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公开(公告)号：EP1553075A4
公开(公告)日：2009-11-04
申请号：EP03733131
申请日：2003-05-28
IPC分类号： A61K31/192 , A61K31/216 , A61K31/402 , A61K31/4035 , A61K31/404 , A61K31/41 , A61K31/4184 , A61K31/4402 , A61K31/445 , A61K31/472 , A61K31/517 , A61K31/5415 , C07C65/40 , C07C235/52
CPC分类号： C07D211/96 , C07C217/58 , C07C233/22 , C07C233/51 , C07C233/63 , C07C233/73 , C07C233/87 , C07C235/34 , C07C235/48 , C07C235/52 , C07C2601/08 , C07D207/12 , C07D207/327 , C07D209/08 , C07D209/12 , C07D209/14 , C07D209/46 , C07D213/65 , C07D213/89 , C07D217/06 , C07D231/12 , C07D231/14 , C07D235/12 , C07D239/91 , C07D257/04 , C07D277/36 , C07D277/56 , C07D279/08 , C07D307/68 , C07D317/68 , C07D333/70
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公开(公告)号：EP1533294A4
公开(公告)日：2007-07-04
申请号：EP03733129
申请日：2003-05-28
IPC分类号： A61P1/16 , A61P3/10 , A61P5/14 , A61P9/02 , A61P9/10 , A61P9/14 , A61P11/00 , A61P13/00 , A61P13/02 , A61P13/08 , A61P13/10 , A61P13/12 , A61P17/06 , A61P19/10 , A61P25/00 , A61P25/02 , A61P25/16 , A61P25/28 , A61P27/02 , A61P27/06 , A61P29/00 , A61P35/00 , A61P35/02 , A61P35/04 , A61P37/00 , A61P43/00 , C07C233/83 , C07C311/46 , C07D209/16 , C07D213/38 , C07D213/40 , C07D217/06 , C07D307/52 , C07D333/20 , C07D401/12 , C07D403/12 , C07D405/12 , C07D409/12
CPC分类号： C07D213/40 , C07C233/83 , C07C311/46 , C07C2602/08 , C07C2602/10 , C07D209/16 , C07D213/38 , C07D217/06 , C07D307/52 , C07D333/20 , C07D401/12 , C07D403/12 , C07D405/12 , C07D409/12
摘要： A compound of the general formula: (I) wherein the symbols are as defined in the description, or a prodrug or salt thereof. This compound engages in LPA receptor bonding and antagonism and hence is useful in the prevention and/or treatment of urologic diseases (symptoms associated with prostate-gland enlargement or neuropathic bladder, bone tomors of the spine, disk herniation, spinal canal stenosis, symptoms attributed to diabetes, lower urinary tract infections (e.g., obstruction of lower urinary tract), inflammation of lower urinary tract and polyuria), cancer-associated diseases (solid tumor, solid tumor metastasis, angiofibroma, myeloma, multiple myeloma, Kaposi’s sarcoma, leukemia and wet metastasis of cancer), proliferative diseases (diseases accompanied by abnormal angiogenesis, blocked artery and lung fibrosis), inflammation/immune diseases (psoriasis, nephropathy, hepatisis and pneumonia), diseases caused by secretion disorder (Sjogren’s syndrome) or brain-associated diseases (brain block, cerebral hemorrhage and cerebral or peripheral nerve disorder).
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3.发明公开REMEDIES FOR STRESS DISEASES COMPRISING MITOCHONDRIAL BENZODIAZEPINE RECEPTOR ANTAGONISTS 审中-公开手段与压力有关的疾病与线粒体苯二氮受体拮抗剂治疗
公开(公告)号：EP1438973A4
公开(公告)日：2005-07-13
申请号：EP02800776
申请日：2002-10-04
发明人： SEKO TAKUYA , KATSUMATA S , KATO M , MANAKO JUN-ICHIRO
IPC分类号： A61K31/166 , A61K31/167 , A61K31/277 , A61K31/381 , A61K31/4015 , A61K31/41 , A61K31/415 , A61K31/4427 , A61K31/47 , A61K31/517 , A61K31/519 , A61P1/00 , A61P1/02 , A61P3/00 , A61P3/04 , A61P3/10 , A61P11/00 , A61P11/06 , A61P15/00 , A61P15/10 , A61P15/12 , A61P17/00 , A61P17/14 , A61P19/02 , A61P27/02 , A61P27/16 , A61P29/00 , A61P35/00 , C07D217/18 , C07D257/04 , C07D307/68 , C07D317/22 , C07D319/20 , C07D333/38 , C07D401/12 , C07D403/12 , C07D405/04 , C07D405/12 , C07D409/04 , A61K45/00
CPC分类号： C07D257/04 , A61K31/166 , A61K31/167 , A61K31/277 , A61K31/381 , A61K31/4015 , A61K31/41 , A61K31/415 , A61K31/4427 , A61K31/47 , A61K31/517 , A61K31/519 , C07D217/18 , C07D307/68 , C07D317/22 , C07D319/20 , C07D333/38 , C07D401/12 , C07D403/12 , C07D405/04 , C07D405/12 , C07D409/04
摘要： Preventives and/or remedies for diseases, which are induced, worsened or made to recrudesce by stressors, comprising mitochondrial benzodiazepine receptor (MBR) antagonists such as compounds represented by the following general formula (I) as the active ingredient: (I) wherein each symbol is as defined in the description. Because of inhibiting the reproduction of neurosteroids, the compounds having an MBR antagonistic activity are useful as preventives and/or remedies for diseases which are induced, worsened or made to recrudesce by stressors.
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4.发明公开FUSED PYRIDAZINE DERIVATIVE COMPOUNDS AND DRUGS CONTAINING THE COMPOUNDS AS THE ACTIVE INGREDIENT 有权简明哒嗪衍生物化合物及化合物作为活性药物含
公开(公告)号：EP1477175A4
公开(公告)日：2006-03-22
申请号：EP03705265
申请日：2003-02-18
IPC分类号： C07D237/32 , A61K31/501 , A61K31/502 , A61K31/5025 , A61K31/53 , A61K31/5377 , A61K31/541 , A61K31/542 , A61K31/55 , A61K31/551 , A61K31/554 , A61P3/10 , A61P7/08 , A61P9/00 , A61P9/10 , A61P13/12 , A61P25/00 , A61P27/06 , A61P29/00 , A61P31/12 , A61P31/18 , A61P35/00 , A61P37/06 , A61P43/00 , C07D237/26 , C07D401/06 , C07D401/12 , C07D403/06 , C07D403/12 , C07D405/06 , C07D405/12 , C07D409/12 , C07D417/12 , C07D471/04 , C07D487/04 , C07D513/04
CPC分类号： C07D403/06 , C07D237/26 , C07D237/32 , C07D401/06 , C07D401/12 , C07D403/12 , C07D405/06 , C07D405/12 , C07D409/12 , C07D417/12 , C07D471/04 , C07D487/04 , C07D513/04
摘要： Fused pyridazine derivatives represented by the following general formula (I) (wherein each symbol is as defined in the description) and pharmaceutically acceptable salts thereof: (I) Because of inhibiting poly(ADP-ribose)polymerase, the compounds represented by the general formula (I) are useful as preventives and/or remedies for various ischemic diseases (in brain, cord, heart, digestive tract, skeletal muscle, retina, etc.), inflammatory diseases (inflammatory bowel disease, multiple cerebrosclerosis, arthritis, etc.), neurodegenerative diseases (extrapyramidal disorder, Alzheimer’s disease, muscular dystrophy, lumbar spinal canal stenosis, etc.), diabetes, shock, head trauma, renal failure, hyperalgesia, etc. Moreover, these compounds are useful as agents against retroviruses (HIV, etc.) and sensitizers and immunosuppressants in treating cancer.
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5.发明公开
公开(公告)号：EP1391199A4
公开(公告)日：2004-12-01
申请号：EP02769553
申请日：2002-05-09
IPC分类号： A61K31/166 , A61K31/167 , A61K31/192 , A61K31/194 , A61K31/196 , A61K31/216 , A61K31/343 , A61K31/381 , A61K31/402 , A61K31/4184 , A61K31/44 , A61K31/4402 , A61K31/4409 , A61K31/5375 , A61P1/00 , A61P1/04 , A61P1/16 , A61P9/00 , A61P9/10 , A61P9/14 , A61P11/00 , A61P13/12 , A61P17/00 , A61P17/02 , A61P19/10 , A61P27/02 , A61P29/00 , A61P31/04 , A61P43/00 , C07C59/68 , C07C229/14 , C07C229/60 , C07C229/62 , C07C233/17 , C07C233/51 , C07C233/73 , C07C235/34 , C07C235/38 , C07C235/66 , C07C237/20 , C07C237/30 , C07C237/32 , C07C237/42 , C07C311/17 , C07C323/62 , C07C323/63 , C07D213/30 , C07D213/40 , C07D213/79 , C07D213/80 , C07D213/82 , C07D235/12 , C07D295/155 , C07D307/60 , C07D333/16
CPC分类号： C07D213/30 , A61K31/166 , A61K31/167 , A61K31/192 , A61K31/194 , A61K31/196 , A61K31/216 , A61K31/343 , A61K31/381 , A61K31/402 , A61K31/4184 , A61K31/44 , A61K31/4402 , A61K31/4409 , A61K31/5375 , C07C59/68 , C07C229/14 , C07C229/60 , C07C229/62 , C07C233/17 , C07C233/51 , C07C233/73 , C07C235/34 , C07C235/38 , C07C235/66 , C07C237/20 , C07C237/30 , C07C237/32 , C07C237/42 , C07C311/17 , C07C323/62 , C07C323/63 , C07D213/40 , C07D213/79 , C07D213/80 , C07D213/82 , C07D235/12 , C07D295/155 , C07D307/60 , C07D333/16
摘要： Compounds represented by the following general formula (I), prodrugs thereof, salts thereof and drugs containing the same as the active ingredient: (I) wherein each symbol has the meaning as defined in the specification. Because of having an EDG-1 agonism, the compounds of the general formula (I) are useful in preventing and/or treating arteriosclerosis obliterans, thromboangiitis obliterans, Buerger’s disease, peripheral arterial disease of diabetic neuropathy, sepsis, angiitis, nephritis, pneumonia, brain infarction, myocardial infarction, edematous diseases, arteriosclerosis, hemorrhoid, anal fissure, varicosity such as anal fistula, dissecting aneurysm, angina, DIC, pleuritis, congestive heart failure, multiorgan failure, bedsore, ambustion, ulcerative colitis, Crohn’s disease, heart transplantation, kidney transplantation, skin transplantation, liver transplantation, osteoporosis, pulmonary fibrosis, interstitial pneumonia, chronic hepatitis, cirrhosis, chronic renal failure or glomerular sclerosis.
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6.发明公开AMINO ACID DERIVATIVES AND DRUGS CONTAINING THE SAME AS THE ACTIVE INGREDIENT 审中-公开氨基酸衍生物和药物，如活性成分含
公开(公告)号：EP1097929A4
公开(公告)日：2005-12-21
申请号：EP99929813
申请日：1999-07-13
发明人： SEKO TAKUYA , KATO MASASHI
IPC分类号： C07D277/06 , C07D401/12 , C07D417/06 , C07D417/12 , C07D417/14 , C07D277/04 , A61K31/425 , A61K31/44 , A61K31/445 , A61K31/535 , A61K38/05 , C07K5/078
CPC分类号： C07D417/12 , C07D277/06 , C07D417/06 , C07D417/14
摘要： Compounds represented by general formula (I) and salts thereof, wherein each symbol is as defined in the specification. The compounds of general formula (I) inhibit the N-type calcium channel, which makes them useful as preventives and/or remedies for brain infraction, transient cerebral ischemic attack, postoperative cerebrospinal failure, spinal vascular failure, stress hypertension, neurosis, epilepsy, asthma, frequent urination, etc. or remedies for pain.
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7.发明公开2H-PHTHALAZIN-1-ONE DERIVATIVES AND DRUGS COMPRISING THESE DERIVATIVES AS THE ACTIVE INGREDIENT 审中-公开-2H-二氮杂萘-1-酮衍生物AND DRUG组合物含有这些衍生物作为活性成分包括
公开(公告)号：EP1148053A4
公开(公告)日：2002-03-06
申请号：EP00900889
申请日：2000-01-24
发明人： SEKO TAKUYA , TAKEUCHI JUN , TAKAHASHI SHINYA , NAKA MASAO
IPC分类号： A61K31/502 , C07D237/32 , C07D401/12 , C07D403/12 , C07D405/12 , C07D409/12 , C07D417/12
CPC分类号： C07D401/12 , A61K31/502 , C07D237/32 , C07D403/12 , C07D405/12 , C07D409/12 , C07D417/12
摘要： Poly(ADP-ribose)polymerase inhibitors containing as the active ingredient 2H-phthalazin-1-one derivatives represented by general formula (I) (wherein each symbol is as defined in the description) or salts thereof. The compounds of the general formula (I) inhibit poly(ADP-ribose)polymerase and are useful as preventives and/or remedies for various ischemic diseases (brain, heart, digestive tract, skeletal muscle, retina, etc.), inflammatory diseases (inflammatory intestinal diseases, multiple encephalosclerosis, arthritis, etc.), nerve degeneration diseases (extrapyramidal disorder, Alzheimer's disease, muscular dystrophy, etc.), diabetes, shock, head trauma, renal insufficiency, hyperalgesia, etc. These compounds are also useful as sensitizers for agents against retroviruses (HIV, etc.) and chemotherapy for cancer.
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公开(公告)号：EP0783488A4
公开(公告)日：1998-01-07
申请号：EP95934464
申请日：1995-09-27
发明人： LEE SUNG JAI , SEKO TAKUYA , FRIERSON MANTON RODGERS , SIRCAR JAGADISH CHANDRA , CAO CHARLES XIAN
IPC分类号： A61K31/34 , A61K31/341 , A61K31/381 , A61K31/40 , A61K31/4025 , A61K31/4035 , A61K31/4164 , A61K31/4172 , A61K31/4178 , A61K31/443 , A61K31/4436 , A61K31/4439 , A61P17/00 , A61P43/00 , C07D207/32 , C07D207/333 , C07D207/337 , C07D233/54 , C07D233/64 , C07D263/32 , C07D277/20 , C07D277/30 , C07D307/54 , C07D333/24 , C07D403/10 , C07D405/06 , C07D409/06 , C07D409/10 , A61K31/415 , A61K31/42 , A61K31/425 , C07D277/24 , C07D307/46 , C07D333/22
CPC分类号： C07D207/337 , A61K31/341 , A61K31/381 , A61K31/40 , A61K31/4025 , A61K31/4035 , A61K31/4164 , A61K31/4172 , A61K31/4174 , A61K31/4178 , A61K31/443 , A61K31/4436 , A61K31/4439 , C07D233/64 , C07D307/54 , C07D333/24 , C07D403/10 , C07D405/06 , C07D409/06 , C07D409/10
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9.发明公开AMINO ACID DERIVATIVES AND DRUGS CONTAINING THE SAME AS THE ACTIVE INGREDIENT 审中-公开AMINOSÄUREDERIVATEUND MEDIKAMENTE DIE DIESE ALS WIRKSTOFF ENTHALTEN
公开(公告)号：EP1090912A4
公开(公告)日：2010-01-06
申请号：EP99928205
申请日：1999-06-25
发明人： SEKO TAKUYA , KATO MASASHI
IPC分类号： A61K31/445 , A61K38/00 , A61P9/00 , C07C323/60 , C07D207/14 , C07D211/26 , C07D211/58 , C07D213/74 , C07D277/06 , C07D295/135 , C07D295/185 , C07D409/12 , C07D417/12 , C07K5/06 , C07K5/078 , A61K31/165 , A61K31/425 , A61K31/495 , A61K31/535 , C07D295/12 , C07D295/18
CPC分类号： C07D213/74 , A61K38/00 , C07B2200/07 , C07C323/60 , C07C2601/14 , C07D211/26 , C07D211/58 , C07D277/06 , C07D295/135 , C07D295/185 , C07D409/12 , C07D417/12 , C07K5/06139 , C07K5/06191
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10.发明公开N-CARBAMOYL NITROGEN-CONTAINING FUSED RING COMPOUNDS AND DRUGS CONTAINING THESE COMPOUNDS AS THE ACTIVE INGREDIENT 审中-公开含氮N-氨基甲酰基稠环，和药物含有这些化合物作为活性CONTAIN
公开(公告)号：EP1475368A4
公开(公告)日：2006-03-29
申请号：EP03705105
申请日：2003-02-13
IPC分类号： A61P1/00 , A61P1/04 , A61P1/16 , A61P1/18 , A61P43/00 , C07D223/16 , C07D401/12 , A61K31/395 , A61K31/553 , A61K35/55 , C07D225/06 , C07D405/12 , C07D409/12 , C07D413/12 , C07D417/12 , C07D471/04 , C07D495/04
CPC分类号： C07D401/12 , C07D223/16
摘要： Compounds represented by the following general formula (I): (I) wherein each symbol is as defined in the description; mitochondrial benzodiazepine receptor (MBR) antagonists comprising these compounds; and preventives and/or remedies for diseases caused by stress which comprise the above compounds as the active ingredient. Because of having an MBR antagonistic activity and inhibiting the production of neurosteroids, the compounds represented by the general formula (I) are useful as preventives and/or remedies for diseases caused by stress.
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