公开(公告)号：EP3036340B1

公开(公告)日：2018-08-01

申请号：EP15728937.2

申请日：2015-05-08

申请人： Kao Corporation

发明人： ITO, Shotaro ,  ISHIKAWA, Junko

IPC分类号： C12Q1/533 ,  G01N33/68

CPC分类号： G01N33/6893 ,  C12Q1/533 ,  G01N33/50 ,  G01N33/6881 ,  G01N2333/99 ,  G01N2500/00 ,  G01N2800/20

摘要： To provide a method for quickly and accurately evaluating a condition of skin dryness and a method for efficiently searching a substance to improve dry skin. A method for evaluating a condition of skin dryness, the method comprising measuring the expression levels of AGR2 and/or AGR3 in skin cells collected from subjects.

公开(公告)号：EP2410050B1

公开(公告)日：2017-06-21

申请号：EP10753285.5

申请日：2010-03-15

申请人： Toppan Printing Co., Ltd. ,  Osaka University ,  Kyushu Bunka Gakuen School Foundation

发明人： IRIE, Shinji ,  TSUJIMURA, Akira ,  MIYAGAWA, Yasushi ,  TANAKA, Hiromitsu

IPC分类号： C12N15/09 ,  C07K16/40 ,  C12N9/90 ,  C12Q1/533 ,  C12Q1/68 ,  G01N33/53

CPC分类号： G01N33/689 ,  C12Q1/6883 ,  C12Q2600/156 ,  C12Q2600/158 ,  G01N2333/99

公开(公告)号：EP3036340A1

公开(公告)日：2016-06-29

申请号：EP15728937.2

申请日：2015-05-08

申请人： Kao Corporation

发明人： ITO, Shotaro ,  ISHIKAWA, Junko

IPC分类号： C12Q1/533 ,  G01N33/68

CPC分类号： G01N33/6893 ,  C12Q1/533 ,  G01N33/50 ,  G01N33/6881 ,  G01N2333/99 ,  G01N2500/00 ,  G01N2800/20

摘要： To provide a method for quickly and accurately evaluating a condition of skin dryness and a method for efficiently searching a substance to improve dry skin. A method for evaluating a condition of skin dryness, the method comprising measuring the expression levels of AGR2 and/or AGR3 in skin cells collected from subjects.

摘要翻译： 提供快速，准确地评价皮肤干燥状态的方法以及有效地检索物质以改善皮肤干燥的方法。 一种用于评估皮肤干燥状况的方法，所述方法包括测量从受试者收集的皮肤细胞中AGR2和/或AGR3的表达水平。

公开(公告)号：EP2315841A1

公开(公告)日：2011-05-04

申请号：EP09807924.7

申请日：2009-08-14

申请人： Novozymes A/S

发明人： LENHARD, Thomas ,  BJOERNVAD, Mads Eskelund ,  PEDERSEN, Poul Erik

IPC分类号： C12Q1/02 ,  C12Q1/533

CPC分类号： C12Q1/02 ,  C12Q1/533 ,  G01N2333/99

摘要： The invention provides methods of screening a microbial host cell for a property of interest in a microfluidic device, the method comprising the steps of: a) transforming a d-alanine racemase-deficient microbial host cell with a polynucleotide construct comprising: i) one or more polynucleotide region providing the property of interest when present in the host cell, and ii) at least one polynucleotide region complementing the d-alanine racemase deficiency when present in the host cell; and b) screening the transformed host cell for the property of interest in the microfluidic device in the absence of externally provided d-alanine.

公开(公告)号：EP2238261A1

公开(公告)日：2010-10-13

申请号：EP08870439.0

申请日：2008-12-22

申请人： Verenium Corporation

发明人： WEINER, David ,  BURKE, Ellen ,  LUGINBUHL, Peter ,  BUENO, Analia ,  CUENCA, Joslin ,  DE SOUZA, Mervyn, L. ,  KOLLMANN, Sherry

IPC分类号： C12Q1/533 ,  C12N9/90 ,  C12N15/61 ,  A61K38/52 ,  C07K16/40

CPC分类号： C12N9/90 ,  A01K67/0275 ,  A01K2217/05 ,  A01K2227/10 ,  A23G3/366 ,  A23G4/123 ,  A23G4/14 ,  A23K20/189 ,  A23L29/06 ,  A23V2002/00 ,  A61K38/00 ,  A61K38/52 ,  C12Q1/533 ,  C12Y501/00 ,  C12Y501/01

摘要： This invention relates generally to enzymes, polynucleotides encoding the enzymes, the use of such polynucleotides and polypeptides and more specifically to enzymes having isomerase activity, e.g., racemase activity, e.g., amino acid racemase activity, alanine racemase activity, and/or epimerase activity, and/or catalyze the re¬ arrangement of atoms within a molecule, catalyze the conversion of one isomer into another, catalyze the conversion of an optically active substrate into a raceme, which is optically inactive, catalyze the interconversion of substrate enantiomers, catalyze the stereochemical inversion around the asymmetric carbon atom in a substrate having only one center of asymmetry, catalyze the stereochemical inversion of the configuration around an asymmetric carbon atom in a substrate having more than one asymmetric center, and/or catalyze the racemization of amino acids. Thus, the invention provides enzymes, compositions, methods for production of pharmaceutical compositions, pharmaceutical intermediates, antibiotics, sweeteners, peptide enzymes, peptide hormones, fuel and fuel additive compositions, foods and food additives, beverage and beverage additives, feeds and feed additives, drugs and drug additives, dietary supplements, textiles, wood, paper, pulp, and detergents comprising the polypeptides or polynucleotides in accordance with the invention.

公开(公告)号：EP1141308B1

公开(公告)日：2007-02-07

申请号：EP99962422.4

申请日：1999-12-22

申请人： Microscience Limited

发明人： HUGHES, Martin John Glenton ,  SANTANGELO, J. D. c/o Microsciences Limited ,  LANE, Jonathan Douglas Microscience Limited ,  EVEREST, Paul ,  FELDMAN, Robert Microscience Limited ,  MOORE, Joanne Christine Microscience Limited ,  WILSON, Rebecca Kerry ,  DOBSON, Richard James ,  DOUGAN, Gordon

IPC分类号： C12N15/31 ,  C12N15/57 ,  C12N15/53 ,  C12N15/56 ,  C12N15/61 ,  C12N1/21 ,  A61K39/09 ,  C12Q1/37 ,  C12Q1/32 ,  C12Q1/34 ,  C12Q1/533 ,  G01N33/68 ,  C07K16/12 ,  A61K48/00

CPC分类号： A61K39/092 ,  A61K39/00 ,  A61K48/00 ,  C07K14/315 ,  G01N33/56944 ,  Y02A50/401

摘要： According to the present invention, a series of genes are identified in Group B Streptococcus, the products of which may be associated with the outer surface of the organism. The genes, or functional fragments thereof, may be useful in the preparation of therapeutics, e.g. vaccines to immunise a patient against microbial infection.

公开(公告)号：EP1532242A4

公开(公告)日：2005-12-07

申请号：EP02757337

申请日：2002-08-23

申请人： PFIZER PROD INC ,  KAROLINSKA INNOVATIONS AB

发明人： JAKOBSSON PER-JOHAN ,  WEINANDER ROLF ,  MORGENSTERN RALF ,  LAMBALOT RALPH H

IPC分类号： G01N33/50 ,  A61K38/43 ,  A61K45/00 ,  A61P1/02 ,  A61P1/04 ,  A61P1/12 ,  A61P1/16 ,  A61P3/10 ,  A61P3/14 ,  A61P7/06 ,  A61P9/00 ,  A61P9/10 ,  A61P11/00 ,  A61P11/06 ,  A61P13/00 ,  A61P13/12 ,  A61P17/00 ,  A61P17/02 ,  A61P17/06 ,  A61P17/16 ,  A61P19/00 ,  A61P19/02 ,  A61P19/06 ,  A61P19/08 ,  A61P19/10 ,  A61P21/00 ,  A61P21/04 ,  A61P25/04 ,  A61P25/28 ,  A61P27/02 ,  A61P27/14 ,  A61P29/00 ,  A61P35/00 ,  A61P35/04 ,  A61P37/00 ,  A61P37/08 ,  A61P41/00 ,  A61P43/00 ,  B01J20/281 ,  C12N1/15 ,  C12N1/19 ,  C12N1/21 ,  C12N5/10 ,  C12N9/90 ,  C12N15/09 ,  C12P31/00 ,  C12Q1/533 ,  G01N30/14 ,  G01N30/26 ,  G01N30/88 ,  G01N33/15 ,  G01N33/68

CPC分类号： C12N9/90 ,  C07K2319/00

公开(公告)号：EP1322957A4

公开(公告)日：2005-11-02

申请号：EP02734211

申请日：2002-05-04

申请人： BIOSITE INC

发明人： VALKIRS GUNARS E ,  DAHLEN JEFFREY R ,  KIRCHICK HOWARD ,  BUECHLER KENNETH F

IPC分类号： C12N15/09 ,  C12Q1/25 ,  C12Q1/37 ,  C12Q1/48 ,  C12Q1/50 ,  C12Q1/527 ,  C12Q1/533 ,  C12Q1/70 ,  G01N33/53 ,  G01N33/68

CPC分类号： G01N33/53 ,  G01N33/6887 ,  G01N33/6893 ,  G01N2333/58 ,  G01N2800/324

摘要： The present invention relates to methods for the diagnosis and evaluation of acute coronary syndromes. In particular, patient test samples are analyzed for the presence and amount of members of a panel of markers comprising one or more specific markers for myocardial injury and one or more non-specific markers for myocardial injury. A variety of markers are disclosed for assembling a panel of markers for such diagnosis and evaluation. In various aspects, the invention provides methods for the early detection and differentiation of stable angina, unstable angina, and myocardial infarction. Invention methods provide rapid, sensitive and specific assays that can greatly increase the number of patients that can receive beneficial treatment and therapy, reduce the costs associated with incorrect diagnosis, and provide important information about the prognosis of the patient.

公开(公告)号：EP1574569A1

公开(公告)日：2005-09-14

申请号：EP03780880.5

申请日：2003-12-18

申请人： RIKEN ,  OSAKA BIOSCIENCE INSTITUTE

发明人： MIYANO, Masashi c/o RIKEN, Harima Institute ,  YAMAMOTO, Masaki c/o RIKEN, Harima Institute ,  KUMASAKA, Takashi c/o RIKEN, Harima Institute ,  AGO, Hideo c/o RIKEN, Harima Institute ,  URADE, Y. 503, Granshitio-Shimogamo-Shikisaikan, ,  IRIKURA, Daisuke ,  ARITAKE, Kosuke

IPC分类号： C12N9/90 ,  C12N9/99 ,  C12N15/09 ,  C12Q1/533 ,  C07D401/06 ,  G06F17/30 ,  G06F17/50 ,  G01N33/50

CPC分类号： C12N9/0004 ,  C07K2299/00 ,  C12Q1/533

摘要： Crystals of lipocalin-type prostaglandin D synthase are produced and analyzed by X-ray difratometry to give the three dimensional structure of enzyme based on which an inhibitor of the enzyme can be designed and selected.

摘要翻译： 通过X射线分光光度法测定脂笼蛋白型前列腺素D合成酶的晶体，得到酶的三维结构，根据该结构可以设计和选择酶的抑制剂。

公开(公告)号：EP1130110A3

公开(公告)日：2005-02-23

申请号：EP01201784.4

申请日：1993-12-17

申请人： MERCK FROSST CANADA & CO.

发明人： Cromlish, Wanda A. ,  Kennedy, Brian P. ,  O'Neill, Gary ,  Vickers, Philip J. ,  Wong, Elizabeth ,  Mancini, Joseph A.

IPC分类号： C12Q1/533 ,  G01N33/88 ,  G01N33/50

CPC分类号： C12N9/0083 ,  C12Q1/48 ,  C12Q1/61 ,  C12Y114/99001 ,  G01N33/5005 ,  G01N33/88 ,  G01N2333/90241

摘要： An assay for determining the cyclooxygenase-2 activity of a sample comprising the steps of: (a) adding(1) a human osteosarcoma cell preparation,(2) a sample, said sample comprising a putative cyclooxygenase-2 inhibitor, and(3) arachidonic acid; and (b) determining the amount of prostaglandin E2 produced in step (a).