公开(公告)号：EP2376515A1

公开(公告)日：2011-10-19

申请号：EP09793688.4

申请日：2009-12-23

申请人： Pharmasset, Inc.

发明人： CHUN, Byoung-kwon ,  DU, Jinfa ,  RACHAKONDA, Suguna ,  ROSS, Bruce, S. ,  SOFIA, Michael, Joseph ,  PAMULAPATI, Ganapati, Reddy ,  CHANG, Wonsuk ,  ZHANG, Hai-ren ,  NAGARATHNAM, Dhanapalan

IPC分类号： C07H19/167 ,  C07H19/20 ,  C07H19/213 ,  A61K31/7076 ,  A61P31/14

CPC分类号： C07H19/20 ,  C07H1/00 ,  C07H5/02 ,  C07H15/04 ,  C07H19/167 ,  C07H19/213 ,  Y02P20/55

摘要： A process for preparing phosphoramidate prodrugs or cyclic phosphate prodrugs of nucleoside derivatives, which is a compound, its stereoisomers, salts (acid or basic addition salts), hydrates, solvates, or crystalline forms thereof.

公开(公告)号：EP2203462A2

公开(公告)日：2010-07-07

申请号：EP08732818.3

申请日：2008-03-26

申请人： Pharmasset, Inc.

发明人： SOFIA, Michael, Joseph ,  DU, Jinfa ,  WANG, Peiyuan ,  NAGARATHNAM, Dhanapalan

IPC分类号： C07H19/10 ,  C07H19/20 ,  C07H19/04 ,  C07H19/06 ,  A61K31/7064 ,  A61K31/7076 ,  A61K31/706 ,  A61P31/14

CPC分类号： A61K31/7072 ,  A61K31/706 ,  A61K31/7064 ,  A61K31/7068 ,  A61K31/7076 ,  A61K45/06 ,  C07D417/14 ,  C07H17/02 ,  C07H19/04 ,  C07H19/06 ,  C07H19/073 ,  C07H19/10 ,  C07H19/20 ,  Y02A50/463

摘要： Disclosed herein are phosphoramidate prodrugs of nucleoside derivatives for the treatment of viral infections in mammals, which is a compound represented by the following structure: Also disclosed are methods of treatment, uses, and processes for preparing the compounds represented by formula I.

公开(公告)号：EP2376514A2

公开(公告)日：2011-10-19

申请号：EP09795668.4

申请日：2009-12-23

申请人： Pharmasset, Inc.

发明人： BAO, Donghui ,  CHANG, Wosnuk ,  NAGARATHNAM, Dhanapalan ,  SOFIA, Michael, Joseph

IPC分类号： C07H19/04 ,  C07H21/00

CPC分类号： C07H19/20 ,  C07H19/10

摘要： A purified compound having activity against hepatitis C virus is disclosed.

公开(公告)号：EP2376088A2

公开(公告)日：2011-10-19

申请号：EP09795670.0

申请日：2009-12-23

申请人： Pharmasset, Inc.

发明人： SOFIA, Michael, Joseph ,  DU, Jinfa ,  WANG, Peiyuan ,  NAGARATHNAM, Dhanapalan

IPC分类号： A61K31/7076

CPC分类号： C07H19/20

摘要： A nucleoside compound having activity against hepatitis C virus is disclosed.

摘要翻译： 公开了具有抗丙型肝炎病毒活性的核苷化合物。

公开(公告)号：EP2313422A2

公开(公告)日：2011-04-27

申请号：EP09763386.1

申请日：2009-06-08

申请人： Pharmasset, Inc.

发明人： DU, Jinfa ,  NAGARATHNAM, Dhanapalan ,  PAMULAPATI, Ganapati, Reddy ,  ROSS, Bruce, S. ,  SOFIA, Michael, Joseph

IPC分类号： C07H19/10 ,  C07H19/20 ,  C07D473/18

CPC分类号： C07D473/18 ,  C07H19/10 ,  C07H19/20

摘要： Cyclic phosphate of nucleoside derivatives for the treatment of viral infections in mammals, which is a compound, its stereoisomers, salts (acid or basic addition salts), hydrates, solvates, or crystalline forms thereof, represented by the following structure: Formula (I)