Compounds represented by the following general formula (I), prodrugs thereof, salts thereof and drugs containing the same as the active ingredient: (I) wherein each symbol has the meaning as defined in the specification. Because of having an EDG-1 agonism, the compounds of the general formula (I) are useful in preventing and/or treating arteriosclerosis obliterans, thromboangiitis obliterans, Buerger’s disease, peripheral arterial disease of diabetic neuropathy, sepsis, angiitis, nephritis, pneumonia, brain infarction, myocardial infarction, edematous diseases, arteriosclerosis, hemorrhoid, anal fissure, varicosity such as anal fistula, dissecting aneurysm, angina, DIC, pleuritis, congestive heart failure, multiorgan failure, bedsore, ambustion, ulcerative colitis, Crohn’s disease, heart transplantation, kidney transplantation, skin transplantation, liver transplantation, osteoporosis, pulmonary fibrosis, interstitial pneumonia, chronic hepatitis, cirrhosis, chronic renal failure or glomerular sclerosis.