发明授权
US4971996A Hydroxystyrene compounds which are useful as tyrosine kinase inhibitors
失效
可用作酪氨酸激酶抑制剂的羟基苯乙烯化合物
- 专利标题: Hydroxystyrene compounds which are useful as tyrosine kinase inhibitors
- 专利标题(中): 可用作酪氨酸激酶抑制剂的羟基苯乙烯化合物
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申请号: US283992申请日: 1988-11-10
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公开(公告)号: US4971996A公开(公告)日: 1990-11-20
- 发明人: Tadayoshi Shiraishi , Keiji Kameyama , Takeshi Domoto , Naohiro Imai , Yoshio Shimada , Yutaka Ariki , Kazunori Hosoe , Masaji Kawatsu , Ikuo Katsumi , Takayoshi Hidaka , Kiyoshi Watanabe
- 申请人: Tadayoshi Shiraishi , Keiji Kameyama , Takeshi Domoto , Naohiro Imai , Yoshio Shimada , Yutaka Ariki , Kazunori Hosoe , Masaji Kawatsu , Ikuo Katsumi , Takayoshi Hidaka , Kiyoshi Watanabe
- 申请人地址: JPX Osaka
- 专利权人: Kanegafuchi Kagaku Kogyo Kabushiki Kaisha
- 当前专利权人: Kanegafuchi Kagaku Kogyo Kabushiki Kaisha
- 当前专利权人地址: JPX Osaka
- 优先权: JPX62-55965 19870311; JPX62-55966 19870311; JPX62-57256 19870312
- 主分类号: B21B31/16
- IPC分类号: B21B31/16 ; A61K31/26 ; A61K31/27 ; A61K31/275 ; A61K31/34 ; A61K31/425 ; B21B31/02 ; B21B31/20 ; B21B33/00 ; B21B37/18 ; B21B37/72 ; C07C253/30 ; C07C255/34 ; C07C255/41 ; C07C255/44 ; C07C255/53 ; C07D207/38 ; C07D209/34 ; C07D231/36 ; C07D277/20 ; C07D277/36 ; C07D277/54 ; C07D279/16 ; C07D307/32 ; C07D307/33 ; C07D307/52 ; C07D307/58 ; C07D417/12 ; C09K3/00
摘要:
A hydroxystyrene derivative represented by the formula (I): ##STR1## wherein when R.sup.1 and R.sup.2 : phenyl group, benzyl group or phenethyl group, or R.sup.1 : R.sup.5 O-- (R.sup.5 : H, a C.sub.1 to C.sub.5 alkyl group or benzyl group) and R.sup.2 : benzyl group or PhSCH.sub.2, R.sup.3 and R.sup.4 are taken together to represent --CONH--CS--S--, ##STR2## (X.sup.1 : H, a halogen, methyl group, ethyl group, R.sup.7 O-- (R.sup.7 : methyl or ethyl group), nitro group, aminosulfonyl group or amino group, m.sup.1 : 1 or 2), pyridyl group, furyl group or thienyl group, n.sup.1 : an integer of 0 to 3); when R.sup.1 and R.sup.2 : phenyl group, benzyl group or phenethyl group, or R.sup.1 : R.sup.5 O-- (R.sup.5 : as defined above) and R.sup.2 : benzyl group, R.sup.3 : cyano group and R.sup.4 : a carbamoyl group, or R.sup.3 and R.sup.4 are taken together to represent --CO--Y--CH.sub.2 CH.sub.2 -- (Y: O or --NH--) or ##STR3## and when R.sup.1 and R.sup.2 : a C.sub.1 to C.sub.3 alkyl group, R.sup.3 and R.sup.4 are taken together to represent ##STR4## (n.sup.1, R.sup.6 : as defined above), or a salt thereof. The hydroxystyrene derivative or a salt thereof is a compound which is useful as an active ingredient of an antiallergic agent, a 5-lipoxygenase inhibiting agent, an antibacterial agent, a tryosine kinase inhibiting agent, an ultraviolet absorber or a reverse transcriptase inhibiting agent, and also is useful as an intermediate for preparing various organic compounds.
公开/授权文献
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