-
公开(公告)号：EP3700903A1
公开(公告)日：2020-09-02
申请号：EP18785687.7
申请日：2018-10-18
发明人： MEIBOM, Daniel , MEYER, Jutta , COLLINS, Karl , ORTEGA HERNANDEZ, Nuria , STAMPFUSS, Jan , WUNDER, Frank , FREUDENBERGER, Till , MONDRITZKI, Thomas , SCHEERER, Nina Alexandra , LEINEWEBER, Kirsten , SCHAMBERGER, Jens , STRAUB, Alexander , GERICKE Kersten, Matthias , KROH, Walter , LOBELL, Mario , MÜNTER, Klaus
IPC分类号： C07D471/04 , C07D519/00 , A61P9/00 , A61K31/437
-
公开(公告)号：EP3197896A1
公开(公告)日：2017-08-02
申请号：EP15771891.7
申请日：2015-09-22
发明人： ROEHRIG, Susanne , HILLISCH, Alexander , STRASSBURGER, Julia , HEITMEIER, Stefan , SCHMIDT, Martina Victoria , SCHLEMMER, Karl-Heinz , TERSTEEGEN, Adrian , BUCHMÜLLER, Anja , GERDES, Christoph , SCHÄFER, Martina , TELLER, Henrik , JIMÉNEZ NÚNEZ, Eloisa , SCHIROK, Hartmut , KLAR, Juergen , LOBELL, Mario
IPC分类号： C07D471/04 , A61K31/435 , A61K31/437 , A61P7/02
CPC分类号： C07D471/04
摘要： The invention relates to substituted oxopyridine derivatives and methods for the production thereof, as well as to the use thereof in the production of medicinal drugs for treating and/or preventing diseases, especially diseases of the cardiovascular system, preferably thrombotic or thromboembolic diseases, as well as oedemas, and also ophthalmological diseases.
-
3.发明授权DISUBSTITUTED BENZOTHIENYL-PYRROLOTRIAZINES AND THEIR USE AS FGFR KINASE INHIBITORS 有权二取代噻吩基吡咯并三及其作为FGFR激酶抑制剂
公开(公告)号：EP2791140B1
公开(公告)日：2016-06-15
申请号：EP12798738.6
申请日：2012-12-10
发明人： BROHM, Dirk , HEROULT, Melanie , COLLIN, Marie-Pierre , HÜBSCH, Walter , LOBELL, Mario , LUSTIG, Klemens , GRÜNEWALD, Sylvia , BÖMER, Ulf , VÖHRINGER, Verena
IPC分类号： C07D487/04 , A61K31/53 , A61P35/00
CPC分类号： C07D487/04 , A61K31/53 , A61K31/5355 , A61K31/5377 , A61K31/541
-
公开(公告)号：EP3774796A1
公开(公告)日：2021-02-17
申请号：EP19715095.6
申请日：2019-04-03
IPC分类号： C07D471/04 , A61K31/4427 , A61P7/02
-
公开(公告)号：EP3086814B1
公开(公告)日：2020-06-24
申请号：EP14833342.0
申请日：2014-12-10
发明人： LERCHEN, Hans-Georg , WITTROCK, Sven , GRIEBENOW, Nils , STELTE-LUDWIG, Beatrix , SOMMER, Anette , BERNDT, Sandra , MAHLERT, Christoph , LOBELL, Mario , TERJUNG, Carsten , GREVEN, Simone , CANCHO GRANDE, Yolanda
IPC分类号： A61K47/22 , C07D233/64 , C07D207/335 , A61K35/00 , A61K47/68 , A61K31/40 , A61K31/415 , A61P35/00
-
6.发明授权HYDROXYMETHYLARYL-SUBSTITUTED PYRROLOTRIAZINES AS ALK1 INHIBITORS 有权HYDROXYMETHYLARYL-取代的吡咯并三ALK1抑制剂
公开(公告)号：EP2726482B1
公开(公告)日：2016-07-20
申请号：EP12730515.9
申请日：2012-06-26
发明人： KLAR, Jürgen , VOEHRINGER, Verena , TELSER, Joachim , LOBELL, Mario , SÜßMEIER, Frank , LI, Volkhart Min-Jian , BÖTTGER, Michael , GOLZ, Stefan , LANG, Dieter , SCHLEMMER, Karl-Heinz , SCHLANGE, Thomas , SCHALL, Andreas , FU, Wenlang
IPC分类号： C07D487/04 , A61K31/53 , A61P27/00
CPC分类号： A61K31/5377 , A61K31/4427 , A61K31/53 , C07D401/04 , C07D487/04
-
7.发明公开SUBSTITUIERTE PYRIDOBENZODIAZEPINON-DERIVATE UND IHRE VERWENDUNG 审中-公开SUBSTITUIERTE PYRIDOBENZODIAZEPINON-DERIVATE和IHRE VERWENDUNG
公开(公告)号：EP3223821A1
公开(公告)日：2017-10-04
申请号：EP15797685.3
申请日：2015-11-23
发明人： SCHALL, Andreas , KLAR, Jürgen , LOBELL, Mario , SCHIROK, Hartmut , TELSER, Joachim , MÜLLER, Steffen , BROHM, Dirk , BRIEM, Hans , JÖRISSEN, Hannah , BÖTTGER, Michael , DEGENFELD VON, Georges , SCHLANGE, Thomas , BÖMER, Ulf , LINDNER, Niels , EILKEN, Hanna , HRISTODOROV, Dmitrij , WASNAIRE, Pierre , GERICKE, Kersten Matthias , BÄRFACKER, Lars
IPC分类号： A61K31/5513 , A61P27/02 , C07D487/04 , A61P35/00
CPC分类号： C07D487/04 , A61K31/5513 , A61K39/39558
摘要： The invention relates to novel (3-hydroxyphenyl)amino-substituted pyrido[2,3-
b ]-[1,5]benzodiazepine-5-one-derivatives, to methods for the production thereof, use thereof alone or in combination for treating and/or for preventing diseases and use thereof in producing medicaments for treating and/or preventing diseases, especially angiogenic disorders and hyperproliferative disorders with a neovascularization component, such as opthalmologic disorders such as cancers and tumor diseases. Such treatments can be carried out as monotherapy or also in combination with other medicaments or additional therapeutic measures.摘要翻译： 本申请涉及新的（3-羟基苯基）氨基取代的吡啶并[2,3-b] [1,5]苯并二氮杂-5-酮衍生物，涉及其制备方法，其单独或组合用于治疗 和/或预防疾病及其用于制备用于治疗和/或预防疾病，尤其是新生血管形成起作用的血管生成病症和过度增殖性疾病（例如眼科疾病和癌症和肿瘤）的药物的用途。 这些治疗可以作为单一疗法或者与其他药物或其他治疗措施组合进行。
-
8.发明公开DISUBSTITUTED BENZOTHIENYL-PYRROLOTRIAZINES AND THEIR USE AS FGFR KINASE INHIBITORS 有权二取代噻吩基吡咯并三及其作为FGFR激酶抑制剂
公开(公告)号：EP2791140A1
公开(公告)日：2014-10-22
申请号：EP12798738.6
申请日：2012-12-10
发明人： BROHM, Dirk , HEROULT, Melanie , COLLIN, Marie-Pierre , HÜBSCH, Walter , LOBELL, Mario , LUSTIG, Klemens , GRÜNEWALD, Sylvia , BÖMER, Ulf , VÖHRINGER, Verena
IPC分类号： C07D487/04 , A61K31/53 , A61P35/00
CPC分类号： C07D487/04 , A61K31/53 , A61K31/5355 , A61K31/5377 , A61K31/541
摘要： This invention relates to novel substituted 5-(1-benzothiophen-2-yl) pyrrolo[2,1-f][1,2,4]triazin-4-amine derivatives of formula (I) wherein R
1 is hydrogen, chloro, methyl or methoxy, R
2 is hydrogen or methoxy, with the proviso that at least one of R
1 and R
2 is other than hydrogen, G
1 represents chloro, (C
1 -C
4 )-alkyl, (C
1 -C
4 )-alkoxycarbonyl, 5-membered aza-heteroaryl, or the group -CH
2 -OR
3 , -CH
2 -NR
4 R
5 or -C(=0)- NR
4 R
6 , and G
2 represents chloro, cyano, (C
1 -C
4 )-alkyl, or the group - CR
8A R
8B -OH, -CH
2 -NR
9 R
10 , -C(=0)-NR
11 R
12 or -CH
2 -OR
15 , having protein tyrosine kinase inhibitory activities, to processes for the preparation of such compounds, to pharmaceutical compositions containing such compounds, and to the use of such compounds or compositions for treating proliferative disorders, in particular cancer and tumor diseases.-
9.发明公开HYDROXYMETHYLARYL-SUBSTITUTED PYRROLOTRIAZINES AS ALK1 INHIBITORS 有权HYDROXYMETHYLARYL-取代的吡咯并三ALK1抑制剂
公开(公告)号：EP2726482A1
公开(公告)日：2014-05-07
申请号：EP12730515.9
申请日：2012-06-26
发明人： KLAR, Jürgen , VOEHRINGER, Verena , TELSER, Joachim , LOBELL, Mario , SÜßMEIER, Frank , LI, Volkhart Min-Jian , BÖTTGER, Michael , GOLZ, Stefan , LANG, Dieter , SCHLEMMER, Karl-Heinz , SCHLANGE, Thomas , SCHALL, Andreas , FU, Wenlang
IPC分类号： C07D487/04 , A61K31/53 , A61P27/00
CPC分类号： A61K31/5377 , A61K31/4427 , A61K31/53 , C07D401/04 , C07D487/04
摘要： This invention relates to novel 5-[(hydroxymethyl)aryl] -substituted pyrrolo[2, 1-f][1, 2, 4] triazin-4-amines of formula (I), to processes for the preparation of such compounds, to pharmaceutical compositions containing such compounds, and to the use of such compounds or compositions for treating angiogenesis-related disorders, in particular angiogenesis-related ocular disorders.
-
公开(公告)号：EP3086814A1
公开(公告)日：2016-11-02
申请号：EP14833342.0
申请日：2014-12-10
发明人： LERCHEN, Hans-Georg , WITTROCK, Sven , GRIEBENOW, Nils , STELTE-LUDWIG, Beatrix , SOMMER, Anette , BERNDT, Sandra , MAHLERT, Christoph , LOBELL, Mario , TERJUNG, Carsten , GREVEN, Simone , CANCHO GRANDE, Yolanda
IPC分类号： A61K47/48 , C07D233/64 , C07D207/335 , A61K35/00
摘要： The invention relates to novel antibody drug conjugates (ADCs), active metabolites of said ADCs, to methods for producing said ADCs, to the use of said ADCs for the treatment and/or prevention of diseases, and to the use of said ADCs for the production of medicaments for the treatment and/or prevention of diseases, in particular hyperproliferative and angiogenic diseases, such as cancer diseases. Such treatments can be effected as monotherapy or else in combination with other medicaments or further therapeutic measures.
-
-
-
-
-
-
-
-
-
搜索结果
21 条记录 (耗时 0.038 秒)
