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公开(公告)号：EP1539962A4
公开(公告)日：2006-12-27
申请号：EP04761767
申请日：2004-09-10
IPC分类号： A61K31/513 , A61K31/70 , A61K31/704 , A61P31/04 , C07C279/14 , C07D309/10 , C07H5/04 , C07H5/06 , C12N15/31 , C12N15/52 , C12P7/42 , C12P7/64 , C12P13/00 , C12P17/06 , C12P17/16 , C12P19/44 , A61K31/35 , C07D493/04 , C12N1/20 , C12N15/63 , C12P1/04 , C12P21/02
CPC分类号： C07C279/14 , C07C2601/10 , C07D309/10 , C07H5/04 , C07H5/06 , C12N15/52 , C12P7/42 , C12P13/001 , C12P13/02 , C12P17/06 , C12P17/16 , C12P19/44 , C12R1/01 , Y10S435/821
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2.发明公开POLYENE OXAZOLES WITH ANTITUMOUR ACTIVITY AND PROCESSES FOR THEIR PREPARATION USING A STREPTOMYCES STRAIN 有权POLYENOXAZOLE具有抗肿瘤效应AND METHOD FOR THE PRODUCTION BY链霉菌的菌株来
公开(公告)号：EP1633352A1
公开(公告)日：2006-03-15
申请号：EP04737813.8
申请日：2004-06-14
发明人： MCALPINE, James, B. , FARNET, Chris, M , ZAZOPOULOS, Emmanuel , ISMAIL, Nargis , BACHMANN, Brian, O.
IPC分类号： A61K31/422 , C07D413/12 , A61K31/421 , C07D263/32 , C12P17/16 , C12R1/60 , A61P35/00
CPC分类号： C12R1/60 , C07D263/32 , C07D413/12 , C12P17/14
摘要： This invention relates to novel biologically active polyene oxazoles of Formula (I), their pharmaceutically acceptable salts and derivatives, and to methods of obtaining them. One method for obtaining the compounds is by cultivation of Streptomyces sparsogenes NRRL 2940 or a mutant or variant thereof. The pharmaceutical composition comprising a compound of the invention is useful as a cytotoxic agent and for inhibiting the growth of cancer cells.
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公开(公告)号：EP1733758A1
公开(公告)日：2006-12-20
申请号：EP06010101.1
申请日：2006-05-16
IPC分类号： A61P35/00 , A61K31/5513 , A61K31/551 , C07D243/10 , A61K9/08
CPC分类号： A61K9/0019 , A61K31/551 , A61K31/5513 , A61K47/10
摘要： This invention relates to compositions and methods for inhibiting growth and proliferation of a neoplastic cell, and methods of treating neoplasms in a mammal using the compound of Formula I or a pharmaceutically acceptable salt, prodrug thereof. More particularly, the invention relates to the use of the compound of Formula I as a continuous intravenous infusion administrable preparation for the treatment of neoplastic disorders.
摘要翻译： 本发明涉及用于抑制肿瘤细胞生长和增殖的组合物和方法，以及使用式I化合物或其药学上可接受的盐的前药治疗哺乳动物肿瘤的方法。 更具体地，本发明涉及式I化合物作为用于治疗肿瘤性疾病的连续静脉输注可用制剂的用途。
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公开(公告)号：EP1461434A2
公开(公告)日：2004-09-29
申请号：EP02787310.8
申请日：2002-12-24
IPC分类号： C12N15/52
摘要： The invention relates to isolated polypeptides involved in lipopeptide biosynthesis and polynucleotides encoding such polypeptides. In particular, the isolated polypeptide may be an acyl-specific C-domain, an adenylating enzyme, or an acyl carrier. The invention also relates to methods for detecting a polypeptide involved in lipopeptide biosynthesis or a polynucleotide encoding such a polypeptide, as well as relevant useful computer readable medium and computer systems.
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公开(公告)号：EP1458868A2
公开(公告)日：2004-09-22
申请号：EP02787309.0
申请日：2002-12-24
摘要： Genes and proteins involved in the biosynthesis of lipopeptides by microorganisms, in particular the nucleic acids forming the biosynthetic locus for the A54145 lipopeptide from Streptomyces fradiae and the A54145-like lipopeptide from Streptomyces refuineus. These nucleic acids can be used to make expression constructs and transformed host cells for the production of lipopeptides. The genes and proteins allow direct manipulation of lipopeptides and related chemical structures via chemical engineering of the proteins involved in the biosynthesis of A54145.
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公开(公告)号：EP1409686B1
公开(公告)日：2006-03-22
申请号：EP02750735.9
申请日：2002-07-26
摘要： Genes and proteins involved in the biosynthesis of macrolides by microorganisms, in particular the nucleic acids forming the biosynthetic locus for the 16-member macrolide rosaramicin from Micromonospora carbonacea. These nucleic acids can be used to make expression constructs and transformed host cells for the production of rosaramicin. The genes and proteins allow direct manipulation of macrolides and related chemical structures via chemical engineering of the proteins involved in the biosynthesis of rosaramicin.
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公开(公告)号：EP1381685B1
公开(公告)日：2005-09-14
申请号：EP02724065.4
申请日：2002-04-26
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8.发明公开
公开(公告)号：EP1524318A1
公开(公告)日：2005-04-20
申请号：EP04029857.2
申请日：2002-04-26
摘要： Genes and proteins involved in the biosynthesis of polyketides by microorganisms, including the genes and proteins forming the biosynthetic loci for the polyketide dorrigocin from Streptomyces platensis subsp. rosaceus and the polyketide lactimidomycin from Streptomyces amphibiosporus . The genes and proteins allow direct manipulation of dorrigocin, lactimidomycin and related chemical structures via chemical engineering of the enzymes involved in the biosynthesis of dorrigocin and lactimidomycin.
摘要翻译： 涉及通过微生物生物合成聚酮化合物的基因和蛋白质，包括形成来自Streptomyces platensis subsp。的聚酮化合物达拉根霉素的生物合成基因座的基因和蛋白质。 红曲霉和来自水from链霉菌的聚酮化蓖麻毒霉素。 这些基因和蛋白质可以通过化学工程来参与杜鹃肽和类似物的生物合成酶直接操作杜鹃肽，阿魏霉素和相关的化学结构。
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9.发明公开GENES AND PROTEINS INVOLVED IN THE BIOSYNTHESIS OF ENEDIYNE RING STRUCTURES 审中-公开基因和蛋白相对于烯二炔环系结构生物合成
公开(公告)号：EP1390507A2
公开(公告)日：2004-02-25
申请号：EP02729707.6
申请日：2002-05-21
摘要： Five protein families cooperate to form the warhead structure that characterizes enediyne compounds, both chromoprotein enediynes and non-chromoprotein enediynes. The protein families include a polyketide synthase and thioesterase protein which form a polyketide synthase catalytic complex involved in warhead formation in enediynes. Genes encoding a member of each of the five protein families are found in all enediyne biosynthetic loci. The genes and proteins may be used in genetic engineering applications to design new enediyne compounds and in methods to identify new enediyne biosynthetic loci.
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10.发明授权POLYENE OXAZOLES WITH ANTITUMOUR ACTIVITY AND PROCESSES FOR THEIR PREPARATION USING A STREPTOMYCES STRAIN 有权具有抗肿瘤活性的聚烯烃恶唑及其使用链霉菌制备它们的方法
公开(公告)号：EP1633352B1
公开(公告)日：2006-11-02
申请号：EP04737813.8
申请日：2004-06-14
发明人： MCALPINE, James, B. , FARNET, Chris, M , ZAZOPOULOS, Emmanuel , ISMAIL, Nargis , BACHMANN, Brian, O.
IPC分类号： A61K31/422 , C07D413/12 , A61K31/421 , C07D263/32 , C12P17/16 , C12R1/60 , A61P35/00
CPC分类号： C12R1/60 , C07D263/32 , C07D413/12 , C12P17/14
摘要： This invention relates to novel biologically active polyene oxazoles of Formula (I), their pharmaceutically acceptable salts and derivatives, and to methods of obtaining them. One method for obtaining the compounds is by cultivation of Streptomyces sparsogenes NRRL 2940 or a mutant or variant thereof. The pharmaceutical composition comprising a compound of the invention is useful as a cytotoxic agent and for inhibiting the growth of cancer cells.
摘要翻译： 本发明涉及式（I）的新型生物活性多烯恶唑类，它们的药学上可接受的盐和衍生物，以及获得它们的方法。 一种获得化合物的方法是通过培育产卵链霉菌NRRL 2940或其突变体或变体。 包含本发明化合物的药物组合物可用作细胞毒剂并用于抑制癌细胞的生长。
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