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公开(公告)号：EP4367100A1
公开(公告)日：2024-05-15
申请号：EP22754961.5
申请日：2022-07-05
发明人： BEN-SASSON, Shmuel , GROSS, Einav
IPC分类号： C07D231/12 , C07D231/18 , C07D233/64 , C07D233/84 , C07D249/04 , C07D249/12 , A61P1/16 , A61P1/18 , A61P3/10 , A61P9/04 , A61P9/10 , A61P9/12 , A61P11/00 , A61P19/02 , A61P19/10
CPC分类号： C07D231/12 , C07D231/18 , C07D233/64 , C07D233/84 , C07D249/04 , C07D249/12 , A61P1/16 , A61P1/18 , A61P3/10 , A61P9/04 , A61P9/10 , A61P9/12 , A61P11/00 , A61P19/02 , A61P19/10 , A61P25/16 , A61P25/28 , A61P27/00 , A61P35/00
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2.发明公开
公开(公告)号：EP3873447A1
公开(公告)日：2021-09-08
申请号：EP19801119.9
申请日：2019-10-29
申请人： Hadasit Medical Research Services and Development Ltd. , YISSUM RESEARCH DEVELOPMENT COMPANY OF THE HEBREW UNIVERSITY OF JERUSALEM LTD
发明人： YOVELL, Yoram , BEN-SASSON, Shmuel
IPC分类号： A61K31/135 , A61K31/137 , A61K31/222 , A61K31/439 , A61K31/4468 , A61K31/485 , A61K31/554 , A61P25/00 , A61P25/04 , A61P25/18 , A61P25/24 , A61K31/475
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公开(公告)号：EP2802320B1
公开(公告)日：2019-02-20
申请号：EP12850186.3
申请日：2012-11-15
发明人： BEN-SASSON, Shmuel , DAGAN, Arie , PERLES, Sharon
IPC分类号： A61K31/14
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5.发明公开IGF-1R SIGNALING PATHWAY INHIBITORS USEFUL IN THE TREATMENT OF NEURODEGENERATIVE DISEASES 审中-公开IGF-1R SIGNALWEGINHIBITOREN用于治疗神经退行性疾病
公开(公告)号：EP3021944A1
公开(公告)日：2016-05-25
申请号：EP14825966.6
申请日：2014-07-13
IPC分类号： A61P25/00 , A61K31/5415 , C07C327/44 , A61K31/165 , C07D277/36
CPC分类号： A61K31/5415 , A61K31/165 , A61K2300/00 , C07D279/08
摘要： The present invention provides compounds acting as Insulin/IGF signaling modulators useful in the treatment of neurodegenerative diseases and disorders. The invention provides pharmaceutical compositions including such compounds, and methods of using these compounds and compositions for the treatment of neurodegenerative diseases, in particular neurodegenerative diseases caused by proteotoxicity such as Alzheimer's disease.
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公开(公告)号：EP2608771A1
公开(公告)日：2013-07-03
申请号：EP11764342.9
申请日：2011-08-18
发明人： BEN-SASSON, Shmuel
摘要： The present invention relates to compositions, including pharmaceutical compositions for oral administration, comprising: at least one therapeutically active agent; at least one surface active agent; at least one ester of poly-carboxylic acid and/or at least one ester of an aromatic carboxylic acid; and a non-aqueous medium, for use in the gastric absorption of said at least one therapeutically active agent of the composition and methods of oral administration of at least one therapeutically active agent utilizing compositions of the invention.
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公开(公告)号：EP2608771B1
公开(公告)日：2018-12-12
申请号：EP11764342.9
申请日：2011-08-18
发明人： BEN-SASSON, Shmuel
摘要： The present invention relates to compositions, including pharmaceutical compositions for oral administration, comprising: at least one therapeutically active agent; at least one surface active agent; at least one ester of poly-carboxylic acid and/or at least one ester of an aromatic carboxylic acid; and a non-aqueous medium, for use in the gastric absorption of said at least one therapeutically active agent of the composition and methods of oral administration of at least one therapeutically active agent utilizing compositions of the invention.
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公开(公告)号：EP4146189A1
公开(公告)日：2023-03-15
申请号：EP21726210.4
申请日：2021-05-03
发明人： BEN-SASSON, Shmuel
IPC分类号： A61K31/216 , A61K31/225 , A61P11/00 , A61P11/06 , A61P11/08 , A61P11/14
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公开(公告)号：EP3083672A1
公开(公告)日：2016-10-26
申请号：EP14835585.2
申请日：2014-12-17
发明人： BEN-SASSON, Shmuel , REUVENI, Hadas
IPC分类号： C07K14/705 , A61K38/00
CPC分类号： C07K14/705 , A61K9/0024 , A61K9/008 , A61K38/00 , A61K38/1816 , A61K38/1825 , A61K38/19 , A61K47/34 , A61L27/54 , A61L31/16 , A61L2300/25 , A61L2300/412 , C07K5/0817 , C07K5/10 , C07K5/1019 , C07K7/06 , C07K2319/033 , A61K2300/00
摘要： Short bioactive sequences derived from the 2nd loop of the 7-transmembranal receptor of endothelial differentiation gene 3 (EDG3) useful in stimulation of angiogenesis, and peptide conjugates comprising a permeability enhancing moiety, are provided. Also provided are pharmaceutical compositions comprising the peptides and methods of use in conditions were insufficient blood-supply occurs, or which are associated with endothelia dysfunction such as peripheral vascular diseases, coronary artery diseases, cerebrovascular diseases, diabetes and delayed wound healing, pulmonary disease, eye diseases and pathological condition related to severe infection.
摘要翻译： 提供了衍生自可用于刺激血管发生的内皮分化基因3（EDG3）的7-跨膜受体的第二环的短生物活性序列和包含渗透性增强部分的肽缀合物。 还提供了包含肽的药物组合物和在条件中使用的方法不足，或与外周血管疾病，冠状动脉疾病，脑血管疾病，糖尿病和延迟伤口愈合，肺部疾病等内皮功能障碍相关的药物组合物， 眼病与严重感染相关的病理状况。
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公开(公告)号：EP2802320A1
公开(公告)日：2014-11-19
申请号：EP12850186.3
申请日：2012-11-15
发明人： BEN-SASSON, Shmuel , DAGAN, Arie , PERLES, Sharon
IPC分类号： A61K31/14
CPC分类号： C07D209/88 , C07D209/86
摘要： Tricyclic compounds, compositions and uses thereof in the treatment of at least one disease, disorder or condition such as for example obesity, overweight, abnormal fat- distribution and any conditions or disease associated therewith.
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