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    Compositions comprising bone marrow cells together with demineralized and/or mineralized bone matrix and uses thereof in the induction of bone and cartilage formation
    1.
    发明申请
    Compositions comprising bone marrow cells together with demineralized and/or mineralized bone matrix and uses thereof in the induction of bone and cartilage formation 审中-公开
    包含骨髓细胞以及脱矿质和/或矿化骨基质的组合物及其在诱导骨和软骨形成中的用途

    公开(公告)号：US20070264240A1

    公开(公告)日：2007-11-15

    申请号：US11825894

    申请日：2007-07-09

    申请人： Shimon Slavin ,  Olga Gurevitch ,  Basan Kurkalli ,  Tatyana Prigozhina

    发明人： Shimon Slavin ,  Olga Gurevitch ,  Basan Kurkalli ,  Tatyana Prigozhina

    IPC分类号： C12N5/06 ,  A61K39/00 ,  A61P19/02

    CPC分类号： A61K35/32 ,  A61K35/28 ,  A61K38/1875 ,  A61K2300/00

    摘要： A composition comprising bone marrow cells (BMC) and demineralized bone matrix (DBM) and/or mineralized bone matrix (MBM) and optionally comprising bone morphogenetic protein/s (BMP) and/or other active agents, particularly for use in the transplantation of mesenchymal progenitor cells into a joint and/or a cranio-facial maxillary bone, for restoring and/or enhancing the formation of a new hyaline cartilage and subchondral bone structure. The composition of the invention and method of treatment employing the same may be used for the treatment of hereditary or acquired bone disorders, hereditary or acquired cartilage disorders, malignant bone or cartilage disorders, metabolic bone diseases, bone infections, conditions involving bone or cartilage deformities and Paget's disease. The composition and method may further be used for the correction of complex fractures, bone replacement and formation of new bone in plastic or sexual surgery, for support of implants of joints, cranio-facial-maxillary bones, or other musculoskeletal implants, including artificial implants. The method of the invention may further be used for treating damaged joints or degenerative arthropathy associated with malformation and/or dysfunction of cartilage and/or subchondral bone. A kit is provided for performing transplantation into a joint or a cranio-facial-maxillary bone of a mammal of the composition of the invention.

    摘要翻译： 包含骨髓细胞（BMC）和去矿化骨基质（DBM）和/或矿化骨基质（MBM）和任选地包含骨形态发生蛋白（BMP）和/或其他活性剂的组合物，特别是用于移植 间质祖细胞进入关节和/或头颅上颌骨，用于恢复和/或增强新型透明软骨和软骨下骨结构的形成。 本发明的组合物及其使用方法可用于治疗遗传性或获得性骨病，遗传性或获得性软骨疾病，恶性骨或软骨疾病，代谢性骨病，骨感染，涉及骨或软骨畸形的病症 和佩吉特病。 组合物和方法还可用于矫正复合骨折，骨替代和塑性或性手术中新骨形成，以支持关节植入物，颅面上颌骨或其他肌骨骼植入物，包括人造植入物 。 本发明的方法还可用于治疗与软骨和/或软骨下骨的畸形和/或功能障碍相关的损伤关节或退行性关节病。 提供用于进行移植到本发明组合物的哺乳动物的关节或头颅面上颌骨中的试剂盒。

    Methods of treatment of hematopoietic disorders
    3.
    发明授权
    Methods of treatment of hematopoietic disorders 有权
    造血障碍治疗方法

    公开(公告)号：US07347999B2

    公开(公告)日：2008-03-25

    申请号：US10471048

    申请日：2002-03-05

    申请人： Shimon Slavin ,  Olga Gurevitch ,  Basan Gowda S. Kurkalli ,  Tatyana Prigozhina

    发明人： Shimon Slavin ,  Olga Gurevitch ,  Basan Gowda S. Kurkalli ,  Tatyana Prigozhina

    IPC分类号： A61K35/32 ,  A61K35/28

    CPC分类号： A61K35/32 ,  A61K35/28 ,  A61K38/1875 ,  A61K2300/00

    摘要： A composition comprising bone marrow cells (BMC) and demineralized bone matrix (DBM) and/or mineralized bone matrix (MBM), optionally comprising bone morphogenetic protein (BMP), particularly for use in bone marrow transplantation, into bone marrow cavity or into extraskeletal sites, and methods of transplantation/implantation thereof. The composition and methods of the invention enable restoring and/or enhancing the formation of hematopoiectic microenvironment originating from the transplanted BMC, and are useful in the treatment of hematopoietic disorders, such as deficiency of stem cells and/or their products, genetic conditions resulting in abnormal stem cells and/or products, or hematopoietic disorders of malignant or non-malignant origin. The composition and method of the invention may also be used for the induction of graft tolerence, for the prevention of graft-v-host disease. It is mostly important that the compositions and methods of the invention may be applied for the treatment of diseases affecting primarily or secondarily the stromal microenvironment that supports and regulates hematopoiesis. Further provided is a kit for transplantation into a mammal of BMC in admixture with DBM and/or MBM.

    摘要翻译： 包含骨髓细胞（BMC）和去矿物质骨基质（DBM）和/或矿化骨基质（MBM）的组合物，任选地包括骨形态发生蛋白（BMP），特别是用于骨髓移植，进入骨髓腔或骨骼外 位点及其移植/植入方法。 本发明的组合物和方法能够恢复和/或增强源自移植的BMC的造血微环境的形成，并且可用于治疗造血障碍，例如干细胞和/或其产物的缺乏，导致 异常干细胞和/或产物，或恶性或非恶性起源的造血障碍。 本发明的组合物和方法也可用于诱导移植物穿刺，用于预防移植物抗宿主病。 最重要的是，本发明的组合物和方法可以用于治疗主要或二次影响支持和调节造血的基质微环境的疾病。 还提供了用于与DBM和/或MBM混合的用于移植到BMC的哺乳动物中的试剂盒。

    Compositions comprising bone marrow cells, demineralized bone matrix and various site-reactive polymers for use in the induction of bone and cartilage formation
    4.
    发明申请
    Compositions comprising bone marrow cells, demineralized bone matrix and various site-reactive polymers for use in the induction of bone and cartilage formation 审中-公开
    包含骨髓细胞，去矿物质骨基质和用于诱导骨和软骨形成的各种位点反应性聚合物的组合物

    公开(公告)号：US20060177387A1

    公开(公告)日：2006-08-10

    申请号：US10526597

    申请日：2003-09-04

    申请人： Shimon Slavin ,  Olga Gurevitch ,  Basan Kurkalli ,  Daniel Cohn ,  Aleiandro Sosnik

    发明人： Shimon Slavin ,  Olga Gurevitch ,  Basan Kurkalli ,  Daniel Cohn ,  Aleiandro Sosnik

    IPC分类号： A61K35/32

    CPC分类号： A61L27/3645 ,  A61K35/28 ,  A61K35/32 ,  A61K38/1875 ,  A61L27/227 ,  A61L27/26 ,  A61L27/3608 ,  A61L27/3821 ,  A61L27/3834 ,  A61L27/3843 ,  A61K2300/00

    摘要： A composition comprising bone marrow cells (BMC) and demineralized bone matrix (DBM) or demineralized tooth matrix (DTM), together with a site-responsive polymer, optionally further comprising bone morphogenetic proteins (BMP) and/or other active agents, particularly for use in the transplantation of mesenchymal progenitor cells into a joint or a cranio-facial-maxillary bone, alveolar bone of maxilla and mandibula, spine, pelvis or long bones, or for construction or reconstruction of any extra skeletal bone, including for mechanical or biological support of artificial implants to the joint or of the joint or to the bone, for restoring and/or enhancing the formation of a new hyaline cartilage and subchondral bone structure. A kit is provided for performing transplantation of the composition into a joint, maxillary or mandibular alveolar bone or any bony structure of a mammal, including support of artificial implants.

    摘要翻译： 包含骨髓细胞（BMC）和脱矿质骨基质（DBM）或脱矿质牙质基质（DTM）的组合物与位点反应性聚合物一起，任选地还包含骨形态发生蛋白（BMP）和/或其它活性剂，特别是 用于将间充质祖细胞移植到关节或颅面上颌骨，上颌骨和下颌骨，脊柱，骨盆或长骨的牙槽骨中，或用于构建或重建任何额外的骨骼骨，包括用于机械或生物 将人造植入物支撑到关节或关节或骨骼，用于恢复和/或增强新型透明软骨和软骨下骨结构的形成。 提供了用于将组合物移植到关节，上颌骨或下颌骨牙槽骨或哺乳动物的任何骨结构（包括人造植入物的支撑）中的试剂盒。