Invention Grant
- Patent Title: Serum albumin-binding fibronectin type III domains
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Application No.: US16549462Application Date: 2019-08-23
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Publication No.: US11203630B2Publication Date: 2021-12-21
- Inventor: Tracy S. Mitchell , Michael L. Gosselin , Dasa Lipovsek , Rex Parker , Ray Camphausen , Jonathan H. Davis , David Fabrizio
- Applicant: BRISTOL-MYERS SQUIBB COMPANY
- Applicant Address: US NJ Princeton
- Assignee: BRISTOL-MYERS SQUIBB COMPANY
- Current Assignee: BRISTOL-MYERS SQUIBB COMPANY
- Current Assignee Address: US NJ Princeton
- Agency: Nelson Mullins Riley & Scarborough LLP
- Agent Jane E. Remillard, Esq.; Cynthia L. Kanik
- Main IPC: C07H21/04
- IPC: C07H21/04 ; C12P21/06 ; C12N15/87 ; C12N5/20 ; C12N1/20 ; C12N15/00 ; C07K14/78 ; A61K47/64 ; A61K38/00
Abstract:
The present invention relates to polypeptides which include tenth fibronectin type III domains (10Fn3) that binds to serum albumin, with south pole loop substitutions. The invention further relates to fusion molecules comprising a serum albumin-binding 10Fn3 joined to a heterologous protein for use in diagnostic and therapeutic applications.
Public/Granted literature
- US20200048328A1 SERUM ALBUMIN-BINDING FIBRONECTIN TYPE III DOMAINS Public/Granted day:2020-02-13
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