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公开(公告)号：US20170182219A1
公开(公告)日：2017-06-29
申请号：US15398412
申请日：2017-01-04
发明人： Charlotte Hauser , Wei Yang Seow
CPC分类号： A61L27/3804 , A61K9/06 , A61K35/33 , A61K38/02 , A61K47/42 , A61L26/0028 , A61L26/0061 , A61L26/008 , A61L27/22 , A61L27/38 , A61L27/50 , A61L27/52 , A61L2300/412 , A61L2300/426 , A61L2400/06 , A61L2430/00 , A61L2430/06 , A61L2430/38 , C12N5/0018 , C12N5/0062 , C12N5/0068 , C12N5/0671 , C12N5/0691 , C12N2513/00 , C12N2533/50 , C12N2533/54 , C12N2537/10
摘要： The present invention relates to hydrogels comprising a plurality of amphiphilic peptides and/or peptoids capable of self-assembling into three-dimensional macromolecular nanofibrous networks, which entrap water and form said hydrogels, wherein at least a portion of said plurality of amphiphilic peptides and/or peptoids is chemically cross-linked. The present invention further relates to methods for preparing such hydrogels and to various uses of such hydrogels, e.g. as cell culture substrates, for drug and gene delivery, as wound dressing, as an implant, as an injectable agent that gels in situ, in pharmaceutical or cosmetic compositions, in regenerative medicine, in tissue engineering and tissue regeneration, or in electronic devices. It also relates to a method of tissue regeneration or tissue replacement using a hydrogel in accordance with the present invention.
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公开(公告)号：US09687591B2
公开(公告)日：2017-06-27
申请号：US14639035
申请日：2015-03-04
发明人： Charlotte Hauser , Wei Yang Seow
IPC分类号： A01N25/00 , A61K47/00 , A61L27/52 , A61L27/22 , A61L27/38 , A61L27/50 , A61L26/00 , C12N5/00 , A61L27/60
CPC分类号： A61L27/52 , A61L26/0028 , A61L26/0061 , A61L26/008 , A61L27/22 , A61L27/38 , A61L27/50 , A61L27/60 , A61L2430/06 , A61L2430/16 , C12N5/0068 , C12N2533/50 , C12N2533/54 , C12N2537/10
摘要： The present invention relates to hydrogel membranes comprising a hydrogel, said hydrogel comprising a plurality of tetramer amphiphilic peptides and/or peptoids capable of self-assembling into three-dimensional macromolecular nanofibrous networks, which entrap water and form said hydrogels, wherein at least a portion of said plurality of tetramer amphiphilic peptides and/or peptoids is chemically cross-linked. The present invention further relates to stratisfied biostructures and devices comprising at least two hydrogel membranes of the invention, which can be used e.g. to rebuild human skin and for tissue engineering of organs and tissues. The present invention further relates to corneal implants and devices comprising a hydrogel membrane of the invention.
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公开(公告)号：US20150273114A1
公开(公告)日：2015-10-01
申请号：US14634559
申请日：2015-02-27
发明人： Charlotte Hauser , Wei Yang Seow
CPC分类号： A61L27/3804 , A61K9/06 , A61K35/33 , A61K38/02 , A61K47/42 , A61L26/0028 , A61L26/0061 , A61L26/008 , A61L27/22 , A61L27/38 , A61L27/50 , A61L27/52 , A61L2300/412 , A61L2300/426 , A61L2400/06 , A61L2430/00 , A61L2430/06 , A61L2430/38 , C12N5/0018 , C12N5/0062 , C12N5/0068 , C12N5/0671 , C12N5/0691 , C12N2513/00 , C12N2533/50 , C12N2533/54 , C12N2537/10
摘要： The present invention relates to hydrogels comprising a plurality of amphiphilic peptides and/or peptoids capable of self-assembling into three-dimensional macromolecular nanofibrous networks, which entrap water and form said hydrogels, wherein at least a portion of said plurality of amphiphilic peptides and/or peptoids is chemically cross-linked. The present invention further relates to methods for preparing such hydrogels and to various uses of such hydrogels, e.g. as cell culture substrates, for drug and gene delivery, as wound dressing, as an implant, as an injectable agent that gels in situ, in pharmaceutical or cosmetic compositions, in regenerative medicine, in tissue engineering and tissue regeneration, or in electronic devices. It also relates to a method of tissue regeneration or tissue replacement using a hydrogel in accordance with the present invention.
摘要翻译： 本发明涉及水凝胶，其包含能够自组装成三维大分子纳米纤维网络的多个两亲肽和/或拟肽，其夹带水并形成所述水凝胶，其中所述多个两亲肽的至少一部分和/ 或拟肽化学交联。 本发明还涉及制备这种水凝胶的方法和这种水凝胶的各种用途，例如， 作为用于药物和基因递送的细胞培养底物，作为伤口敷料，作为植入物，作为原位凝胶的药物或化妆品组合物，再生医学，组织工程和组织再生或电子装置中的注射剂。 它还涉及使用根据本发明的水凝胶的组织再生或组织置换的方法。
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公开(公告)号：US20140349933A1
公开(公告)日：2014-11-27
申请号：US14356116
申请日：2012-11-05
IPC分类号： A61K47/36 , A61K38/18 , C12N5/00 , A61K31/7088 , A61K47/48 , A61K47/18 , C12N15/113
CPC分类号： A61K47/36 , A61K31/7088 , A61K35/28 , A61K35/51 , A61K35/545 , A61K38/06 , A61K38/07 , A61K38/08 , A61K38/18 , A61K38/1825 , A61K38/19 , A61K47/183 , A61L26/0052 , A61L26/0066 , A61L26/008 , A61L26/0095 , A61L27/26 , A61L27/3834 , A61L27/48 , A61L27/52 , A61L27/54 , C08L5/00 , C08L5/04 , C08L5/08 , C08L5/10 , C08L5/16 , C08L71/02 , C08L89/00 , C12N5/0068 , C12N15/113 , C12N2310/11 , C12N2320/32 , C12N2533/30 , C12N2533/50 , C12N2533/72
摘要： The present invention relates to composite hydrogels comprising at least one non-peptidic polymer and at least one peptide having the general formula: Z—(X)m—(Y)n—Z′p, wherein Z is an N-terminal protecting group; X is, at each occurrence, independently selected from an aliphatic amino acid, an aliphatic amino acid derivative and a glycine; Y is, at each occurrence, independently selected from a polar amino acid and a polar amino acid derivative; Z′ is a C-terminal protecting group; m is an integer selected from 2 to 6; n is selected from 1 or 2; and p is selected from 0 or 1. The present invention further relates to methods of producing the composite hydrogels, to uses of the composite hydrogels for the delivery of drugs and other bioactive agents/moieties, as an implant or injectable agent that facilitates tissue regeneration, and as a topical agent for wound healing. The present invention further relates to devices and pharmaceutical or cosmetic compositions comprising the composite hydrogels and to medical uses of the composite hydrogels.
摘要翻译： 本发明涉及包含至少一种非肽聚合物和至少一种具有以下通式的肽的复合水凝胶：Z-（X）m-（Y）n-Z'p，其中Z是N-末端保护基 ; X在每次出现时独立地选自脂族氨基酸，脂族氨基酸衍生物和甘氨酸; Y在每次出现时独立地选自极性氨基酸和极性氨基酸衍生物; Z'是C端保护基; m是选自2至6的整数; n选自1或2; 本发明还涉及生产复合水凝胶的方法，使用复合水凝胶来递送药物和其它生物活性剂/部分，作为促进组织再生的植入物或可注射剂 ，以及作为伤口愈合的局部剂。 本发明还涉及包含复合水凝胶的装置和药物或化妆品组合物以及复合水凝胶的医疗用途。
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公开(公告)号：US20140093473A1
公开(公告)日：2014-04-03
申请号：US13731525
申请日：2012-12-31
发明人： Charlotte Hauser , Yihua Loo
CPC分类号： C07K7/06 , A61K9/0019 , A61K9/06 , A61K9/7023 , A61K38/06 , A61K38/07 , A61K38/08 , A61K47/42 , A61L15/32 , A61L15/44 , A61L15/60 , A61L27/22 , A61L27/52 , A61L27/54 , A61L31/043 , A61L31/145 , A61L31/16 , A61L2300/25 , A61L2400/06 , C07K5/08 , C07K5/0808 , C07K5/10 , C07K5/101 , C07K7/00
摘要： The present invention provides an amphiphilic linear peptide and/or peptoid as well as a hydrogel that includes the amphiphilic linear peptide/peptoid.
摘要翻译： 本发明提供两亲性线性肽和/或拟肽以及包含两亲性线性肽/拟肽的水凝胶。
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公开(公告)号：US10286111B2
公开(公告)日：2019-05-14
申请号：US15398412
申请日：2017-01-04
发明人： Charlotte Hauser , Wei Yang Seow
IPC分类号： A61K38/00 , A01N25/00 , A61K47/00 , C12N5/00 , C12N5/02 , A61L27/38 , A61K47/42 , A61K38/02 , A61L27/22 , A61L27/50 , A61L27/52 , A61L26/00 , A61K9/06 , A61K35/33 , C12N5/071
摘要： The present invention relates to hydrogels comprising a plurality of amphiphilic peptides and/or peptoids capable of self-assembling into three-dimensional macromolecular nanofibrous networks, which entrap water and form said hydrogels, wherein at least a portion of said plurality of amphiphilic peptides and/or peptoids is chemically cross-linked. The present invention further relates to methods for preparing such hydrogels and to various uses of such hydrogels, e.g. as cell culture substrates, for drug and gene delivery, as wound dressing, as an implant, as an injectable agent that gels in situ, in pharmaceutical or cosmetic compositions, in regenerative medicine, in tissue engineering and tissue regeneration, or in electronic devices. It also relates to a method of tissue regeneration or tissue replacement using a hydrogel in accordance with the present invention.
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公开(公告)号：US09555163B2
公开(公告)日：2017-01-31
申请号：US14634559
申请日：2015-02-27
发明人： Charlotte Hauser , Wei Yang Seow
IPC分类号： A61K38/00 , A61P43/00 , A01N25/00 , A61K47/00 , C12N5/00 , C12N5/02 , A61L27/52 , A61K47/42 , A61K38/02 , A61L27/22 , A61L27/38 , A61L27/50 , A61L26/00 , A61K9/06
摘要： The present invention relates to hydrogels comprising a plurality of amphiphilic peptides and/or peptoids capable of self-assembling into three-dimensional macromolecular nanofibrous networks, which entrap water and form said hydrogels, wherein at least a portion of said plurality of amphiphilic peptides and/or peptoids is chemically cross-linked. The present invention further relates to methods for preparing such hydrogels and to various uses of such hydrogels, e.g. as cell culture substrates, for drug and gene delivery, as wound dressing, as an implant, as an injectable agent that gels in situ, in pharmaceutical or cosmetic compositions, in regenerative medicine, in tissue engineering and tissue regeneration, or in electronic devices. It also relates to a method of tissue regeneration or tissue replacement using a hydrogel in accordance with the present invention.
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公开(公告)号：US08999916B2
公开(公告)日：2015-04-07
申请号：US13751295
申请日：2013-01-28
发明人： Charlotte Hauser , Wei Yang Seow
IPC分类号： A61K38/00 , A01N25/00 , A61K47/00 , C12N5/00 , C12N5/02 , A61K47/42 , A61K38/02 , A61L27/22 , A61L27/38 , A61L27/50 , A61L27/52 , A61L26/00
CPC分类号： A61L27/3804 , A61K9/06 , A61K35/33 , A61K38/02 , A61K47/42 , A61L26/0028 , A61L26/0061 , A61L26/008 , A61L27/22 , A61L27/38 , A61L27/50 , A61L27/52 , A61L2300/412 , A61L2300/426 , A61L2400/06 , A61L2430/00 , A61L2430/06 , A61L2430/38 , C12N5/0018 , C12N5/0062 , C12N5/0068 , C12N5/0671 , C12N5/0691 , C12N2513/00 , C12N2533/50 , C12N2533/54 , C12N2537/10
摘要： The present invention relates to hydrogels comprising a plurality of amphiphilic peptides and/or peptoids capable of self-assembling into three-dimensional macromolecular nanofibrous networks, which entrap water and form said hydrogels, wherein at least a portion of said plurality of amphiphilic peptides and/or peptoids is chemically cross-linked. The present invention further relates to methods for preparing such hydrogels and to various uses of such hydrogels, e.g. as cell culture substrates, for drug and gene delivery, as wound dressing, as an implant, as an injectable agent that gels in situ, in pharmaceutical or cosmetic compositions, in regenerative medicine, in tissue engineering and tissue regeneration, or in electronic devices. It also relates to a method of tissue regeneration or tissue replacement using a hydrogel in accordance with the present invention.
摘要翻译： 本发明涉及水凝胶，其包含能够自组装成三维大分子纳米纤维网络的多个两亲肽和/或拟肽，其夹带水并形成所述水凝胶，其中所述多个两亲肽的至少一部分和/ 或拟肽化学交联。 本发明还涉及制备这种水凝胶的方法和这种水凝胶的各种用途，例如， 作为用于药物和基因递送的细胞培养底物，作为伤口敷料，作为植入物，作为原位凝胶的药物或化妆品组合物，再生医学，组织工程和组织再生或电子装置中的注射剂。 它还涉及使用根据本发明的水凝胶的组织再生或组织置换的方法。
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公开(公告)号：US10286110B2
公开(公告)日：2019-05-14
申请号：US15398288
申请日：2017-01-04
发明人： Charlotte Hauser , Wei Yang Seow
IPC分类号： A61K38/00 , A01N25/00 , A61K47/00 , C12N5/00 , C12N5/02 , A61L27/38 , A61K47/42 , A61K38/02 , A61L27/22 , A61L27/50 , A61L27/52 , A61L26/00 , A61K9/06 , A61K35/33 , C12N5/071
摘要： The present invention relates to hydrogels comprising a plurality of amphiphilic peptides and/or peptoids capable of self-assembling into three-dimensional macromolecular nanofibrous networks, which entrap water and form said hydrogels, wherein at least a portion of said plurality of amphiphilic peptides and/or peptoids is chemically cross-linked. The present invention further relates to methods for preparing such hydrogels and to various uses of such hydrogels, e.g. as cell culture substrates, for drug and gene delivery, as wound dressing, as an implant, as an injectable agent that gels in situ, in pharmaceutical or cosmetic compositions, in regenerative medicine, in tissue engineering and tissue regeneration, or in electronic devices. It also relates to a method of tissue regeneration or tissue replacement using a hydrogel in accordance with the present invention.
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公开(公告)号：US20170182217A1
公开(公告)日：2017-06-29
申请号：US15398254
申请日：2017-01-04
发明人： Charlotte Hauser , Wei Yang Seow
CPC分类号： A61L27/3804 , A61K9/06 , A61K35/33 , A61K38/02 , A61K47/42 , A61L26/0028 , A61L26/0061 , A61L26/008 , A61L27/22 , A61L27/38 , A61L27/50 , A61L27/52 , A61L2300/412 , A61L2300/426 , A61L2400/06 , A61L2430/00 , A61L2430/06 , A61L2430/38 , C12N5/0018 , C12N5/0062 , C12N5/0068 , C12N5/0671 , C12N5/0691 , C12N2513/00 , C12N2533/50 , C12N2533/54 , C12N2537/10
摘要： The present invention relates to hydrogels comprising a plurality of amphiphilic peptides and/or peptoids capable of self-assembling into three-dimensional macromolecular nanofibrous networks, which entrap water and form said hydrogels, wherein at least a portion of said plurality of amphiphilic peptides and/or peptoids is chemically cross-linked. The present invention further relates to methods for preparing such hydrogels and to various uses of such hydrogels, e.g. as cell culture substrates, for drug and gene delivery, as wound dressing, as an implant, as an injectable agent that gels in situ, in pharmaceutical or cosmetic compositions, in regenerative medicine, in tissue engineering and tissue regeneration, or in electronic devices. It also relates to a method of tissue regeneration or tissue replacement using a hydrogel in accordance with the present invention.
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