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1.发明公开NON-ANNULATED THIOPHENYLAMIDES AS INHIBITORS OF FATTY ACID BINDING PROTEINI(FABP) 4 AND/OR 5 审中-公开NICHT-ANNELIERTE THIOPHENYLAMIDE ALS INHIBITOREN DERFETTSÄUREBINDENDENPROTEINE（FABP）4 UND / ODER 5
公开(公告)号：EP2895481A1
公开(公告)日：2015-07-22
申请号：EP13762429.2
申请日：2013-09-09
发明人： BUETTELMANN, Bernd , CECCARELLI, Simona M. , KUEHNE, Holger , KUHN, Bernd , NEIDHART, Werner , OBST SANDER, Ulrike , RICHTER, Hans
IPC分类号： C07D413/14 , C07D333/36 , C07D413/04 , C07D417/04 , C07D417/14 , A61P3/10 , A61P9/10 , A61P35/00 , A61P13/12 , A61P1/16 , A61K31/381 , A61K31/427 , A61K31/4245 , A61K31/433
摘要： The invention provides novel compounds having the general formula (I) wherein R1, R2, R3, R4, R5, R6, R7, A, E and n are as described herein, compositions including the compounds and methods of using the compounds.
摘要翻译： 本发明提供具有通式（I）的新化合物，其中R1，R2，R3，R4，R5，R6，R7，A，E和n如本文所述，包括该化合物的组合物和使用该化合物的方法。
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公开(公告)号：EP2658848A1
公开(公告)日：2013-11-06
申请号：EP11799718.9
申请日：2011-12-22
发明人： AEBI, Johannes , BINGGELI, Alfred , HERTEL, Cornelia , KONKAR, Anish Ashok , KUEHNE, Holger , KUHN, Bernd , MAERKI, Hans P. , WANG, Haiyan
IPC分类号： C07D305/08 , C07D405/12 , C07D405/14 , C07D413/12 , C07D413/14 , C07D417/14 , A61K31/337 , A61P13/12
CPC分类号： C07D305/08 , C07D405/12 , C07D405/14 , C07D413/12 , C07D413/14 , C07D417/14
摘要： The invention provides novel compounds having the general formula (I) wherein R
1 , R
2 , R
3 , R
4 , R
5 , R
6 , R
7 , R
8 , R
9 , R
10 , R
11 , R
12 and A are as described herein, compositions including the compounds and methods of using the compounds.摘要翻译： 本发明提供了具有通式（I）的新化合物，其中R 1，R 2，R 3，R 4，R 5，R 6，R 7，R 8，R 9，R 10，R 11，R 12和A 如本文所述，包含所述化合物的组合物和使用所述化合物的方法。
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公开(公告)号：EP2861574B1
公开(公告)日：2016-04-20
申请号：EP13728748.8
申请日：2013-06-14
发明人： BUETTELMANN, Bernd , CECCARELLI, Simona M. , KUEHNE, Holger , KUHN, Bernd , NEIDHART, Werner , OBST SANDER, Ulrike , RICHTER, Hans
IPC分类号： C07D333/66 , C07D409/04 , C07D409/14 , C07D413/04 , C07D413/14 , C07D417/04 , C07D417/14 , C07D495/04 , C07D495/10 , A61K31/381 , A61P3/10 , A61P35/00
CPC分类号： C07D417/04 , C07D333/50 , C07D333/66 , C07D409/04 , C07D409/14 , C07D413/04 , C07D413/14 , C07D417/14 , C07D495/04 , C07D495/10
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公开(公告)号：EP2888245A1
公开(公告)日：2015-07-01
申请号：EP13750576.4
申请日：2013-08-19
发明人： BUETTELMANN, Bernd , CONTE, Aurelia , KUEHNE, Holger , KUHN, Bernd , NEIDHART, Werner , OBST SANDER, Ulrike , RICHTER, Hans
IPC分类号： C07D401/14 , C07D215/48 , C07D401/04 , C07D401/06 , C07D471/04 , A61K31/4353 , A61K31/47 , A61P3/10
CPC分类号： C07D491/052 , C07D215/54 , C07D221/04 , C07D401/04 , C07D401/14 , C07D405/14 , C07D409/14 , C07D413/14 , C07D471/04 , C07D495/04
摘要： The invention provides novel compounds having the general formula (I) wherein R
1 , R
2 , R
3 , R
4 , R
5 , R
6 , R
7 , R
8 , R
9 , R
10 , R
11 , A
1 , A
2 , A
3 , m, n and p are as described herein, compositions including the compounds and methods of using the compounds.-
公开(公告)号：EP2440521A1
公开(公告)日：2012-04-18
申请号：EP10724803.1
申请日：2010-06-08
发明人： BANNER, David , CECCARELLI, Simona M. , GRETHER, Uwe , HAAP, Wolfgang , HILPERT, Hans , KUEHNE, Holger , MAUSER, Harald , PLANCHER, Jean-Marc , SANCHEZ, Rubén Alvarez
IPC分类号： C07C317/44 , C07D205/04 , C07D207/02 , C07D211/36 , C07D213/60 , C07D231/12 , C07D233/18 , C07D249/04 , C07D261/08 , C07D265/30 , C07D295/185 , C07D309/12 , C07D335/02 , A61K31/277 , A61P3/10
CPC分类号： C07C317/44 , C07C2601/02 , C07C2601/04 , C07C2601/08 , C07D205/04 , C07D207/06 , C07D207/10 , C07D207/16 , C07D211/18 , C07D211/38 , C07D211/46 , C07D211/66 , C07D213/34 , C07D213/61 , C07D213/64 , C07D213/65 , C07D213/68 , C07D213/71 , C07D231/12 , C07D237/08 , C07D237/14 , C07D237/16 , C07D239/26 , C07D249/06 , C07D261/08 , C07D277/26 , C07D279/12 , C07D295/096 , C07D295/185 , C07D309/12 , C07D333/18 , C07D335/02 , C07D401/12 , C07D403/12 , C07D403/14 , C07D405/06 , C07D405/12 , C07D409/12 , C07D491/08 , C07D491/107
摘要： The invention relates to compounds of formula (I) wherein A
1 , R
1 , R
2 , R
3 , R
4 and R
5 are defined in the description and in the claims, which are preferential inhibitors of the cysteine protease cathepsin, in particular of the cysteine protease cathepsin S or L, making them useful as medicaments, particularly in the treatment of diabetes, atherosclerosis, abdominal aortic aneurysm, peripheral arterial disease or diabetic nephropathy.摘要翻译： 本发明涉及式（I）化合物，其中A1和R1至R5如在说明书和权利要求书中所定义。 式（I）化合物可以用作药物。
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公开(公告)号：EP2081889A1
公开(公告)日：2009-07-29
申请号：EP07803544.1
申请日：2007-09-18
发明人： HAAP, Wolfgang , HEBEISEN, Paul , KITAS, Eric, A. , KOHLER, Philipp Christoph , KUEHNE, Holger , RUF, Armin
IPC分类号： C07C311/37 , C07C303/38 , A61K31/18 , C07D307/12 , C07D333/10 , C07D333/12 , C07D333/16
CPC分类号： C07C311/58 , C07D307/64 , C07D317/62 , C07D333/34 , C07D333/38
摘要： Compounds of formula (I) as well as pharmaceutically acceptable salts and esters thereof, wherein L, R1, R2, m and n have the meaning given in claim 1 and which can be used in the form of pharmaceutical compositions.
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公开(公告)号：EP2773619B1
公开(公告)日：2016-11-16
申请号：EP12780486.2
申请日：2012-10-29
发明人： CECCARELLI, Simona M. , CONTE, Aurelia , KUEHNE, Holger , KUHN, Bernd , NEIDHART, Werner , OBST SANDER, Ulrike , RUDOLPH, Markus
IPC分类号： C07D215/56 , C07D401/04 , C07D401/14 , C07D413/04 , A61K31/47 , A61K31/4709 , A61P3/10 , A61P35/00
CPC分类号： C07D491/048 , C07D215/00 , C07D215/02 , C07D215/227 , C07D215/54 , C07D401/04 , C07D401/14 , C07D413/04 , C07D413/14
摘要： The invention provides novel compounds having the general formula (I) wherein R1, R2, R3, R4, R5, R6 and n are as described herein, compositions including the compounds and methods of using the compounds. The present compounds are useful as fatty-acid binding protein (FABP) 4 and/or 5 inhibitors and may be used for the treatment or prophylaxis of lipodystrophy, type 2 diabetes, dyslipidemia, atherosclerosis, liver diseases involving inflammation, steatosis and/or fibrosis, such as non-alcoholic fatty liver disease, in particular non-alcoholic steatohepatitis, metabolic syndrome, obesity, chronic inflammatory and autoimmune inflammatory diseases.
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公开(公告)号：EP2668155A2
公开(公告)日：2013-12-04
申请号：EP12702199.6
申请日：2012-01-18
发明人： AEBI, Johannes , BINGGELI, Alfred , HERTEL, Cornelia , KONKAR, Anish Ashok , KUEHNE, Holger , KUHN, Bernd , MAERKI, Hans P. , WANG, Haiyan
IPC分类号： C07C237/24
CPC分类号： C07C237/24 , C07C2602/02 , C07C2602/08 , C07C2602/10 , C07D257/04 , C07D271/06 , C07D271/10 , C07D305/08 , C07D401/10 , C07D401/14 , C07D405/10 , C07D405/12 , C07D409/10 , C07D409/14 , C07D413/10 , C07D413/12 , C07D413/14
摘要： The invention provides novel compounds having the general formula (I) wherein R1, R2, R3, R4, R5, R6, R7, R8, R9, R10, R11, R12, A1, A2 and n are as described herein, compositions including the compounds and methods of using the compounds.
摘要翻译： 本发明提供具有通式（I）的新化合物，其中R1，R2，R3，R4，R5，R6，R7，R8，R9，R10，R11，R12，A1，A2和n如本文所述， 化合物和使用该化合物的方法。
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公开(公告)号：EP2421826B1
公开(公告)日：2013-10-23
申请号：EP10713457.9
申请日：2010-04-13
发明人： ALVAREZ SANCHEZ, Ruben , BANNER, David , CECCARELLI, Simona M. , GRETHER, Uwe , HAAP, Wolfgang , HARTMAN, Peter , HARTMANN, Guido , HILPERT, Hans , KUEHNE, Holger , MAUSER, Harald , PLANCHER, Jean-Marc
IPC分类号： C07D207/16 , C07D401/04 , C07D401/06 , C07D401/12 , C07D401/14 , C07D403/04 , C07D403/06 , C07D403/12 , C07D403/14 , C07D405/04 , C07D405/06 , C07D405/12 , C07D405/14 , C07D409/14 , C07D413/12
CPC分类号： C07D207/16 , C07D401/04 , C07D401/06 , C07D401/12 , C07D401/14 , C07D403/04 , C07D403/06 , C07D403/12 , C07D403/14 , C07D405/04 , C07D405/06 , C07D405/12 , C07D405/14 , C07D409/14 , C07D413/12 , C07D417/04 , C07D417/06 , C07D417/14 , C07D471/04 , C07D487/04
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10.发明授权
公开(公告)号：EP2007726B1
公开(公告)日：2011-03-02
申请号：EP07712127.5
申请日：2007-01-29
发明人： FAEH, Christoph , KUEHNE, Holger , LUEBBERS, Thomas , MATTEI, Patrizio , MAUGEAIS, Cyrille , PFLIEGER, Philippe
IPC分类号： C07D213/40
CPC分类号： C07D405/12 , C07D213/40 , C07D213/82 , C07D277/28 , C07D333/58 , C07D333/60 , C07D401/12 , C07D409/12 , C07D417/12
摘要： Compounds of formula (I) processes for their preparation, their use as pharmaceuticals and to pharmaceutical compositions comprising them.
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