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公开(公告)号：US11203630B2
公开(公告)日：2021-12-21
申请号：US16549462
申请日：2019-08-23
Applicant: BRISTOL-MYERS SQUIBB COMPANY
Inventor： Tracy S. Mitchell , Michael L. Gosselin , Dasa Lipovsek , Rex Parker , Ray Camphausen , Jonathan H. Davis , David Fabrizio
IPC: C07H21/04 , C12P21/06 , C12N15/87 , C12N5/20 , C12N1/20 , C12N15/00 , C07K14/78 , A61K47/64 , A61K38/00
Abstract: The present invention relates to polypeptides which include tenth fibronectin type III domains (10Fn3) that binds to serum albumin, with south pole loop substitutions. The invention further relates to fusion molecules comprising a serum albumin-binding 10Fn3 joined to a heterologous protein for use in diagnostic and therapeutic applications.
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2.发明申请FIBRONECTIN BASED SCAFFOLD DOMAINS LINKED TO SERUM ALBUMIN OR MOIETY BINDING THERETO 审中-公开基于FIBRONECTIN的SCAFFAIN域连接到血清白蛋白或环状结合蛋白公开(公告)号：US20160152686A1
公开(公告)日：2016-06-02
申请号：US14774229
申请日：2014-03-12
Applicant: BRISTOL-MYERS SQUIBB COMPANY
Inventor： Ray Camphausen , Tracy S. Mitchell
IPC: C07K14/765 , C07K14/78
CPC classification number: C07K14/765 , A61K38/00 , C07K14/78 , C07K2319/00
Abstract: Provided herein are fusion proteins comprising a first moiety comprising a fibronectin based scaffold and a second moiety comprising serum albumin or a biologically active fragment thereof or a serum albumin binding domain or a biologically active fragment thereof.
Abstract translation: 本文提供了融合蛋白，其包含包含基于纤连蛋白的支架的第一部分和包含血清白蛋白或其生物活性片段或血清白蛋白结合结构域或其生物活性片段的第二部分。
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公开(公告)号：US10947297B2
公开(公告)日：2021-03-16
申请号：US15819925
申请日：2017-11-21
Applicant: Bristol-Myers Squibb Company
Inventor： Ray Camphausen , Jonathan H. Davis , Sharon T. Cload , Fabienne M. Denhez , Amna Saeed-Kothe , Dasa Lipovsek , Ching-Hsiung Frederick Lo , Chee Meng Low , Bowman Miao , Tracy S. Mitchell , Rex A. Parker , Ginger C. Rakestraw , Katie A. Russo , Doree F. Sitkoff
IPC: A61K39/00 , A61K39/44 , C07K4/00 , C07K14/00 , C07K14/78 , A61K38/39 , C12N9/64 , A61K47/60 , A61K47/54 , C07K16/18 , C07K16/40
Abstract: The present invention relates to fibronectin based scaffold domain proteins that bind PCSK9. The invention also relates to the use of the innovative proteins in therapeutic applications to treat atherosclerosis, hypercholesterolemia and other cholesterol related diseases. The invention further relates to cells comprising such proteins, polynucleotides encoding such proteins or fragments thereof, and to vectors comprising the polynucleotides encoding the innovative protein.
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公开(公告)号：US09856309B2
公开(公告)日：2018-01-02
申请号：US14956698
申请日：2015-12-02
Applicant: Bristol-Myers Squibb Company
Inventor： Ray Camphausen , Jonathan H. Davis , Sharon T. Cload , Fabienne M. Denhez , Amna Saeed-Kothe , Dasa Lipovsek , Ching-Hsiung Frederick Lo , Chee Meng Low , Bowman Miao , Tracy S. Mitchell , Rex A. Parker , Ginger C. Rakestraw , Katie A. Russo , Doree F. Sitkoff
CPC classification number: C07K14/78 , A61K38/39 , A61K47/549 , A61K47/60 , C07K16/18 , C07K16/40 , C07K2318/20 , C07K2319/30 , C07K2319/31 , C07K2319/70 , C12N9/6424
Abstract: The present invention relates to fibronectin based scaffold domain proteins that bind PCSK9. The invention also relates to the use of the innovative proteins in therapeutic applications to treat atherosclerosis, hypercholesterolemia and other cholesterol related diseases. The invention further relates to cells comprising such proteins, polynucleotides encoding such proteins or fragments thereof, and to vectors comprising the polynucleotides encoding the innovative protein.
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公开(公告)号：US09234027B2
公开(公告)日：2016-01-12
申请号：US13835639
申请日：2013-03-15
Applicant: Bristol-Myers Squibb Company
Inventor： Ray Camphausen , Jonathan H. Davis , Sharon T. Cload , Fabienne M. Denhez , Amna Saeed-Kothe , Dasa Lipovsek , Ching-Hsiung Frederick Lo , Chee Meng Low , Bowman Miao , Tracy S. Mitchell , Rex A. Parker , Ginger C. Rakestraw , Katie A. Russo , Doree F. Sitkoff
CPC classification number: C07K14/78 , A61K38/39 , A61K47/549 , A61K47/60 , C07K16/18 , C07K16/40 , C07K2318/20 , C07K2319/30 , C07K2319/31 , C07K2319/70 , C12N9/6424
Abstract: The present invention relates to fibronectin based scaffold domain proteins that bind PCSK9. The invention also relates to the use of the innovative proteins in therapeutic applications to treat atherosclerosis, hypercholesterolemia and other cholesterol related diseases. The invention further relates to cells comprising such proteins, polynucleotides encoding such proteins or fragments thereof, and to vectors comprising the polynucleotides encoding the innovative protein.
Abstract translation: 本发明涉及结合PCSK9的基于纤连蛋白的支架结构域蛋白。 本发明还涉及创新的蛋白质在治疗应用中用于治疗动脉粥样硬化，高胆固醇血症和其它胆固醇相关疾病的用途。 本发明还涉及包含这种蛋白质的细胞，编码这种蛋白质或其片段的多核苷酸，以及包含编码该创新蛋白质的多核苷酸的载体。
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Patent Agency Ranking
公开(公告)号：US11434275B2
公开(公告)日：2022-09-06
申请号：US16748085
申请日：2020-01-21
Applicant: BRISTOL-MYERS SQUIBB COMPANY
Inventor： Stanley Richard Krystek, Jr. , Tracy S. Mitchell , Michael L. Gosselin , Dasa Lipovsek , Juhi Juneja
IPC: C07K14/78 , C07K14/765 , C12N15/85
Abstract: Provided herein are polypeptides which include tenth fibronectin type III domains (10Fn3) that binds to serum albumin. Also provided are fusion molecules comprising a serum albumin binding 10Fn3 joined to a heterologous protein for use in diagnostic and therapeutic applications.
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公开(公告)号：US20160159883A1
公开(公告)日：2016-06-09
申请号：US14956698
申请日：2015-12-02
Applicant: Bristol-Myers Squibb Company
Inventor： Ray Camphausen , Jonathan H. Davis , Sharon T. Cload , Fabienne M. Denhez , Amna Saeed-Kothe , Dasa Lipovsek , Ching-Hsiung Frederick Lo , Chee Meng Low , Bowman Miao , Tracy S. Mitchell , Rex A. Parker , Ginger C. Rakestraw , Katie A. Russo , Doree F. Sitkoff
CPC classification number: C07K14/78 , A61K38/39 , A61K47/549 , A61K47/60 , C07K16/18 , C07K16/40 , C07K2318/20 , C07K2319/30 , C07K2319/31 , C07K2319/70 , C12N9/6424
Abstract: The present invention relates to fibronectin based scaffold domain proteins that bind PCSK9. The invention also relates to the use of the innovative proteins in therapeutic applications to treat atherosclerosis, hypercholesterolemia and other cholesterol related diseases. The invention further relates to cells comprising such proteins, polynucleotides encoding such proteins or fragments thereof, and to vectors comprising the polynucleotides encoding the innovative protein.
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8.发明申请公开(公告)号：US20130210703A1
公开(公告)日：2013-08-15
申请号：US13835639
申请日：2013-03-15
Applicant: Bristol-Myers Squibb Company
Inventor： Ray Camphausen , Jonathan H. Davis , Sharon T. Cload , Fabienne M. Denhez , Amna Saeed-Kothe , Dasa Lipovsek , Ching-Hsiung Frederick Lo , Cheen Meng Low , Bowman Miao , Tracy S. Mitchell , Rex A. Parker , Ginger C. Rackestraw , Katie A. Russo , Doree F. Sitkoff
IPC: C07K14/78
CPC classification number: C07K14/78 , A61K38/39 , A61K47/549 , A61K47/60 , C07K16/18 , C07K16/40 , C07K2318/20 , C07K2319/30 , C07K2319/31 , C07K2319/70 , C12N9/6424
Abstract: The present invention relates to fibronectin based scaffold domain proteins that bind PCSK9. The invention also relates to the use of the innovative proteins in therapeutic applications to treat atherosclerosis, hypercholesterolemia and other cholesterol related diseases. The invention further relates to cells comprising such proteins, polynucleotides encoding such proteins or fragments thereof, and to vectors comprising the polynucleotides encoding the innovative protein.
Abstract translation: 本发明涉及结合PCSK9的基于纤连蛋白的支架结构域蛋白。 本发明还涉及创新的蛋白质在治疗应用中用于治疗动脉粥样硬化，高胆固醇血症和其它胆固醇相关疾病的用途。 本发明还涉及包含这种蛋白质的细胞，编码这些蛋白质或其片段的多核苷酸，以及包含编码该创新蛋白质的多核苷酸的载体。
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公开(公告)号：US20240239870A1
公开(公告)日：2024-07-18
申请号：US18512487
申请日：2023-11-17
Applicant: Bristol-Myers Squibb Company
Inventor： Ray CAMPHAUSEN , Jonathan H. Davis , Sharon T. Cload , Fabienne M. Denhez , Amna Saeed-Kothe , Dasa Lipovsek , Ching-Hsiung Frederick Lo , Chee Meng Low , Bowman Miao , Tracy S. Mitchell , Rex A. Parker , Ginger C. Rakestraw , Katie A. Russo , Doree F. Sitkoff
CPC classification number: C07K14/78 , A61K38/39 , A61K47/549 , A61K47/60 , C07K16/18 , C07K16/40 , C12N9/6424 , C07K2318/20 , C07K2319/30 , C07K2319/31 , C07K2319/70
Abstract: The present invention relates to fibronectin based scaffold domain proteins that bind PCSK9. The invention also relates to the use of the innovative proteins in therapeutic applications to treat atherosclerosis, hypercholesterolemia and other cholesterol related diseases. The invention further relates to cells comprising such proteins, polynucleotides encoding such proteins or fragments thereof, and to vectors comprising the polynucleotides encoding the innovative protein.
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公开(公告)号：US11858979B2
公开(公告)日：2024-01-02
申请号：US17177179
申请日：2021-02-16
Applicant: Bristol-Myers Squibb Company
Inventor： Ray Camphausen , Jonathan H. Davis , Sharon T. Cload , Fabienne M. Denhez , Amna Saeed-Kothe , Dasa Lipovsek , Ching-Hsiung Frederick Lo , Chee Meng Low , Bowman Miao , Tracy S. Mitchell , Rex A. Parker , Ginger C. Rakestraw , Katie A. Russo , Doree F. Sitkoff
IPC: C12N5/02 , C12N1/20 , C12N15/00 , C07H21/04 , C07K14/78 , A61K38/39 , C12N9/64 , A61K47/60 , A61K47/54 , C07K16/18 , C07K16/40
CPC classification number: C07K14/78 , A61K38/39 , A61K47/549 , A61K47/60 , C07K16/18 , C07K16/40 , C12N9/6424 , C07K2318/20 , C07K2319/30 , C07K2319/31 , C07K2319/70
Abstract: The present invention relates to fibronectin based scaffold domain proteins that bind PCSK9. The invention also relates to the use of the innovative proteins in therapeutic applications to treat atherosclerosis, hypercholesterolemia and other cholesterol related diseases. The invention further relates to cells comprising such proteins, polynucleotides encoding such proteins or fragments thereof, and to vectors comprising the polynucleotides encoding the innovative protein.
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