![1-(chloromethyl)-2,3-dihydro-1H-benzo[E]indole dimer antibody-drug conjugate compounds, and methods of use and treatment](/docs/US/2019-10-15/US10442836B2/abs.jpg.600x600.jpg)
- 专利标题： 1-(chloromethyl)-2,3-dihydro-1H-benzo[E]indole dimer antibody-drug conjugate compounds, and methods of use and treatment
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申请号： US14305643申请日： 2014-06-16
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公开(公告)号： US10442836B2公开(公告)日： 2019-10-15
- 发明人: John Flygare , Thomas Pillow , Brian Safina , Vishal Verma , Binqing Wei , William Denny , Anna Giddens , Ho Lee , Guo-Liang Lu , Christian Miller , Gordon Rewcastle , Moana Tercel , Muriel Bonnet
- 申请人： Genentech, Inc.
- 申请人地址： US CA South San Francisco
- 专利权人： Genentech, Inc.
- 当前专利权人： Genentech, Inc.
- 当前专利权人地址： US CA South San Francisco
- 代理机构： Viksnins Harris Padys Malen LLP
- 主分类号： A61K47/68
- IPC分类号： A61K47/68 ; C07K16/28 ; C07D207/40 ; C07D209/60 ; C07K5/062 ; C07D487/04 ; C07D209/62 ; C07D401/14 ; C07D403/14 ; C07F9/6558 ; C07H15/24 ; C07K16/32 ; C07D401/12 ; C07D471/04 ; C07K16/00 ; C07K16/30 ; A61K47/55 ; C07F9/572 ; C07F9/6561
![1-(chloromethyl)-2,3-dihydro-1H-benzo[E]indole dimer antibody-drug conjugate compounds, and methods of use and treatment](/abs-image/US/2019/10/15/US10442836B2/abs.jpg.150x150.jpg)
摘要：
The invention provides antibody-drug conjugates comprising an antibody conjugated to a 1-(chloromethyl)-2,3-dihydro-1H-benzo[e]indole (CBI) dimer drug moiety via a linker, and methods of using the antibody-drug conjugates.