发明申请
- 专利标题： Prodrugs activated by targeted catalytic proteins
- 专利标题（中）： 由靶向催化蛋白激活的前药
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申请号： US10699966申请日： 2003-11-03
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公开(公告)号： US20050123533A1公开(公告)日： 2005-06-09
- 发明人: John Kenten , Reid Borstel , Jan Casadei , Balreddy Kamireddy , Mark Martin , Richard Massey , Andrew Napper , David Simpson , Rodger Smith , Richard Titmas , Richard Williams
- 申请人： John Kenten , Reid Borstel , Jan Casadei , Balreddy Kamireddy , Mark Martin , Richard Massey , Andrew Napper , David Simpson , Rodger Smith , Richard Titmas , Richard Williams
- 主分类号： A61K31/195
- IPC分类号： A61K31/195 ; A61K31/425 ; A61K31/505 ; A61K31/70 ; A61K31/7028 ; A61K31/7034 ; A61K31/704 ; A61K31/7042 ; A61K31/7052 ; A61K31/7064 ; A61K31/7068 ; A61K31/7072 ; A61K39/385 ; A61K39/395 ; A61K47/48 ; A61P31/12 ; A61P43/00 ; C07C311/19 ; C07D227/02 ; C07D233/64 ; C07D233/88 ; C07D405/04 ; C07D417/12 ; C07D417/14 ; C07F9/24 ; C07F9/26 ; C07F9/40 ; C07F9/6509 ; C07F9/6571 ; C07F9/6574 ; C07H15/252 ; C07H19/04 ; C07H19/067 ; C07H19/09 ; C07H19/10 ; C07H19/11 ; C07K16/46 ; C12N15/09 ; C12P21/08 ; C12R1/92 ; G01N33/50 ; G01N33/53 ; C07H15/24 ; C07K16/18
摘要：
Disclosed and claimed are prodrugs activated by catalytic proteins, such as enzymes and catalytic antibodies. The invention comprehends such prodrugs, as well as haptens, to elicit catalytic antibodies to activate the prodrugs. The prodrugs are useful as cytotoxic chemotherapeutic agents; e.g., as antitumor agents.
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