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1.发明公开SCHNELLE REAKTIONSKINETIK VON ENZYMEN MIT NIEDRIGER AKTIVITÄT IN TROCKENEN CHEMIESCHICHTEN 有权快速反应动力学。酶低活性的干化学LAYERS
公开(公告)号：EP2398909A1
公开(公告)日：2011-12-28
申请号：EP10704923.1
申请日：2010-02-12
发明人： HORN, Carina , GÄSSLER-DIETSCHE, Claudia , HEINDL, Dieter , HÖNES, Joachim , MEIER, Thomas , SCHMUCK, Rainer
IPC分类号： C12Q1/32
摘要： The present invention relates to a method for determining an analyte and to a diagnostic element suitable therefor.
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2.发明授权SCHNELLE REAKTIONSKINETIK VON ENZYMEN MIT NIEDRIGER AKTIVITÄT IN TROCKENEN CHEMIESCHICHTEN 有权快速反应动力学。酶低活性的干化学LAYERS
公开(公告)号：EP2398909B1
公开(公告)日：2015-07-22
申请号：EP10704923.1
申请日：2010-02-12
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公开(公告)号：EP3562841A1
公开(公告)日：2019-11-06
申请号：EP17821604.0
申请日：2017-12-19
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公开(公告)号：EP4107182A1
公开(公告)日：2022-12-28
申请号：EP21705555.7
申请日：2021-02-19
申请人： Universiteit Maastricht , F. Hoffmann-La Roche AG , Roche Diagnostics GmbH , Academisch ziekenhuis Maastricht
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公开(公告)号：EP3562845A2
公开(公告)日：2019-11-06
申请号：EP17832237.6
申请日：2017-12-22
发明人： GERG, Michael , HEINDL, Dieter , HILLRINGHAUS, Lars , HIRZEL, Klaus , HOJER, Caroline Dorothea , HUBER, Florian , JOSEL, Hans-Peter , MEIER, Thomas , SCHRAEML, Michael , VOSS, Edgar
IPC分类号： C07K16/44 , C07D495/04 , G01N33/82 , A61K47/51 , A61K31/4188 , C07K16/00 , C07K16/40 , G01N33/53
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6.发明公开NOVEL COMPOUNDS USEFUL FOR FRET AND METHODS RELATED THERETO 审中-公开ZUGEHÖRIGEVERFAHREN上的VERBINDUNGENFÜRFRE
公开(公告)号：EP3004372A1
公开(公告)日：2016-04-13
申请号：EP14728188.5
申请日：2014-06-04
IPC分类号： C12Q1/00 , C12Q1/26 , G01N33/533 , G01N33/535 , G01N33/542 , G01N33/573 , G01N33/58 , C12Q1/68
CPC分类号： C07H19/207 , C12Q1/26 , G01N21/6428 , G01N33/533 , G01N33/535 , G01N33/542 , G01N33/5735 , G01N33/581 , G01N33/582 , G01N2201/062 , G01N2333/90248
摘要： The invention relates to compounds, which are useful for intramolecular fluorescence resonance energy transfer (FRET), comprising the oxidized form of a carbaNADH-based first fluorophore and a second fluorophore that is excitable at a wave-length of between 445 to 540 nm and that has an emission maximum of greater than 560 nm, and methods, kits and compositions related thereto.
摘要翻译： 本发明还涉及可用于分子内荧光共振能量转移（FRET）的化合物，其包含氧化形式的基于carbaNADH的第一荧光团和第二荧光团，其波长在445至540之间是可激发的 nm，并且具有大于560nm的发射最大值，以及与其相关的方法，试剂盒和组合物。
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公开(公告)号：EP3781600A1
公开(公告)日：2021-02-24
申请号：EP19715804.1
申请日：2019-04-16
发明人： DUEFEL, Hartmut , ENGEL, Alfred , KRONER, Frank , MEIER, Thomas , RUTZ, Sandra , SCHRAEML, Michael , TABARES, Gloria , KURTKAYA, Ulrike , PINCHUK, Boris , ZIMMERMANN, Christina
IPC分类号： C07K16/40 , G01N33/577
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公开(公告)号：EP3394086A1
公开(公告)日：2018-10-31
申请号：EP16822170.3
申请日：2016-12-22
IPC分类号： C07K14/435 , C09K11/07 , C12Q1/68
CPC分类号： C12Q1/68 , C09K11/07 , C12N9/1241 , C12Q1/686 , C12Q2527/101 , C12Q2527/127 , C12Q2531/113 , C12Q2563/107 , C12Q2563/119
摘要： The present disclosure provides an aqueous composition comprising a purified thermostable polypeptide with biological activity, and a purified thermolabile water-soluble substance which in a functional conformation at a permissive temperature absorbs light and/or exhibits fluorescence, wherein the maximal permissive temperature of the polypeptide is above the maximal permissive temperature of the substance. The present disclosure further provides methods employing such a composition, and kits containing ingredients to form such a composition.
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公开(公告)号：EP1360284B1
公开(公告)日：2008-07-16
申请号：EP02750504.9
申请日：2002-02-08
发明人： MUELLER, Rainer , THALHOFER, Johann-Peter , REXER, Bernhard , SCHMUCK, Rainer , GEIPEL, Frank , GLASER, Stephan , SCHOEN, Helmut , MEIER, Thomas , RUDOLPH, Rainer , LILIE, Hauke , SCHOTT, Bjoern
CPC分类号： C12N9/58 , C07K2319/00 , C12Y304/21064
摘要： The invention relates to recombinant proteinase K and to a method for producing recombinant proteinase K, which is characterised by the following steps: a) transformation of a host cell containing a recombinant nucleic acid that codes for the zymogenic precursor of the proteinase K, b) cultivation of the host cell in such a way that the zymogenic precursor of proteinase K occurs in the form of inclusion bodies in said host cell, c) isolation of the inclusion bodies and re-naturing under conditions, from which the protease part of the zymogenic precursor emerges in its natural conformation, d) activation and purification of the re-natured proteinase K.
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公开(公告)号：EP1360284A2
公开(公告)日：2003-11-12
申请号：EP02750504.9
申请日：2002-02-08
发明人： MUELLER, Rainer , THALHOFER, Johann-Peter , REXER, Bernhard , SCHMUCK, Rainer , GEIPEL, Frank , GLASER, Stephan , SCHOEN, Helmut , MEIER, Thomas , RUDOLPH, Rainer , LILIE, Hauke , SCHOTT, Bjoern
CPC分类号： C12N9/58 , C07K2319/00 , C12Y304/21064
摘要： The invention relates to recombinant proteinase K and to a method for producing recombinant proteinase K, which is characterised by the following steps: a) transformation of a host cell containing a recombinant nucleic acid that codes for the zymogenic precursor of the proteinase K, b) cultivation of the host cell in such a way that the zymogenic precursor of proteinase K occurs in the form of inclusion bodies in said host cell, c) isolation of the inclusion bodies and re-naturing under conditions, from which the protease part of the zymogenic precursor emerges in its natural conformation, d) activation and purification of the re-natured proteinase K.
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