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1.发明公开
公开(公告)号：EP1658283A2
公开(公告)日：2006-05-24
申请号：EP04735296.8
申请日：2004-05-28
发明人： SALMAN, Mohammad , SATTIGERI, Jitendra , KUMAR, Yatendra , ARYAN, Ram Chander , RAMANATHAN, Vikram Krishna , CHUGH, Anita
IPC分类号： C07D405/06
CPC分类号： C07D207/34 , A61K31/40 , C07C69/716 , C07C69/738 , C07D401/12 , C07D403/04 , C07D405/06 , C07D405/14 , C07D413/04
摘要： The present invention relates to substituted pyrrole derivatives of formula I, which can be used as 3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reductase inhibitors. Compounds disclosed herein can function as cholesterol lowering agents and can be used for the treatment of cholesterol-related diseases and related symptoms. Processes for the preparation of disclosed compounds are provided, as well as pharmaceutical compositions containing the disclosed compounds, and methods of treating cholesterol-related diseases and related symptoms. Its pharmaceutically acceptable salts, pharmaceutically acceptable solvates, prodrugs, metabolites, polymorphs, tautomers, racemates, pure enantiomers, diastereoisomers or N-oxides wherein Formula (II).
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公开(公告)号：EP1643988A1
公开(公告)日：2006-04-12
申请号：EP04735291.9
申请日：2004-05-28
IPC分类号： A61K31/4025 , C07D417/12 , C07D417/14 , A61P3/06 , C07D401/04 , C07D405/14 , C07D405/04 , C07D409/04 , C07D409/14 , C07D403/12 , A61P9/10
CPC分类号： C07D401/04 , C07D403/12 , C07D405/04 , C07D405/14 , C07D409/04 , C07D409/14 , C07D417/12 , C07D417/14
摘要： The present invention relates to substituted pyrrole derivatives of Formula (I), wherein (Y), with the proviso that one of R2, R4 and R5 is a heterocycle and with the further provision that if R2 is not a heterocycle then either R4 or R5 alone is not unsubstituted pyridyl, which can be used as 3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reductase inhibitors. Compounds disclosed herein can function as cholesterol lowering agents and can be used for the treatment of cholesterol-related diseases and related symptoms. Processes for the preparation of disclosed compounds are provided, as well as pharmaceutical compositions containing the disclosed compounds, and methods of treating cholesterol-related diseases and related symptoms.
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公开(公告)号：EP1606279A1
公开(公告)日：2005-12-21
申请号：EP04715971.0
申请日：2004-03-01
IPC分类号： C07D401/12 , A61K31/4439 , A61P1/04
CPC分类号： A61K31/4439
摘要： This invention relates to polymorphic forms of the S-enantiomer of omeprazole which is S-5-methoxy-2-[[(4-methoxy-3,5-dimethyl-2-pyridinyl)-methyl]sulfinyl]-1Hbenzimidazole. The invention also relates to processes for preparing the polymorphic forms. More particularly, it relates to the preparation of two polymorphic forms of Someprazole, referred to as `Form I' and `Form II' and pharmaceutical compositions that include the `Form I' and `Form II'.
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公开(公告)号：EP1578733A1
公开(公告)日：2005-09-28
申请号：EP02781613.1
申请日：2002-12-10
发明人： KUMAR, Yatendra , MEERAN, Hashim N.P.N.,Uzhijethu House , DE, Shantanu , RAFEEQ, Mohammad , SATHYANARAYANA, Swargam
IPC分类号： C07D239/42 , C07F9/535 , C07F7/18
CPC分类号： C07D239/42 , C07F7/1856 , C07F9/5352
摘要： The present invention relates to a process for the preparation of rosuvastatin calcium, a promising new HMG-CoA reductase inhibitor.
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公开(公告)号：EP1395530A1
公开(公告)日：2004-03-10
申请号：EP02727916.5
申请日：2002-05-17
发明人： KUMAR, Yatendra , TYAGI, Om, Dutt , ROHTAGI, Amit
CPC分类号： C07C319/28 , C12N9/48 , C07C323/59
摘要： The present invention relates to a cost effective and industrially advantageous process for the preparation of amorphous cilastatin sodium.
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公开(公告)号：EP1383741A2
公开(公告)日：2004-01-28
申请号：EP02703802.5
申请日：2002-03-14
IPC分类号： C07C303/00 , C07C307/00 , C07C309/00 , C07C311/00 , C07D223/04 , C07D487/00 , C07D491/00 , C07D498/00 , C07D513/00
CPC分类号： C07C303/28 , C07D223/16 , C07C309/65
摘要： The present invention relates to an improved process for the preparation of trifluoromethanesulfonic ester of ethyl (R)-2-hydroxy-4-phenylbutyrate, referred to here as triflate in structural Formula I, and to the use of this compound as intermediate for the preparation of ACE (Angiotensin Converting Enzyme) inhibitor, benazepril.
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公开(公告)号：EP1608371A1
公开(公告)日：2005-12-28
申请号：EP04722342.5
申请日：2004-03-22
发明人： KUMAR, Yatendra , PRASAD, Mohan , NATH, Asok , MAHESHWARI, Nitin
IPC分类号： A61K31/4465 , C07D211/32 , C07D213/50
CPC分类号： C07D211/32 , A61K31/4465 , C07D213/50
摘要： The invention relates to processes for the preparation of piperidylmethyl-indanones, and to the use of these compounds as intermediates for the preparation of benzyl-piperidylmethyl-indanones which are active compounds for the treatment of CNS disorders. The invention also relates to a process for the preparation of donepezil or a pharmaceutically acceptable salt thereof, and pharmaceutical compositions that include the donepezil or a pharmaceutically acceptable salt thereof.
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8.发明公开A PROCESS FOR THE PREPARATION OF GANCICLOVIR INTERMEDIATE N2-ACETYL-9-(1,3-DIACETOXY-2-PROPOXYMETHYL) GUANINE 审中-公开PROCESS FOR更昔洛韦中间体N 2 - 乙酰基-9-（1,3-二乙酰氧基-2-丙氧甲基）鸟嘌呤的制备
公开(公告)号：EP1453833A2
公开(公告)日：2004-09-08
申请号：EP02775077.7
申请日：2002-10-15
IPC分类号： C07D473/18
CPC分类号： C07D473/00 , C07D473/18
摘要： The present invention relates to an improved process for the preparation of N2-acetyl-9-(1,3-diacetoxy-2-propoxymethyl)guanine, referred to here as the N-9 alkylated isomer, useful as intermediate for the preparation of antiviral compound, ganciclovir, including addition of a monoacetyl guanine, and optionally, addition of N2-acetyl-9-(1,3-diacetoxy-2-propoxymethyl) guanine, referred to herein as the N-7 alkylated isomer.
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公开(公告)号：EP1419135A1
公开(公告)日：2004-05-19
申请号：EP02755412.0
申请日：2002-08-02
IPC分类号： C07C209/02
CPC分类号： C07C213/02 , C07C217/62
摘要： The present invention relates to a cost effective and industrially advantageous process for the preparation of tolterodine and pharmaceutically acceptable salts thereof.
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10.发明公开PROCESS FOR THE PREPARATION OF CRYSTALLINE N-FORMIMIDOYL THIENAMYCIN MONOHYDRATE (IMIPENEM MONOHYDRATE) 有权用于生产结晶N-亚胺甲基硫霉素一水合物（亚胺培南一水合物）
公开(公告)号：EP1334105A1
公开(公告)日：2003-08-13
申请号：EP01980805.4
申请日：2001-11-05
IPC分类号： C07D477/20
CPC分类号： C07D477/20
摘要： The present invention relates to a cost effective and commercially viable process for the preparation of crystalline N-formimidoyl thienamycin monohydrate (Imipenem monohydrate) of Formula I.
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