公开(公告)号：EP1049721A1

公开(公告)日：2000-11-08

申请号：EP99900524.2

申请日：1999-01-13

申请人： Sanofi-Synthélabo ,  Akzo Nobel N.V.

发明人： BASTEN, Johannes ,  DREEF-TROMP, Cornelia ,  DRIGUEZ, Pierre-Alexandre ,  DUCHAUSSOY, Philippe ,  HERBERT, Jean-Marc ,  PETITOU, Maurice ,  VAN BOECKEL, Constant

IPC分类号： C08B37/00 ,  A61K31/725

CPC分类号： C08B37/0063

摘要： The invention relates to synthetic polysaccharides in an acid form and their pharmaceutically acceptable salts, the anionic form of which complies with one of the formulas (I) to (V) described in claim 1. Said polysaccharides can be used in the treatment of diseases linked to coagulation disorders.

公开(公告)号：EP1791872A1

公开(公告)日：2007-06-06

申请号：EP05805571.6

申请日：2005-09-07

申请人： Sanofi-Aventis

发明人： DUCHAUSSOY, Philippe ,  HERAULT, Jean, Pascal ,  HERBERT, Jean, Marc ,  PETITOU, Maurice ,  SAVI, Pierre

IPC分类号： C08B37/00 ,  A61K31/715

CPC分类号： C08B37/00 ,  A61K31/715 ,  A61L27/34 ,  A61L31/10 ,  C08L5/00

摘要： The invention concerns novel biotinylated hexadecasaccharides of general formula (I) wherein: Biot is a biotin derivative; R, R1 and R2, represent independently of one another a C1-C6 alkoxy or and -OSO3; R3 represents a C1-C6 alkoxy or an -OSO3, or R3 constitutes a -O-CH2- bridge; Pe represents a saccharide concatenation; as well as their pharmaceutically acceptable salts, and their use as medicines.

公开(公告)号：EP1049721B1

公开(公告)日：2001-11-21

申请号：EP99900524.2

申请日：1999-01-13

申请人： SANOFI-SYNTHELABO ,  Akzo Nobel N.V.

发明人： BASTEN, Johannes ,  DREEF-TROMP, Cornelia ,  DRIGUEZ, Pierre-Alexandre ,  DUCHAUSSOY, Philippe ,  HERBERT, Jean-Marc ,  PETITOU, Maurice ,  VAN BOECKEL, Constant

IPC分类号： C08B37/00 ,  A61K31/715

CPC分类号： C08B37/0063

摘要： The invention relates to synthetic polysaccharides in an acid form and their pharmaceutically acceptable salts, the anionic form of which complies with one of the formulas (I) to (V) described in claim 1. Said polysaccharides can be used in the treatment of diseases linked to coagulation disorders.

公开(公告)号：EP0904299A1

公开(公告)日：1999-03-31

申请号：EP97928337.0

申请日：1997-06-11

申请人： SANOFI ,  Akzo Nobel N.V.

发明人： DUCHAUSSOY, Philippe ,  HERBERT, Jean-Marc ,  JAURAND, Guy ,  PETITOU, Maurice ,  VAN BOECKEL, Constant

IPC分类号： A61K31 ,  A61K45 ,  A61P7 ,  A61P31 ,  A61P35 ,  A61P37 ,  C08B37

CPC分类号： C08B37/006 ,  A61K31/435 ,  A61K31/445 ,  A61K31/505 ,  A61K31/60 ,  A61K31/715 ,  A61K45/06 ,  C08B37/00

摘要： Synthetic polysaccharides are disclosed containing 8-24 monosaccharide units made up of a concatenation of disaccharides consisting of a uronic acid and a hexose, wherein the hydroxyl groups of the polysaccharides are etherified with a C1-6 alkyl group or esterified in the form of a sulpho group, each disaccharide being at least monoetherified; and salts thereof, are disclosed.

公开(公告)号：EP2464359A2

公开(公告)日：2012-06-20

申请号：EP10761048.7

申请日：2010-08-12

申请人： SANOFI

发明人： DUCHAUSSOY, Philippe ,  FONS, Pierre ,  FROIDBISE, Alexandre

IPC分类号： A61K31/737 ,  C08B37/00 ,  A61P7/00 ,  A61P9/00 ,  A61P11/00 ,  A61P17/00 ,  A61P19/00 ,  A61P21/00 ,  A61P25/00 ,  A61P27/02 ,  A61P37/00

CPC分类号： C08B37/0063 ,  A61K31/737 ,  C07H11/00 ,  C07H15/04 ,  C07H15/203 ,  C08B37/0075

摘要： The invention relates to FGF receptor-activating N-sulfate oligosaccharides having Formula (I), wherein R
1 , R
4 , R
6 , and R
8 are –OSO
3 - or hydroxyl groups, R
2 is an –O-alkyl group or a monosaccharide having Formula (II), R
3 is a disaccharide having Formula (III), R
5 is a disaccharide having Formula (IV), R
7 is a hydroxyl group or a disaccharide having Formula (VI), and R
9 is a hydroxyl or –O-alkyl group or a disaccharide having Formula (VII), where R
10 is an –O-alkyl group. The invention further relates to the preparation of said oligosaccharides and to the therapeutic use thereof.

公开(公告)号：EP1322673B1

公开(公告)日：2007-09-26

申请号：EP01972171.1

申请日：2001-09-20

申请人： Sanofi-Aventis

发明人： DUCHAUSSOY, Philippe ,  HERBERT, Jean-Marc ,  PETITOU, Maurice ,  SAVI, Pierre

IPC分类号： C08B37/00 ,  A61K31/715

CPC分类号： C08B37/006 ,  A61K31/715 ,  C08B37/00 ,  C08B37/0063

摘要： The invention concerns novel synthetic polysaccharides, with antithrombotic activity, having at least a covalent bond with biotin or a biotin derivative and a method using avidin or streptavidin for neutralising said polysaccharides.

摘要翻译： 本发明涉及新的合成的多糖与抗血栓形成活性表现出与生物素或生物素衍生物和一种方法，用人抗生物素蛋白或链霉这使得能够以中和论文多糖的至少一个共价键。

公开(公告)号：EP1322673A1

公开(公告)日：2003-07-02

申请号：EP01972171.1

申请日：2001-09-20

申请人： SANOFI-SYNTHELABO ,  Akzo Nobel N.V.

发明人： DUCHAUSSOY, Philippe ,  HERBERT, Jean-Marc ,  PETITOU, Maurice ,  SAVI, Pierre

IPC分类号： C08B37/00 ,  A61K31/715

CPC分类号： C08B37/006 ,  A61K31/715 ,  C08B37/00 ,  C08B37/0063

摘要： The invention concerns novel synthetic polysaccharides, with antithrombotic activity, having at least a covalent bond with biotin or a biotin derivative and a method using avidin or streptavidin for neutralising said polysaccharides.

公开(公告)号：EP1032579A1

公开(公告)日：2000-09-06

申请号：EP98958248.1

申请日：1998-11-16

申请人： Akzo Nobel N.V. ,  Sanofi-Synthélabo

发明人： VAN BOECKEL, Constant, Adriaan, Anton ,  PETITOU, Maurice ,  DUCHAUSSOY, Philippe ,  DREEF-TROMP, Cornelia, Maria ,  BASTEN, Johannes, Egbertus, Maria

IPC分类号： C07H3/06 ,  A61K31/70 ,  C07H11/00 ,  C07H15/04

CPC分类号： C07H15/04 ,  C07H3/06 ,  C07H11/00

摘要： The invention relates to a carbohydrate derivative having formula (I) wherein R1 is (1-4C)alkoxy; R?2, R3 and R4¿ are independently (1-4C)alkoxy or OSO¿3?-; the total number of sulfate groups is 4, 5 or 6; and the twisted lines represent bonds either above or below the plane of the six-membered ring to which they are attached; or a pharmaceutically acceptable salt thereof. The compounds of the invention have antithrombotic activity and may be used for treating or preventing thrombosis and for inhibiting smooth muscle cell proliferation.

公开(公告)号：EP2464667A2

公开(公告)日：2012-06-20

申请号：EP10761049.5

申请日：2010-08-12

申请人： SANOFI

发明人： DRIGUEZ, Pierre Alexandre ,  DUCHAUSSOY, Philippe ,  FONS, Pierre ,  HERBERT, Corentin ,  LASSALLE, Gilbert

IPC分类号： C08B37/00 ,  A61K31/737 ,  A61P7/00 ,  A61P9/00 ,  A61P11/00 ,  A61P17/00 ,  A61P19/00 ,  A61P21/00 ,  A61P25/00 ,  A61P27/02 ,  A61P37/00

CPC分类号： C08B37/0063 ,  A61K31/737 ,  C07H11/00 ,  C07H15/04 ,  C07H15/203 ,  C08B37/0075

摘要： The invention relates to FGF receptor-activating N-acyl octasaccharides having Formula (I), wherein: R
1 is an O-alkyl group optionally replaced by one or more aryl or cycloalkyl groups, R
2 is an OSO
3 - or hydroxyl group, R
3 is an alkyl, cycloalkyl, or alky-cycloalkyl group, R
4 is a disaccharide having Formula (II), R
6 is a disaccharide having Formula (III), and R
8 is a disaccharide having Formula (IV), where R
5 , R
7 , and R
9 have OSO
3 or hydroxyl groups. The invention further relates to the preparation of said octasaccharides and to the therapeutic use thereof.

公开(公告)号：EP1032579B1

公开(公告)日：2003-05-02

申请号：EP98958248.1

申请日：1998-11-16

申请人： Akzo Nobel N.V. ,  SANOFI-SYNTHELABO

发明人： VAN BOECKEL, Constant, Adriaan, Anton ,  PETITOU, Maurice ,  DUCHAUSSOY, Philippe ,  DREEF-TROMP, Cornelia, Maria ,  BASTEN, Johannes, Egbertus, Maria

IPC分类号： C07H3/06 ,  A61K31/70 ,  C07H11/00 ,  C07H15/04

CPC分类号： C07H15/04 ,  C07H3/06 ,  C07H11/00

摘要： The invention relates to a carbohydrate derivative having formula (I) wherein R1 is (1-4C)alkoxy; R?2, R3 and R4¿ are independently (1-4C)alkoxy or OSO¿3?-; the total number of sulfate groups is 4, 5 or 6; and the twisted lines represent bonds either above or below the plane of the six-membered ring to which they are attached; or a pharmaceutically acceptable salt thereof. The compounds of the invention have antithrombotic activity and may be used for treating or preventing thrombosis and for inhibiting smooth muscle cell proliferation.