发明授权
US5286484A Nucleotide sequence coding for an outer membrane protein from Neisseria
meningitidis and use of said protein in vaccine preparations
失效
编码来自脑膜炎奈瑟氏球菌的外膜蛋白的核苷酸序列和在疫苗制剂中使用所述蛋白质
- 专利标题： Nucleotide sequence coding for an outer membrane protein from Neisseria meningitidis and use of said protein in vaccine preparations
- 专利标题（中）： 编码来自脑膜炎奈瑟氏球菌的外膜蛋白的核苷酸序列和在疫苗制剂中使用所述蛋白质
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申请号： US754918申请日： 1991-09-05
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公开(公告)号： US5286484A公开(公告)日： 1994-02-15
- 发明人: Silva Rodriquez , Selman H. Sosa , Guillen Nieto , Saturnino H. Martinez , Julio R. F. Maso , Lidia I. N. Perez , Juan M. Grillo , Vivian M. Cordova , Sonia G. Blanco , Beatriz T. Santos , Jesus A. del Valle Rosales , Evelin C. Menendez , Anabel A. Acosta , Edelgis C. Rodriquez , Silian C. Leon , Alexis M. Lasa
- 申请人： Silva Rodriquez , Selman H. Sosa , Guillen Nieto , Saturnino H. Martinez , Julio R. F. Maso , Lidia I. N. Perez , Juan M. Grillo , Vivian M. Cordova , Sonia G. Blanco , Beatriz T. Santos , Jesus A. del Valle Rosales , Evelin C. Menendez , Anabel A. Acosta , Edelgis C. Rodriquez , Silian C. Leon , Alexis M. Lasa
- 申请人地址： CUX
- 专利权人： Centro de Ingenieria Genetica y Biotecnologia
- 当前专利权人： Centro de Ingenieria Genetica y Biotecnologia
- 当前专利权人地址： CUX
- 优先权： CUX145/90 19900709
- 主分类号： A61K39/095
- IPC分类号： A61K39/095 ; A61K39/00 ; A61K39/395 ; A61P31/04 ; C07K14/00 ; C07K14/195 ; C07K14/22 ; C07K14/41 ; C07K16/00 ; C07K16/12 ; C07K16/40 ; C07K19/00 ; C12N1/21 ; C12N9/02 ; C12N9/10 ; C12N15/00 ; C12N15/09 ; C12N15/31 ; C12N15/53 ; C12N15/54 ; C12N15/70 ; C12P21/02 ; C12P21/08 ; C12R1/19 ; A61K39/02 ; C07H15/12 ; C12P21/06
摘要：
The present invention is concerned with a method for the isolation of a nucleotide sequence which codes for a protein having a molecular weight of about 64,000 daltons, which is located on the outer membrane of N. meningitidis, as well as with the recombinant DNA obtained therefrom, which is used for the transformation of a host microorganism. The technical object pursued with the invention is the identification of a nucleotide sequence coding for a highly conserved and common protein for the majority of pathogenic Neisseria strains, the production of this protein with a high level of purity and in commercially useful amounts using the recombinant way, so that it can be used in diagnostic methods and vaccine preparations with a broad immunoprotection spectrum.
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