公开(公告)号：EP1675508A2

公开(公告)日：2006-07-05

申请号：EP04780392.9

申请日：2004-08-05

申请人： Nuvasive, Inc.

发明人： MILES, Patrick ,  MARTINELLI, Scot ,  ARAMBULA, Jared ,  GHARIB, James ,  FARQUHAR, Allen ,  KAULA, Norbert ,  BLEWETT, Jeffrey

IPC分类号： A61B5/04

CPC分类号： A61B5/04001 ,  A61B5/4041 ,  A61B17/1626 ,  A61B17/1671 ,  A61B17/3472 ,  A61B17/848 ,  A61N1/36003 ,  A61N1/36014

摘要： The present invention involves systems (20) and related methods for performing dynamic pedicle integrity assessments involving the use of neurophysiology.

公开(公告)号：EP2348981B1

公开(公告)日：2017-08-30

申请号：EP09820909.1

申请日：2009-10-15

申请人： Nuvasive, Inc.

发明人： GHARIB, James ,  FARQUHAR, Allen ,  LAYMAN, Doug ,  POTHIER, Albert

IPC分类号： A61B5/05 ,  A61B5/0484 ,  A61B5/0488

CPC分类号： A61B5/0484 ,  A61B5/0488 ,  A61B5/407

公开(公告)号：EP1804660A2

公开(公告)日：2007-07-11

申请号：EP05804448.8

申请日：2005-10-07

申请人： NuVasive, Inc.

发明人： GHARIB, James ,  FARQUHAR, Allen ,  HOWELL, Kelli ,  LAYMAN, Doug ,  POTHIER, Albert

IPC分类号： A61B5/05 ,  A61B5/04

CPC分类号： A61B19/46 ,  A61B5/04001 ,  A61B5/0488 ,  A61B5/1106 ,  A61B5/4836 ,  A61B5/6823 ,  A61B17/02 ,  A61B17/17 ,  A61B17/8875 ,  A61B90/06 ,  A61B2505/05 ,  A61B2562/046 ,  A61N1/0456

摘要： The present invention involves a system and methods for assessing the state of the neuromuscular pathway to ensure further nerve tests aimed at detecting at least one of a breach in a pedicle wall, nerve proximity, nerve direction, and nerve pathology, are not conducted when neuromuscular blockade levels may decrease the reliability of the results.

公开(公告)号：EP1675508B1

公开(公告)日：2016-04-20

申请号：EP04780392.9

申请日：2004-08-05

申请人： NuVasive, Inc.

发明人： MILES, Patrick ,  MARTINELLI, Scot ,  ARAMBULA, Jared ,  GHARIB, James ,  FARQUHAR, Allen ,  KAULA, Norbert ,  BLEWETT, Jeffrey

IPC分类号： A61B5/04 ,  A61N1/36 ,  A61B17/16 ,  A61B17/34 ,  A61B17/84

CPC分类号： A61B5/04001 ,  A61B5/4041 ,  A61B17/1626 ,  A61B17/1671 ,  A61B17/3472 ,  A61B17/848 ,  A61N1/36003 ,  A61N1/36014

公开(公告)号：EP1450681B1

公开(公告)日：2011-01-05

申请号：EP02789358.5

申请日：2002-10-30

申请人： Nuvasive, Inc.

发明人： MILES, Patrick ,  MARTINELLI, Scot ,  FINLEY, Eric ,  ELBANNA, Jamil ,  GHARIB, James ,  FARQUHAR, Allen ,  KAULA, Norbert ,  BLEWETT, Jeffrey DI

IPC分类号： A61N1/05 ,  A61B5/04

CPC分类号： A61B5/0488 ,  A61B5/4893 ,  A61B17/7092 ,  A61N1/0551 ,  A61N1/08

摘要： The present invention involves systems (20) and related methods for performing percutaneous pedicle integrity assessments involving the use of neurophysiology. The fundamental method steps for performing the percutaneous pedicle integrity assessments include (a) percutaneously introducing an insulation member to a pedicle target site; (b) establishing electrical communication between a stimulation element and an interior of a pedicle screw pilot hole; (c) applying a stimulation signal to the stimulation element; and (d) monitoring to assess whether nerves adjacent the pedicle are innervating as a result of the step of applying the stimulation signal to the stimulation element.

公开(公告)号：EP1933935A2

公开(公告)日：2008-06-25

申请号：EP06815356.8

申请日：2006-09-22

申请人： Nuvasive, Inc.

发明人： CALANCIE, Blair ,  GHARIB, James ,  FARQUHAR, Allen ,  LAYMAN, Doug

IPC分类号： A61N1/08

CPC分类号： A61B5/0488 ,  A61B5/4041 ,  A61B5/407 ,  A61B5/4893 ,  A61N1/36003 ,  A61N1/36014 ,  A61N1/37247

摘要： The present invention includes a system and methods aimed at surgery, and more particularly to a system and methods for monitoring nervous tissue to assess the integrity of a pedicle wall during or after pilot hole formation and before, during, or after screw implantation, particularly in the thoracic spine. The system also performs other neurophysiologic assessments including, but not necessarily limited to, neuromuscular pathway status, nerve proximity detection, nerve pathology monitoring, and spinal cord health monitoring.

公开(公告)号：EP1435828A2

公开(公告)日：2004-07-14

申请号：EP02778359.6

申请日：2002-09-25

申请人： Nuvasive Inc.

发明人： GHARIB, James ,  KAULA, Norbert ,  BLEWETT, Jeffrey DI ,  FARQUHAR, Allen ,  FINLEY, Eric ,  ELBANNA, Jamil ,  MARTINELLI, Scot

IPC分类号： A61B1/00

CPC分类号： A61F2/4611 ,  A61B1/32 ,  A61B5/04001 ,  A61B5/0492 ,  A61B5/4893 ,  A61B5/6828 ,  A61B5/6831 ,  A61B17/0218 ,  A61B17/3417 ,  A61B17/3421 ,  A61B17/3423 ,  A61B34/20 ,  A61B34/25 ,  A61B90/36 ,  A61B90/37 ,  A61B2017/00039 ,  A61B2017/00199 ,  A61B2017/0262 ,  A61B2034/2053 ,  A61B2034/2072 ,  A61F2/4455 ,  A61F2002/4635 ,  A61N1/0551 ,  A61N1/0553 ,  A61N1/36 ,  A61N1/36135 ,  A61N1/36142 ,  A61N1/36157 ,  A61N1/37247

摘要： The present invention involves systems and related methods for performing surgical procedures and assessments, including the use of neurophysiology-based monitoring to: (a) determine nerve proximity and nerve direction to surgical instruments employed in accessing a surgical target site; (b) assess the pathology (health or status) of a nerve or nerve root before, during, or after a surgical procedure; and/or (c) assess pedicle integrity before, during or after pedicle screw placement, all in an automated, easy to use, and easy to interpret fashion so as to provide a surgeon-driven system.

摘要翻译： 本发明涉及用于执行外科手术和评估的系统和相关方法，包括使用基于神经生理学的监测来：（a）确定在进入手术靶位点时使用的手术器械的神经接近度和神经方向; （b）在外科手术之前，期间或之后评估神经或神经根的病理学（健康或状况）; 和/或（c）在椎弓根螺钉放置之前，期间或之后评估椎弓根完整性，全部采用自动化，易于使用和易于解释的方式，以提供外科医生驱动的系统。

公开(公告)号：EP3231365A1

公开(公告)日：2017-10-18

申请号：EP17172919.7

申请日：2009-10-15

申请人： Nuvasive, Inc.

发明人： GHARIB, James ,  FARQUHAR, Allen ,  LAYMAN, Doug ,  POTHIER, Albert

IPC分类号： A61B5/0484 ,  A61B5/0488 ,  A61B5/05

CPC分类号： A61B5/0484 ,  A61B5/0488 ,  A61B5/407

摘要： A system (10) for performing somatosensory evoked potential monitoring during surgery comprises a stimulator (22) to deliver an electrical stimulation signal to a peripheral nerve, a sensor (24) to detect somatosensory responses evoked by the stimulation signal and a control unit (12) communicating with the stimulator and the sensor. The control unit is configured to direct transmission of the stimulation signal and receive the response data from the sensor. In addition, the control unit is configured to optimize signal parameters of the stimulation signal based on the response data, assess spinal cord health by identifying a relationship between the response to a first stimulation and to a second stimulation, the relationship being at least one of a change in latency and a change in amplitude between the first and second responses. The control unit is also configured to communicate the assessment to a user.

摘要翻译： 用于在手术期间执行体感诱发电位监测的系统（10）包括：将电刺激信号递送至周围神经的刺激器（22），检测由刺激信号引起的体感反应的传感器（24），以及控制单元（12 ）与刺激器和传感器进行通信。 控制单元被配置为引导刺激信号的传输并从传感器接收响应数据。 另外，控制单元被配置为基于响应数据优化刺激信号的信号参数，通过识别对第一刺激和第二刺激的响应之间的关系来评估脊髓健康，所述关系是以下中的至少一个： 第一和第二响应之间等待时间的改变和振幅的改变。 控制单元还被配置为将评估传达给用户。

公开(公告)号：EP2142087B1

公开(公告)日：2016-06-29

申请号：EP08742578.1

申请日：2008-04-03

申请人： Nuvasive Inc.

发明人： GHARIB, James ,  FARQUHAR, Allen ,  LAYMAN, Doug ,  SCHOLL, Thomas ,  POTHIER, Albert ,  MARTINELLI, Scot ,  IVANKO, Dave ,  FERNANDES, Antonio

IPC分类号： A61B5/04 ,  A61B5/0488 ,  A61B5/0492 ,  A61B17/16 ,  A61B17/17 ,  A61B5/00 ,  A61N1/05 ,  A61N1/08 ,  A61B5/05 ,  A61N1/36 ,  A61B17/00

CPC分类号： A61B5/04001 ,  A61B5/0488 ,  A61B5/0492 ,  A61B5/05 ,  A61B5/407 ,  A61B5/4566 ,  A61B5/4893 ,  A61B5/7271 ,  A61B5/7405 ,  A61B5/742 ,  A61B5/7455 ,  A61B5/746 ,  A61B17/00 ,  A61B17/1626 ,  A61B17/1671 ,  A61B17/1757 ,  A61B34/20 ,  A61B2017/00022 ,  A61B2017/00026 ,  A61N1/0551 ,  A61N1/08 ,  A61N1/36014

公开(公告)号：EP1846094A2

公开(公告)日：2007-10-24

申请号：EP06720282.0

申请日：2006-02-02

申请人： Nuvasive, Inc.

发明人： GHARIB, James ,  FARQUHAR, Allen ,  LAYMAN, Doug ,  BALZER, Jeff ,  CALANCIE, Blair

IPC分类号： A61N1/18

CPC分类号： A61B5/0488 ,  A61B5/4041 ,  A61B5/407 ,  A61B5/4504 ,  A61B5/4893 ,  A61B5/7475 ,  A61N1/0548 ,  A61N1/36003 ,  A61N1/36014 ,  A61N1/37247

摘要： A system (10) for performing neurophysiologic assessments during surgery comprises a stimulator (21) to deliver an electrical stimulation signal to a peripheral nerve of a patient, the peripheral nerve exiting the spinal cord inferior to a surgical target site at the patient's spine, at least one sensor (32) to detect electrical action potential from nervous tissue situated superior to the surgical target site and a control unit (12) in communication with the stimulator (21) and the sensor (32). The control unit directs transmission of the stimulation signal, receives electrical action potential data from the sensor, assesses spinal cord health by identifying a relationship between the stimulation signal and the action potential and communicates the relationship to a user.