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公开(公告)号：EP0773785B1
公开(公告)日：2002-06-26
申请号：EP95927034.9
申请日：1995-07-28
申请人： THE UNIVERSITY COURT OF THE UNIVERSITY OF GLASGOW , THE WISTAR INSTITUTE OF ANATOMY AND BIOLOGY
发明人： MACLEAN, Alasdair, Roderick , BROWN, Susanne, Moira , FRASER, Nigel, William , RANDAZZO, Bruce, Paul
CPC分类号： C12N7/00 , A61K35/763 , C12N2710/16621 , C12N2710/16632
摘要： Use as an anti-cancer agent of a mutant herpes simplex virus wherein the mutant virus comprises a modification in the gamma 34.5 gene in the long repeat region (RL) such that the gamma 34.5 gene is non-functional, manufacture of medicaments and methods of testing cancer in mammals employing HSV mutant.
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公开(公告)号：EP0980205A1
公开(公告)日：2000-02-23
申请号：EP98920098.5
申请日：1998-04-30
CPC分类号： C12N5/0694 , A61K31/704 , A61K33/24 , A61K35/17 , A61K38/00 , A61K45/06 , A61K2035/124 , C12N2501/23 , C12N2510/02 , A61K2300/00
摘要： A method of treating tumors which involves a synergistic combination of chemotherapy and cell therapy is provided. The method of the invention permits reduced amounts of chemotherapeutic agents to be administered, resulting in a reduction of the side effects often associated therewith.
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93.发明公开
公开(公告)号：EP0964686A1
公开(公告)日：1999-12-22
申请号：EP97937292.0
申请日：1997-08-14
发明人： GONCZOL, Eva , BERENCSI, Klara
IPC分类号： C12N15 , A01K67 , A61K31 , A61K35 , A61K38 , A61K39 , A61K45 , A61K48 , A61P9 , C07K14 , C12R1
CPC分类号： C07K14/295 , A01K67/0271 , A61K38/162 , A61K39/00 , A61K39/118 , A61K39/12 , A61K48/00 , A61K2039/51 , A61K2039/5252 , A61K2039/5254 , A61K2039/58 , C07K14/005 , C12N2710/16122 , C12N2710/16134
摘要： A method for preventing or retarding the development of atherosclerotic lesions or restenosis involves administering to a subject, preferably a human, an effective amount of an anti-viral composition directed against CMV, and optionally an anti-microbial composition directed against C. pneumoniae. These compositions may be conventional chemical anti-microbial pharmaceutics. Alternatively, the compositions may contain a cytomegalovirus (CMV) protein or fragment thereof (or nucleic acid containing compositions expressing such protein or fragment). Such compositions may contain an immunogenic C. pneumoniae protein or fragment thereof (or nucleic acid containing compositions expressing such protein or fragment). The protein/nucleic acid compositions are administered in an amount capable of inducing cell mediated immunity and/or antibody response in the subject.
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公开(公告)号：EP0773785A2
公开(公告)日：1997-05-21
申请号：EP95927034.0
申请日：1995-07-28
申请人： MEDICAL RESEARCH COUNCIL , THE WISTAR INSTITUTE OF ANATOMY AND BIOLOGY , THE UNIVERSITY COURT OF THE UNIVERSITY OF GLASGOW
发明人： MACLEAN, Alasdair, Roderick , BROWN, Susanne, Moira , FRASER, Nigel, William , RANDAZZO, Bruce, Paul
CPC分类号： C12N7/00 , A61K35/763 , C12N2710/16621 , C12N2710/16632
摘要： Use as an anti-cancer agent of a mutant herpes simplex virus wherein the mutant virus comprises a modification in the gamma 34.5 gene in the long repeat region (RL) such that the gamma 34.5 gene is non-functional, manufacture of medicaments and methods of testing cancer in mammals employing HSV mutant.
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公开(公告)号：EP0759071A1
公开(公告)日：1997-02-26
申请号：EP95918949.0
申请日：1995-04-25
CPC分类号： C07K16/3061 , C07K16/30 , C12N2799/026 , Y10S435/975 , Y10S530/809
摘要： The present invention provides three unique monoclonal antibodies directed against a portion of the Wilms' tumor antigen, and methods of use therefor in detecting, monitoring and diagnosing malignancies characterized by over-expression or inappropriate expression of the WT1 protein.
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96.发明授权Vaccine for generating an immunogenic T cell response protective against a virus 失效用于产生对病毒的免疫原性细胞应答保护的疫苗
公开(公告)号：EP0203676B1
公开(公告)日：1992-01-29
申请号：EP86301223.3
申请日：1986-02-20
IPC分类号： A61K39/12 , A61K37/02 , A61K39/245 , A61K39/385 , C07K17/00
CPC分类号： A61K39/245 , A61K9/127 , A61K39/12 , A61K39/205 , A61K47/542 , A61K2039/5252 , A61K2039/55555 , A61K2039/55566 , A61K2039/6018 , C07K14/005 , C12N2710/16622 , C12N2710/16634
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97.发明公开
公开(公告)号：EP0327363A3
公开(公告)日：1990-12-05
申请号：EP89301010.8
申请日：1989-02-02
IPC分类号： G01N27/26
CPC分类号： G01N27/44773
摘要： DNA molecules are separated by a gel electrophoresis method which employes alternating higher and lower strength, electric fields applied in opposite directions to a gel matrix containing DNA. The higher strength field is maintained for a shorter interval than the lower strength field, and the ratio of the product of the lower strength field and its pulse interval to the product of the higher strength field and its pulse interval is greater than 4:1 and sufficient to produce a net migration of the DNA molecules in the direction of the lower strength field.
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公开(公告)号：EP0143841B1
公开(公告)日：1990-08-08
申请号：EP84902245.4
申请日：1984-05-09
CPC分类号： C12N15/85 , C12N2710/10322 , C12N2710/16622 , C12N2710/22022 , Y10S435/849
摘要： pML BK is a hybrid plasmid which is constructed of pML which contains the entire nucleotide sequence of the plasmid pBR322 except for deletion of nucleotide sequences 1120-2490 bp and 0 to 375 bp, and BK which contains the entire nucleotide sequence of the Gardner strain of BK virus except for deletion of nucleotide sequences between bp 5089-5196. Into the pML BK plasmid may be inserted a viral or human gene X to be expressed, an example of which is TK which represents the Bam HI generated 3,600 bp DNA fragment of herpes simplex virus type 1 which contains the herpes simplex virus type 1 TK DNA. The majority of the pML BK X DNA molecules remain in the episomal or free state in the human cells 143B and express the gene X.
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公开(公告)号：EP0323708A1
公开(公告)日：1989-07-12
申请号：EP88311331.8
申请日：1988-11-30
发明人： Plotkin, Stanley A. , Clark, H. Fred , Offit, Paul
IPC分类号： A61K39/15
CPC分类号： C07K14/005 , A61K39/00 , A61K39/12 , A61K39/15 , A61K2039/542 , C12N7/00 , C12N2720/12321 , C12N2720/12322 , C12N2720/12334
摘要： The present invention provides novel rotavirus reassortants, vaccines employing the novel reassortants and methods for their preparation and administration. The reassortant contains at least the gene encoding the vp3 neutralization antigen of bovine rotavirus of the WC3 strain and the gene encoding the vp7 neutralization antigen of a selected human rotavirus.
摘要翻译： 本发明提供了新型轮状病毒重配体，采用该新型重配体的疫苗及其制备和给药方法。 重配体至少含有编码WC3株轮状病毒的vp3中和抗原的基因和编码所选人轮状病毒的vp7中和抗原的基因。
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100.发明公开Vaccine, method for its preparation and use thereof in vaccinating humans against rotavirus infection 失效疫苗，准备同样的方法及其抗轮状病毒感染人类的疫苗接种。
公开(公告)号：EP0192404A2
公开(公告)日：1986-08-27
申请号：EP86300941.1
申请日：1986-02-12
IPC分类号： A61K39/12
CPC分类号： A61K39/15 , A61K39/12 , A61K2039/5254 , A61K2039/542 , A61K2039/545 , A61K2039/575 , C12N2720/12334 , Y10S424/813
摘要： A live rotavirus vaccine against bovine and human rotaviruses comprising a strain of live bovine rotavirus which does not hemagglutinate primate red blood cells, gives at least about 20 fold higher titers when neutralized with antiserum therefor as compared to heterologous bovine or primate rotaviruses, and has a migration pattern of its RNA genome segments when determined by PAGE substantially as shown by lane WC3 in Figure 1, the strain of bovine rotavirus having been serially passaged in primate kidney tissue culture a sufficient number of times that when administered to humans the vaccine is immunogenic without causing disease.
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