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公开(公告)号：US20180201665A1
公开(公告)日：2018-07-19
申请号：US15819925
申请日：2017-11-21
Applicant: Bristol-Myers Squibb Company
Inventor： Ray Camphausen , Jonathan H. Davis , Sharon T. Cload , Fabienne M. Denhez , Amna Saeed-Kothe , Dasa Lipovsek , Ching-Hsiung Frederick Lo , Chee Meng Low , Bowman Miao , Tracy S. Mitchell , Rex A. Parker , Ginger C. Rakestraw , Katie A. Russo , Doree F. Sitkoff
Abstract: The present invention relates to fibronectin based scaffold domain proteins that bind PCSK9. The invention also relates to the use of the innovative proteins in therapeutic applications to treat atherosclerosis, hypercholesterolemia and other cholesterol related diseases. The invention further relates to cells comprising such proteins, polynucleotides encoding such proteins or fragments thereof, and to vectors comprising the polynucleotides encoding the innovative protein.
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公开(公告)号：US10947297B2
公开(公告)日：2021-03-16
申请号：US15819925
申请日：2017-11-21
Applicant: Bristol-Myers Squibb Company
Inventor： Ray Camphausen , Jonathan H. Davis , Sharon T. Cload , Fabienne M. Denhez , Amna Saeed-Kothe , Dasa Lipovsek , Ching-Hsiung Frederick Lo , Chee Meng Low , Bowman Miao , Tracy S. Mitchell , Rex A. Parker , Ginger C. Rakestraw , Katie A. Russo , Doree F. Sitkoff
IPC: A61K39/00 , A61K39/44 , C07K4/00 , C07K14/00 , C07K14/78 , A61K38/39 , C12N9/64 , A61K47/60 , A61K47/54 , C07K16/18 , C07K16/40
Abstract: The present invention relates to fibronectin based scaffold domain proteins that bind PCSK9. The invention also relates to the use of the innovative proteins in therapeutic applications to treat atherosclerosis, hypercholesterolemia and other cholesterol related diseases. The invention further relates to cells comprising such proteins, polynucleotides encoding such proteins or fragments thereof, and to vectors comprising the polynucleotides encoding the innovative protein.
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公开(公告)号：US09856309B2
公开(公告)日：2018-01-02
申请号：US14956698
申请日：2015-12-02
Applicant: Bristol-Myers Squibb Company
Inventor： Ray Camphausen , Jonathan H. Davis , Sharon T. Cload , Fabienne M. Denhez , Amna Saeed-Kothe , Dasa Lipovsek , Ching-Hsiung Frederick Lo , Chee Meng Low , Bowman Miao , Tracy S. Mitchell , Rex A. Parker , Ginger C. Rakestraw , Katie A. Russo , Doree F. Sitkoff
CPC classification number: C07K14/78 , A61K38/39 , A61K47/549 , A61K47/60 , C07K16/18 , C07K16/40 , C07K2318/20 , C07K2319/30 , C07K2319/31 , C07K2319/70 , C12N9/6424
Abstract: The present invention relates to fibronectin based scaffold domain proteins that bind PCSK9. The invention also relates to the use of the innovative proteins in therapeutic applications to treat atherosclerosis, hypercholesterolemia and other cholesterol related diseases. The invention further relates to cells comprising such proteins, polynucleotides encoding such proteins or fragments thereof, and to vectors comprising the polynucleotides encoding the innovative protein.
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公开(公告)号：US09234027B2
公开(公告)日：2016-01-12
申请号：US13835639
申请日：2013-03-15
Applicant: Bristol-Myers Squibb Company
Inventor： Ray Camphausen , Jonathan H. Davis , Sharon T. Cload , Fabienne M. Denhez , Amna Saeed-Kothe , Dasa Lipovsek , Ching-Hsiung Frederick Lo , Chee Meng Low , Bowman Miao , Tracy S. Mitchell , Rex A. Parker , Ginger C. Rakestraw , Katie A. Russo , Doree F. Sitkoff
CPC classification number: C07K14/78 , A61K38/39 , A61K47/549 , A61K47/60 , C07K16/18 , C07K16/40 , C07K2318/20 , C07K2319/30 , C07K2319/31 , C07K2319/70 , C12N9/6424
Abstract: The present invention relates to fibronectin based scaffold domain proteins that bind PCSK9. The invention also relates to the use of the innovative proteins in therapeutic applications to treat atherosclerosis, hypercholesterolemia and other cholesterol related diseases. The invention further relates to cells comprising such proteins, polynucleotides encoding such proteins or fragments thereof, and to vectors comprising the polynucleotides encoding the innovative protein.
Abstract translation: 本发明涉及结合PCSK9的基于纤连蛋白的支架结构域蛋白。 本发明还涉及创新的蛋白质在治疗应用中用于治疗动脉粥样硬化，高胆固醇血症和其它胆固醇相关疾病的用途。 本发明还涉及包含这种蛋白质的细胞，编码这种蛋白质或其片段的多核苷酸，以及包含编码该创新蛋白质的多核苷酸的载体。
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公开(公告)号：US20240239870A1
公开(公告)日：2024-07-18
申请号：US18512487
申请日：2023-11-17
Applicant: Bristol-Myers Squibb Company
Inventor： Ray CAMPHAUSEN , Jonathan H. Davis , Sharon T. Cload , Fabienne M. Denhez , Amna Saeed-Kothe , Dasa Lipovsek , Ching-Hsiung Frederick Lo , Chee Meng Low , Bowman Miao , Tracy S. Mitchell , Rex A. Parker , Ginger C. Rakestraw , Katie A. Russo , Doree F. Sitkoff
CPC classification number: C07K14/78 , A61K38/39 , A61K47/549 , A61K47/60 , C07K16/18 , C07K16/40 , C12N9/6424 , C07K2318/20 , C07K2319/30 , C07K2319/31 , C07K2319/70
Abstract: The present invention relates to fibronectin based scaffold domain proteins that bind PCSK9. The invention also relates to the use of the innovative proteins in therapeutic applications to treat atherosclerosis, hypercholesterolemia and other cholesterol related diseases. The invention further relates to cells comprising such proteins, polynucleotides encoding such proteins or fragments thereof, and to vectors comprising the polynucleotides encoding the innovative protein.
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Patent Agency Ranking
公开(公告)号：US11858979B2
公开(公告)日：2024-01-02
申请号：US17177179
申请日：2021-02-16
Applicant: Bristol-Myers Squibb Company
Inventor： Ray Camphausen , Jonathan H. Davis , Sharon T. Cload , Fabienne M. Denhez , Amna Saeed-Kothe , Dasa Lipovsek , Ching-Hsiung Frederick Lo , Chee Meng Low , Bowman Miao , Tracy S. Mitchell , Rex A. Parker , Ginger C. Rakestraw , Katie A. Russo , Doree F. Sitkoff
IPC: C12N5/02 , C12N1/20 , C12N15/00 , C07H21/04 , C07K14/78 , A61K38/39 , C12N9/64 , A61K47/60 , A61K47/54 , C07K16/18 , C07K16/40
CPC classification number: C07K14/78 , A61K38/39 , A61K47/549 , A61K47/60 , C07K16/18 , C07K16/40 , C12N9/6424 , C07K2318/20 , C07K2319/30 , C07K2319/31 , C07K2319/70
Abstract: The present invention relates to fibronectin based scaffold domain proteins that bind PCSK9. The invention also relates to the use of the innovative proteins in therapeutic applications to treat atherosclerosis, hypercholesterolemia and other cholesterol related diseases. The invention further relates to cells comprising such proteins, polynucleotides encoding such proteins or fragments thereof, and to vectors comprising the polynucleotides encoding the innovative protein.
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公开(公告)号：US20200247873A1
公开(公告)日：2020-08-06
申请号：US16740248
申请日：2020-01-10
Applicant: BRISTOL-MYERS SQUIBB COMPANY
Inventor： Dasa Lipovsek , Jonathan H. Davis
Abstract: Fibronectin type III (10Fn3) binding domains having novel designs that are associated with reduced immunogenicity are provided. The application describes alternative 10Fn3 binding domains in which certain immunogenic regions are not modified when producing a binder in order to maintain recognition as a self antigen by the host organism. The application also describes 10Fn3 binding domains in which HLA anchor regions have been destroyed thereby reducing the immunogenic contribution of the adjoining region. Also provided are 10Fn3 domains having novel combinations of modified regions that can bind to a desired target with high affinity.
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公开(公告)号：US11203630B2
公开(公告)日：2021-12-21
申请号：US16549462
申请日：2019-08-23
Applicant: BRISTOL-MYERS SQUIBB COMPANY
Inventor： Tracy S. Mitchell , Michael L. Gosselin , Dasa Lipovsek , Rex Parker , Ray Camphausen , Jonathan H. Davis , David Fabrizio
IPC: C07H21/04 , C12P21/06 , C12N15/87 , C12N5/20 , C12N1/20 , C12N15/00 , C07K14/78 , A61K47/64 , A61K38/00
Abstract: The present invention relates to polypeptides which include tenth fibronectin type III domains (10Fn3) that binds to serum albumin, with south pole loop substitutions. The invention further relates to fusion molecules comprising a serum albumin-binding 10Fn3 joined to a heterologous protein for use in diagnostic and therapeutic applications.
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公开(公告)号：US20150361159A1
公开(公告)日：2015-12-17
申请号：US14764215
申请日：2014-01-30
Applicant: BRISTOL-MYERS SQUIBB COMPANY
Inventor： Dasa LIPOVSEK , Jonathan H. Davis
IPC: C07K14/78
CPC classification number: C07K14/78 , C07K16/244 , C07K16/28 , C07K16/2833 , C07K16/2857 , C07K2317/76 , C07K2317/92 , C07K2318/20 , C12N15/1044 , G01N33/6845
Abstract: Fibronectin type III (10Fn3) binding domains having novel designs are provided. Also provided are 10Fn3 domains having combinations of modified regions that can bind to a desired target.
Abstract translation: 提供具有新颖设计的纤连蛋白III型（10Fn3）结合域。 还提供了具有可以结合期望靶标的修饰区域的组合的10Fn3结构域。
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公开(公告)号：US11447538B2
公开(公告)日：2022-09-20
申请号：US16740248
申请日：2020-01-10
Applicant: BRISTOL-MYERS SQUIBB COMPANY
Inventor： Dasa Lipovsek , Jonathan H. Davis
Abstract: Fibronectin type III (10Fn3) binding domains having novel designs that are associated with reduced immunogenicity are provided. The application describes alternative 10Fn3 binding domains in which certain immunogenic regions are not modified when producing a binder in order to maintain recognition as a self antigen by the host organism. The application also describes 10Fn3 binding domains in which HLA anchor regions have been destroyed thereby reducing the immunogenic contribution of the adjoining region. Also provided are 10Fn3 domains having novel combinations of modified regions that can bind to a desired target with high affinity.
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