Invention Grant
- Patent Title: Modified polynucleotides for the production of cytoplasmic and cytoskeletal proteins
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Application No.: US15425645Application Date: 2017-02-06
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Publication No.: US10463751B2Publication Date: 2019-11-05
- Inventor: Antonin De Fougerolles , Justin Guild
- Applicant: ModernaTX, Inc.
- Applicant Address: US MA Cambridge
- Assignee: ModernaTX, Inc.
- Current Assignee: ModernaTX, Inc.
- Current Assignee Address: US MA Cambridge
- Agency: Clark & Elbing LLP
- Main IPC: A61K48/00
- IPC: A61K48/00 ; A61K31/7115 ; A61K38/17 ; A61K47/54 ; A61K9/127 ; C07K14/005 ; C12N15/11 ; C12N9/00 ; C12N15/85 ; C07K14/47 ; C07K14/62 ; C12N9/88 ; C07K14/705 ; C07K14/505 ; C07K14/535 ; C12N9/64 ; C12N9/10 ; C12N9/42 ; C12N15/87 ; C12P13/04 ; A61K38/45 ; C12N9/16 ; C12N9/24 ; C12N15/52 ; C07K14/435 ; C12P21/00 ; C07K14/485 ; C07H21/02 ; C07K14/475 ; C07K14/495 ; C07K14/525 ; C07K14/54 ; C07K14/56 ; C07K14/61 ; C07K14/745 ; C07K16/28 ; C07K16/40 ; C12N9/02 ; C12N9/12 ; C12N9/68 ; A61K9/14 ; A61K9/51 ; A61K38/18 ; A61K38/19 ; A61K38/21 ; A61K38/48 ; C07K14/515 ; C07K16/00 ; A61K38/00
Abstract:
The invention relates to compositions including polynucleotides encoding polypeptides which have been chemically modified by replacing the uridines with 1-methyl-pseudouridine to improve one or more of the stability and/or clearance in tissues, receptor uptake and/or kinetics, cellular access by the compositions, engagement with translational machinery, mRNA half-life, translation efficiency, immune evasion, protein production capacity, secretion efficiency, accessibility to circulation, protein half-life and/or modulation of a cell's status, function, and/or activity.
Public/Granted literature
- US20170368200A1 MODIFIED POLYNUCLEOTIDES FOR THE PRODUCTION OF CYTOPLASMIC AND CYTOSKELETAL PROTEINS Public/Granted day:2017-12-28
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