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公开(公告)号：EP4032539A1
公开(公告)日：2022-07-27
申请号：EP20865705.6
申请日：2020-09-20
发明人： ULITIN, Andrei Borisovich , KONONOV, Aleksey Vladimirovich , AGEEV, Sergei Andreevich , GORDEEV, Aleksandr Andreevich , VINOGRADOVA, Elena Vladimirovna , EVDOKIMOV, Stanislav Rudolfovich , SHMAKOVA, Aleksandra Pavlovna , MITROSHIN, Ivan Vladimirovich , MOROZOV, Dmitry Valentinovich
IPC分类号： A61K38/20 , A61K39/395 , A61P35/00 , C07K14/54 , C07K14/715 , C07K16/28 , C07K19/00 , C12N15/13 , C12N15/24 , C12N15/62
摘要： The present invention relates to an immunocytokine comprising an heterodimeric protein complex based on IL-15/IL-15Rα, and to use thereof as a therapeutic agent, in particular as an agent for the treatment of cancer and an autoimmune disease. The present invention further relates to an immunocytokine comprising a heterodimeric protein complex based on an IL-15/IL-15Rα and an immunomodulatory antibody, and to use thereof as a therapeutic agent, in particular as an agent for the treatment of cancer and an autoimmune disease.
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公开(公告)号：EP3964525A2
公开(公告)日：2022-03-09
申请号：EP20794288.9
申请日：2020-04-23
发明人： ULITIN, Andrei Borisovich , KOZLOVA, Olesya Nikolaevna , GORDEEV, Aleksandr Andreevich , BURNYSHEVA, Ksenia Mihailovna , ISHUTINOVA, Anastasia Nikolaevna , SOZONOVA, Aleksandra Aleksandrovna , AGEEV, Sergei Andreevich , DORONIN, Aleksandr Nikolaevich , TSYMPILOV, Vladimir Sergeevich , MITROSHIN, Ivan Vladimirovich , SOLOVYEV, Valery Vladimirovich , USTIUGOV, Iakov Iurevich , IVANOV, Roman Alekseevich , MOROZOV, Dmitry Valentinovich
IPC分类号： C07K16/24 , C07K16/28 , C12N5/10 , C12N15/13 , C12N15/63 , C12P21/08 , A61K39/395 , A61P35/00
摘要： The present invention relates to biotechnology, in particular to antibodies or antigen-binding fragments thereof, and to use thereof. More particularly, the present invention relates to monoclonal antibodies that specifically bind to GITR. The invention also relates to a nucleic acid encoding said antibody or antigen-binding fragment thereof, an expression vector, a method for preparing said antibody, and use of said antibody in treatment of diseases or disorders associated with GITR.
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公开(公告)号：EP3450456A1
公开(公告)日：2019-03-06
申请号：EP16900649.1
申请日：2016-12-02
发明人： MOROZOV, Dmitry Valentinovich , ULITIN, Andrei Borisovich , ZUBAREVA, Ekaterina Sergeevna , USTIUGOV, Iakov Iurevich , KARABELSKII, Aleksandr Vladimirovich , KORZHAVIN, Dmitry Valeryevich , CHERNOVSKAYA, Tatiana Veniaminovna , GRACHEV, Aleksandr Valerevich , BASOVSKIY, Yury Ivanovich , LOMKOVA, Ekaterina Aleksandrovna , USATOVA, Veronika Sergeevna , ALEKSANDROV, Aleksei Aleksandrovich , MOROZOVA, Elena Leonidovna , IVANOV, Roman Alekseevich , IAKOVLEV, Pavel Andreevich
摘要： The present invention relates to the field of biotechnology and provides monoclonal tri-specific binding molecules that specifically bind to human IL-17A, human IL-17F, and a human pro-inflammatory molecule (in particular, TNFα) with high affinity. The invention also relates to DNA constructs encoding said binding molecules, related expression vectors and methods of production, and methods of treatment using said binding molecules.
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4.发明公开
公开(公告)号：EP3502135A1
公开(公告)日：2019-06-26
申请号：EP17841757.2
申请日：2017-08-03
发明人： EVDOKIMOV, Stanislav Rudolfovich , ULITIN, Andrei Borisovich , SOLOVYEV, Valery Vladimirovich , ALEKSANDROV, Aleksei Aleksandrovich , CHERNYKH, Yulia Sergeevna , NEMANKIN, Timofey Aleksandrovich , VLADIMIROVA, Anna Konstantinovna , SMOTROV, Oleg Igorevich , CHERNOVSKAYA, Tatiana Veniaminovna , MOSHCHENKO, Aleksandr Aleksandrovich , NALOBINA, Viktoriia Evgenevna , IVANOV, Roman Alekseevich , MOROZOV, Dmitry Valentinovich
摘要： The invention relates to medicine. The problem addressed by the present invention consists in creating alternative antibodies or fragments thereof which are capable of specifically binding to a human receptor of interleukin-6 and which would be useful as drugs for treating or diagnosing diseases, or for relieving symptoms, mediated by interleukin-6.
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公开(公告)号：EP3486257A1
公开(公告)日：2019-05-22
申请号：EP17828049.1
申请日：2017-07-04
发明人： EKIMOVA, Viktoriia Mikhailovna , KORZHAVIN, Dmitry Valeryevich , CHERNYKH, Yulia Sergeevna , NEMANKIN, Timofey Aleksandrovich , SOLOVYEV, Valery Vladimirovich , VLADIMIROVA, Anna Konstantinovna , BULANKINA, Irina Andreevna , DIDUK, Sergei Vasilyevich , EROSHOVA, Anna Vladimirovna , USTIUGOV, Iakov Iurevich , ARTIUKHOVA, Marina Vladimirovna , ULITIN, Andrei Borisovich , IVANOV, Roman Alekseevich , MOROZOV, Dmitry Valentinovich
IPC分类号： C07K16/28 , C12N15/13 , C12N15/63 , A61K39/395
摘要： The present invention relates to biotechnology and comprises isolated monoclonal antibodies, in particular human monoclonal antibodies, which specifically bind to PD-1 with high affinity. The antibodies according to the invention may be chimeric, humanized or human antibodies, or antigen-binding fragments thereof, and may be used as a medicinal agent in oncology and immuno-oncology, for treating diseases associated with various cell proliferation or development disorders. The invention also relates to methods for producing said antibodies and a method for treating human diseases using said antibodies.
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公开(公告)号：EP3693390A1
公开(公告)日：2020-08-12
申请号：EP18864490.0
申请日：2018-10-03
发明人： SOLOVYEV, Kirill Vladimirovich , ULITIN, Andrei Borisovich , NEMANKIN, Timofey Aleksandrovich , SOLOVYEV, Valery Vladimirovich , MOROZOV, Dmitry Valentinovich
摘要： The present invention relates to the field of bioengineering, specifically to antibodies or their antigen-binding fragments, and to the use thereof. More particularly, the present invention relates to antibodies that bind specifically to CD47 and PD-L1. The invention also relates to a nucleic acid that codes for the given antibody or for the antigen-binding fragment thereof, to an expression vector, to a method of producing the antibody, and to a use of the aforementioned antibodies and compositions in cancer treatment.
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公开(公告)号：EP3613770A2
公开(公告)日：2020-02-26
申请号：EP18786945.8
申请日：2018-04-11
发明人： ULITIN, Andrei Borisovich , EKIMOVA, Viktoriia Mikhailovna , SOFRONOVA, Ekaterina Vladimirovna , CHERNYKH, Yulia Sergeevna , AGEEV, Sergei Andreevich , VLADIMIROVA, Anna Konstantinovna , ALEKSANDROV, Aleksei Aleksandrovich , GREBNEV, Pavel Alekseevich , SOLOVYEV, Valery Vladimirovich , USTIUGOV, Iakov Iurevich , IAKOVLEV, Pavel Andreevich , NEMANKIN, Timofey Aleksandrovich , MOROZOV, Dmitry Valentinovich
摘要： The present invention relates to the field of biotechnology and provides antibodies that specifically binds to PD-L1. The invention also relates to DNA encoding said antibodies, to corresponding expression vectors and to methods of producing, and to methods of treatment using said antibodies.
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