发明授权
- 专利标题： Modified recombinant vaccinia virus and expression vectors thereof
- 专利标题（中）： 改良的重组痘苗病毒及其表达载体
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申请号： US709209申请日： 1996-08-21
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公开(公告)号： US5762938A公开(公告)日： 1998-06-09
- 发明人: Enzo Paoletti , Marion E. Perkus , Jill Taylor , James Tartaglia , Elizabeth K. Norton , Michel Riviere , Charles de Taisne , Keith J. Limbach , Gerard P. Johnson , Steven E. Pincus , William I. Cox , Jean-Christophe Francis Audonnet , Russell Robert Gettig
- 申请人： Enzo Paoletti , Marion E. Perkus , Jill Taylor , James Tartaglia , Elizabeth K. Norton , Michel Riviere , Charles de Taisne , Keith J. Limbach , Gerard P. Johnson , Steven E. Pincus , William I. Cox , Jean-Christophe Francis Audonnet , Russell Robert Gettig
- 申请人地址： NY Troy
- 专利权人： Virogenetics Corporation
- 当前专利权人： Virogenetics Corporation
- 当前专利权人地址： NY Troy
- 主分类号： A61K39/12
- IPC分类号： A61K39/12 ; A61K39/00 ; A61K39/08 ; A61K39/15 ; A61K39/165 ; A61K39/17 ; A61K39/175 ; A61K39/205 ; A61K39/21 ; A61K39/23 ; A61K39/245 ; A61K39/275 ; A61K39/285 ; A61K39/29 ; A61P31/04 ; A61P31/12 ; A61P31/14 ; A61P31/16 ; A61P31/18 ; A61P31/20 ; A61P31/22 ; C07H21/04 ; C07K1/00 ; C07K14/015 ; C07K14/02 ; C07K14/03 ; C07K14/035 ; C07K14/045 ; C07K14/05 ; C07K14/06 ; C07K14/065 ; C07K14/07 ; C07K14/11 ; C07K14/12 ; C07K14/125 ; C07K14/145 ; C07K14/15 ; C07K14/155 ; C07K14/16 ; C07K14/175 ; C07K14/18 ; C07K14/33 ; C12N7/00 ; C12N7/01 ; C12N7/04 ; C12N7/08 ; C12N15/00 ; C12N15/09 ; C12N15/86 ; C12N15/863 ; C12P21/06 ; C12R1/93
摘要：
What is described is a modified vector, such as a recombinant poxvirus, particularly recombinant vaccinia virus, having enhanced safety. The modified recombinant virus has nonessential virus-encoded genetic functions inactivated therein so that virus has attenuated virulence. In one embodiment, the genetic functions are inactivated by deleting an open reading frame encoding a virulence factor. In another embodiment, the genetic functions are inactivated by insertional inactivation of an open reading frame encoding a virulence factor. What is also described is a vaccine containing the modified recombinant virus having nonessential virus-encoded genetic functions inactivated therein so that the vaccine has an increased level of safety compared to known recombinant virus vaccines.
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