发明申请
- 专利标题： Osteogenic growth oligopeptides as stimulants of hematopoiesis
- 专利标题（中）： 成骨生长寡肽作为造血的兴奋剂
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申请号： US10766527申请日： 2004-01-29
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公开(公告)号： US20050004037A1公开(公告)日： 2005-01-06
- 发明人: Itai Bab , Michael Chorev , Arye Shteyer , Andras Muhlrad , Nura Mansur , Olga Gurevitch , Zvi Greenberg , Sergio Rosini , Silvia Trasciatti , Mario Petrini
- 申请人： Itai Bab , Michael Chorev , Arye Shteyer , Andras Muhlrad , Nura Mansur , Olga Gurevitch , Zvi Greenberg , Sergio Rosini , Silvia Trasciatti , Mario Petrini
- 申请人地址： IL Jerusalem
- 专利权人： Yissum Research Development Company of the Hebrew University of Jerusalem
- 当前专利权人： Yissum Research Development Company of the Hebrew University of Jerusalem
- 当前专利权人地址： IL Jerusalem
- 主分类号： A61K35/12
- IPC分类号： A61K35/12 ; A61K35/14 ; A61K35/28 ; A61K38/00 ; A61K38/07 ; A61K38/08 ; A61K38/22 ; A61P7/00 ; A61P7/06 ; A61P35/00 ; A61P35/02 ; A61P37/00 ; A61P41/00 ; A61P43/00 ; C12N5/0789 ; A61K38/06
摘要：
The present invention relates to a pharmaceutical composition comprising as an effective ingredient an oligopeptide identical or analogous to the C-terminal portion of OGP, having stimulatory activity on the production of hematopoietic cells. Preferred oligopeptides that are used are Tyr-Gly-Phe-Gly-Gly, Tyr-Gly-Phe-His-Gly, Gly-Phe-Gly-Gly or Met-Tyr-Gly-Phe-Gly-Gly. More specifically, these oligopeptides enhance the engraftment of bone marrow transplants, hemopoietic reconstruction, bone marrow re-population and peripheral stem cell mobilization, preferably after chemotherapy or irradiation. The invention further provides methods of treatment and for using these oligopeptides in the preparation of pharmaceutical compositions.