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1.发明授权
公开(公告)号：EP1115693B1
公开(公告)日：2007-05-02
申请号：EP99969710.5
申请日：1999-09-23
申请人： Monsanto Company
发明人： SIKORSKI, James, A. , DURLEY, Richard, C. , MISCHKE, Deborah, A. , REINHARD, Emily, J. , FOBIAN, Yvette, M. , TOLLEFSON, Michael, B. , WANG, Lijuan , GRAPPERHAUS, Margaret, L. , HICKORY, Brian, S. , MASSA, Mark, A. , NORTON, Monica, B. , VERNIER, William, F. , PARNAS, Barry, L. , PROMO, Michele, A. , HAMME, Ashton, T. , SPANGLER, Dale, P. , RUEPPEL, Melvin, L.
IPC分类号： C07C215/16 , C07C215/76 , C07C215/50 , C07C217/90 , C07C217/84 , C07D263/06 , C07D251/16 , A61K31/135 , A61K31/33
CPC分类号： C07D207/335 , A61K31/135 , A61K31/33 , C07C215/16 , C07C215/50 , C07C215/76 , C07C217/58 , C07C217/84 , C07C217/86 , C07C217/88 , C07C217/90 , C07C219/34 , C07C225/22 , C07C229/60 , C07C233/69 , C07C235/38 , C07C237/30 , C07C237/38 , C07C255/55 , C07C255/58 , C07C275/34 , C07C291/04 , C07C311/04 , C07C311/21 , C07C311/24 , C07C311/60 , C07C317/32 , C07C317/36 , C07C323/19 , C07C323/25 , C07C323/31 , C07C323/32 , C07C323/37 , C07C323/44 , C07C323/65 , C07C2601/02 , C07C2601/08 , C07C2601/14 , C07C2602/10 , C07C2603/18 , C07D209/08 , C07D213/26 , C07D213/30 , C07D213/643 , C07D213/66 , C07D213/85 , C07D239/34 , C07D251/16 , C07D251/42 , C07D263/06 , C07D295/135 , C07D295/192 , C07D307/14 , C07D307/42 , C07D307/52 , C07D309/12 , C07D333/20 , C07D333/28
摘要： The invention relates to substituted polycyclic aryl and heteroaryl tertiary-heteroalkylamine compounds useful as inhibitors of cholesteryl ester transfer protein (CETP; plasma lipid transfer protein-I) and compounds, compositions and methods for treating atherosclerosis and other coronary artery diseases.
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2.发明授权SUBSTITUTED PYRIDINO PENTAAZAMACROCYLE COMPLEXES HAVING SUPEROXIDE DISMUTASE ACTIVITY 有权取代的吡啶基具有超氧化物歧化酶活性的PENTAAZAMAKROZYKLE COMPLEX
公开(公告)号：EP1212323B1
公开(公告)日：2004-06-09
申请号：EP00966722.1
申请日：2000-09-14
申请人： MONSANTO COMPANY
发明人： RILEY, Dennis , NEUMANN, William, L. , HENKE, Susan, L. , LENNON, Patrick , ASTON, Karl, W. , SALVEMINI, Daniela , SIKORSKI, James, A. , FOBIAN, Yvette , GRAPPERHAUS, Margaret, L. , KUSTURIN, Carrie, L.
IPC分类号： C07D471/08 , C07D471/06 , A61K31/555 , A61P29/00
CPC分类号： C07D471/06 , A61K31/555 , C07D471/08 , C07F13/005 , Y02A50/473
摘要： The present invention relates to compounds which are effective as catalysts for dismutating superoxide and, more particularly, the manganese or iron complexes of substituted, unsaturated heterocyclic pentaazacyclopentadecane ligands which catalytically dismutate superoxide.
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3.发明公开
公开(公告)号：EP1115693A1
公开(公告)日：2001-07-18
申请号：EP99969710.5
申请日：1999-09-23
申请人： Monsanto Company
发明人： SIKORSKI, James, A. , DURLEY, Richard, C. , MISCHKE, Deborah, A. , REINHARD, Emily, J. , FOBIAN, Yvette, M. , TOLLEFSON, Michael, B. , WANG, Lijuan , GRAPPERHAUS, Margaret, L. , HICKORY, Brian, S. , MASSA, Mark, A. , NORTON, Monica, B. , VERNIER, William, F. , PARNAS, Barry, L. , PROMO, Michele, A. , HAMME, Ashton, T. , SPANGLER, Dale, P. , RUEPPEL, Melvin, L.
IPC分类号： C07C215/16 , C07C215/76 , C07C215/50 , C07C217/90 , C07C217/84 , C07D263/06 , C07D251/16 , A61K31/135 , A61K31/33
CPC分类号： C07D207/335 , A61K31/135 , A61K31/33 , C07C215/16 , C07C215/50 , C07C215/76 , C07C217/58 , C07C217/84 , C07C217/86 , C07C217/88 , C07C217/90 , C07C219/34 , C07C225/22 , C07C229/60 , C07C233/69 , C07C235/38 , C07C237/30 , C07C237/38 , C07C255/55 , C07C255/58 , C07C275/34 , C07C291/04 , C07C311/04 , C07C311/21 , C07C311/24 , C07C311/60 , C07C317/32 , C07C317/36 , C07C323/19 , C07C323/25 , C07C323/31 , C07C323/32 , C07C323/37 , C07C323/44 , C07C323/65 , C07C2601/02 , C07C2601/08 , C07C2601/14 , C07C2602/10 , C07C2603/18 , C07D209/08 , C07D213/26 , C07D213/30 , C07D213/643 , C07D213/66 , C07D213/85 , C07D239/34 , C07D251/16 , C07D251/42 , C07D263/06 , C07D295/135 , C07D295/192 , C07D307/14 , C07D307/42 , C07D307/52 , C07D309/12 , C07D333/20 , C07D333/28
摘要： The invention relates to substituted polycyclic aryl and heteroaryl tertiary-heteroalkylamine compounds useful as inhibitors of cholesteryl ester transfer protein (CETP; plasma lipid transfer protein-I) and compounds, compositions and methods for treating atherosclerosis and other coronary artery diseases.
摘要翻译： 本发明涉及substituiertem芳基和杂芳基（R） - 手性卤化1- Substitutedamino-第（n + 1）链烷醇化合物可用作胆固醇酯转移蛋白抑制剂（CETP;血浆脂质转移蛋白-I）和化合物，组合物和方法 用于治疗动脉粥样硬化和其它冠状动脉疾病。 新颖高收率，对于从手性和非手性中间体手性substituiertem链烷醇化合物的制备立体有择方法描述。
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4.发明授权(R)-CHIRAL HALOGENATED 1-SUBSTITUTEDAMINO-(N+1)-ALKANOLS USEFUL FOR INHIBITING CHOLESTERYL ESTER TRANSFER PROTEIN ACTIVITY 有权（R）-CHIRALE卤化1 - 取代的氨基（N + 1） - 链烷醇用于抑制胆固醇酯转移蛋白的活性
公开(公告)号：EP1115695B1
公开(公告)日：2005-06-01
申请号：EP99948429.8
申请日：1999-09-23
申请人： Monsanto Company
发明人： SIKORSKI, James, A. , DURLEY, Richard, C. , MISCHKE, Deborah, A. , REINHARD, Emily, J. , FOBIAN, Yvette, M. , TOLLEFSON, Michael, B. , WANG, Lijuan , GRAPPERHAUS, Margaret, L. , HICKORY, Brian, S. , MASSA, Mark, A. , NORTON, Monica, B. , VERNIER, William, F. , PROMO, Michele, A. , HAMME, Ashton, T. , SPANGLER, Dale, P. , RUEPPEL, Melvin, L.
IPC分类号： C07C217/90 , C07C217/84 , C07D263/06 , C07D251/16 , A61K31/135 , A61K31/33 , C07C217/82 , C07C217/86 , C07C239/20
CPC分类号： C07D207/335 , A61K31/135 , A61K31/33 , C07C215/16 , C07C215/50 , C07C215/76 , C07C217/58 , C07C217/84 , C07C217/86 , C07C217/88 , C07C217/90 , C07C219/34 , C07C225/22 , C07C229/60 , C07C233/69 , C07C235/38 , C07C237/30 , C07C237/38 , C07C255/55 , C07C255/58 , C07C275/34 , C07C291/04 , C07C311/04 , C07C311/21 , C07C311/24 , C07C311/60 , C07C317/32 , C07C317/36 , C07C323/19 , C07C323/25 , C07C323/31 , C07C323/32 , C07C323/37 , C07C323/44 , C07C323/65 , C07C2601/02 , C07C2601/08 , C07C2601/14 , C07C2602/10 , C07C2603/18 , C07D209/08 , C07D213/26 , C07D213/30 , C07D213/643 , C07D213/66 , C07D213/85 , C07D239/34 , C07D251/16 , C07D251/42 , C07D263/06 , C07D295/135 , C07D295/192 , C07D307/14 , C07D307/42 , C07D307/52 , C07D309/12 , C07D333/20 , C07D333/28
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5.发明公开(R)-CHIRAL HALOGENATED 1-SUBSTITUTEDAMINO-(N+1)-ALKANOLS USEFUL FOR INHIBITING CHOLESTERYL ESTER TRANSFER PROTEIN ACTIVITY 有权（R）-CHIRALE HALOGENIERTE 1-SUBSTITUIERTE氨基 - （N + 1）-ALKANOLENFÜRDIE HEMMUNG DERAKTIVITÄTDES CHOLESTERYL-ESTER-TRANSFER-PROTEINS
公开(公告)号：EP1115695A1
公开(公告)日：2001-07-18
申请号：EP99948429.8
申请日：1999-09-23
申请人： Monsanto Company
发明人： SIKORSKI, James, A. , DURLEY, Richard, C. , MISCHKE, Deborah, A. , REINHARD, Emily, J. , FOBIAN, Yvette, M. , TOLLEFSON, Michael, B. , WANG, Lijuan , GRAPPERHAUS, Margaret, L. , HICKORY, Brian, S. , MASSA, Mark, A. , NORTON, Monica, B. , VERNIER, William, F. , PROMO, Michele, A. , HAMME, Ashton, T. , SPANGLER, Dale, P. , RUEPPEL, Melvin, L.
IPC分类号： C07C217/90 , C07C217/84 , C07D263/06 , C07D251/16 , A61K31/135 , A61K31/33 , C07C217/82 , C07C217/86 , C07C239/20
CPC分类号： C07D207/335 , A61K31/135 , A61K31/33 , C07C215/16 , C07C215/50 , C07C215/76 , C07C217/58 , C07C217/84 , C07C217/86 , C07C217/88 , C07C217/90 , C07C219/34 , C07C225/22 , C07C229/60 , C07C233/69 , C07C235/38 , C07C237/30 , C07C237/38 , C07C255/55 , C07C255/58 , C07C275/34 , C07C291/04 , C07C311/04 , C07C311/21 , C07C311/24 , C07C311/60 , C07C317/32 , C07C317/36 , C07C323/19 , C07C323/25 , C07C323/31 , C07C323/32 , C07C323/37 , C07C323/44 , C07C323/65 , C07C2601/02 , C07C2601/08 , C07C2601/14 , C07C2602/10 , C07C2603/18 , C07D209/08 , C07D213/26 , C07D213/30 , C07D213/643 , C07D213/66 , C07D213/85 , C07D239/34 , C07D251/16 , C07D251/42 , C07D263/06 , C07D295/135 , C07D295/192 , C07D307/14 , C07D307/42 , C07D307/52 , C07D309/12 , C07D333/20 , C07D333/28
摘要： The invention relates to substituted aryl and heteroaryl (R)-Chiral Halogenated 1-Substitutedamino-(n+1)-Alkanol compounds useful as inhibitors of cholesteryl ester transfer protein (CETP; plasma lipid transfer protein-I) and compounds, compositions and methods for treating atherosclerosis and other coronary artery diseases. Novel high yield, stereoselective processes for the preparation of the chiral substituted alkanol compounds from chiral and achiral intermediates are described.
摘要翻译： 本发明涉及可用作胆固醇酯转移蛋白（CETP;血浆脂质转移蛋白-I）抑制剂的取代芳基和杂芳基（R） - 手性卤代1-取代氨基 - （n + 1） - 烷醇化合物及其化合物，组合物和方法 用于治疗动脉粥样硬化和其他冠状动脉疾病。 描述了从手性和非手性中间体制备手性取代的烷醇化合物的新型高产率立体选择性方法。
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6.发明授权SUBSTITUTED POLYCYCLIC ARYL AND HETEROARYL $i(TERTIARY)-HETEROALKYLAMINES USEFUL FOR INHIBITING CHOLESTERYL ESTER TRANSFER PROTEIN ACTIVITY 有权用于抑制胆固醇酯转移蛋白活性的取代多环芳基和杂芳基亚胺基（第三配体） - 杂芳基胺
公开(公告)号：EP1115693B9
公开(公告)日：2007-12-19
申请号：EP99969710.5
申请日：1999-09-23
申请人： Monsanto Company
发明人： SIKORSKI, James, A. , DURLEY, Richard, C. , MISCHKE, Deborah, A. , REINHARD, Emily, J. , FOBIAN, Yvette, M. , TOLLEFSON, Michael, B. , WANG, Lijuan , GRAPPERHAUS, Margaret, L. , HICKORY, Brian, S. , MASSA, Mark, A. , NORTON, Monica, B. , VERNIER, William, F. , PARNAS, Barry, L. , PROMO, Michele, A. , HAMME, Ashton, T. , SPANGLER, Dale, P. , RUEPPEL, Melvin, L.
IPC分类号： C07C215/16 , C07C215/76 , C07C215/50 , C07C217/90 , C07C217/84 , C07D263/06 , C07D251/16 , A61K31/135 , A61K31/33
CPC分类号： C07D207/335 , A61K31/135 , A61K31/33 , C07C215/16 , C07C215/50 , C07C215/76 , C07C217/58 , C07C217/84 , C07C217/86 , C07C217/88 , C07C217/90 , C07C219/34 , C07C225/22 , C07C229/60 , C07C233/69 , C07C235/38 , C07C237/30 , C07C237/38 , C07C255/55 , C07C255/58 , C07C275/34 , C07C291/04 , C07C311/04 , C07C311/21 , C07C311/24 , C07C311/60 , C07C317/32 , C07C317/36 , C07C323/19 , C07C323/25 , C07C323/31 , C07C323/32 , C07C323/37 , C07C323/44 , C07C323/65 , C07C2601/02 , C07C2601/08 , C07C2601/14 , C07C2602/10 , C07C2603/18 , C07D209/08 , C07D213/26 , C07D213/30 , C07D213/643 , C07D213/66 , C07D213/85 , C07D239/34 , C07D251/16 , C07D251/42 , C07D263/06 , C07D295/135 , C07D295/192 , C07D307/14 , C07D307/42 , C07D307/52 , C07D309/12 , C07D333/20 , C07D333/28
摘要： The invention relates to substituted polycyclic aryl and heteroaryl tertiary-heteroalkylamine compounds useful as inhibitors of cholesteryl ester transfer protein (CETP; plasma lipid transfer protein-I) and compounds, compositions and methods for treating atherosclerosis and other coronary artery diseases.
摘要翻译： 本发明涉及可用作胆固醇酯转移蛋白（CETP;血浆脂质转移蛋白-I）抑制剂的取代的多环芳基和杂芳基叔杂烷基胺化合物以及用于治疗动脉粥样硬化和其他冠状动脉疾病的化合物，组合物和方法。
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7.发明公开SUBSTITUTED PYRIDINO PENTAAZAMACROCYLE COMPLEXES HAVING SUPEROXIDE DISMUTASE ACTIVITY 有权取代的吡啶基具有超氧化物歧化酶活性的PENTAAZAMAKROZYKLE COMPLEX
公开(公告)号：EP1212323A2
公开(公告)日：2002-06-12
申请号：EP00966722.1
申请日：2000-09-14
申请人： MONSANTO COMPANY
发明人： RILEY, Dennis , NEUMANN, William, L. , HENKE, Susan, L. , LENNON, Patrick , ASTON, Karl, W. , SALVEMINI, Daniela , SIKORSKI, James, A. , FOBIAN, Yvette , GRAPPERHAUS, Margaret, L. , KUSTURIN, Carrie, L.
IPC分类号： C07D471/08 , C07D471/06 , A61K31/555 , A61P29/00
CPC分类号： C07D471/06 , A61K31/555 , C07D471/08 , C07F13/005 , Y02A50/473
摘要： The present invention relates to compounds which are effective as catalysts for dismutating superoxide and, more particularly, the manganese or iron complexes of substituted, unsaturated heterocyclic pentaazacyclopentadecane ligands which catalytically dismutate superoxide.
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8.发明公开SUBSTITUTED N-ALIPHATIC-N-AROMATIC (TERTIARY)-HETEROALKYLAMINES USEFUL FOR INHIBITING CHOLESTERYL ESTER TRANSFER PROTEIN ACTIVITY 审中-公开取代的N-脂肪族基-N-芳族叔胺的杂烷基FOR胆固醇酯转移蛋白抑制活性
公开(公告)号：EP1115694A1
公开(公告)日：2001-07-18
申请号：EP99948431.4
申请日：1999-09-23
申请人： Monsanto Company
发明人： SIKORSKI, James, A. , DURLEY, Richard, C. , GRAPPERHAUS, Margaret, L. , MISCHKE, Deborah, A. , REINHARD, Emily, J. , PARNAS, Barry, L. , RUEPPEL, Melvin, L.
IPC分类号： C07C217/52 , C07C215/16 , C07C215/76 , C07C215/50 , C07C217/82 , C07C217/54 , C07D213/74 , C07D309/14 , A61K31/135 , A61K31/33
CPC分类号： C07D493/08 , C07C215/08 , C07C215/12 , C07C217/16 , C07C217/20 , C07C217/30 , C07C217/52 , C07C217/58 , C07C217/90 , C07C229/30 , C07C2601/02 , C07C2601/08 , C07C2601/14 , C07C2602/42 , C07C2603/74 , C07D307/14
摘要： The invention relates to substituted N-Aliphatic-N-Aromatic tertiary-Heteroalkylamine compounds useful as inhibitors of cholesteryl ester transfer protein (CETP; plasma lipid transfer protein-I) and compounds, compositions and methods for treating atherosclerosis, dyslipidemia, and other coronary artery disease.
摘要翻译： 本发明涉及substituiertem的N-脂肪族-N-芳香族叔杂烷基化合物作为胆固醇酯转移蛋白的抑制剂（CETP;血浆脂质转移蛋白-I）和化合物，组合物和用于治疗动脉粥样硬化，血脂异常的方法，和其他的冠状动脉 疾病。
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