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公开(公告)号：EP4426677A1
公开(公告)日：2024-09-11
申请号：EP22813496.1
申请日：2022-11-02
发明人： NICOLAS, Lionel , GEIST, Julie , MONTAGNE, Cyril , MILLET, Anthony , GOURGUES, Mathieu , LOQUE, Dominique , THOMAS, Vincent
IPC分类号： C07D213/82 , C07D215/50 , C07D237/18 , C07D253/07 , A01N43/40 , A01N43/42 , A01N43/58 , A01N43/707
CPC分类号： C07D237/18 , C07D213/82 , C07D215/50 , C07D253/07 , A01N43/40 , A01N43/42 , A01N43/58 , A01N43/707 , A01P3/00
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公开(公告)号：EP2870139B1
公开(公告)日：2016-06-15
申请号：EP13732543.7
申请日：2013-07-01
发明人： KIMBARA, Atsushi , GRETHER, Uwe , NETTEKOVEN, Matthias , PUELLMANN, Bernd , ROGERS-EVANS, Mark , SCHULZ-GASCH, Tanja
IPC分类号： C07D215/08 , C07D215/14 , C07D215/233 , C07D215/50 , C07D215/54 , C07D217/06 , C07D241/42 , C07D271/04 , C07D265/36 , C07D209/08 , C07D209/44 , A61K31/47 , A61K31/403 , A61P29/00
CPC分类号： C07D471/04 , C07D209/08 , C07D209/44 , C07D215/08 , C07D215/14 , C07D215/233 , C07D215/50 , C07D215/54 , C07D217/04 , C07D217/06 , C07D241/42 , C07D265/36
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公开(公告)号：EP2870139A1
公开(公告)日：2015-05-13
申请号：EP13732543.7
申请日：2013-07-01
发明人： KIMBARA, Atsushi , GRETHER, Uwe , NETTEKOVEN, Matthias , PUELLMANN, Bernd , ROGERS-EVANS, Mark , SCHULZ-GASCH, Tanja
IPC分类号： C07D215/08 , C07D215/14 , C07D215/233 , C07D215/50 , C07D215/54 , C07D217/06 , C07D241/42 , C07D271/04 , C07D265/36 , C07D209/08 , C07D209/44 , A61K31/47 , A61K31/403 , A61P29/00
CPC分类号： C07D471/04 , C07D209/08 , C07D209/44 , C07D215/08 , C07D215/14 , C07D215/233 , C07D215/50 , C07D215/54 , C07D217/04 , C07D217/06 , C07D241/42 , C07D265/36
摘要： The invention relates to a compound of formula (I), wherein i.a. A
1 is -CH2- or -C(O)-; one of R
1 and R
2 is hydrogen and the other one is -A
2 -C(O)-R
3 ; A
2 is NH- or absent; and R
3 is (A), (B) or (C) The compounds are preferential agonists of the cannabinoid receptor 2 (CB2) and can be used as medicaments for the treatment of pain, inflammation, ischemia, etc.-
公开(公告)号：EP2757093A4
公开(公告)日：2015-02-25
申请号：EP12831685
申请日：2012-09-14
申请人： ASTELLAS PHARMA INC
发明人： FUJIYASU JIRO , OHNE KAZUHIKO , YAMAKI SUSUMU , IMAIZUMI TOMOYOSHI , HONDO TAKESHI , MATSUURA KEISUKE , SATOU TOMOHKI , SASAMURA SATOSHI
IPC分类号： C07C279/18 , A61K31/155 , A61K31/404 , A61P13/12 , A61P43/00 , C07C307/10 , C07D207/16 , C07D209/20 , C07D209/42 , C07D211/62 , C07D213/79 , C07D215/20 , C07D215/48 , C07D215/50 , C07D233/64 , C07D257/04 , C07D271/06 , C07D277/20 , C07D277/56 , C07D295/12 , C07D333/38
CPC分类号： C07C279/18 , C07B2200/07 , C07C2601/02 , C07C2601/14 , C07D207/16 , C07D209/20 , C07D209/42 , C07D211/62 , C07D213/79 , C07D215/20 , C07D215/48 , C07D215/50 , C07D217/26 , C07D233/64 , C07D257/04 , C07D271/06 , C07D271/07 , C07D277/20 , C07D277/56 , C07D295/12 , C07D295/13 , C07D333/38 , C07D333/40
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公开(公告)号：EP2710119A4
公开(公告)日：2015-02-18
申请号：EP12786757
申请日：2012-05-10
申请人： CLEAVE BIOSCIENCES INC , CALIFORNIA INST OF TECHN , ROUFFLET MATTHIEU , DESHAIES RAYMOND J , COHEN SETH
发明人： ZHOU HAN-JIE , PARLATI FRANCESCO , ROUFFLET MATTHIEU , EMBERLEY ETHAN , DESHAIES RAYMOND J , COHEN SETH
CPC分类号： C07K5/06 , A61K31/4709 , A61K38/05 , C07D215/18 , C07D215/36 , C07D215/42 , C07D215/48 , C07D215/50 , C07D215/54
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6.发明公开QUINOLINONE CARBOXAMIDE INHIBITORS OF ENDOTHELIAL LIPASE 有权CHINOLINON-CARBOXAMID-INHIBITOREN DER ENDOTHELIALEN LIPASE
公开(公告)号：EP2760840A1
公开(公告)日：2014-08-06
申请号：EP12770386.6
申请日：2012-09-24
发明人： QIAO, Jennifer X. , HU, Carol Hui , WANG, Tammy C.
IPC分类号： C07D215/22 , C07D401/12 , C07D417/12 , C07D401/14 , C07D403/12 , C07D413/12 , C07D417/14 , A61K31/4704 , A61K31/4709 , A61P3/06
CPC分类号： C07D215/50 , C07D215/22 , C07D215/54 , C07D401/12 , C07D401/14 , C07D403/12 , C07D413/12 , C07D417/12 , C07D417/14 , C07D419/12
摘要： The present invention provides compounds of Formula (I): as defined in the specification and compositions comprising any of such novel compounds. These compounds are endothelial lipase inhibitors which may be used as medicaments.
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7.发明公开
公开(公告)号：EP2655323A1
公开(公告)日：2013-10-30
申请号：EP11808566.1
申请日：2011-12-22
发明人： GRUE-SØRENSEN, Gunnar , LIANG, Xifu , HÖGBERG, Thomas , MÅNSSON, Kristoffer , VEDSØ, Per , VIFIAN, Thomas
IPC分类号： C07C271/34 , C07C249/06 , C07D261/18 , C07D277/32 , C07D309/08 , C07D333/38 , C07D401/04 , C07D295/21 , A61K31/27 , A61K31/215 , A61P35/00 , A61K31/381 , A61K31/4192 , A61K31/42 , A61K31/426
CPC分类号： C07D261/18 , A61K31/365 , A61K31/381 , A61K31/404 , A61K31/415 , A61K31/416 , A61K31/4192 , A61K31/42 , A61K31/472 , A61K31/502 , A61K31/5375 , A61K31/538 , C07C271/34 , C07C271/36 , C07C271/38 , C07C2603/86 , C07D209/08 , C07D209/42 , C07D213/79 , C07D215/50 , C07D217/26 , C07D231/14 , C07D231/56 , C07D233/90 , C07D237/28 , C07D239/28 , C07D249/04 , C07D249/06 , C07D261/20 , C07D263/34 , C07D265/36 , C07D271/08 , C07D277/32 , C07D277/56 , C07D277/587 , C07D295/182 , C07D295/205 , C07D295/21 , C07D307/00 , C07D307/68 , C07D307/94 , C07D309/08 , C07D333/38 , C07D333/40 , C07D401/04 , C07D405/06 , C07D471/04 , C07D493/08 , C07D495/04 , C07D513/04
摘要： The invention relates to compounds of general formula I wherein R is heteroaryl optionally substituted by R7; or R is heterocycloalkyl or heterocycloalkenyl, optionally substituted by R8; or R is X wherein X is —NR11R12; and pharmaceutically acceptable salts, hydrates, or solvates thereof, for use—alone or in combination with one or more other pharmaceutically active compounds—in therapy, for preventing, treating or ameliorating diseases or conditions responsive to stimulation of neutrophil oxidative burst, responsive to stimulation of keratinocyte IL-8 release or responsive to induction of necrosis.
摘要翻译： 本发明涉及通式I的化合物，其中R是任选被R 7取代的杂芳基; 或R为任选被R 8取代的杂环烷基或杂环烯基; 或R为X，其中X为-NR 11 R 12; 和其药学上可接受的盐，水合物或溶剂化物，其用于治疗中，单独使用或与一种或多种其它药学活性化合物组合用于预防，治疗或改善对刺激中性粒细胞氧化性突发的响应刺激的疾病或病症 的角质形成细胞IL-8释放或响应于坏死的诱导。
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8.发明授权
公开(公告)号：EP2113502B1
公开(公告)日：2012-11-14
申请号：EP09166657.8
申请日：2005-01-31
申请人： Clinigenetics
发明人： Marguerie, Gérard , Malaud, Eric
IPC分类号： C07D333/70 , C07D307/54 , C07D333/38 , C07D307/68 , C07D209/18 , C07D279/16 , C07D215/50 , C07D209/80 , C07D405/12 , A61K31/47 , A61K31/40 , A61K31/54 , A61K31/335 , A61K31/38 , C07C251/00
CPC分类号： C07D279/16 , C07C251/86 , C07D209/18 , C07D209/80 , C07D215/50 , C07D307/54 , C07D307/68 , C07D333/38 , C07D333/70 , C07D405/12
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公开(公告)号：EP1318140B1
公开(公告)日：2011-05-18
申请号：EP01967682.4
申请日：2001-09-14
发明人： NAKAMURA, Mitsuharu , KAMAHORI, Takao , ISHIBUCHI, Seigo , NAKA, Yoichi , SUMICHIKA, Hiroshi , ITOH, Katsuhiko
IPC分类号： C07C233/59 , C07C233/60 , C07C233/62 , C07C235/82 , C07C255/29 , C07C255/60 , C07C317/32 , C07C321/28 , C07D295/182 , C07D309/12 , C07D335/06 , C07D215/227 , C07D317/58 , C07D231/12 , C07D213/40 , C07D213/74 , C07D213/65 , C07D213/64 , C07D513/04 , C07D333/20 , C07D213/69
CPC分类号： C07D213/40 , C07C233/59 , C07C233/60 , C07C233/62 , C07C235/40 , C07C255/29 , C07C255/60 , C07C317/32 , C07C317/40 , C07C323/40 , C07C327/46 , C07C2601/14 , C07C2602/08 , C07C2602/10 , C07C2602/12 , C07D213/64 , C07D213/65 , C07D213/69 , C07D213/74 , C07D213/75 , C07D215/50 , C07D231/12 , C07D233/56 , C07D249/08 , C07D277/28 , C07D295/13 , C07D295/135 , C07D295/185 , C07D309/12 , C07D311/04 , C07D311/66 , C07D317/58 , C07D317/66 , C07D319/18 , C07D333/20 , C07D333/36 , C07D335/06 , C07D401/06 , C07D401/12 , C07D401/14 , C07D405/12 , C07D409/06 , C07D409/14 , C07D417/12 , C07D417/14 , C07D513/04
摘要： Amide derivatives represented by the following general formula (1) which have a C5α receptor antagonism, wherein each symbol has the meaning as defined in the description. These amide derivatives, optically active isomers thereof or pharmaceutically acceptable salts of the same are useful as preventives and remedies for diseases or syndromes caused by inflammation induced by C5α [for example, immunological diseases such as rheumatism and systemic lupus erythematosus, allergic diseases such as sepsis, adult respiratory distress syndrome, chronic obstructive pulmonary disease and asthma, atherosclerosis, heart infarction, brain infarction, psoriasis, Alzheimer's disease and important organistic breakdown (for example, pneumonia, nephritis, hepatitis, pancreatitis) induced by leukocyte activation caused by ischemic reperfusion, burn or surgical invasion]. Moreover, they are useful as preventives and remedies for infection with bacteria and viruses mediated by C5α receptor.
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公开(公告)号：EP1751115A4
公开(公告)日：2010-10-20
申请号：EP05754265
申请日：2005-05-23
申请人： HOUSEY GERARD M
发明人： HOUSEY GERARD M
IPC分类号： C07D213/81 , C07D213/87 , C07D215/50 , C07D231/14 , C07D237/02 , C07D239/42 , C07D239/48 , C07D239/84 , C07D253/065 , C07D401/12 , C07D405/12 , C07D409/12
CPC分类号： A61K31/5377 , A61K31/166 , A61K31/175 , A61K31/195 , A61K31/27 , A61K31/415 , A61K31/4196 , A61K31/44 , A61K31/4436 , A61K31/444 , A61K31/47 , A61K31/4709 , A61K31/495 , A61K31/505 , A61K31/506 , A61K31/517 , A61K31/53 , C07C243/38 , C07D213/77 , C07D213/81 , C07D213/86 , C07D213/87 , C07D215/38 , C07D215/50 , C07D231/14 , C07D239/42 , C07D239/48 , C07D239/84 , C07D253/065 , C07D253/075 , C07D401/12 , C07D403/12 , C07D405/12 , C07D409/12 , G01N33/5011 , G01N33/502 , G01N33/5041 , G01N33/573 , G01N33/574 , G01N2500/00 , G01N2500/10
摘要： This invention relates to agents that are inhibitors or activators of variant forms of endogenous proteins and novel methods of identifying such variants. Of particular interest are inhibitors and activators of endogenous protein variants, encoded by genes which have mutated, which variants often arise or are at least first identified as having arisen following exposure to a chemical agent which is known to be an inhibitor or activator of the corresponding unmutated endogenous protein.
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