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公开(公告)号：EP3708162A1
公开(公告)日：2020-09-16
申请号：EP19382179.0
申请日：2019-03-12
发明人： FERNÁNDEZ MEDARDE, Antonio , VINUESA NAVARRO, María de los Ángeles , SÁNCHEZ LÓPEZ, José María , BOLAÑOS HERNÁNDEZ, Juan Pedro , ALMEIDA PARRA, María de los Ángeles , FERNANDEZ SANCHEZ, Emilio
IPC分类号： A61K31/407 , A61K9/00 , A61P25/28 , A61P39/06
摘要： Compounds of general formula
wherein
the wavy bond ∼ is either a double bond or the epoxide,
or pharmaceutically acceptable salts, solvates, tautomers, or stereoisomers thereof, for use in the treatment of diseases associated with oxidative stress.-
2.发明授权CYTOTOXIC ALKALOID DERIVATIVES INCLUDING ASMARINE A AND B ISOLATED FROM A SPONGE 有权细胞毒性生物碱衍生物Asmarine A和B EMBRACE，并从海绵ISOLATED WERE
公开(公告)号：EP1070067B1
公开(公告)日：2005-03-02
申请号：EP98962610.6
申请日：1998-12-23
发明人： KASHMAN, Yoel, Pharma Mar S.A. , RUDI, Amira, Pharma Mar S.A. , YOSIEF, Tesfamariam, Pharma Mar S.A. , GRAVALOS, Dolores G., Pharma Mar S.A.
IPC分类号： C07D487/06 , A61K31/505
CPC分类号： C07D487/16
摘要： Asmarine A and B, novel cytotoxic diterpene-alkaloids, have been isolated from the sponge Raspailia sp. The structure of these compounds have been established on the basis of NMR data and confirmed by X-ray analysis. Also claimed are compounds (I) or (II), wherein R1 represents hydrogen or lower alkyl or lower alkanoyl; R2 represents hydrogen or lower alkyl; R3 is either an alkyl or a cycloalkyl group containing one or more isopreneunits, or a monoterpene or a sesquiterpene or a sesquiterpene or a diterpene group; R4 or R5 represent hydrogen or lower alkyl; R6 represents lower alkyl; X represents F or Cl or Br or (I).
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公开(公告)号：EP1210346B1
公开(公告)日：2003-07-02
申请号：EP00958872.4
申请日：2000-09-11
发明人： CIMINO, Guido, Inst. Chimica di Molecole , FONTANA, Angelo, Inst.Chimica di Molecole , GARCIA GRAVALOS, Dolores, Pharma Mar, S.A. , WAHIDULLA, Solimabi, Nat. Inst. of Oceanography , NAIK, Chandrakant, Govind, Nat.Inst.Oceanography
IPC分类号： C07D471/18 , A61K31/4995 , A61P35/00
CPC分类号： C07D471/18 , A61K31/4995
摘要： New antitumour alkaloids of general formula (I) where R1 is hydrogen, alkyl or acyl and R2 is hydrogen or acyl, include jorumycin, where R1 is hydrogen and R2 is acetyl, extracted from the mollusc Jorunna funebris.
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公开(公告)号：EP1189908A1
公开(公告)日：2002-03-27
申请号：EP00940633.1
申请日：2000-06-28
发明人： GARCIA GRAVALOS, DoloresPharma Mar S.A. , PEREZ, JuliaInstituto Biomar S.A. , CANEDO, Librada MariaInstituto Biomar S.A. , ROMERO, FranciscoInstituto Biomar S.A. , ESPLIEGO, FernandoInstituto Biomar S.A.
IPC分类号： C07D498/22 , A61K31/553 , A61P35/00
CPC分类号： C07D498/22
摘要： The invention provides compounds of formula (1) wherein R1 is a hydrogen atom, an alkyl group having 1 to 6 carbon atoms or an alkoxy group having 1 to 6 carbon atoms; and R2 is a hydrogen atom, an alkyl group having 1 to 6 carbon atoms or an alkoxy group having 1 to 6 carbon atoms; and pharmaceutically acceptable salts thereof. The invention also relates to a process for obtaining the compounds, compositions containing them and their therapeutic use. The compounds display excellent activity against mammalian cancer cell lines.
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公开(公告)号：EP3937931B1
公开(公告)日：2024-08-07
申请号：EP20712264.9
申请日：2020-03-12
IPC分类号： A61K31/407 , A61P39/06 , A61P25/28 , A61K9/00
CPC分类号： A61K31/407 , A61P25/28 , A61P39/06
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6.发明公开USE OF COLLISMYCIN AND DERIVATIVES THEREOF AS OXIDATIVE STRESS INHIBITORS 有权使用collismycin A作为氧化应激的抑制剂
公开(公告)号：EP1909912A2
公开(公告)日：2008-04-16
申请号：EP06762898.2
申请日：2006-07-28
发明人： MARTÍNEZ GIL, Ana , USÁN EGEA, Paola , MEDINA PADILLA, Miguel , GARCÍA PALOMERO, Esther , PÉREZ BAZ, Julia , FERNÁNDEZ CHIMENO, Rosa Isabel , FERNÁNDEZ MEDARDE, Antonio , CAÑEDO HERNÁNDEZ, Librada María , ROMERO MILLÁN, Francisco , CASTRO MORENA, Ana , ALONSO CASCÓN, Mercedes , SÁNCHEZ QUESADA, Jorge
CPC分类号： A61K31/44
摘要： The present invention relates to the use of Collismycin and derivatives thereof as inhibitors of oxidative stress in cells and their use for the preparation of medicaments for the treatment and/or prevention of oxidative stress-induced diseases or conditions, especially neurodegenerative diseases, such as Alzheimer´s Disease and Parkinson's Disease.
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公开(公告)号：EP1210346A2
公开(公告)日：2002-06-05
申请号：EP00958872.4
申请日：2000-09-11
发明人： CIMINO, Guido,Inst. Chimica di Molecole , FONTANA, Angelo,Inst.Chimica di Molecole , GARCIA GRAVALOS, Dolores,Pharma Mar, S.A. , WAHIDULLA, Solimabi,Nat. Inst. of Oceanography , NAIK, Chandrakant, Govind,Nat.Inst.Oceanography
IPC分类号： C07D471/18 , A61K31/4995 , A61P35/00
CPC分类号： C07D471/18 , A61K31/4995
摘要： New antitumour alkaloids of general formula (I) where R1 is hydrogen, alkyl or acyl and R2 is hydrogen or acyl, include jorumycin, where R1 is hydrogen and R2 is acetyl, extracted from the mollusc Jorunna funebris.
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公开(公告)号：EP1051420A1
公开(公告)日：2000-11-15
申请号：EP99903797.1
申请日：1999-01-27
发明人： HIGA, Tatsuo,Instituto Biomar S.A. , GARCIA GRAVALOS, Dolores,Instituto Biomar S.A. , FERNANDEZ-PUENTES, Jose Luis,Instituto Biomar S.A
IPC分类号： C07D498/22 , A61K31/42
CPC分类号： C07D498/22
摘要： HA-1 and TH-2, two novel cytotoxic tris(oxazole)-containing macrolides, have been shown. These compounds have been obtained by chemical modification of marine natural products. The structure of these compounds has been established on the basis of NMR data.
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9.发明公开Use of collismycin and derivatives thereof as oxidative stress inhibitors 审中-公开Verwendung von Collismycin und Derivaten davon als oxidative Stresshemmer
公开(公告)号：EP2444121A1
公开(公告)日：2012-04-25
申请号：EP12151913.6
申请日：2006-07-28
发明人： Martínez Gil, Ana , Castro Morera, Ana , Alonso Cascón, Mercedes , Sánchez Quesada, Jorge , Usán Egea, Paola , Medina Padilla, Miguel , García Palomero, Esther , Pérez Baz, Julia , Fernández Chimeno, Rosa Isabel , Fernández Medarde, Antonio , Cañedo Hernández, Librada María , Romero Millán, Francisco
CPC分类号： A61K31/44
摘要： The present invention relates to the use of Collismycin and derivatives thereof as inhibitors of oxidative stress in cells and their use for the preparation of medicaments for the treatment and/or prevention of oxidative stress-induced diseases or conditions, especially neurodegenerative diseases, such as Alzheimer's Disease and Parkinson's Disease.
摘要翻译： 本发明涉及Collismycin及其衍生物作为细胞氧化应激抑制剂及其在制备用于治疗和/或预防氧化应激诱发的疾病或病症，特别是神经变性疾病如阿尔茨海默病的药物中的应用。 疾病和帕金森病。
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公开(公告)号：EP2167073A1
公开(公告)日：2010-03-31
申请号：EP08760990.5
申请日：2008-06-13
发明人： CAÑEDO HERNÁNDEZ, Librada María , VINUESA-NAVARRO, María De Los Ángeles , FERNÁNDEZ-MEDARDE, Antonio
IPC分类号： A61K31/336 , A61P31/10 , A61P17/00 , A61P17/06 , A61P17/08
CPC分类号： A61K31/336
摘要： The present invention relates to the use of some terpenes, for example chlovalicin, ovalicin or fumagillin, as antifungal against Malassezia species and to their use in the manufacture of medicaments for the treatment of human skin diseases caused by these Malassezia species, such as pityriasis versicolor, seborrheic dermatitis, dandruff, atopic dermatitis, psoriasis, confluent and reticulated papillomatosis, onychomycosis, and transient acantholytic dermatosis.
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