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公开(公告)号：EP1265596B1
公开(公告)日：2007-09-26
申请号：EP01920707.5
申请日：2001-03-23
发明人： LYONS, Robert, T. , DILLARD, David, H. , FIEGGEN, Bruce , RAUKER, Robert, M. , BLUNI, Scott, T.
IPC分类号： A61K9/107
CPC分类号： A61K9/0019 , A61B17/320758 , A61K9/1075 , B82Y5/00 , Y10S514/937 , Y10S514/938
摘要： A medical lubricant suitable for injection into the blood stream of a patient. The lubricant is suitable for use with rotating equipment such as atherectomy drive shafts moving within sheaths and over guide wires and other minimally invasive medical devices introduced into a patient through a catheter like instrument. The lubricant is an oil-in-water emulsion including a surfactant, a co-surfactant, and a pH buffer. The lubricant can further include a cryogenic agent and a pH adjusting agent. One lubricant includes olive oil as an emulsified oil, egg yolk phospholipid as a surfactant, sodium deoxycholate as a co-surfactant, glycerin as a cryogenic agent, L-histidine as a pH buffer, and is pH adjusted using sodium hydroxide. The lubricant can also include a therapeutic agent. The lubricant can withstand freeze/thaw cycles as well as saline dilution, heating, and shear stress without significant creaming, separation, or unacceptable increases in oil droplet size. Compared to saline, the lubricant provides significantly increased lubrication efficiency for rapidly moving parts.
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公开(公告)号：EP1396249A2
公开(公告)日：2004-03-10
申请号：EP03028012.7
申请日：1997-04-09
申请人： Fresenius Kabi AB
CPC分类号： B32B27/08 , A61J1/00 , A61J1/10 , A61J1/2024 , A61J1/2093 , A61M2207/00 , B32B7/02 , B32B7/12 , B32B27/306 , B32B27/32 , B32B27/36 , B32B2307/412 , B32B2307/7244 , B32B2323/04 , B32B2323/10 , B32B2367/00 , B32B2439/00 , B65D81/268
摘要： A flexible transparent container for improved storage of oxygen sensitive parenterally administerable agents comprising an inner, primary container enclosed in a substantially oxygen impermeable outer envelope. The inner container is made of a polypropylene containing flexible polymeric material compatible with lipophilic agents capable of forming both permanent and peelable seals, while the envelope is made of a substantially water impermeable flexible multilayered polymeric material comprising a first outer substantially water impermeable polymeric film with oxygen barrier forming capacity, assembled with a second, inner polymeric film with a supplementary oxygen barrier forming capacity. The container essentially maintains its characteristics after being subjected to sterilization by steam or radiation.
摘要翻译： 一种柔性透明容器，用于改善对氧气敏感性肠胃外给药剂的储存，其包括封闭在基本上不透氧外层的内部主要容器。 内部容器由含有柔性聚合材料的聚丙烯制成，其与能够形成永久性和可剥离密封剂的亲脂性试剂相容，而外壳由基本上不透水的柔性多层聚合物材料制成，其包含具有氧的第一外部基本不透水的聚合物膜 阻挡层形成能力，与具有辅助氧气阻挡层形成能力的第二内部聚合物膜组装。 容器基本上通过蒸汽或辐射灭菌后保持其特性。
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公开(公告)号：EP1024791B1
公开(公告)日：2003-11-05
申请号：EP98946997.8
申请日：1998-09-14
IPC分类号： A61K9/107
CPC分类号： A61K9/1075 , A61B17/320758 , Y10S514/937 , Y10S514/938
摘要： A medical lubricant suitable for injection into the blood stream of a patient. The lubricant is suitable for use with rotating equipment such as atherectomy drive shafts moving within sheaths and over guide wires. The lubricant is an oil-in-water emulsion including a surfactant and a co-surfactant. The lubricant can include a cryogenic agent and a pH buffer and be pH adjusted. One lubricant includes olive oil as an emulsified oil, egg yolk phospholipid as a surfactant, sodium deoxycholate as a co-surfactant, glycerin as a cryogenic agent, L-histidine as a pH buffer, and is pH adjusted using sodium hydroxide. The lubricant can withstand freeze/thaw cycles as well as saline dilution, heating, and shear stress without significant creaming, separation, or unacceptable 15 increases in oil droplet size. Compared to saline, the lubricant provides significantly increased lubrication efficiency for rapidly moving parts.
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公开(公告)号：EP0711155B1
公开(公告)日：2000-03-22
申请号：EP94920632.0
申请日：1994-07-01
申请人： Fresenius Kabi AB
发明人： LINDGREN, Svante , ALHADEFF, Paul , JONSSON, Uno , ROSENKVIST, Kenneth , SANDBERG, Göran , SKOGHOLM, Clas , WAHLEN, Raymond
IPC分类号： A61K31/195 , A61K31/20
CPC分类号： A61K31/23
摘要： The present invention relates to preparations to be used in therapy or nutrition containing stabilized or solubilized forms of amino acids otherwise unstable in solution or poorly soluble in aqueous fluids. The sensitive amino acids are included in the said preparations as glyceryl esters of compounds chosen among at least one amino acid and fatty acids.
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6.发明公开Diorthosubstituted benzene derivatives, especially for use in a method of therapy, processes for their preparation, and pharmaceutical compositions containing them 失效二邻取代的苯衍生物，特别是用于治疗性治疗，以及含有它们的药物组合物的方法中使用。
公开(公告)号：EP0000826A1
公开(公告)日：1979-02-21
申请号：EP78300227.2
申请日：1978-08-01
申请人： Kabi AB
发明人： Joensson, Aake Nils , Merenyi, Ferenc , Moses, Pinchas , Karlsson, Lennart Olof , Hanshoff, Gunnar
IPC分类号： C07C143/74 , C07C143/78 , C07C143/80 , C07C149/453 , A61K31/18 , A61K31/63
CPC分类号： C07D209/48 , C07C309/00
摘要： New compounds of the general formula I
wherein R' and R 2 each independently represent an alkyl group containing 1 to 4 carbon atoms, or an alkoxy group containing 1 to 3 carbon atoms, or halogen, R' represents hydrogen, halogen, an alkyl group containing 1 to 4 carbon atoms, an alkoxv group containing 1 to 3 carbon atoms, an amino group or a nitro group, A represents
which is bonded to the benzene ring by its sulphu r or nitrogen atom and in which R' is hydrogen or an alkyl group containing to 4 carbon atoms; together with salts thereof with I physiologically acceptable acids and, when R' is hydrogen, with physiologically acceptable bases are described. The compounds are of use in inhibiting thrombosis formation, in treating thrombosis and in fibronolytic therapy. Various methods of producing the new compound are described involving the building up of the -A-CH 2 -CH 2 -S-CH 2 CH 2 -NH 2 side chain from aromatic precursors having an imcomplete side chain or by introducing at least one of R 1 , R or R'substituents into a precursor lacking that substituent or from an amino-protected precursor.-
公开(公告)号：EP0893982B1
公开(公告)日：2003-12-10
申请号：EP97919845.4
申请日：1997-04-09
申请人： Fresenius Kabi AB
CPC分类号： B32B27/08 , A61J1/00 , A61J1/10 , A61J1/2024 , A61J1/2093 , A61M2207/00 , B32B7/02 , B32B7/12 , B32B27/306 , B32B27/32 , B32B27/36 , B32B2307/412 , B32B2307/7244 , B32B2323/04 , B32B2323/10 , B32B2367/00 , B32B2439/00 , B65D81/268
摘要： A flexible transparent container for improved storage of oxygen sensitive parenterally administerable agents comprising an inner, primary container enclosed in a substantially oxygen impermeable outer envelope with an oxygen absorber, capable of consuming essentially all residual oxygen after the outer envelope is sealed, and for sufficient period also the oxygen penetrating said envelope. The inner container is made of a polypropylene containing flexible polymeric material compatible with lipophilic agents capable of forming both permanent and peelable seals, while the envelope is made of a substantially water impermeable flexible multilayered polymeric material comprising a first outer substantially water impermeable polymeric film with oxygen barrier forming capacity, assembled with a second, inner polymeric film with a supplementary oxygen barrier forming capacity. The container essentially maintains its characteristics after being subjected to sterilization by steam or radiation.
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公开(公告)号：EP1265596A2
公开(公告)日：2002-12-18
申请号：EP01920707.5
申请日：2001-03-23
发明人： LYONS, Robert, T. , DILLARD, David, H. , FIEGGEN, Bruce , RAUKER, Robert, M. , BLUNI, Scott, T.
IPC分类号： A61K9/107
CPC分类号： A61K9/0019 , A61B17/320758 , A61K9/1075 , B82Y5/00 , Y10S514/937 , Y10S514/938
摘要： A medical lubricant suitable for injection into the blood stream of a patient. The lubricant is suitable for use with rotating equipment such as atherectomy drive shafts moving within sheaths and over guide wires and other minimally invasive medical devices introduced into a patient through a catheter like instrument. The lubricant is an oil-in-water emulsion including a surfactant, a co-surfactant, and a pH buffer. The lubricant can further include a cryogenic agent and a pH adjusting agent. One lubricant includes olive oil as an emulsified oil, egg yolk phospholipid as a surfactant, sodium deoxycholate as a co-surfactant, glycerin as a cryogenic agent, L-histidine as a pH buffer, and is pH adjusted using sodium hydroxide. The lubricant can also include a therapeutic agent. The lubricant can withstand freeze/thaw cycles as well as saline dilution, heating, and shear stress without significant creaming, separation, or unacceptable increases in oil droplet size. Compared to saline, the lubricant provides significantly increased lubrication efficiency for rapidly moving parts.
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9.发明授权
公开(公告)号：EP0961735B1
公开(公告)日：2002-09-11
申请号：EP98905914.2
申请日：1998-02-19
申请人： Fresenius Kabi AB
发明人： ANDERSSON, Gunnar , MULLIGAN, Des
CPC分类号： B29C45/14 , B29C35/16 , B29C37/005 , B29C45/00 , B29C45/0053 , B29C45/16 , B29C71/0072 , B29K2023/12 , B29L2031/565 , B65D51/002
摘要： The invention relates to a process of preparing pharmaceutical closures for containers made of flexible polymeric materials which are suitable to be filled with parenterally administerable fluids prior to their sealing and sterilization. The process involves a specific relaxation period for the elastomer material of the closure which thereby can settle and develop resealing characteristics. The closures will have an excellent resealing capacity after being penetrated by a piercing device for establishing fluid communication with the container, even after multiple entries into the container.
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公开(公告)号：EP1115362A1
公开(公告)日：2001-07-18
申请号：EP99948808.3
申请日：1999-09-21
申请人： Fresenius Kabi AB
发明人： ANDERSSON, Gunnar , PETTERSON, Bert
IPC分类号： A61J1/00
CPC分类号： B65D47/24 , A61J1/1425 , A61J1/1468 , A61J1/1481 , A61J1/1487 , A61J1/18 , A61J1/201 , A61J1/2096 , Y10S604/905
摘要： A device for storing and administering a medical fluid comprising a sealed flexible formed container (10) with an opening part (12) in its front end in which an insert (20) is positioned. Over the insert, the container extends into a removable sealing cap (14). After removal of the sealing cap an injection means is attached to the insert and fluid administration through the insert is admitted in one direction by squeezing the container.
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