公开(公告)号：US20050004037A1

公开(公告)日：2005-01-06

申请号：US10766527

申请日：2004-01-29

申请人： Itai Bab ,  Michael Chorev ,  Arye Shteyer ,  Andras Muhlrad ,  Nura Mansur ,  Olga Gurevitch ,  Zvi Greenberg ,  Sergio Rosini ,  Silvia Trasciatti ,  Mario Petrini

发明人： Itai Bab ,  Michael Chorev ,  Arye Shteyer ,  Andras Muhlrad ,  Nura Mansur ,  Olga Gurevitch ,  Zvi Greenberg ,  Sergio Rosini ,  Silvia Trasciatti ,  Mario Petrini

IPC分类号： A61K35/12 ,  A61K35/14 ,  A61K35/28 ,  A61K38/00 ,  A61K38/07 ,  A61K38/08 ,  A61K38/22 ,  A61P7/00 ,  A61P7/06 ,  A61P35/00 ,  A61P35/02 ,  A61P37/00 ,  A61P41/00 ,  A61P43/00 ,  C12N5/0789 ,  A61K38/06

CPC分类号： A61K38/08 ,  A61K38/07 ,  A61K2035/124 ,  C12N5/0647 ,  C12N2501/998

摘要： The present invention relates to a pharmaceutical composition comprising as an effective ingredient an oligopeptide identical or analogous to the C-terminal portion of OGP, having stimulatory activity on the production of hematopoietic cells. Preferred oligopeptides that are used are Tyr-Gly-Phe-Gly-Gly, Tyr-Gly-Phe-His-Gly, Gly-Phe-Gly-Gly or Met-Tyr-Gly-Phe-Gly-Gly. More specifically, these oligopeptides enhance the engraftment of bone marrow transplants, hemopoietic reconstruction, bone marrow re-population and peripheral stem cell mobilization, preferably after chemotherapy or irradiation. The invention further provides methods of treatment and for using these oligopeptides in the preparation of pharmaceutical compositions.

摘要翻译： 本发明涉及一种药物组合物，其包含与OGP的C末端部分相同或相似的寡肽作为有效成分，对造血细胞的产生具有刺激活性。 使用的优选的寡肽是Tyr-Gly-Phe-Gly-Gly，Tyr-Gly-Phe-His-Gly，Gly-Phe-Gly-Gly或Met-Tyr-Gly-Phe-Gly-Gly。 更具体地，这些寡肽增强了骨髓移植的植入，造血重建，骨髓再生和周边干细胞动员，优选化疗或照射后。 本发明还提供了治疗和使用这些寡肽在制备药物组合物中的方法。

公开(公告)号：US5461034A

公开(公告)日：1995-10-24

申请号：US79637

申请日：1993-06-18

申请人： Gideon A. Rodan ,  John W. Jacobs ,  Mohinder K. Sardana ,  Dan Gazit ,  Michael Chorev ,  Andras Muhlrad ,  Arye Shteyer ,  Nura Mansur ,  Zvi Greenberg ,  Shimon Slavin ,  Olga Gurevitch ,  Itai A. Bab

发明人： Gideon A. Rodan ,  John W. Jacobs ,  Mohinder K. Sardana ,  Dan Gazit ,  Michael Chorev ,  Andras Muhlrad ,  Arye Shteyer ,  Nura Mansur ,  Zvi Greenberg ,  Shimon Slavin ,  Olga Gurevitch ,  Itai A. Bab

IPC分类号： A61K38/00 ,  C07K14/51 ,  A61K38/08 ,  A61F2/02 ,  A61K35/32 ,  A61K38/39

CPC分类号： C07K14/51 ,  A61K38/00 ,  Y10S530/84 ,  Y10S530/841

摘要： A biochemically pure polypeptide(s), termed osteogenic growth polypeptide (OGP), which exhibits stimulatory effects on osteoblastic cells, in vivo bone formation and hemopoietic reconstruction. OGP, identified from regenerating bone marrow, has an amino acid sequence ofAla-Leu-Lys-Arg-Gln-Gly-Arg-Thr-Leu-Tyr-Gly-Phe-Gly-Gly.

摘要翻译： 称为成骨生长多肽（OGP）的生物化学纯多肽，其对成骨细胞表现出刺激作用，体内骨形成和造血重建。 由再生骨髓鉴定的OGP具有Ala-Leu-Lys-Arg-Gln-Gly-Arg-Thr-Leu-Tyr-Gly-Phe-Gly-Gly的氨基酸序列。

公开(公告)号：US07241417B2

公开(公告)日：2007-07-10

申请号：US11188799

申请日：2005-07-26

申请人： Martin Jerome Lee ,  Zvi Greenberg ,  Eitan Rogel

发明人： Martin Jerome Lee ,  Zvi Greenberg ,  Eitan Rogel

IPC分类号： G01N21/00 ,  G01N31/22 ,  G01N15/06 ,  G01N33/53 ,  G01N1/10 ,  C12Q1/68 ,  C12Q1/00 ,  B32B5/02 ,  C12M1/00 ,  C12M1/34 ,  C12M3/00

CPC分类号： B01L3/5023 ,  B01L2200/027 ,  B01L2300/0825 ,  B01L2400/0683 ,  Y10T436/2575

摘要： A device for carrying out a lateral flow assay on a sample comprising: (a) a sample containing unit comprising a sample container, said sample container being closed off at one end by a bottom wall, said bottom wall having a hole sealed by a plug; and (b) a housing located under said sample container and capable of holding a test strip, said sample containing unit and said housing being coupled so as to allow rotation one relative to the other, said housing comprising a cutting arrangement capable of cutting said plug; wherein rotation of said sample containing unit and said housing one relative to the other results in said cutting arrangement cutting said plug, thereby unplugging the hole in said bottom wall. Also disclosed is a method for determining the presence or absence of an analyte in a sample, using the device.

摘要翻译： 一种用于对样品进行横向流动测定的装置，包括：（a）包含样品容器的样品容纳单元，所述样品容器在一端由底壁封闭，所述底壁具有由插塞密封的孔 ; 和（b）位于所述样品容器下方并且能够保持测试条的壳体，所述样品容纳单元和所述壳体联接成允许相对于另一个旋转，所述壳体包括能够切割所述插塞的切割装置 ; 其中所述样品容纳单元和所述壳体相对于另一个的旋转导致所述切割装置切割所述塞子，从而拔掉所述底壁中的孔。 还公开了使用该装置来确定样品中有无分析物的方法。

公开(公告)号：US20050109951A1

公开(公告)日：2005-05-26

申请号：US10500186

申请日：2002-12-26

申请人： Falk Fish ,  Zvi Greenberg ,  Ouriel Faktor

发明人： Falk Fish ,  Zvi Greenberg ,  Ouriel Faktor

IPC分类号： G01N21/64 ,  G01N21/75 ,  G01N21/77 ,  G01N21/86

CPC分类号： G01N21/645 ,  G01N21/64 ,  G01N21/8483 ,  G01N33/549 ,  G01N2021/6439 ,  G01N2021/757 ,  G01N2021/7759 ,  G01N2021/7763 ,  G01N2021/7786 ,  G01N2201/0221 ,  G01N2201/0222 ,  G01N2201/0245 ,  G01N2201/062 ,  G01N2201/0628

摘要： A device, system and method for portable fluorescence detection. The portable device of the present invention features a low power light, in which a wavelength range is defined as at least one wavelength of light. The light source is preferably highly energy efficient, such that a majority of the electrical power which is consumed is then converted into transmitted light. The emitted light from the excited fluorophore is then preferably detected with any low cost and low power photodetector. Although optionally a highly sensitive optical detector may be used, preferably fluorescence is detected with any light sensing device, such as a regular photodiode or a CCD (charge-coupled device) sensor for example.

摘要翻译： 用于便携式荧光检测的装置，系统和方法。 本发明的便携式装置具有低功率光，其中波长范围被定义为至少一个波长的光。 光源优选地是高能量的，使得消耗的大部分电功率然后被转换成透射光。 然后优选用任何低成本和低功率光电检测器检测来自激发的荧光团的发射光。 尽管可选地使用高灵敏度的光学检测器，但是优选地，例如使用诸如常规光电二极管或CCD（电荷耦合器件）传感器的任何光感测装置来检测荧光。

公开(公告)号：US20060024843A1

公开(公告)日：2006-02-02

申请号：US11188799

申请日：2005-07-26

申请人： Martin Lee ,  Zvi Greenberg ,  Eitan Rogel

发明人： Martin Lee ,  Zvi Greenberg ,  Eitan Rogel

IPC分类号： G01N33/558

CPC分类号： B01L3/5023 ,  B01L2200/027 ,  B01L2300/0825 ,  B01L2400/0683 ,  Y10T436/2575

摘要： A device for carrying out a lateral flow assay on a sample comprising: (a) a sample containing unit comprising a sample container, said sample container being closed off at one end by a bottom wall, said bottom wall having a hole sealed by a plug; and (b) a housing located under said sample container and capable of holding a test strip, said sample containing unit and said housing being coupled so as to allow rotation one relative to the other, said housing comprising a cutting arrangement capable of cutting said plug; wherein rotation of said sample containing unit and said housing one relative to the other results in said cutting arrangement cutting said plug, thereby unplugging the hole in said bottom wall. Also disclosed is a method for determining the presence or absence of an analyte in a sample, using the device.

摘要翻译： 一种用于对样品进行横向流动测定的装置，包括：（a）包含样品容器的样品容纳单元，所述样品容器在一端由底壁封闭，所述底壁具有由插塞密封的孔 ; 和（b）位于所述样品容器下方并且能够保持测试条的壳体，所述样品容纳单元和所述壳体联接成允许相对于另一个旋转，所述壳体包括能够切割所述插塞的切割装置 ; 其中所述样品容纳单元和所述壳体相对于另一个的旋转导致所述切割装置切割所述塞子，从而拔掉所述底壁中的孔。 还公开了使用该装置来确定样品中有无分析物的方法。

公开(公告)号：US5814610A

公开(公告)日：1998-09-29

申请号：US530277

申请日：1996-01-05

申请人： Itai Bab ,  Andras Muhlrad ,  Michael Chorev ,  Arie Shteyer ,  Zvi Greenberg ,  Nura Mansur

发明人： Itai Bab ,  Andras Muhlrad ,  Michael Chorev ,  Arie Shteyer ,  Zvi Greenberg ,  Nura Mansur

IPC分类号： A61K38/00 ,  A61K38/22 ,  A61P19/00 ,  A61P43/00 ,  C07K5/08 ,  C07K5/10 ,  C07K7/06 ,  C07K14/51 ,  C12N15/06 ,  A61K35/18 ,  A61K37/02 ,  C07K7/08

CPC分类号： C07K14/51 ,  A61K38/00

摘要： The invention relates to biochemically pure oligopeptides having stimulatory activity on osteoblastic and/or fibroblastic cells having a molecular weight between 200 and 2,000. Preferred oligopeptides according to the invention comprise the amino acid sequences Tyr-Gly-Phe-His-Gly (SEQ.ID.No.2) and Gly-Phe-Gly-Gly (SEQ.ID.No.3). The invention further relates to pharmaceutical compositions for the stimulation of formation of osteoblastic or fibroblastic cells, enhanced bone formation in osteogenic pathological conditions, fracture repair, healing of wounds, intraosseous implants and bone supplementation, or other conditions requiring enhanced bone formation cells comprising a therapeutically effective amount of an oligopeptide according to the invention.

摘要翻译： PCT No.PCT / GB94 / 00416 Sec。 371日期1996年1月5日 102（e）日期1996年1月5日PCT 1994年3月4日PCT公布。 出版物WO94 / 20529 日期1994年9月15日本发明涉及对成骨细胞和/或分子量在200和2,000之间的成纤维细胞和/或成纤维细胞具有刺激活性的生物化学纯的寡肽。 根据本发明的优选的寡肽包含氨基酸序列Tyr-Gly-Phe-His-Gly（SEQ.ID.No.2）和Gly-Phe-Gly-Gly（SEQ.ID.No.3）。 本发明进一步涉及用于刺激成骨细胞或成纤维细胞形成的药物组合物，在成骨病理状况下增强骨形成，骨折修复，伤口愈合，骨内植入物和补骨，或需要增强的骨形成细胞的其它条件，其包括治疗 有效量的根据本发明的寡肽。