公开(公告)号：EP1849779A1

公开(公告)日：2007-10-31

申请号：EP06712293.7

申请日：2006-01-25

申请人： SUNTORY LIMITED

发明人： FUKAMI, Harukazu ,  NAKAO, Masahiro ,  NAMIKAWA, Koshi ,  MAEDA, Mitsuru

IPC分类号： C07D311/62 ,  A01N43/16 ,  A23L3/3517

CPC分类号： C12P17/06 ,  A01N43/16 ,  A23L3/3472 ,  A23L3/3517 ,  A61K8/498 ,  A61Q17/005 ,  C07D311/62

摘要： The present invention provides substances having sufficiently antibacterial activity against heat-resistant spore-forming bacteria that they can be used to improve the shelf life of beverages and processed foods, as well as to control the growth of microorganisms in cosmetics.
The present invention provides a catechin ester in which at least one of the hydroxyl groups of a catechin is esterified with a medium-chain fatty acid. This medium-chain fatty acid ester of a catechin, which may be used either alone or as a composition, shows a strong growth suppressing effect on heat-resistant spore-forming bacteria and, if added to foods or beverages, can prevent them from rotting or deterioration and, if added to cosmetics, can prevent their rotting or deterioration.

摘要翻译： 本发明提供了具有针对thatthey可用于改善饮料和加工食品的货架期，以及用于控制微生物在化妆品中的生长充分的耐热孢子形成细菌的抗菌活性的物质。 本发明提供了其中A儿茶素的羟基中的至少一个被酯化与中链脂肪酸儿茶素酯。 儿茶素，其可以单独地或作为组合物中使用的这种中链脂肪酸酯，表现出强的生长在抑制效果耐热孢子形成的细菌，并且如果添加到食品或饮料，可以防止它们腐烂 或变质，如果添加到化妆品中，可以防止其腐败变质。

公开(公告)号：EP1790733A1

公开(公告)日：2007-05-30

申请号：EP05780915.4

申请日：2005-08-24

申请人： SUNTORY LIMITED

发明人： UEDA, Mitsuyoshi ,  NAKAO, Masahiro ,  ASAMI, Maki ,  OCHIAI, Misa ,  FUKAMI, Harukazu

IPC分类号： C12Q1/02 ,  C12Q1/34 ,  C12M1/34

CPC分类号： C12Q1/34 ,  C12Q1/04

摘要： A method and apparatus for screening a microorganism or protein having a useful function by using a micro-chamber array.
Using the screening method and screening apparatus in accordance with the present invention, a target protein having an enzymatic activity or a microorganism producing such a protein is screened from a sample serving as a screening object by using a base plate having a plurality of micro-chambers arranged in the form of an array. With this method and apparatus, a protein having an enzymatic activity or a microorganism producing such a protein that is present in a micro-chamber is detected by detecting a fluorescence produced by an enzyme reaction of the protein having an enzymatic activity and a fluorescence substrate.

摘要翻译： 用于通过使用微室阵列筛选具有有用功能的微生物或蛋白质的方法和装置。 使用根据本发明的筛选方法和筛选装置，通过使用具有多个微室的基板，从作为筛选对象的样品筛选具有酶活性的靶蛋白或产生这种蛋白质的微生物 以阵列的形式排列。 使用该方法和装置，通过检测由具有酶活性的蛋白质和荧光底物的酶反应产生的荧光来检测具有酶活性的蛋白质或产生存在于微室中的蛋白质的微生物。

公开(公告)号：EP1964917A1

公开(公告)日：2008-09-03

申请号：EP06834353.2

申请日：2006-12-08

申请人： Suntory Limited

发明人： NAKAO, Masahiro ,  KANAMORI, Masaki ,  FUKAMI, Harukazu ,  KASAI, Hiroaki ,  OCHIAI, Misa

IPC分类号： C12N15/00 ,  C12N1/15 ,  C12N1/19 ,  C12N1/21 ,  C12N5/10 ,  C12N9/20 ,  C12N15/09 ,  C12P7/62

CPC分类号： C12N9/20 ,  C12P7/6409 ,  C12P7/6436 ,  C12R1/01

摘要： The present invention provides a novel lipase with a molecular weight of about 32 kDa, which is produced by a strain belonging to the genus Tetrasphaera, as well as a gene encoding the same. This lipase has the ability to recognize a medium-chain fatty acid as a substrate. The present invention also provides a novel lipase with a molecular weight of about 40 kDa, which is produced by a strain belonging to the genus Tetrasphaera and has the ability to recognize both a medium-chain fatty acid and a long-chain fatty acid as substrates, as well as a polynucleotide encoding the same. The present invention further provides Tetrasphaera sp. strain NITE P-154. The lipase of the present invention can be used as an immobilized enzyme and is useful in fields such as production of diaestants and/or flavorings, production of clinical laboratory reagents, detergent enzymes and/or fats, as well as production of optically active intermediates for agricultural chemicals and pharmaceutical preparations.

摘要翻译： 本发明提供了一种分子量约为32kDa的新型脂肪酶，其由属于Tetrasphaera属的菌株产生，以及编码它的基因。 该脂肪酶具有识别中链脂肪酸作为底物的能力。 本发明还提供一种分子量约为40kDa的新型脂肪酶，其由属于Tetrasphaera属的菌株产生，并且具有识别中链脂肪酸和长链脂肪酸作为底物的能力 以及编码其的多核苷酸。 本发明进一步提供了Tetrasphaera sp。 菌株NITE P-154。 本发明的脂肪酶可以用作固定化酶，并且可用于例如生产调味剂和/或调味剂，生产临床实验室试剂，洗涤剂酶和/或脂肪的领域，以及用于制备光学活性中间体 农药和药物制剂。

公开(公告)号：EP1640025A1

公开(公告)日：2006-03-29

申请号：EP04746481.3

申请日：2004-06-25

申请人： SUNTORY LIMITED

发明人： MAEDA, Mitsuru ,  NAKAO, Masahiro ,  FUKAMI, Harukazu

IPC分类号： A61L31/00 ,  A61K8/40 ,  A61K8/41

CPC分类号： A61Q19/02 ,  A61K8/676 ,  A61K8/99 ,  A61K31/704 ,  A61K2800/522 ,  A61K2800/70 ,  A61K2800/75 ,  A61K2800/782 ,  A61Q19/00 ,  Y10S435/913 ,  Y10S435/914 ,  Y10S435/918

摘要： A composition for external use, comprising 2-O-(β-D-glucopyranosyl)ascorbic acid represented by the formula (I):

or a salt or ester thereof which is safe to the human body, and a koji mold or a processed koji. The composition for external use is excellent in skin permeability, containing an ascorbic acid derivative which is excellent in stability, utilized persistently in the living body, and strong in antioxidant activity, and has little skin irritation.

摘要翻译： 一种外用组合物，其包含由式（I）表示的2-O-（2-D-吡喃葡萄糖基）抗坏血酸：或其对人体安全的盐或酯，以及曲霉或加工曲 。 外用组合物的皮肤透过性优异，含有稳定性优异，抗生素活性强，抗氧化活性强的抗坏血酸衍生物。

公开(公告)号：EP1500645A1

公开(公告)日：2005-01-26

申请号：EP03728006.2

申请日：2003-04-28

申请人： SUNTORY LIMITED

发明人： SUMIDA, Motoo ,  NAKAO, Masahiro ,  TOMIMORI, Namino ,  NAMIKAWA, Koshi ,  FUKAMI, Harukazu

IPC分类号： C07C403/24 ,  C12P23/00 ,  A61K7/025 ,  A23L1/30

CPC分类号： C07C403/24 ,  A23L33/10 ,  A23L33/115 ,  A61K8/37 ,  A61Q1/06 ,  C12P7/62 ,  C12P7/6436 ,  C12P7/6454 ,  C12P23/00

摘要： The present invention provides an astaxanthin medium-chain fatty acid ester, which is expected to be applied in the fields of food, cosmetics and pharmaceuticals, and has higher digestibility and tissue penetration than long chain fatty acid ester form astaxanthins.
When the synthesis of an astaxanthin medium-chain fatty acid ester is attempted using the catalytic action of lipase by conventional methods, ester cannot be formed. However, according to the present invention, a composition comprising an astaxanthin medium-chain fatty acid monoester and/or diester is produced by adding a certain amount of water into a reaction system and reacting an astaxanthin or a long chain fatty acid ester thereof with a medium-chain fatty acid, a triglyceride thereof or a suitable ester. Moreover, these monoesters and/or diesters are isolated, as necessary. The present invention further provides food or cosmetics comprising the composition of the present invention.

摘要翻译： 本发明提供了虾青素中链脂肪酸酯，所有这些都预期在食品，化妆品和药品等领域得到应用，并具有较高的消化率和组织穿透比长链脂肪酸酯形式的虾青素。 <？>当虾青素中链脂肪酸酯的合成使用由常规方法脂肪酶的催化作用尝试，酯不能形成。 然而，雅鼎在本发明中，包含虾青素中链脂肪酸的单酯和/或二酯的组合物是通过将水一定量到反应体系，并用反应到虾青素或一个长链脂肪酸及其酯生成 中链脂肪酸，它们的甘油三酯或合适的酯。 更完了，论文的单酯和/或二酯是分离的，因为是必要的。 本发明还提供了食品或化妆品含有本发明的组合物。

公开(公告)号：EP1461347A1

公开(公告)日：2004-09-29

申请号：EP02793462.9

申请日：2002-12-27

申请人： SUNTORY LIMITED

发明人： MAEDA, Mitsuru ,  NAKAO, Masahiro ,  FUKAMI, Harukazu

IPC分类号： C07H17/04 ,  A23L1/302 ,  C12P19/60 ,  C07H1/08 ,  A61K7/48 ,  A61K31/7048 ,  A61P17/16

CPC分类号： A61K8/676 ,  A23L33/105 ,  A23L33/15 ,  A23V2002/00 ,  A61K8/602 ,  A61K31/375 ,  A61K2800/52 ,  A61Q17/04 ,  A61Q19/00 ,  A61Q19/02 ,  C07H1/08 ,  C07H17/04 ,  C12P19/60 ,  A23V2250/708

摘要： The present invention provides a novel ascorbic acid derivative as a provitamin C with improved stability in the body and prolonged life in the body compared to conventionally known 2-O-(α-D-glucopyranosyl)ascorbic acid. The composition comprising the novel compound 2-O-(β-D-glucopyranosyl)ascorbic acid has been extracted from plants such as from Ningxia Lycium barbarum L. and/or Lycium chinense Mill. The compositions comprising 2-O-(β-D-glucopyranosyl)ascorbic acid may be enzymatically synthesized using β-D-glucosyltransferase. Pure 2-O-(β-D-glucopyranosyl)ascorbic acid may be produced from such compositions. Alternatively, 2-O-(β-D-glucopyranosyl)ascorbic acid may be produced by chemical synthesis. The 2-O-(β-D-glucopyranosyl)ascorbic acid results in higher stability and a prolonged life of vitamin C when ingested in the body compared to the corresponding α-D-glucopyranosyl derivative, and is therefore highly suitable as a provitamin C to be used in cosmetics and foods.