公开(公告)号：US20220204589A1

公开(公告)日：2022-06-30

申请号：US17527238

申请日：2021-11-16

Applicant: Bristol-Myers Squibb Company

Inventor： Tracy S. MITCHELL ,  Michael L. Gosselin ,  Dasa Lipovsek ,  Rex Parker ,  Ray Camphausen ,  Jonathan H. Davis ,  David Fabrizio

IPC: C07K14/78 ,  A61K47/64

Abstract: The present invention relates to polypeptides which include tenth fibronectin type III domains (10Fn3) that binds to serum albumin, with south pole loop substitutions. The invention further relates to fusion molecules comprising a serum albumin-binding 10Fn3 joined to a heterologous protein for use in diagnostic and therapeutic applications.

公开(公告)号：US11203630B2

公开(公告)日：2021-12-21

申请号：US16549462

申请日：2019-08-23

Applicant: BRISTOL-MYERS SQUIBB COMPANY

Inventor： Tracy S. Mitchell ,  Michael L. Gosselin ,  Dasa Lipovsek ,  Rex Parker ,  Ray Camphausen ,  Jonathan H. Davis ,  David Fabrizio

IPC: C07H21/04 ,  C12P21/06 ,  C12N15/87 ,  C12N5/20 ,  C12N1/20 ,  C12N15/00 ,  C07K14/78 ,  A61K47/64 ,  A61K38/00

Abstract: The present invention relates to polypeptides which include tenth fibronectin type III domains (10Fn3) that binds to serum albumin, with south pole loop substitutions. The invention further relates to fusion molecules comprising a serum albumin-binding 10Fn3 joined to a heterologous protein for use in diagnostic and therapeutic applications.

公开(公告)号：US10442851B2

公开(公告)日：2019-10-15

申请号：US15127166

申请日：2015-03-19

Applicant: BRISTOL-MYERS SQUIBB COMPANY

Inventor： Tracy S. Mitchell ,  Michael L. Gosselin ,  Dasa Lipovsek ,  Rex Parker ,  Ray Camphausen ,  Jonathan Davis ,  David Fabrizio

IPC: C07K14/78 ,  A61K47/64 ,  A61K38/00

Abstract: The present invention relates to polypeptides which include tenth fibronectin type III domains (10Fn3) that binds to serum albumin, with south pole loop substitutions. The invention further relates to fusion molecules comprising a serum albumin-binding 10Fn3 joined to a heterologous protein for use in diagnostic and therapeutic applications.