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公开(公告)号：EP2714387B1
公开(公告)日：2019-10-16
申请号：EP12793589.8
申请日：2012-05-29
发明人： JIANG, Wenping , MALSHE, Ajay, P.
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公开(公告)号：EP2084000B1
公开(公告)日：2019-02-13
申请号：EP07852840.3
申请日：2007-10-18
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公开(公告)号：EP3091075B1
公开(公告)日：2018-06-13
申请号：EP16169069.8
申请日：2008-04-09
申请人： The Board of Trustees of The University of Arkansas , National University Corporation Kagawa University , Ochsner Clinic Foundation
CPC分类号： C07K14/635 , A61K8/64 , A61K8/66 , A61K9/0019 , A61K35/28 , A61K38/164 , A61K38/29 , A61K38/4886 , A61K2800/86 , A61K2800/91 , A61Q7/00 , C07K2319/00 , C07K2319/50 , C07K2319/70 , C12N9/1088 , C12N9/50 , C12N9/52 , C12N9/6489 , C12Y205/01018 , C12Y304/24003 , C12Y304/24007
摘要： This document relates to fusion proteins containing active agonist or antagonist fragments of parathyroid hormone (PTH) and parathyroid hormone related peptide (PTHrP) coupled to a collagen-binding domain. In particular, a composition comprising: a ColH or ColG bacterial collagen-binding polypeptide segment linked to a PTH/PTHrP receptor modulator; wherein the PTH / PTHrP receptor modulator is an agonist of the PTH/PTHrP receptor and comprises a sequence selected from the group consisting of residues 1-33 of SEQ ID NO: 1, PTH (SEQ ID NO: 7), residues 1-14 of SEQ ID NO: 1, residues 1-34 of SEQ ID NO: 7 and SEQ ID NO: 8; or wherein the PTH / PTHrP receptor modulator is an antagonist of the PTH/PTHrP receptor and comprises a sequence selected from the group consisting of residues 7-34 of SEQ ID NO: 7, residues 7-14 of SEQ ID NO: 7, residues 7-33 of SEQ ID NO: 7, residues 7-34 of SEQ ID NO: 8, and SEQ ID NO: 11.
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公开(公告)号：EP2624702B1
公开(公告)日：2016-03-02
申请号：EP11831602.5
申请日：2011-10-06
IPC分类号： A01N43/90 , A01N65/00 , A01N65/34 , A01P1/00 , A61K38/14 , A61K38/15 , A61K36/75 , A61K36/76 , A61K36/77 , A61K36/87 , A61K36/88
CPC分类号： A01N43/90 , A01N65/00 , A01N65/34 , A61K31/19 , A61K31/192 , A61K31/352 , A61K31/366 , A61K31/43 , A61K31/431 , A61K31/496 , A61K31/65 , A61K31/7048 , A61K31/7056 , A61K36/185 , A61K36/21 , A61K36/23 , A61K36/24 , A61K36/28 , A61K36/40 , A61K36/45 , A61K36/48 , A61K36/49 , A61K36/51 , A61K36/52 , A61K36/53 , A61K36/57 , A61K36/61 , A61K36/73 , A61K36/75 , A61K36/76 , A61K36/77 , A61K36/87 , A61K36/88 , A61K36/896 , A61K38/12 , A61K38/14 , A61K38/15 , Y02A50/478 , A61K2300/00
摘要： The present invention provides polyphenolic compositions derived from a plant that inhibit the formation of a biofilm. Also provided are combinations that comprise at least one phenolic phytochemical and at least one antimicrobial agent that inhibit the growth of an established biofilm. Further, the present invention provides methods for inhibiting the formation and growth of biofilms.
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5.发明授权REPEAT SEQUENCES OF THE CA125 GENE AND THEIR USE FOR DIAGNOSTIC INTERVENTIONS 有权CA125基因的重复序列及它们在诊断过程
公开(公告)号：EP1414477B1
公开(公告)日：2015-06-10
申请号：EP02723852.6
申请日：2002-04-12
发明人： O'BRIEN, Timothy , BEARD, John , UNDERWOOD, Lowell
IPC分类号： C07K14/47 , A61K38/17 , C07K16/30 , G01N33/574
CPC分类号： C07K14/47 , A61K38/00 , C12Q1/6886 , C12Q2600/158
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公开(公告)号：EP2066339B1
公开(公告)日：2014-08-13
申请号：EP07842706.9
申请日：2007-09-18
发明人： BOTTJE, Walter , HARGIS, Billy , BERGHMAN, Luc , KWON, Young, Min , COLE, Kimberly , COX, Mandy , LAYTON, Sherryll
IPC分类号： A61K39/00 , A61K39/02 , A61K39/112 , A61K49/00 , C12P1/00 , C12P21/06 , C12N1/00 , C12N15/00 , C12N15/74 , C07H21/02 , C07H21/04
CPC分类号： A61K39/145 , A61K35/74 , A61K39/00 , A61K39/0275 , A61K39/12 , A61K2035/11 , A61K2039/522 , A61K2039/523 , A61K2039/552 , A61K2039/55516 , A61K2039/6006 , A61K2039/6031 , C07H21/04 , C12N15/102 , C12N2760/16134 , Y02A50/482
摘要： Provided herein are Salmonella enteritidis 13A strains and compositions comprising these strains. Also provided are methods of enhancing an immune response against Influenza A and methods of reducing morbidity associated with an Influenza A infection. Methods of enhancing an immune response to a vaccine vector by expressing a polypeptide of CD154 capable of binding CD40 are also disclosed. Methods of developing a bacterial vaccine vector are disclosed. Methods of generating scarless site-specific mutations in a bacterium are also disclosed.
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公开(公告)号：EP1663394B1
公开(公告)日：2014-05-21
申请号：EP04783246.4
申请日：2004-09-03
CPC分类号： A61B17/22004 , A61B2017/22008 , A61B2017/22027 , A61B2017/22084 , A61B2017/22089 , A61N7/02 , A61N2007/0073 , A61N2007/0078 , A61N2007/0095
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8.发明公开NEW MARKERS FOR EARLY DIAGNOSIS OF OVARIAN CANCER, MONITORING DURING THERAPY, AND NEW THERAPY OPTIONS DURING AND AFTER CHEMATHERAPY 审中-公开新标记为卵巢癌适当的控制治疗和新的治疗选项，以在中和适用化疗后早期诊断
公开(公告)号：EP2721417A2
公开(公告)日：2014-04-23
申请号：EP12800956.0
申请日：2012-06-18
IPC分类号： G01N33/68 , G01N33/574
CPC分类号： C12Q1/37 , G01N33/57442 , G01N33/57449 , G01N2800/52 , G01N2800/56
摘要： The inventors have identified several proteases and a protease inhibitor that are overexpressed in ovarian cancer tumors. They have developed monoclonal antibodies against the proteins and shown that they can be detected in serum and the levels of the proteins in serum fluctuate during cancer treatment. They have shown that serum assays for the proteases and protease inhibitor can be used for early detection of ovarian cancer, and for monitoring cancer treatment.
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公开(公告)号：EP2714387A2
公开(公告)日：2014-04-09
申请号：EP12793589.8
申请日：2012-05-29
发明人： JIANG, Wenping , MALSHE, Ajay, P.
IPC分类号： B32B18/00
摘要： A cutting tool formed by a coating layer on a substrate has cutting edges that feature serrations. The linear dimensions of the serrations may vary from a few nanometers up to 10 microns. The serrations result in a smoother cut edge on the workpiece, particularly when the workpiece is formed of certain materials that are seen as particularly difficult to cut, such as hardened steels.
摘要翻译： 由基板上的涂层形成的切削工具具有锯齿状的切削刃。 锯齿的线性尺寸可以从几纳米到10微米变化。 锯齿在工件上产生更平滑的切割边缘，特别是当工件由被认为特别难切割的某些材料形成时，例如硬化钢。
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10.发明公开Use of gene expression profiling to predict survival in cancer patient 有权Verwendung von Genexpressionsprofilen zur Prognose derÜberlebensratebei Krebspatienten
公开(公告)号：EP2537942A1
公开(公告)日：2012-12-26
申请号：EP12150351.0
申请日：2005-05-20
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6886 , C12Q2600/106 , C12Q2600/118 , C12Q2600/158
摘要： Gene expression profiling in multiple myeloma patients identifies genes that distinguish between patients with subsequent early death or long survival after treatment. Poor survival is linked to over-expression of genes such as ASPM, OPN3 and CKS1B which are located in chromosome 1 q. Given the frequent amplification of 1 q in many cancers, it is possible that these genes can be used as powerful prognostic markers and therapeutic targets for multiple myeloma and other cancer.
摘要翻译： 在多发性骨髓瘤患者中进行基因表达谱鉴定鉴定了随后早期死亡或治疗后长期存活的患者之间的基因。 差的存活与位于染色体1q的基因如ASPM，OPN3和CKS1B的过表达有关。 鉴于许多癌症中1q的频繁扩增，这些基因可能被用作多种骨髓瘤和其他癌症的强大的预后标志物和治疗靶点。
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