-
公开(公告)号：US5756103A
公开(公告)日：1998-05-26
申请号：US457007
申请日：1995-06-01
申请人： Enzo Paoletti , Marion E. Perkus , Jill Taylor , James Tartaglia , Elizabeth K. Norton , Michel Riviere , Charles de Taisne , Keith J. Limbach , Gerard P. Johnson , Steven E. Pincus , William I. Cox , Jean-Christophe Francis Audonnet , Russell Robert Gettig
发明人： Enzo Paoletti , Marion E. Perkus , Jill Taylor , James Tartaglia , Elizabeth K. Norton , Michel Riviere , Charles de Taisne , Keith J. Limbach , Gerard P. Johnson , Steven E. Pincus , William I. Cox , Jean-Christophe Francis Audonnet , Russell Robert Gettig
IPC分类号： A61K39/12 , A61K39/00 , A61K39/08 , A61K39/15 , A61K39/165 , A61K39/17 , A61K39/175 , A61K39/205 , A61K39/21 , A61K39/23 , A61K39/245 , A61K39/275 , A61K39/285 , A61K39/29 , A61P31/04 , A61P31/12 , A61P31/14 , A61P31/16 , A61P31/18 , A61P31/20 , A61P31/22 , C07H21/04 , C07K1/00 , C07K14/015 , C07K14/02 , C07K14/03 , C07K14/035 , C07K14/045 , C07K14/05 , C07K14/06 , C07K14/065 , C07K14/07 , C07K14/11 , C07K14/12 , C07K14/125 , C07K14/145 , C07K14/15 , C07K14/155 , C07K14/16 , C07K14/175 , C07K14/18 , C07K14/33 , C12N7/00 , C12N7/01 , C12N7/04 , C12N7/08 , C12N15/00 , C12N15/09 , C12N15/86 , C12N15/863 , C12P21/06 , C12R1/93
CPC分类号： C12N15/86 , C07K14/005 , C07K14/33 , A61K2039/5254 , A61K39/00 , C07K2319/00 , C07K2319/02 , C07K2319/40 , C12N2710/16122 , C12N2710/16222 , C12N2710/16622 , C12N2710/16722 , C12N2710/24022 , C12N2710/24043 , C12N2710/24122 , C12N2710/24143 , C12N2730/10122 , C12N2740/13022 , C12N2740/15022 , C12N2740/16122 , C12N2740/16222 , C12N2750/14322 , C12N2760/12122 , C12N2760/16122 , C12N2760/18122 , C12N2760/18422 , C12N2760/18722 , C12N2760/20122 , C12N2770/24122 , C12N2770/24322 , Y10S530/826
摘要： What is described is a modified vector, such as a recombinant poxvirus, particularly recombinant vaccinia virus, having enhanced safety. The modified recombinant virus has nonessential virus-encoded genetic functions inactivated therein so that virus has attenuated virulence. In one embodiment, the genetic functions are inactivated by deleting an open reading frame encoding a virulence factor. In another embodiment, the genetic functions are inactivated by insertional inactivation of an open reading frame encoding a virulence factor. What is also described is a vaccine containing the modified recombinant virus having nonessential virus-encoded genetic functions inactivated therein so that the vaccine has an increased level of safety compared to known recombinant virus vaccines.
摘要翻译： 描述的是具有增强的安全性的修饰载体，例如重组痘病毒，特别是重组痘苗病毒。 修饰的重组病毒具有在其中灭活的非必需病毒编码的遗传功能，使得病毒具有减毒毒力。 在一个实施方案中，通过删除编码毒力因子的开放阅读框来使遗传功能失活。 在另一个实施方案中，通过插入失活编码毒力因子的开放阅读框来使遗传功能失活。 还描述了含有修饰的重组病毒的疫苗，其具有在其中灭活的非必需的病毒编码的遗传功能，使得疫苗与已知的重组病毒疫苗相比具有提高的安全性水平。
-
公开(公告)号：US5766599A
公开(公告)日：1998-06-16
申请号：US458101
申请日：1995-06-01
申请人： Enzo Paoletti , Marion E. Perkus , Jill Taylor , James Tartaglia , Elizabeth K. Norton , Michel Riviere , Charles de Taisne , Keith J. Limbach , Gerard P. Johnson , Steven E. Pincus , William I. Cox , Jean-Christophe Francis Audonnet , Russell Robert Gettig
发明人： Enzo Paoletti , Marion E. Perkus , Jill Taylor , James Tartaglia , Elizabeth K. Norton , Michel Riviere , Charles de Taisne , Keith J. Limbach , Gerard P. Johnson , Steven E. Pincus , William I. Cox , Jean-Christophe Francis Audonnet , Russell Robert Gettig
IPC分类号： A61K39/12 , A61K39/00 , A61K39/08 , A61K39/15 , A61K39/165 , A61K39/17 , A61K39/175 , A61K39/205 , A61K39/21 , A61K39/23 , A61K39/245 , A61K39/275 , A61K39/285 , A61K39/29 , A61P31/04 , A61P31/12 , A61P31/14 , A61P31/16 , A61P31/18 , A61P31/20 , A61P31/22 , C07H21/04 , C07K1/00 , C07K14/015 , C07K14/02 , C07K14/03 , C07K14/035 , C07K14/045 , C07K14/05 , C07K14/06 , C07K14/065 , C07K14/07 , C07K14/11 , C07K14/12 , C07K14/125 , C07K14/145 , C07K14/15 , C07K14/155 , C07K14/16 , C07K14/175 , C07K14/18 , C07K14/33 , C12N7/00 , C12N7/01 , C12N7/04 , C12N7/08 , C12N15/00 , C12N15/09 , C12N15/86 , C12N15/863 , C12P21/06 , C12R1/93
CPC分类号： C12N15/86 , C07K14/005 , C07K14/33 , A61K2039/5254 , A61K39/00 , C07K2319/00 , C07K2319/02 , C07K2319/40 , C12N2710/16122 , C12N2710/16222 , C12N2710/16622 , C12N2710/16722 , C12N2710/24022 , C12N2710/24043 , C12N2710/24122 , C12N2710/24143 , C12N2730/10122 , C12N2740/13022 , C12N2740/15022 , C12N2740/16122 , C12N2740/16222 , C12N2750/14322 , C12N2760/12122 , C12N2760/16122 , C12N2760/18122 , C12N2760/18422 , C12N2760/18722 , C12N2760/20122 , C12N2770/24122 , C12N2770/24322 , Y10S530/826
摘要： What is described is a modified vector, such as a recombinant poxvirus, particularly recombinant vaccinia virus, having enhanced safety. The modified recombinant virus has nonessential virus-encoded genetic functions inactivated therein so that virus has attenuated virulence. In one embodiment, the genetic functions are inactivated by deleting an open reading frame encoding a virulence factor. In another embodiment, the genetic functions are inactivated by insertional inactivation of an open reading frame encoding a virulence factor. What is also described is a vaccine containing the modified recombinant virus having nonessential virus-encoded genetic functions inactivated therein so that the vaccine has an increased level of safety compared to known recombinant virus vaccines.
摘要翻译： 描述的是具有增强的安全性的修饰载体，例如重组痘病毒，特别是重组痘苗病毒。 修饰的重组病毒具有在其中灭活的非必需病毒编码的遗传功能，使得病毒具有减毒毒力。 在一个实施方案中，通过删除编码毒力因子的开放阅读框来使遗传功能失活。 在另一个实施方案中，通过插入失活编码毒力因子的开放阅读框来使遗传功能失活。 还描述了含有在其中灭活的非必需病毒编码的遗传功能的修饰的重组病毒的疫苗，使得疫苗与已知重组病毒疫苗相比具有提高的安全性水平。
-
公开(公告)号：US5762938A
公开(公告)日：1998-06-09
申请号：US709209
申请日：1996-08-21
申请人： Enzo Paoletti , Marion E. Perkus , Jill Taylor , James Tartaglia , Elizabeth K. Norton , Michel Riviere , Charles de Taisne , Keith J. Limbach , Gerard P. Johnson , Steven E. Pincus , William I. Cox , Jean-Christophe Francis Audonnet , Russell Robert Gettig
发明人： Enzo Paoletti , Marion E. Perkus , Jill Taylor , James Tartaglia , Elizabeth K. Norton , Michel Riviere , Charles de Taisne , Keith J. Limbach , Gerard P. Johnson , Steven E. Pincus , William I. Cox , Jean-Christophe Francis Audonnet , Russell Robert Gettig
IPC分类号： A61K39/12 , A61K39/00 , A61K39/08 , A61K39/15 , A61K39/165 , A61K39/17 , A61K39/175 , A61K39/205 , A61K39/21 , A61K39/23 , A61K39/245 , A61K39/275 , A61K39/285 , A61K39/29 , A61P31/04 , A61P31/12 , A61P31/14 , A61P31/16 , A61P31/18 , A61P31/20 , A61P31/22 , C07H21/04 , C07K1/00 , C07K14/015 , C07K14/02 , C07K14/03 , C07K14/035 , C07K14/045 , C07K14/05 , C07K14/06 , C07K14/065 , C07K14/07 , C07K14/11 , C07K14/12 , C07K14/125 , C07K14/145 , C07K14/15 , C07K14/155 , C07K14/16 , C07K14/175 , C07K14/18 , C07K14/33 , C12N7/00 , C12N7/01 , C12N7/04 , C12N7/08 , C12N15/00 , C12N15/09 , C12N15/86 , C12N15/863 , C12P21/06 , C12R1/93
CPC分类号： C12N15/86 , C07K14/005 , C07K14/33 , A61K2039/5254 , A61K39/00 , C07K2319/00 , C07K2319/02 , C07K2319/40 , C12N2710/16122 , C12N2710/16222 , C12N2710/16622 , C12N2710/16722 , C12N2710/24022 , C12N2710/24043 , C12N2710/24122 , C12N2710/24143 , C12N2730/10122 , C12N2740/13022 , C12N2740/15022 , C12N2740/16122 , C12N2740/16222 , C12N2750/14322 , C12N2760/12122 , C12N2760/16122 , C12N2760/18122 , C12N2760/18422 , C12N2760/18722 , C12N2760/20122 , C12N2770/24122 , C12N2770/24322 , Y10S530/826
摘要： What is described is a modified vector, such as a recombinant poxvirus, particularly recombinant vaccinia virus, having enhanced safety. The modified recombinant virus has nonessential virus-encoded genetic functions inactivated therein so that virus has attenuated virulence. In one embodiment, the genetic functions are inactivated by deleting an open reading frame encoding a virulence factor. In another embodiment, the genetic functions are inactivated by insertional inactivation of an open reading frame encoding a virulence factor. What is also described is a vaccine containing the modified recombinant virus having nonessential virus-encoded genetic functions inactivated therein so that the vaccine has an increased level of safety compared to known recombinant virus vaccines.
摘要翻译： 描述的是具有增强的安全性的修饰载体，例如重组痘病毒，特别是重组痘苗病毒。 修饰的重组病毒具有在其中灭活的非必需病毒编码的遗传功能，使得病毒具有减毒毒力。 在一个实施方案中，通过删除编码毒力因子的开放阅读框来使遗传功能失活。 在另一个实施方案中，通过插入失活编码毒力因子的开放阅读框来使遗传功能失活。 还描述了含有在其中灭活的非必需病毒编码的遗传功能的修饰的重组病毒的疫苗，使得疫苗与已知重组病毒疫苗相比具有提高的安全性水平。
-
公开(公告)号：US5494807A
公开(公告)日：1996-02-27
申请号：US105483
申请日：1993-08-12
申请人： Enzo Paoletti , Marion E. Perkus , Jill Taylor , James Tartaglia , Elizabeth K. Norton , Michel Riviere , Charles de Taisne , Keith J. Limbach , Gerard P. Johnson , Steven E. Pincus , William I. Cox , Jean-Christophe F. Audonnet , Russell R. Gettig
发明人： Enzo Paoletti , Marion E. Perkus , Jill Taylor , James Tartaglia , Elizabeth K. Norton , Michel Riviere , Charles de Taisne , Keith J. Limbach , Gerard P. Johnson , Steven E. Pincus , William I. Cox , Jean-Christophe F. Audonnet , Russell R. Gettig
IPC分类号： A61K39/12 , A61K39/00 , A61K39/08 , A61K39/15 , A61K39/165 , A61K39/17 , A61K39/175 , A61K39/205 , A61K39/21 , A61K39/23 , A61K39/245 , A61K39/275 , A61K39/285 , A61K39/29 , A61P31/04 , A61P31/12 , A61P31/14 , A61P31/16 , A61P31/18 , A61P31/20 , A61P31/22 , C07H21/04 , C07K1/00 , C07K14/015 , C07K14/02 , C07K14/03 , C07K14/035 , C07K14/045 , C07K14/05 , C07K14/06 , C07K14/065 , C07K14/07 , C07K14/11 , C07K14/12 , C07K14/125 , C07K14/145 , C07K14/15 , C07K14/155 , C07K14/16 , C07K14/175 , C07K14/18 , C07K14/33 , C12N7/00 , C12N7/01 , C12N7/04 , C12N7/08 , C12N15/00 , C12N15/09 , C12N15/86 , C12N15/863 , C12P21/06 , C12R1/93 , A61K39/295 , C12N15/63
CPC分类号： C12N15/86 , C07K14/005 , C07K14/33 , A61K2039/5254 , A61K39/00 , C07K2319/00 , C07K2319/02 , C07K2319/40 , C12N2710/16122 , C12N2710/16222 , C12N2710/16622 , C12N2710/16722 , C12N2710/24022 , C12N2710/24043 , C12N2710/24122 , C12N2710/24143 , C12N2730/10122 , C12N2740/13022 , C12N2740/15022 , C12N2740/16122 , C12N2740/16222 , C12N2750/14322 , C12N2760/12122 , C12N2760/16122 , C12N2760/18122 , C12N2760/18422 , C12N2760/18722 , C12N2760/20122 , C12N2770/24122 , C12N2770/24322 , Y10S530/826
摘要： What is described is a modified vector, such as a recombinant poxvirus, particularly recombinant vaccinia virus, having enhanced safety. The modified recombinant virus has nonessential virus-encoded genetic functions inactivated therein so that virus has attenuated virulence. In one embodiment, the genetic functions are inactivated by deleting an open reading frame encoding a virulence factor. In another embodiment, the genetic functions are inactivated by insertional inactivation of an open reading frame encoding a virulence factor. What is also described is a vaccine containing the modified recombinant virus having nonessential virus-encoded genetic functions inactivated therein so that the vaccine has an increased level of safety compared to known recombinant virus vaccines.
摘要翻译： 描述的是具有增强的安全性的修饰载体，例如重组痘病毒，特别是重组痘苗病毒。 修饰的重组病毒具有在其中灭活的非必需病毒编码的遗传功能，使得病毒具有减毒毒力。 在一个实施方案中，通过删除编码毒力因子的开放阅读框来使遗传功能失活。 在另一个实施方案中，通过插入失活编码毒力因子的开放阅读框来使遗传功能失活。 还描述了含有在其中灭活的非必需病毒编码的遗传功能的修饰的重组病毒的疫苗，使得疫苗与已知重组病毒疫苗相比具有提高的安全性水平。
-
公开(公告)号：US5364773A
公开(公告)日：1994-11-15
申请号：US36217
申请日：1993-03-24
申请人： Enzo Paoletti , Marion E. Perkus
发明人： Enzo Paoletti , Marion E. Perkus
IPC分类号： A61K39/00 , C07K14/015 , C07K14/02 , C07K14/03 , C07K14/035 , C07K14/045 , C07K14/05 , C07K14/06 , C07K14/065 , C07K14/07 , C07K14/11 , C07K14/12 , C07K14/125 , C07K14/145 , C07K14/15 , C07K14/155 , C07K14/16 , C07K14/175 , C07K14/18 , C07K14/33 , C12N15/863 , C12P21/02 , C12N7/00 , C12N15/00 , C12P19/34
CPC分类号： C12N15/86 , C07K14/005 , C07K14/33 , A61K2039/5254 , A61K39/00 , C07K2319/00 , C12N2710/16222 , C12N2710/16622 , C12N2710/16722 , C12N2710/24022 , C12N2710/24122 , C12N2710/24143 , C12N2730/10122 , C12N2740/13022 , C12N2740/15022 , C12N2740/16122 , C12N2740/16222 , C12N2750/14322 , C12N2760/12022 , C12N2760/16122 , C12N2760/18122 , C12N2760/18722 , C12N2760/20022 , C12N2770/24022 , C12N2770/24122
摘要： What is described is a modified vector, such as a recombinant poxvirus, particularly recombinant vaccinia virus, having enhanced safety. The modified recombinant virus has nonessential virus-encoded genetic functions inactivated therein so that virus has attenuated virulence. In one embodiment, the genetic functions are inactivated by deleting an open reading frame encoding a virulence factor. In another embodiment, the genetic functions are inactivated by insertional inactivation of an open reading frame encoding a virulence factor. What is also described is a vaccine containing the modified recombinant virus having nonessential virus-encoded genetic functions inactivated therein so that the vaccine has an increased level of safety compared to known recombinant virus vaccines.
摘要翻译： 描述的是具有增强的安全性的修饰载体，例如重组痘病毒，特别是重组痘苗病毒。 修饰的重组病毒具有在其中灭活的非必需病毒编码的遗传功能，使得病毒具有减毒毒力。 在一个实施方案中，通过删除编码毒力因子的开放阅读框来使遗传功能失活。 在另一个实施方案中，通过插入失活编码毒力因子的开放阅读框来使遗传功能失活。 还描述了含有在其中灭活的非必需病毒编码的遗传功能的修饰的重组病毒的疫苗，使得疫苗与已知重组病毒疫苗相比具有提高的安全性水平。
-
-
-
-
搜索结果
5 条记录 (耗时 0.075 秒)
