，HPC)或具有高穿透性的前药(high penetration prodrugs，HPP)。HPC/HPP穿透生物屏障后可被转化成母药或药物代谢物，从而提供治疗。此外，该HPC/HPP可到达母药不能到达的区域，或者可在靶向作用区域达到足够高的浓度，从而提供一种全新的治疗方式。
摘要（英）：

High penetration comp1ositions (HPCs) or prodrugs (HPPs) of antimicrobials and antimicrobial-related compounds are provided. The HPCs/HPPs are capable of being converted to parent drugs or drug metabolites after crossing the biological barrier and thus can render treatments. Additionally, the HPCs/HPPs are capable of reaching areas that their parent drugs may not be able to access and rendering a sufficient concentration at the target areas and therefore render novel treatments.

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