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公开(公告)号：EP2244706B1
公开(公告)日：2016-04-06
申请号：EP09715751.5
申请日：2009-02-02
申请人： Merck Patent GmbH
IPC分类号： C07D409/14 , A61K31/4155 , A61K31/4178 , A61K31/4184 , A61K31/4196 , A61K31/427 , A61K31/433 , A61K31/4439 , A61K31/4436 , A61K31/501 , A61K31/506 , A61P3/10 , C07D417/12 , C07D409/12 , C07D413/12
CPC分类号： C07D409/12 , A61K31/4155 , A61K31/4178 , A61K31/4184 , A61K31/4196 , A61K31/427 , A61K31/433 , A61K31/4436 , A61K31/4439 , A61K31/501 , A61K31/506 , C07D409/14 , C07D413/12 , C07D417/12
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2.发明授权2-ADAMANTYLUREA DERIVATIVES AS SELECTIVE 11BETA-HSD1 INHIBITORS 有权2-ADAMANTYLUREA衍生物作为选择性11BETA-HSD1抑制剂
公开(公告)号：EP1960352B1
公开(公告)日：2013-08-07
申请号：EP06818709.5
申请日：2006-11-22
申请人： Merck Patent GmbH
IPC分类号： C07D261/14 , C07C275/26 , C07C275/30 , C07C275/34 , C07C323/44 , C07D213/40 , C07D213/75 , C07D233/54 , C07D249/14 , C07D295/088 , C07D295/215 , C07D307/52 , C07D319/08 , C07D333/20 , C07D333/36
CPC分类号： C07D261/14 , C07C275/26 , C07C275/28 , C07C275/30 , C07C275/34 , C07C323/44 , C07C2601/08 , C07C2602/08 , C07C2603/74 , C07D213/40 , C07D213/75 , C07D233/54 , C07D249/14 , C07D295/088 , C07D295/215 , C07D307/52 , C07D319/08 , C07D333/20 , C07D333/36
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3.发明公开ARYLPYRAZINONE DERIVATIVES INSULIN SECRETION STIMULATORS, METHODS FOR OBTAINING THEM AND USE THEREOF FOR THE TREATMENT OF DIABETES 有权ARYLPYRAZINONDERIVATE ALS INSULINAUSSCHEIDUNGSSTIMULATOREN，用于治疗糖尿病的生产工艺和用途
公开(公告)号：EP2268624A1
公开(公告)日：2011-01-05
申请号：EP09737783.2
申请日：2009-03-31
申请人： Merck Patent GmbH
IPC分类号： C07D241/18 , C07D241/38 , C07D401/04 , C07D403/04 , C07D405/04
CPC分类号： C07D241/08 , C07D241/18 , C07D241/38 , C07D401/04 , C07D403/04 , C07D405/04
摘要： The present invention relates to arylpyrazinone derivatives of formula (I), wherein R1, R2, R3 and A are as defined in claim 1, as insulin secretion stimulators. The invention also relates to the preparation and use of these pyrazinone derivatives for the prophylaxis and/or treatment of diabetes and pathologies associated.
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4.发明公开5-OXO-2, 3,4,5-TETRAHYDRO-BENZO[B]OXEPINE-4-CARBOXYLIC ACID AMIDES AND 2,3-DIHYDRO-BENZO[B]OXEPINE-4-CARBOXYLIC ACID AMIDES FOR TREATMENT AND PREVENTION OF DIABETES TYP 1 AND 2 有权5-氧代-2,3,4,5-四氢 - 苯并[b]氧杂-4-甲酸酰胺和2,3-二氢 - 苯并[b]氧杂-4-甲酸在治疗酰胺和糖尿病TYP防治方案 1和2
公开(公告)号：EP2247587A1
公开(公告)日：2010-11-10
申请号：EP09716230.9
申请日：2009-02-05
申请人： Merck Patent GmbH
发明人： SAAL, Christoph , BURGDORF, Lars, Thore , EMDE, Ulrich , BEIER, Norbert , GLEITZ, Johannes , CHARON, Christine
IPC分类号： C07D405/12 , C07D417/12 , A61K31/427 , A61K31/4427 , A61P3/04 , A61P3/10
CPC分类号： C07D405/12 , C07D417/12
摘要： The present invention relates to novel compounds of general formula (I) for use as glucokinase activators in the treatment of diabetes and obesity.
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5.发明授权2-ADAMANTYL-BUTYRAMIDE DERIVATIVES AS SELECTIVE 11 BETA-HSD1 INHIBITORS 有权2-金刚BUTYRAMIDDERIVATE作为选择性11-β-HSD1抑制剂
公开(公告)号：EP2094263B1
公开(公告)日：2013-10-16
申请号：EP07856225.3
申请日：2007-11-22
申请人： Merck Patent GmbH
IPC分类号： A61K31/41 , A61K31/16 , A61K31/4402 , A61K31/426 , A61K31/4453 , A61K31/4245 , A61K31/194 , A61K31/19 , C07C233/06 , C07C233/08 , C07C233/13 , C07C233/15 , C07C233/23 , C07C233/26 , C07C235/22
CPC分类号： C07D413/04 , C07C233/06 , C07C233/08 , C07C233/13 , C07C233/15 , C07C233/23 , C07C233/26 , C07C235/14 , C07C235/22 , C07D207/27 , C07D213/40 , C07D213/75 , C07D271/06 , C07D277/46 , C07D295/18 , C07D295/185
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6.发明授权NIP THIAZOLE DERIVATIVES AS INHIBITORS OF 11-BETA-HYDROXYSTEROID DEHYDROGENASE-1 有权NIP-噻唑衍生物作为11-β羟类固醇脱氢酶-1抑制剂
公开(公告)号：EP2271405B1
公开(公告)日：2013-07-24
申请号：EP09741800.8
申请日：2009-04-08
申请人： Merck Patent GmbH
IPC分类号： A61K31/454 , A61K31/4545 , C07D417/04 , C07D417/14 , A61P3/06 , A61P3/04 , A61P1/18 , A61P3/10 , A61P9/12 , A61P3/08 , A61P5/46 , A61P9/10 , A61P13/00 , A61P17/06 , A61P19/10 , A61P25/22 , A61P25/24 , A61P25/28 , A61P27/06
CPC分类号： A61K31/4545 , C07D417/04 , C07D417/14 , Y02A50/473
摘要： The present invention relates to NIP thiazole derivatives of formula (I) as selective inhibitors of the enzyme 11-beta-hydroxysteroid dehydrogenase type 1 (11-beta-HSD-1) and the use of such compounds for the treatment and prevention of metabolic syndrome, diabetes, insulin resistance, obesity, lipid disorders, glaucoma, osteoporosis, cognitive disorders, anxiety, depression, immune disorders, hypertension and other diseases and conditions.
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公开(公告)号：EP2231640B1
公开(公告)日：2012-06-06
申请号：EP08871581.8
申请日：2008-12-23
申请人： Merck Patent GmbH
发明人： BENDER, Stefan , BURGDORF, Lars, Thore , EMDE, Ulrich , BEIER, Norbert , GLEITZ, Johannes , CHARON, Christine
IPC分类号： C07D401/12 , C07D401/14 , C07D403/12 , C07D405/14 , C07D409/14 , C07D413/12 , C07D417/14 , A61K31/4439 , A61K31/427 , A61K31/433 , A61K31/498 , A61K31/506 , A61K31/4155 , A61K31/4178 , A61K31/42
CPC分类号： C07D401/12 , C07D401/14 , C07D403/12 , C07D405/14 , C07D409/14 , C07D413/12 , C07D417/14
摘要： Novel heterocyclic compounds of the Formula (I) in which R1, R2, R2', R2', R3, R4, R5, R6, R7 and R8 have the meanings indicated in Claim 1, are activators of glucokinase and can be used for the prevention and/or treatment of Diabetes Typ 1 and 2, obesity, neuropathy and/or nephropathy.
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8.发明公开2-ADAMANTYL-BUTYRAMIDE DERIVATIVES AS SELECTIVE 11 BETA-HSD1 INHIBITORS 有权2-金刚BUTYRAMIDDERIVATE作为选择性11-β-HSD1抑制剂
公开(公告)号：EP2094263A1
公开(公告)日：2009-09-02
申请号：EP07856225.3
申请日：2007-11-22
申请人： Merck Patent GmbH
IPC分类号： A61K31/41 , A61K31/16 , A61K31/4402 , A61K31/426 , A61K31/4453 , A61K31/4245 , A61K31/194 , A61K31/19 , C07C233/06 , C07C233/08 , C07C233/13 , C07C233/15 , C07C233/23 , C07C233/26 , C07C235/22
CPC分类号： C07D413/04 , C07C233/06 , C07C233/08 , C07C233/13 , C07C233/15 , C07C233/23 , C07C233/26 , C07C235/14 , C07C235/22 , C07D207/27 , C07D213/40 , C07D213/75 , C07D271/06 , C07D277/46 , C07D295/18 , C07D295/185
摘要： The present invention relates to 2-adamantyl-butyramide derivatives of formula I as selective inhibitors of the enzyme 11-beta-hydroxysteroid dehydrogenase type 1 (11β-HSD-1) and the use of such compounds for the treatment and prevention of metabolic syndrome, diabetes, insulin resistance, obesity, lipid disorders, glaucoma, osteoporosis, cognitive disorders, anxiety, depression, immune disorders, hypertension and other diseases and conditions.
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9.发明授权QUINOXALINONE DERIVATIVES AS INSULIN SECRETION STIMULATORS, METHODS FOR OBTAINING THEM AND USE THEREOF FOR THE TREATMENT OF DIABETES 有权CHINOXALINONDERIVATE ALS INSULINAUSSCHEIDUNGSSTIMULATOREN，用于治疗糖尿病的生产工艺和用途
公开(公告)号：EP2247580B1
公开(公告)日：2015-07-08
申请号：EP09718118.4
申请日：2009-01-15
申请人： Merck Patent GmbH
IPC分类号： C07D241/44 , C07D403/04 , C07D405/04 , A61K31/498 , A61P3/10
CPC分类号： C07D413/10 , C07D241/44 , C07D401/04 , C07D403/04 , C07D403/10 , C07D405/04 , C07D405/10
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10.发明授权
公开(公告)号：EP2197849B1
公开(公告)日：2013-02-27
申请号：EP08801938.5
申请日：2008-09-09
申请人： Merck Patent GmbH
发明人： BURGDORF, Lars, Thore , CARNIATO, Denis , EMDE, Ulrich , BEIER, Norbert , GLEITZ, Johannes , CHARON, Christine
IPC分类号： C07D231/40 , C07D401/06 , C07D409/12 , C07D409/14 , A61K31/4155 , A61P3/04 , A61P3/10
CPC分类号： C07D401/06 , C07D231/40 , C07D409/12 , C07D409/14
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