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公开(公告)号：EP1565422B1
公开(公告)日：2009-02-04
申请号：EP03781741.8
申请日：2003-11-20
发明人： BUNEL, Emilio, Enrique , GAJEWSKI, Robert, Peter , JONES, Charles, David , LU, Jianliang , MA, Tianwei , NAGPAL, Sunil , YEE, Ying, Kwong
IPC分类号： C07C59/90 , C07C62/24 , C07C69/78 , C07C235/34 , C07C311/50 , C07C317/28 , C07D257/06 , C07D277/34 , A61K31/12 , A61K31/165 , A61K31/18 , A61K31/19 , A61K31/192 , A61K31/235 , A61K31/41 , A61K31/426
CPC分类号： C07D207/27 , C07C59/48 , C07C59/64 , C07C59/66 , C07C59/90 , C07C65/24 , C07C65/34 , C07C65/40 , C07C69/732 , C07C69/734 , C07C69/738 , C07C69/76 , C07C69/94 , C07C235/34 , C07C235/42 , C07C311/51 , C07C317/28 , C07D207/26 , C07D233/78 , C07D257/04 , C07D257/06 , C07D261/12 , C07D271/113 , C07D277/34 , C07D295/185
摘要： The present invention relates to novel, non-secosteroidal, diaryl compounds with vitamin D receptor (VDR) modulating activity that are less hypercalcemic than 1a,25 dihydroxy vitamin D3. These compounds are useful for treating bone disease and psoriasis.
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公开(公告)号：EP1511740A1
公开(公告)日：2005-03-09
申请号：EP03728782.8
申请日：2003-05-22
发明人： DAHNKE, Karl, Robert , GAJEWSKI, Robert, Peter , JONES, Charles, David , LINEBARGER, Jared, Harris , LU, Jianliang , MA, Tianwei , NAGPAL, Sunil , SIMARD, Todd, Parker , YEE, Ying, Kwong , BUNEL, Emilio, Enrique , STITES, Ryan, Edward
IPC分类号： C07D333/38 , C07D333/16 , C07D333/18 , C07D333/22 , C07D409/12 , C07D409/06 , C07D333/34 , C07D413/04 , C07D409/04 , A61K31/381 , A61K31/401 , A61K31/41 , A61K31/4245 , A61P19/10
CPC分类号： C07F9/655345 , C07D333/18 , C07D333/20 , C07D333/22 , C07D333/24 , C07D333/34 , C07D333/38 , C07D333/40 , C07D409/06 , C07D409/12 , C07D413/04
摘要： The present invention relates to novel, non-secosteroidal, phenyl-thiophene compounds with vitamin D receptor (VDR) modulating activity that are less hypercalcemic than 1α,25 dihydroxy vitamin D3. These compounds are useful for treating bone disease and psoriasis.
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公开(公告)号：EP1565422A1
公开(公告)日：2005-08-24
申请号：EP03781741.8
申请日：2003-11-20
发明人： BUNEL, Emilio, Enrique , GAJEWSKI, Robert, Peter , JONES, Charles, David , LU, Jianliang , MA, Tianwei , NAGPAL, Sunil , YEE, Ying, Kwong
IPC分类号： C07C59/90 , C07C62/24 , C07C69/78 , C07C235/34 , C07C311/50 , C07C317/28 , C07D257/06 , C07D277/34 , A61K31/12 , A61K31/165 , A61K31/18 , A61K31/19 , A61K31/192 , A61K31/235 , A61K31/41 , A61K31/426
CPC分类号： C07D207/27 , C07C59/48 , C07C59/64 , C07C59/66 , C07C59/90 , C07C65/24 , C07C65/34 , C07C65/40 , C07C69/732 , C07C69/734 , C07C69/738 , C07C69/76 , C07C69/94 , C07C235/34 , C07C235/42 , C07C311/51 , C07C317/28 , C07D207/26 , C07D233/78 , C07D257/04 , C07D257/06 , C07D261/12 , C07D271/113 , C07D277/34 , C07D295/185
摘要： The present invention relates to novel, non-secosteroidal, diaryl compounds with vitamin D receptor (VDR) modulating activity that are less hypercalcemic than 1a,25 dihydroxy vitamin D3. These compounds are useful for treating bone disease and psoriasis.
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公开(公告)号：EP1511740B1
公开(公告)日：2009-07-08
申请号：EP03728782.8
申请日：2003-05-22
发明人： DAHNKE, Karl, Robert , GAJEWSKI, Robert, Peter , JONES, Charles, David , LINEBARGER, Jared, Harris , LU, Jianliang , MA, Tianwei , NAGPAL, Sunil , SIMARD, Todd, Parker , YEE, Ying, Kwong , BUNEL, Emilio, Enrique , STITES, Ryan, Edward
IPC分类号： C07D333/38 , C07D333/16 , C07D333/18 , C07D333/22 , C07D409/12 , C07D409/06 , C07D333/34 , C07D413/04 , C07D409/04 , A61K31/381 , A61K31/401 , A61K31/41 , A61K31/4245 , A61P19/10
CPC分类号： C07F9/655345 , C07D333/18 , C07D333/20 , C07D333/22 , C07D333/24 , C07D333/34 , C07D333/38 , C07D333/40 , C07D409/06 , C07D409/12 , C07D413/04
摘要： The present invention relates to novel, non-secosteroidal, phenyl-thiophene compounds with vitamin D receptor (VDR) modulating activity that are less hypercalcemic than 1α,25 dihydroxy vitamin D3. These compounds are useful for treating bone disease and psoriasis.
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公开(公告)号：EP1687258A2
公开(公告)日：2006-08-09
申请号：EP04800873.4
申请日：2004-11-16
发明人： BUNEL, Emilio, Enrique , GAJEWSKI, Robert, Peter , JONES, Charles, David , LU, Jianliang , NAGPAL, Sunil , MA, Tianwei , YEE, Ying, Kwong
IPC分类号： C07C235/42 , C07C235/84 , C07C63/04 , C07C69/76 , C07D257/06 , C07D257/04 , A61K31/18 , A61K31/255 , A61P19/08 , A61P19/10
CPC分类号： C07C235/42 , C07C65/19 , C07C69/92 , C07C235/84 , C07C2601/08 , C07C2601/14 , C07D257/04 , C07D257/06
摘要： The present invention relates to novel, non-secosteroidal, hydroxyl substituted, carbon- linked diaryl compounds with vitamin D receptor (VDR) modulating activity that are less hypercalcemic than 1α,25 dihydroxy vitamin D3. These compounds are useful for treating bone disease and psoriasis.
摘要翻译： 本发明涉及具有维生素D受体（VDR）调节活性的新型非 - 非甾体羟基取代的碳键二芳基化合物，其比1α，25二羟基维生素D3低钙血红素。 这些化合物可用于治疗骨病和牛皮癣。
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