公开(公告)号：US20120156749A1

公开(公告)日：2012-06-21

申请号：US13403212

申请日：2012-02-23

申请人： Hiroshi AWAJI ,  Ashutosh KUMAR ,  Akira KOBAYASHI ,  Naohiro IMAI

发明人： Hiroshi AWAJI ,  Ashutosh KUMAR ,  Akira KOBAYASHI ,  Naohiro IMAI

IPC分类号： C12N11/10

CPC分类号： C12N5/0639 ,  C07K1/22 ,  C07K14/42 ,  C12N5/0645

摘要： The present invention provides a novel material useful for selectively isolating a cell such as monocyte and the like or a protein from a body fluid and a production method thereof, a physiological material using the material and an isolation material using the physiological material, as well as a method of harvesting a cell such as monocyte and the like using the isolation material, a method of harvesting a protein and a method of preparing a dendritic cell.

公开(公告)号：US20090186009A1

公开(公告)日：2009-07-23

申请号：US12298449

申请日：2007-04-24

申请人： Masao Sato ,  Takashi Ueda ,  Yoshiyuki Shinagawa ,  Shinsuke Akao ,  Naohiro Imai ,  Shiro Kitamura

发明人： Masao Sato ,  Takashi Ueda ,  Yoshiyuki Shinagawa ,  Shinsuke Akao ,  Naohiro Imai ,  Shiro Kitamura

IPC分类号： A61K31/122

CPC分类号： A61K31/05 ,  A23L33/10 ,  A23V2002/00 ,  A61K9/1075 ,  A61K9/1652 ,  A61K9/1658 ,  A61K9/1694 ,  A61K31/122 ,  A23V2200/326 ,  A23V2250/314 ,  A23V2200/254

摘要： The present invention provides a coenzyme Q-containing solid wherein coenzyme Q fine particles are dispersed in particles made of a physically crosslinked polymer. In addition, the present invention provides a method of producing a coenzyme Q-containing solid, which includes a step of bringing an atomized water-soluble polymer solution capable of forming a physical gel, wherein coenzyme Q is dispersed, into contact with an atomized gelling solution.In the solid of the present invention, the disintegratability is suppressed in the stomach, and rapidly disintegrated in the intestine. Accordingly, coenzyme Q is more quickly absorbed from the intestine, which in turn enhances the absorbability of coenzyme Q from the intestine. In addition, the production method of the present invention is industrially advantageous.

摘要翻译： 本发明提供了一种辅酶Q固体，其中辅酶Q细颗粒分散在由物理交联的聚合物制成的颗粒中。 另外，本发明提供了含有辅酶Q的固体的制造方法，该方法包括使能够形成物理凝胶的雾化的水溶性聚合物溶液（其中辅酶Q分散）与雾化胶凝剂接触的步骤 解。 在本发明的实施方案中，胃中的崩解性被抑制，并且在肠中迅速分解。 因此，辅酶Q更快地从肠中吸收，这又增强了辅酶Q从肠中的吸收性。 另外，本发明的制造方法在工业上是有利的。

公开(公告)号：US20090142835A1

公开(公告)日：2009-06-04

申请号：US12091029

申请日：2006-10-20

申请人： Akira Kobayashi ,  Kazuaki Yamamoto ,  Shinya Yoshida ,  Hideo Niwa ,  Naohiro Imai ,  Hirokazu Kurata ,  Yoshiaki Miyamoto

发明人： Akira Kobayashi ,  Kazuaki Yamamoto ,  Shinya Yoshida ,  Hideo Niwa ,  Naohiro Imai ,  Hirokazu Kurata ,  Yoshiaki Miyamoto

IPC分类号： C12N5/06

CPC分类号： C12N5/0607 ,  B01D39/1623 ,  B01D39/1692 ,  B01D2239/0414 ,  C12M33/14 ,  C12M47/02

摘要： The present invention has its object to provide a material for separating stem cell and a filter for separating stem cell, each is capable of selectively separating and recovering, in a simple and easy manner, stem cells from body fluids or biological tissue-derived treated fluids, a method for separating and recovering stem cells, and stem cells obtained by such method. The present invention is a material for separating stem cell which has a density K of 1.0×104≦K≦1.0×106 and a fiber diameter of 3 to 40 μm; a filter for separating stem cell which comprises the material for separating stem cell as packed in a container having a fluid inlet port and a fluid outlet port; a method of separating and recovering stem cells which comprises using the material for separating stem cell or the filter for separating stem cell; and a method of producing a multipotent cell fraction.

摘要翻译： 本发明的目的是提供用于分离干细胞的材料和用于分离干细胞的过滤器，每种能够以简单和容易的方式从体液或生物组织衍生的处理液中分离和回收干细胞 ，分离和回收干细胞的方法和通过这种方法获得的干细胞。 本发明是一种用于分离密度K为1.0×104 <= K <= 1.0×10 6，纤维直径为3〜40μm的干细胞的材料。 用于分离干细胞的过滤器，其包括用于分离干细胞的材料，所述干细胞包装在具有流体入口和流体出口的容器中; 分离和回收干细胞的方法，其包括使用用于分离干细胞的材料或用于分离干细胞的过滤器; 以及多能细胞部分的制造方法。

公开(公告)号：US5202341A

公开(公告)日：1993-04-13

申请号：US735581

申请日：1991-07-25

申请人： Tadayoshi Shiraishi ,  Keiji Kameyama ,  Takeshi Domoto ,  Naohiro Imai ,  Yoshio Shimada ,  Yutaka Ariki ,  Kazunori Hosoe ,  Masaji Kawatsu ,  Ikuo Katsumi ,  Takayoshi Hidaka ,  Kiyoshi Watanabe

发明人： Tadayoshi Shiraishi ,  Keiji Kameyama ,  Takeshi Domoto ,  Naohiro Imai ,  Yoshio Shimada ,  Yutaka Ariki ,  Kazunori Hosoe ,  Masaji Kawatsu ,  Ikuo Katsumi ,  Takayoshi Hidaka ,  Kiyoshi Watanabe

IPC分类号： A61K31/26 ,  C07C255/34 ,  C07D207/38 ,  C07D209/34 ,  C07D231/36 ,  C07D277/20 ,  C07D277/36 ,  C07D277/54 ,  C07D279/16 ,  C07D307/58 ,  C07D417/12

CPC分类号： C07D277/20 ,  C07C255/00 ,  C07C255/34 ,  C07D207/38 ,  C07D209/34 ,  C07D231/36 ,  C07D277/36 ,  C07D277/54 ,  C07D279/16 ,  C07D307/58 ,  C07D417/12

摘要： A hydroxystyrene derivative represented by the formula (I): ##STR1## wherein when R.sup.1 and R.sup.2 : phenyl group, benzyl group or phenethyl group, or R.sup.1 : R.sup.5 O- (R.sup.5 : H, a C.sub.1 to C.sub.5 alkyl group or benzyl group) and R.sup.2 : benzyl group or PhSCH.sub.2, R.sup.3 and R.sup.4 are taken together to represent --CONH--CS--S--, ##STR2## (X.sup.1 : H, a halogen, methyl group, ethyl group, R.sup.7 O-- (R.sup.7 : methyl or ethyl group), nitro group, aminosulfonyl group or amino group, m.sup.1 : 1 or 2), pyridyl group, furyl group or thienyl group, n.sup.1 : an integer of 0 to 3); when R.sup.1 and R.sup.2 : phenyl group, benzyl group or phenethyl group, or R.sup.1 : R.sup.5 O-- (R.sup.5 : as defined above) and R.sup.2 : benzyl group, R.sup.3 : cyano group and R.sup.4 : a carbamoyl group, or R.sup.3 and R.sup.4 are taken together to represent --CO--Y--CH.sub.2 CH.sub.2 -- (Y: O or --NH--) or ##STR3## and when R.sup.1 and R.sup.2 : a C.sub.1 to C.sub.3 alkyl group, R.sup.3 and R.sup.4 are taken together to represent ##STR4## (n.sup.1, R.sup.6 : as defined above), or a salt thereof. The hydroxystyrene derivative or a salt thereof is a compound which is useful as an active ingredient of an antiallergic agent, a 5-lipoxygenase inhibiting agent, an antibacterial agent, a tyrosine kinase inhibiting agent, an ultraviolet absorber or a reverse transcriptase inhibiting agent, and also is useful as an intermediate for preparing various organic compounds.

摘要翻译： 由式（I）表示的羟基苯乙烯衍生物：其中当R1和R2：苯基，苄基或苯乙基或R1：R5O-（R5：H，C1-C5烷基或苄基 基团）和R 2：苄基或PhSCH 2，R 3和R 4一起表示-CONH-CS-S-，或（X1：H，卤素，甲基，乙基，R7O-（ R7：甲基或乙基），硝基，氨基磺酰基或氨基，m1：1或2），吡啶基，呋喃基或噻吩基，n1：0〜3的整数）。 当R1和R2：苯基，苄基或苯乙基或R1：R5O-（R5：如上定义）和R2：苄基，R3：氰基和R4：氨基甲酰基，或R3和R4合在一起 表示-CO-Y-CH 2 CH 2 - （Y：O或-NH-）或，并且当R 1和R 2为C 1至C 3烷基时，R 3和R 4一起表示（n1，R6 ：如上所定义），或其盐。 羟基苯乙烯衍生物或其盐是可用作抗变应性剂的活性成分，5-脂氧合酶抑制剂，抗菌剂，酪氨酸激酶抑制剂，紫外线吸收剂或逆转录酶抑制剂的化合物，以及 也可用作制备各种有机化合物的中间体。

公开(公告)号：US09057052B2

公开(公告)日：2015-06-16

申请号：US12091029

申请日：2006-10-20

申请人： Akira Kobayashi ,  Kazuaki Yamamoto ,  Shinya Yoshida ,  Hideo Niwa ,  Naohiro Imai ,  Hirokazu Kurata ,  Yoshiaki Miyamoto

发明人： Akira Kobayashi ,  Kazuaki Yamamoto ,  Shinya Yoshida ,  Hideo Niwa ,  Naohiro Imai ,  Hirokazu Kurata ,  Yoshiaki Miyamoto

IPC分类号： C12M1/12 ,  C12M1/00 ,  C12M1/36 ,  C12N5/00 ,  C12N5/074 ,  B01D39/16 ,  C12M1/26

CPC分类号： C12N5/0607 ,  B01D39/1623 ,  B01D39/1692 ,  B01D2239/0414 ,  C12M33/14 ,  C12M47/02

摘要： The present invention has its object to provide a material for separating stem cell and a filter for separating stem cell, each is capable of selectively separating and recovering, in a simple and easy manner, stem cells from body fluids or biological tissue-derived treated fluids, a method for separating and recovering stem cells, and stem cells obtained by such method. The present invention is a material for separating stem cell which has a density K of 1.0×104≦K≦1.0×106 and a fiber diameter of 3 to 40 μm; a filter for separating stem cell which comprises the material for separating stem cell as packed in a container having a fluid inlet port and a fluid outlet port; a method of separating and recovering stem cells which comprises using the material for separating stem cell or the filter for separating stem cell; and a method of producing a multipotent cell fraction.

摘要翻译： 本发明的目的是提供用于分离干细胞的材料和用于分离干细胞的过滤器，每种能够以简单和容易的方式从体液或生物组织衍生的处理液中分离和回收干细胞 ，分离和回收干细胞的方法和通过这种方法获得的干细胞。 本发明是一种分离干细胞的材料，其密度K为1.0×104＆nlE; K＆NlE; 1.0×106，纤维直径为3〜40μm; 用于分离干细胞的过滤器，其包括用于分离干细胞的材料，所述干细胞包装在具有流体入口和流体出口的容器中; 分离和回收干细胞的方法，其包括使用用于分离干细胞的材料或用于分离干细胞的过滤器; 以及多能细胞部分的制造方法。

公开(公告)号：US20090239300A1

公开(公告)日：2009-09-24

申请号：US12302881

申请日：2007-05-25

申请人： Hiroshi Awaji ,  Ashutosh Kumar ,  Akira Kobayashi ,  Naohiro Imai

发明人： Hiroshi Awaji ,  Ashutosh Kumar ,  Akira Kobayashi ,  Naohiro Imai

IPC分类号： C12N5/06 ,  C07K1/00 ,  C07K14/42 ,  C13K5/00 ,  C12M1/00 ,  C08G63/91

CPC分类号： C12N5/0639 ,  C07K1/22 ,  C07K14/42 ,  C12N5/0645

摘要： The present invention provides a novel material useful for selectively isolating a cell such as monocyte and the like or a protein from a body fluid and a production method thereof, a physiological material using the material and an isolation material using the physiological material, as well as a method of harvesting a cell such as monocyte and the like using the isolation material, a method of harvesting a protein and a method of preparing a dendritic cell.

摘要翻译： 本发明提供了用于选择性分离细胞如单核细胞等或来自体液的蛋白质及其制备方法的新型材料，使用该材料的生理材料和使用该生理材料的分离材料，以及 使用分离材料收获细胞如单核细胞等的方法，收获蛋白质的方法和制备树突状细胞的方法。

公开(公告)号：US5089516A

公开(公告)日：1992-02-18

申请号：US584683

申请日：1990-09-19

申请人： Tadayoshi Shiraishi ,  Keiji Kameyama ,  Takeshi Domoto ,  Naohiro Imai ,  Yoshio Shimada ,  Yutaka Ariki ,  Kazunori Hosoe ,  Masaji Kawatsu ,  Ikuo Katsumi ,  Takayoshi Hidaka ,  Kiyoshi Watanabe

发明人： Tadayoshi Shiraishi ,  Keiji Kameyama ,  Takeshi Domoto ,  Naohiro Imai ,  Yoshio Shimada ,  Yutaka Ariki ,  Kazunori Hosoe ,  Masaji Kawatsu ,  Ikuo Katsumi ,  Takayoshi Hidaka ,  Kiyoshi Watanabe

IPC分类号： A61K31/425 ,  C07C255/34 ,  C07D207/38 ,  C07D209/34 ,  C07D231/36 ,  C07D277/20 ,  C07D277/36 ,  C07D277/54 ,  C07D279/16 ,  C07D307/58 ,  C07D417/12 ,  A61K31/415 ,  C07D231/04

CPC分类号： C07D277/20 ,  C07C255/00 ,  C07C255/34 ,  C07D207/38 ,  C07D209/34 ,  C07D231/36 ,  C07D277/36 ,  C07D277/54 ,  C07D279/16 ,  C07D307/58 ,  C07D417/12

摘要： A hydroxystyrene derivative represented by the formula (I): ##STR1## wherein when R.sup.1 and R.sup.2 : phenyl group, benzyl group or phenethyl group, or R.sup.1 : R.sup.5 O-- (R.sup.5 : H, a C.sub.1 to C.sub.5 alkyl group or benzyl group) and R.sup.2 : benzyl group or PhSCH.sub.2, R.sup.3 and R.sup.4 are taken together to represent --CONH--CS--S--, ##STR2## (X.sup.1 : H, a halogen, methyl group, ethyl group, R.sup.7 O-- (R.sup.7 : methyl or ethyl group), nitro group, aminosulfonyl group or amino group, m.sup.1 : 1 or 2), pyridyl group, furyl group or thienyl group, n.sup.1 : an integer of 0 to 3); when R.sup.1 and R.sup.2 : phenyl group, benzyl group or phenethyl group, or R.sup.1 : R.sup.5 O-- (R.sup.5 : as defined above) and R.sup.2 : benzyl group, R.sup.3 : cyano group and R.sup.4 : a carbamoyl group, or R.sup.3 and R.sup.4 are taken together to represent --CO--Y--CH.sub.2 CH.sub.2 -- (Y: O or --NH--) or ##STR3## and when R.sup.1 and R.sup.2 : a C.sub.1 to C.sub.3 alkyl group, R.sup.3 and R.sup.4 are taken together to represent ##STR4## (n.sup.1, R.sup.6 : as defined above), or a salt thereof. The hydroxystyrene derivative or a salt thereof is a compound which is useful as an active ingredient of an antiallergic agent, a 5-lipoxygenase inhibiting agent, an antibacterial agent, a tyrosine kinase inhibiting agent, an ultraviolet absorber or a reverse transcriptase inhibiting agent, and also is useful as an intermediate for preparing various organic compounds.

公开(公告)号：US4971996A

公开(公告)日：1990-11-20

申请号：US283992

申请日：1988-11-10

申请人： Tadayoshi Shiraishi ,  Keiji Kameyama ,  Takeshi Domoto ,  Naohiro Imai ,  Yoshio Shimada ,  Yutaka Ariki ,  Kazunori Hosoe ,  Masaji Kawatsu ,  Ikuo Katsumi ,  Takayoshi Hidaka ,  Kiyoshi Watanabe

发明人： Tadayoshi Shiraishi ,  Keiji Kameyama ,  Takeshi Domoto ,  Naohiro Imai ,  Yoshio Shimada ,  Yutaka Ariki ,  Kazunori Hosoe ,  Masaji Kawatsu ,  Ikuo Katsumi ,  Takayoshi Hidaka ,  Kiyoshi Watanabe

IPC分类号： B21B31/16 ,  A61K31/26 ,  A61K31/27 ,  A61K31/275 ,  A61K31/34 ,  A61K31/425 ,  B21B31/02 ,  B21B31/20 ,  B21B33/00 ,  B21B37/18 ,  B21B37/72 ,  C07C253/30 ,  C07C255/34 ,  C07C255/41 ,  C07C255/44 ,  C07C255/53 ,  C07D207/38 ,  C07D209/34 ,  C07D231/36 ,  C07D277/20 ,  C07D277/36 ,  C07D277/54 ,  C07D279/16 ,  C07D307/32 ,  C07D307/33 ,  C07D307/52 ,  C07D307/58 ,  C07D417/12 ,  C09K3/00

CPC分类号： C07D277/20 ,  B21B31/02 ,  B21B31/203 ,  C07C255/00 ,  C07C255/34 ,  C07D207/38 ,  C07D209/34 ,  C07D231/36 ,  C07D277/36 ,  C07D277/54 ,  C07D279/16 ,  C07D307/58 ,  C07D417/12

摘要： A hydroxystyrene derivative represented by the formula (I): ##STR1## wherein when R.sup.1 and R.sup.2 : phenyl group, benzyl group or phenethyl group, or R.sup.1 : R.sup.5 O-- (R.sup.5 : H, a C.sub.1 to C.sub.5 alkyl group or benzyl group) and R.sup.2 : benzyl group or PhSCH.sub.2, R.sup.3 and R.sup.4 are taken together to represent --CONH--CS--S--, ##STR2## (X.sup.1 : H, a halogen, methyl group, ethyl group, R.sup.7 O-- (R.sup.7 : methyl or ethyl group), nitro group, aminosulfonyl group or amino group, m.sup.1 : 1 or 2), pyridyl group, furyl group or thienyl group, n.sup.1 : an integer of 0 to 3); when R.sup.1 and R.sup.2 : phenyl group, benzyl group or phenethyl group, or R.sup.1 : R.sup.5 O-- (R.sup.5 : as defined above) and R.sup.2 : benzyl group, R.sup.3 : cyano group and R.sup.4 : a carbamoyl group, or R.sup.3 and R.sup.4 are taken together to represent --CO--Y--CH.sub.2 CH.sub.2 -- (Y: O or --NH--) or ##STR3## and when R.sup.1 and R.sup.2 : a C.sub.1 to C.sub.3 alkyl group, R.sup.3 and R.sup.4 are taken together to represent ##STR4## (n.sup.1, R.sup.6 : as defined above), or a salt thereof. The hydroxystyrene derivative or a salt thereof is a compound which is useful as an active ingredient of an antiallergic agent, a 5-lipoxygenase inhibiting agent, an antibacterial agent, a tryosine kinase inhibiting agent, an ultraviolet absorber or a reverse transcriptase inhibiting agent, and also is useful as an intermediate for preparing various organic compounds.

公开(公告)号：US08357522B2

公开(公告)日：2013-01-22

申请号：US12302881

申请日：2007-05-25

申请人： Hiroshi Awaji ,  Ashutosh Kumar ,  Akira Kobayashi ,  Naohiro Imai

发明人： Hiroshi Awaji ,  Ashutosh Kumar ,  Akira Kobayashi ,  Naohiro Imai

IPC分类号： C12N5/06 ,  C07K1/00

CPC分类号： C12N5/0639 ,  C07K1/22 ,  C07K14/42 ,  C12N5/0645

摘要： The present invention provides a novel material useful for selectively isolating a cell such as monocyte and the like or a protein from a body fluid and a production method thereof, a physiological material using the material and an isolation material using the physiological material, as well as a method of harvesting a cell such as monocyte and the like using the isolation material, a method of harvesting a protein and a method of preparing a dendritic cell.

摘要翻译： 本发明提供了用于选择性分离细胞如单核细胞等或来自体液的蛋白质及其制备方法的新型材料，使用该材料的生理材料和使用该生理材料的分离材料，以及 使用分离材料收获细胞如单核细胞等的方法，收获蛋白质的方法和制备树突状细胞的方法。

公开(公告)号：US20120322133A9

公开(公告)日：2012-12-20

申请号：US13403212

申请日：2012-02-23

申请人： Hiroshi AWAJI ,  Ashutosh KUMAR ,  Akira KOBAYASHI ,  Naohiro IMAI

发明人： Hiroshi AWAJI ,  Ashutosh KUMAR ,  Akira KOBAYASHI ,  Naohiro IMAI

IPC分类号： C12N11/10

CPC分类号： C12N5/0639 ,  C07K1/22 ,  C07K14/42 ,  C12N5/0645

摘要： The present invention provides a novel material useful for selectively isolating a cell such as monocyte and the like or a protein from a body fluid and a production method thereof, a physiological material using the material and an isolation material using the physiological material, as well as a method of harvesting a cell such as monocyte and the like using the isolation material, a method of harvesting a protein and a method of preparing a dendritic cell.

摘要翻译： 本发明提供了用于选择性分离细胞如单核细胞等或来自体液的蛋白质及其制备方法的新型材料，使用该材料的生理材料和使用该生理材料的分离材料，以及 使用分离材料收获细胞如单核细胞等的方法，收获蛋白质的方法和制备树突状细胞的方法。