公开(公告)号：EP1533294A4

公开(公告)日：2007-07-04

申请号：EP03733129

申请日：2003-05-28

申请人： ONO PHARMACEUTICAL CO

发明人： HABASHITA HIROMU ,  TERAKADO MASAHIKO ,  NAKADE SHINJI ,  SEKO TAKUYA

IPC分类号： A61P1/16 ,  A61P3/10 ,  A61P5/14 ,  A61P9/02 ,  A61P9/10 ,  A61P9/14 ,  A61P11/00 ,  A61P13/00 ,  A61P13/02 ,  A61P13/08 ,  A61P13/10 ,  A61P13/12 ,  A61P17/06 ,  A61P19/10 ,  A61P25/00 ,  A61P25/02 ,  A61P25/16 ,  A61P25/28 ,  A61P27/02 ,  A61P27/06 ,  A61P29/00 ,  A61P35/00 ,  A61P35/02 ,  A61P35/04 ,  A61P37/00 ,  A61P43/00 ,  C07C233/83 ,  C07C311/46 ,  C07D209/16 ,  C07D213/38 ,  C07D213/40 ,  C07D217/06 ,  C07D307/52 ,  C07D333/20 ,  C07D401/12 ,  C07D403/12 ,  C07D405/12 ,  C07D409/12

CPC分类号： C07D213/40 ,  C07C233/83 ,  C07C311/46 ,  C07C2602/08 ,  C07C2602/10 ,  C07D209/16 ,  C07D213/38 ,  C07D217/06 ,  C07D307/52 ,  C07D333/20 ,  C07D401/12 ,  C07D403/12 ,  C07D405/12 ,  C07D409/12

摘要： A compound of the general formula: (I) wherein the symbols are as defined in the description, or a prodrug or salt thereof. This compound engages in LPA receptor bonding and antagonism and hence is useful in the prevention and/or treatment of urologic diseases (symptoms associated with prostate-gland enlargement or neuropathic bladder, bone tomors of the spine, disk herniation, spinal canal stenosis, symptoms attributed to diabetes, lower urinary tract infections (e.g., obstruction of lower urinary tract), inflammation of lower urinary tract and polyuria), cancer-associated diseases (solid tumor, solid tumor metastasis, angiofibroma, myeloma, multiple myeloma, Kaposi’s sarcoma, leukemia and wet metastasis of cancer), proliferative diseases (diseases accompanied by abnormal angiogenesis, blocked artery and lung fibrosis), inflammation/immune diseases (psoriasis, nephropathy, hepatisis and pneumonia), diseases caused by secretion disorder (Sjogren’s syndrome) or brain-associated diseases (brain block, cerebral hemorrhage and cerebral or peripheral nerve disorder).

公开(公告)号：EP1391199A4

公开(公告)日：2004-12-01

申请号：EP02769553

申请日：2002-05-09

申请人： ONO PHARMACEUTICAL CO

发明人： SEKO TAKUYA ,  TERAKADO MASAHIKO ,  KOHNO HIROSHI ,  TAKAHASHI SHINYA

IPC分类号： A61K31/166 ,  A61K31/167 ,  A61K31/192 ,  A61K31/194 ,  A61K31/196 ,  A61K31/216 ,  A61K31/343 ,  A61K31/381 ,  A61K31/402 ,  A61K31/4184 ,  A61K31/44 ,  A61K31/4402 ,  A61K31/4409 ,  A61K31/5375 ,  A61P1/00 ,  A61P1/04 ,  A61P1/16 ,  A61P9/00 ,  A61P9/10 ,  A61P9/14 ,  A61P11/00 ,  A61P13/12 ,  A61P17/00 ,  A61P17/02 ,  A61P19/10 ,  A61P27/02 ,  A61P29/00 ,  A61P31/04 ,  A61P43/00 ,  C07C59/68 ,  C07C229/14 ,  C07C229/60 ,  C07C229/62 ,  C07C233/17 ,  C07C233/51 ,  C07C233/73 ,  C07C235/34 ,  C07C235/38 ,  C07C235/66 ,  C07C237/20 ,  C07C237/30 ,  C07C237/32 ,  C07C237/42 ,  C07C311/17 ,  C07C323/62 ,  C07C323/63 ,  C07D213/30 ,  C07D213/40 ,  C07D213/79 ,  C07D213/80 ,  C07D213/82 ,  C07D235/12 ,  C07D295/155 ,  C07D307/60 ,  C07D333/16

CPC分类号： C07D213/30 ,  A61K31/166 ,  A61K31/167 ,  A61K31/192 ,  A61K31/194 ,  A61K31/196 ,  A61K31/216 ,  A61K31/343 ,  A61K31/381 ,  A61K31/402 ,  A61K31/4184 ,  A61K31/44 ,  A61K31/4402 ,  A61K31/4409 ,  A61K31/5375 ,  C07C59/68 ,  C07C229/14 ,  C07C229/60 ,  C07C229/62 ,  C07C233/17 ,  C07C233/51 ,  C07C233/73 ,  C07C235/34 ,  C07C235/38 ,  C07C235/66 ,  C07C237/20 ,  C07C237/30 ,  C07C237/32 ,  C07C237/42 ,  C07C311/17 ,  C07C323/62 ,  C07C323/63 ,  C07D213/40 ,  C07D213/79 ,  C07D213/80 ,  C07D213/82 ,  C07D235/12 ,  C07D295/155 ,  C07D307/60 ,  C07D333/16

摘要： Compounds represented by the following general formula (I), prodrugs thereof, salts thereof and drugs containing the same as the active ingredient: (I) wherein each symbol has the meaning as defined in the specification. Because of having an EDG-1 agonism, the compounds of the general formula (I) are useful in preventing and/or treating arteriosclerosis obliterans, thromboangiitis obliterans, Buerger’s disease, peripheral arterial disease of diabetic neuropathy, sepsis, angiitis, nephritis, pneumonia, brain infarction, myocardial infarction, edematous diseases, arteriosclerosis, hemorrhoid, anal fissure, varicosity such as anal fistula, dissecting aneurysm, angina, DIC, pleuritis, congestive heart failure, multiorgan failure, bedsore, ambustion, ulcerative colitis, Crohn’s disease, heart transplantation, kidney transplantation, skin transplantation, liver transplantation, osteoporosis, pulmonary fibrosis, interstitial pneumonia, chronic hepatitis, cirrhosis, chronic renal failure or glomerular sclerosis.

公开(公告)号：EP1553075A4

公开(公告)日：2009-11-04

申请号：EP03733131

申请日：2003-05-28

申请人： ONO PHARMACEUTICAL CO

发明人： TERAKADO MASAHIKO ,  NAKADE SHINJI ,  SEKO TAKUYA ,  TAKAOKA YOSHIKAZU

IPC分类号： A61K31/192 ,  A61K31/216 ,  A61K31/402 ,  A61K31/4035 ,  A61K31/404 ,  A61K31/41 ,  A61K31/4184 ,  A61K31/4402 ,  A61K31/445 ,  A61K31/472 ,  A61K31/517 ,  A61K31/5415 ,  C07C65/40 ,  C07C235/52

CPC分类号： C07D211/96 ,  C07C217/58 ,  C07C233/22 ,  C07C233/51 ,  C07C233/63 ,  C07C233/73 ,  C07C233/87 ,  C07C235/34 ,  C07C235/48 ,  C07C235/52 ,  C07C2601/08 ,  C07D207/12 ,  C07D207/327 ,  C07D209/08 ,  C07D209/12 ,  C07D209/14 ,  C07D209/46 ,  C07D213/65 ,  C07D213/89 ,  C07D217/06 ,  C07D231/12 ,  C07D231/14 ,  C07D235/12 ,  C07D239/91 ,  C07D257/04 ,  C07D277/36 ,  C07D277/56 ,  C07D279/08 ,  C07D307/68 ,  C07D317/68 ,  C07D333/70