Invention Grant
- Patent Title: Self-assembled composite ultrasmall peptide-polymer hydrogels
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Application No.: US14356116Application Date: 2012-11-05
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Publication No.: US10449257B2Publication Date: 2019-10-22
- Inventor: Charlotte Hauser , Yihua Loo , Andrew C. A. Wan , Michael Reithofer
- Applicant: Agency for Science, Technology and Research
- Applicant Address: SG Singapore
- Assignee: Agency for Science, Technology and Research
- Current Assignee: Agency for Science, Technology and Research
- Current Assignee Address: SG Singapore
- Agency: Wolf, Greenfield & Sacks, P.C.
- Priority: SG201108178-3 20111104
- International Application: PCT/SG2012/000421 WO 20121105
- International Announcement: WO2013/066274 WO 20130510
- Main IPC: A61K47/36
- IPC: A61K47/36 ; A61K31/7088 ; A61K35/28 ; A61K35/51 ; A61K35/545 ; A61K38/06 ; A61K38/07 ; A61K38/08 ; A61K38/18 ; A61K38/19 ; A61K47/18 ; A61L26/00 ; A61L27/26 ; A61L27/38 ; A61L27/48 ; A61L27/52 ; A61L27/54 ; C08L5/00 ; C08L5/04 ; C08L5/08 ; C08L5/10 ; C08L5/16 ; C08L71/02 ; C08L89/00 ; C12N5/00 ; C12N15/113

Abstract:
The present invention relates to composite hydrogels comprising at least one non-peptidic polymer and at least one peptide having the general formula: Z—(X)m—(Y)n—Z′p, wherein Z is an N-terminal protecting group; X is, at each occurrence, independently selected from an aliphatic amino acid, an aliphatic amino acid derivative and a glycine; Y is, at each occurrence, independently selected from a polar amino acid and a polar amino acid derivative; Z′ is a C-terminal protecting group; m is an integer selected from 2 to 6; n is selected from 1 or 2; and p is selected from 0 or 1. The present invention further relates to methods of producing the composite hydrogels, to uses of the composite hydrogels for the delivery of drugs and other bioactive agents/moieties, as an implant or injectable agent that facilitates tissue regeneration, and as a topical agent for wound healing. The present invention further relates to devices and pharmaceutical or cosmetic compositions comprising the composite hydrogels and to medical uses of the composite hydrogels.
Public/Granted literature
- US20140349933A1 SELF-ASSEMBLED COMPOSITE ULTRASMALL PEPTIDE-POLYMER HYDROGELS Public/Granted day:2014-11-27
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