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公开(公告)号：EP4063381A1
公开(公告)日：2022-09-28
申请号：EP20897067.3
申请日：2020-12-04
申请人： Shanghai Senhui Medicine Co., Ltd. , Shanghai Shengdi Pharmaceutical Co., Ltd , Jiangsu Hengrui Medicine Co., Ltd.
发明人： HUANG, Jian , ZHU, Lingjian , JIANG, Wei , CAO, Weicou
摘要： The present invention relates to an echinocandin analogue and a preparation method therefor. The compound can be used for preventing or treating fungal infection, or for preventing, stabilizing or inhibiting fungal growth or killing fungi. An exemplary compound is represented by formula I, wherein the definitions of R 1 , R 2 , R 3 and G groups are as described in the description.
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公开(公告)号：EP3991730A1
公开(公告)日：2022-05-04
申请号：EP20831251.2
申请日：2020-06-28
申请人： Shanghai Shengdi Pharmaceutical Co., Ltd , Shanghai Senhui Medicine Co., Ltd. , Jiangsu Hengrui Medicine Co., Ltd.
发明人： HUANG, Jian , ZHU, Lingjian , ZOU, Yang , TANG, Yinggang
IPC分类号： A61K31/438 , C07D471/10 , A61P1/08 , A61P11/06 , A61P11/14 , A61P25/06 , A61P25/22 , A61P25/24
摘要： A compound represented by formula II or a pharmaceutically acceptable salt thereof, and a preparation method therefor. The compound represented by formula II is an antagonist of a neurokinin-1 receptor, can be used for treating diseases related to the neurokinin-1 receptor, and can avoid hemolytic effects of drugs and reduce the side effects of drug administration.
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公开(公告)号：EP4458806A1
公开(公告)日：2024-11-06
申请号：EP22914988.5
申请日：2022-12-29
申请人： Jiangsu Hengrui Pharmaceuticals Co., Ltd. , Shanghai Senhui Medicine Co., Ltd. , Shanghai Shengdi Pharmaceutical Co., Ltd
发明人： ZHU, Lingjian , SHI, Jianyu , LIU, Chongyi , JIANG, Jun , HUANG, Jian
IPC分类号： C07C229/12 , C07C229/16 , C07C217/08 , A61K31/7088 , A61K47/18 , A61K9/127
摘要： Provided are a lipid and a composition used for delivery. Specifically provided is a compound represented by formula I or a salt thereof, wherein R 1 to R 3 , H 1 to H 3 , L 1 , and L 2 are as defined in the description.
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公开(公告)号：EP4349851A1
公开(公告)日：2024-04-10
申请号：EP22815338.3
申请日：2022-06-02
申请人： Shanghai Senhui Medicine Co., Ltd. , Shanghai Shengdi Pharmaceutical Co., Ltd , Jiangsu Hengrui Pharmaceuticals Co., Ltd.
发明人： JIANG, Wei , HUANG, Jian , HU, Junqiang , CAO, Weicou , ZHOU, Yinan
摘要： The present disclosure relates to a method for preparing an anidulafungin derivative. In particular, the present disclosure relates to a method for preparing an anidulafungin derivative as represented by formula (I) and an intermediate thereof.
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公开(公告)号：EP4268818A1
公开(公告)日：2023-11-01
申请号：EP21909544.5
申请日：2021-12-24
申请人： Shanghai Shengdi Pharmaceutical Co., Ltd , Shanghai Senhui Medicine Co., Ltd. , Jiangsu Hengrui Pharmaceuticals Co., Ltd.
发明人： XU, Daping , YANG, Changyong , LIAO, Cheng , ZHANG, Lianshan , HUANG, Jian
IPC分类号： A61K31/438 , A61P1/08 , C07D471/10
摘要： The present disclosure relates to the use of an NK1 antagonist prodrug compound and a 5-HT3 receptor antagonist. In particular, the present disclosure relates to the use of a compound represented by formula (I) or a pharmaceutically acceptable salt thereof in combination with a 5-HT3 receptor antagonist in the preparation of a drug for preventing or treating nausea and/or vomiting.
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公开(公告)号：EP4183774A1
公开(公告)日：2023-05-24
申请号：EP21842032.1
申请日：2021-07-16
申请人： Shanghai Senhui Medicine Co., Ltd. , Shanghai Shengdi Pharmaceutical Co., Ltd , Jiangsu Hengrui Pharmaceuticals Co., Ltd.
发明人： HUANG, Jian , ZHU, Lingjian , YU, Xiuzhao , SUN, Piaoyang
IPC分类号： C07C311/59 , A61K31/64
摘要： The present invention relates to a sulfonylurea derivative and medical uses thereof, specifically relating to the sulfonylurea derivative shown in general formula (I), a preparation method thereof, a pharmaceutical composition containing same, and a use of same for treating diseases and disorders affected by neuronal damage, for example: cerebral stroke, brain damage, neuropathic pain, migraines, inflammatory pain, chronic pain, or depression. The definition of each group in the general formula (I) is the same as that in the description.
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公开(公告)号：EP4144742A1
公开(公告)日：2023-03-08
申请号：EP21796822.1
申请日：2021-04-30
申请人： Shanghai Senhui Medicine Co., Ltd. , Shanghai Shengdi Pharmaceutical Co., Ltd , Jiangsu Hengrui Pharmaceuticals Co., Ltd.
发明人： ZHANG, Lianshan , HUANG, Jian , ZHU, Lingjian , TANG, Yinggang , HUANG, Qi , MENG, Jia
IPC分类号： C07F9/09 , A61K31/683 , A61P9/14
摘要： Involved are an inositol derivative and a use thereof. Specifically, provided is a compound, said compound includes two or many parts, as represented by formula (D), connected via a common central linker L2, where formula (D) is as shown below.
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公开(公告)号：EP4279491A1
公开(公告)日：2023-11-22
申请号：EP22739024.2
申请日：2022-01-12
申请人： Shanghai Senhui Medicine Co., Ltd. , Shanghai Shengdi Pharmaceutical Co., Ltd , Jiangsu Hengrui Pharmaceuticals Co., Ltd.
发明人： HUANG, Jian , ZHU, Lingjian , ZOU, Yang , ZHANG, Cili
IPC分类号： C07D501/46 , A61K31/546 , A61P31/04
摘要： The present disclosure relates to a cephalosporin antibacterial compound and a preparation method therefor. The cephalosporin antibacterial compound can exhibit antibacterial activity against Gram-negative bacteria and other bacteria.
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公开(公告)号：EP4095141A1
公开(公告)日：2022-11-30
申请号：EP21745090.7
申请日：2021-01-22
申请人： Shanghai Senhui Medicine Co., Ltd. , Shanghai Shengdi Pharmaceutical Co., Ltd , Jiangsu Hengrui Pharmaceuticals Co., Ltd.
发明人： HUANG, Jian , ZHU, Lingjian , ZOU, Yang , ZHANG, Cili
IPC分类号： C07D501/46 , A61K31/546 , A61P31/04
摘要： Provided are a cephalosporin compound represented by formula 1-1, 1-2, or 1-3, a pharmaceutical composition comprising same, and use thereof as an antibacterial agent.
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公开(公告)号：EP4293032A1
公开(公告)日：2023-12-20
申请号：EP22752320.6
申请日：2022-02-10
申请人： Shanghai Senhui Medicine Co., Ltd. , Shanghai Shengdi Pharmaceutical Co., Ltd , Jiangsu Hengrui Pharmaceuticals Co., Ltd.
发明人： ZHU, Lingjian , SHI, Jianyu , JI, Changjin , DONG, Bangjie , HUANG, Jian
IPC分类号： C07F9/553 , A61K31/675 , A61P7/02 , A61P9/12 , A61P9/14
摘要： Benzazepine compounds, a preparation method therefor and pharmaceutical use thereof. Specifically, the present invention relates to a compound represented by formula II-1 or formula VIII-1, a pharmaceutical composition containing same, and pharmaceutical use thereof. The benzazepine compounds can be used for treating diseases associated with vasopressin receptors, in particular hypertension, heart disease, etc.
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